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Patent # Description
2017/0327530 METHODS OF TREATING AND PREVENTING GASTROINTESTINAL MOTILITY DISORDERS USING AMINOSTEROLS
This invention relates to methods of stimulating the activity of the human and animal enteric nervous system. The method comprises orally administering an...
2017/0327529 20(R)-GINSENOSIDE RG3 POLYACYLATED DERIVATIVES, PREPARATION AND APPLICATION THEREOF
The present invention provides 20(R)-ginsenoside Rg3 polyacylated derivatives of the formula (I) and preparation method and anti-tumor application thereof: ...
2017/0327528 6-ALKYL-7-HYDROXY-4-EN-3-ONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR
The invention relates to compounds of formula (I), wherein R.sup.1, R.sup.2, Y, R.sup.4 and R.sup.5 are as defined herein. The compounds are intermediates in...
2017/0327527 METHOD FOR SOLUTION PHASE DETRITYLATION OF OLIGOMERIC COMPOUNDS
Provided herein are methods for the synthesis of oligomeric compounds wherein removal of the 5'-terminal trityl group is performed at reduced temperature and...
2017/0327526 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES
Provided herein are formulations, methods and substituted 2'-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae...
2017/0327525 SELECTED MACROLIDES WITH PDE4-INHIBITING ACTIVITY
The application relates to the macrolide compound of the formula (I): ##STR00001## wherein * indicates a stereocentre which is in (R) or (S) configuration, or a...
2017/0327524 GALNAC PHOSPHORAMIDITES, NUCLEIC ACID CONJUGATES THEREOF AND THEIR USE
This invention generally relates to the field of phosphoramidite derivatives. In particular, the invention relates to N-Acetylgalactosamine phosphoramidite...
2017/0327523 METHOD OF COALESCING A SUBSTANCE
Provided is a method of coalescing a substance comprising providing a first mixture comprising a substance, agitating at least a portion of the first mixture...
2017/0327522 PROLIFERATIVE DISEASE TREATMENT METHODS WITH PHOSPHAPLATIN COMPLEXES
Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically...
2017/0327521 PHOSPHAPLATIN COMPLEXES AND METHODS FOR TREATMENT OF PROLIFERATIVE DISEASES USING THE PHOSPHAPLATIN COMPLEXES
Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically...
2017/0327520 CONJUGATED BISPHOSPHONATES FOR THE DIAGNOSIS AND THERAPY OF BONE DISEASES
The invention relates to a compound V for complexing metallic isotopes, comprising a chelator X and one or more targeting vectors conjugated with the chelator...
2017/0327519 OXABOROLE ESTERS AND USES THEREOF
The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas...
2017/0327518 COMPOUND FOR LABELING MITOCHONDRIA AND METHOD OF PRODUCING THE SAME
This invention relates to a compound for labeling mitochondria and a method of producing the same, wherein the compound is represented by Chemical Formula 1 or...
2017/0327517 Boronic Acid Inhibitors of HIV Protease
Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to...
2017/0327516 Method for Producing an Organic Electronic Component, and Organic Electronic Component
A metal complex is disclosed. In an embodiment the metal complex includes at least one metal atom M and at least one ligand L attached to the metal atom M,...
2017/0327515 Broad Spectrum Beta-Lactamase Inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
2017/0327514 FLAP MODULATORS
The present invention relates to compounds of Formula (I), or a form thereof wherein ring A, R.sub.1, L and R.sub.2 are as defined herein, useful as FLAP...
2017/0327513 OXAZIRIDINE COMPOUND AND PRODUCTION METHOD THEREOF
Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a...
2017/0327512 MODULATORS OF VASOPRESSIN RECEPTORS WITH THERAPEUTIC POTENTIAL
Compounds comprising piperazines, piperidines, spiro-furanopiperidines, and analogs thereof are provided that are modulators, such as positive allosteric...
