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Patent # Description
2017/0327581 Anti-Leukocyte Adhesion for the Mitigation of Potential Adverse Events Caused by CD3-Specific Binding Domains
The present invention relates in essence to a compound which decreases or inhibits the binding of mammalian T-cells to mammalian endothelial cells for use in a...
2017/0327580 BISPECIFIC ANTIBODIES AGAINST CD3 EPSILON AND BCMA FOR USE IN TREATMENT OF DISEASES
The disclosure relates to bispecific antibodies against CD3c and BCMA for use in the treatment of diseases. The disclosure provides methods of determining the...
2017/0327579 BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND BCMA
A bispecific antibody specifically binding to the extracellular domain of human BCMA and human CD3.epsilon., characterized in comprising a common antibody...
2017/0327578 ANTI-CEACAM1 RECOMBINANT ANTIBODIES FOR CANCER THERAPY
Provided herein are recombinant monoclonal antibodies and antigen-binding portions thereof useful in inhibiting CEACAM1 in tumor cells, and methods of their...
2017/0327577 METHODS OF CONSTRUCTING AMINO TERMINAL IMMUNOGLOBULIN FUSION PROTEINS AND COMPOSITIONS THEREOF
Disclosed herein are immunoglobulin fusion proteins comprising a first immunoglobulin region attached to a therapeutic peptide at the amino terminus of the...
2017/0327576 ANTI P2X7 RECEPTOR ANTIBODIES AND FRAGMENTS THEREOF
The invention relates to an antigen binding site for binding to a P2X.sub.7 receptor, the antigen binding site being defined by general formula 1:...
2017/0327575 Folate Receptor 1 Antibodies and Immunoconjugates and Uses Thereof
Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using...
2017/0327574 METHODS OF TREATING LIVER CONDITIONS USING NOTCH2 ANTAGONISTS
Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2...
2017/0327573 Composition to induce bone marrow stem cell mobilization
A pharmaceutical composition to induce bone marrow stem cell mobilization from the bone marrow to peripheral blood in patients suffering from pathological...
2017/0327572 TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY ANTAGONISM OF THE IL-20R
The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In...
2017/0327571 ANTI-HUMAN IL-17 MONOCLONAL ANTIBODIES AND USE THEREOF
The present application discloses a novel anti-human IL-17 monoclonal antibody obtained by phage antibody library screening and genetic engineering, or a...
2017/0327570 ANTI-TNF-alpha FULLY HUMAN MONOCLONAL ANTIBODIES WITH LOW IMMUNOGENICITY AND APPLICATION THEREOF
Disclosed herein are low immunogenic human anti-TNF-.alpha. antibodies which can inhibit the apopotosis of cells induced by TNF-.alpha.. The invented low...
2017/0327569 Novel Angiopoietin 2, VEGF Dual Antagonists
The present disclosure relates to chimeric molecules which are fusion proteins comprising two components: an Ang-2 binding peptide linked to either a VEGF...
2017/0327567 COMBINATION OF ANTI-PD-1 ANTIBODIES AND RADIATION TO TREAT CANCER
The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., solid tumors). The methods of the present...
2017/0327566 ANTI-ALPHA-SYNUCLEIN ANTIBODIES AND METHODS OF USE
The invention provides anti-human alpha-synuclein antibodies and methods of using the same.
2017/0327565 CROSS-PROTECTIVE PATHOGEN PROTECTION, METHODS AND COMPOSITIONS THEREOF
The present disclosure provides a method of inducing a cross-protective immune response in a subject against a pathogen, such as influenza, comprising...
2017/0327564 COMPOSITIONS AND METHODS FOR TREATMENT IN BROAD-SPECTRUM, UNDIFFERENTIATED OR MIXED CLINICAL APPLICATIONS
The disclosure provides improved compositions and methods for passive immunization. In embodiments, a composition comprising a synergistic combination of...
2017/0327563 Methods for Treating HIV-Associated Enteropathy Symptoms With Immunoglobulin/Protein Isolate
The present invention provides a method for treating human immunodeficiency virus (HIV)-associated enteropathy in subjects who have been on antiretroviral...
2017/0327562 DESIGNER COLLAGENS AND USE THEREOF
The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound...