2017/0327511 PROCESS FOR THE FORMATION OF HYDROCODONE BITATRATE
There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a...
2017/0327510 PHTHALOCYANINE COMPOUND AND METHOD OF PREPARING THE SAME, COLOR FILTER CONTAINING PHTHALOCYANINE COMPOUND, AND...
Provided is a phthalocyanine compound which has a green hue without having a halogen atom, and exhibits high luminance and an excellent coloring force at the...
2017/0327509 TWO-PHOTON ABSORBING FLUOROPHORES AND METHOD FOR CELLULAR IMAGING USING THE SAME
The present invention relates to new one-photon or two-photon absorbing fluorophores, a method for preparing the same, and a method for cellular imaging using...
2017/0327508 DEUTERATED HETEROARYL SULFONAMIDES AND THEIR USE
Compunds are provided that act as potent antagonists of the CCR2 receptor. These compounds are useful for treating inflammation, a hallmark disease for CCR2....
2017/0327507 PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF
The present invention provides a process for the preparation of baricitinib and an intermediate thereof. The present invention provides a convenient,...
2017/0327506 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
The present invention relates to 6-amino-7-bicyclo-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in...
2017/0327505 SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALT
The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of...
2017/0327504 Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula...
2017/0327503 OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY,...
Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
2017/0327502 IMIDAZOTRIAZINONE COMPOUNDS
The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The...
2017/0327501 CARBOXAMIDE DERIVATIVES USEFUL AS RSK INHIBITORS
Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the...
2017/0327500 SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
2017/0327499 PRODUCTION PROCESS OF CRYSTALS OF DIAZABICYCLOOCTANE DERIVATIVE AND STABLE LYOPHILIZED PREPARATION
A process for producing crystals of a compound represented by the following formula (l): ##STR00001## by crystallizing the compound from an aqueous solution...
2017/0327498 NOVEL TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using...
2017/0327497 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES
Disclosed are compounds of Formula 1, ##STR00001## and pharmaceutically acceptable salts thereof, wherein G, p, R.sup.1, R.sup.2, R.sup.3a, R.sup.4, and R.sup.5...
2017/0327496 INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically...
2017/0327495 PESTICIDALLY ACTIVE AMIDE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers...
2017/0327494 NON-INVASIVE VENTILATION WITH HIGH FREQUENCY OSCILLATIONS
Compounds of the formula (I) wherein X and Y are independently O, S or NR.sup.5, R.sup.1, R.sup.2 and R.sup.4 are independently hydrogen, halogen,...
2017/0327493 CXCR7 RECEPTOR MODULATORS
The present invention relates to derivatives of formula (I) ##STR00001## wherein (R.sup.1).sub.n, ring (A), Y.sup.1, Y.sup.2, X, R.sup.4, L.sup.1, L.sup.2, and...
2017/0327492 TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt
The present invention comprises methods of making 5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-- ...
2017/0327491 DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPOID RECEPTOR AGNISTS
A compound of formula I, for use in pain therapy and a pharmaceutical composition comprising said compound. ##STR00001##
2017/0327490 PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. The present invention is...
2017/0327489 Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid...
2017/0327488 SOLID FORMS OF AN ANTIVIRAL COMPOUND
Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-- ...
2017/0327487 BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS
The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to...
2017/0327486 METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS
Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert...
2017/0327485 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
The present invention relates to a compound of the formula I ##STR00001## wherein R.sup.1 to R.sup.6, A, B, n and m are as defined herein. Such novel sulfonyl...
2017/0327484 PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZAL- DEHYDE
Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzal- dehyde (also referred to herein as...
2017/0327483 Pyridinyl derivatives, pharmaceutical compositions and uses thereof
The invention relates to new pyridinyl derivatives of the formula ##STR00001## wherein R.sup.1 and A are as defined in the description and claims, to their use...
2017/0327482 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCOSITIS
The invention relates to the compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII, or its...
2017/0327481 COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS
The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: ##STR00001##
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