2017/0327561 Anti-Angiogenic Properties of Collagen V Derived Fragments
The present invention relates to a peptide comprising an amino acid sequence at least 85% identical to the amino acid sequence as shown in SEQ ID NO. 1,...
2017/0327560 GDF15 FUSION PROTEINS AND USES THEREOF
Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion...
2017/0327559 VIRAL INACTIVATION USING IMPROVED SOLVENT-DETERGENT METHOD
The present specification discloses methods of inactivating a lipid-coat containing virus and proteins essentially free of a lipid-coat containing virus...
2017/0327558 MAMMALIAN CELL CULTURE PROCESSES FOR PROTEIN PRODUCTION
The present invention describes methods and processes for the production of proteins by animal cell or mammalian cell culture. In one aspect, the methods...
2017/0327557 Efficient delivery of therapeutic molecules to cells of the inner ear
Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by...
2017/0327556 CARTILAGE-BINDING FUSION PROTEINS
Provided herein are fusion proteins comprising a first domain that specifically binds to the extracellular domain of a growth factor receptor, and a second...
2017/0327555 MOLECULES THAT SELECTIVELY ACTIVATE REGULATORY T CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
This invention provides for a fusion protein between an IL2.alpha..beta..gamma. Selective Agonist protein (IL2 Selective Agonist) and a IgG Fe protein. The IL2...
2017/0327554 CHEMOKINE-CYTOKINE FUSION PROTEINS AND THEIR APPLICATIONS
The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine...
2017/0327553 COMPOSITIONS AND METHODS FOR LONG ACTING PROTEINS
The present invention provides peptide tags that can be linked to a therapeutic molecule in order to decrease the clearance of the therapeutic molecule from...
2017/0327552 PEPTIDES AND COMPOSITIONS FOR TREATMENT OF JOINT DAMAGE
The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions...
2017/0327551 METHODS OF USING COMPOSITIONS COMPRISING FUSION VARIANTS OF FGF19 POLYPEPTIDES FOR REDUCING GLUCOSE LEVELS IN A...
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2017/0327550 NBP158 AND USES THEREOF
This invention provides nucleic acid molecules encoding the N-terminal 158 amino acids of secreted human Fibroblast Growth Factor Binding Protein 3 (NBP158),...
2017/0327549 Adenylation Enzyme Inhibitors
The present invention concerns compounds that are capable of covalently entrapping adenylating enzymes. The present invention is essentially based on the...
2017/0327548 Charged Nutritive Fragments, Proteins and Methods
Charged nutritive proteins provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the...
2017/0327547 Novel Chimeric Insecticidal Proteins Toxic or Inhibitory to Lepidopteran Pests
Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide...
2017/0327546 Novel Insecticidal Proteins and Methods for Their Use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2017/0327545 Modified Kappa Light Chain-Binding Polypeptides
A kappa light chain-binding polypeptide comprising or consisting essentially of one or more binding domains of Peptostreptococcus Protein L, each of said...
2017/0327544 RECOMBINANT VIRAL VECTORS
The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The...
2017/0327543 POLYIONIC PAPILLOMA VIRUS-LIKE PARTICLE (VLP) VACCINES
The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle...
2017/0327542 TEICOPLANIN ANALOGS AND USES THEREOF
Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2017/0327541 METHODS FOR SYNTHESIZING alpha4 7 PEPTIDE ANTAGONISTS
The present invention provides methods of making .alpha.4.beta.7 peptide monmer and dimer antagonists. Methods of the present invention include solid phase and...
2017/0327540 METHOD FOR ACYLATING A CYCLIC PEPTIDE
The present invention relates to a process for acylating cyclic peptides bearing an amino group and to the application of said process in the preparation of...
2017/0327539 Peptide and Complex of Same, Scaffold for Tissue Repair and Surface Treatment Method for Same, and Surface...
A peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a...
2017/0327538 Peptide Inhibitors of Sodium Channels
The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium...
2017/0327537 BINDING LIGAND LINKED DRUG DELIVERY CONJUGATES OF TUBULYSINS
Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include...
2017/0327536 NEUROTOXIC TARGET FOR AMYLOSPHEROID, METHOD AND MATERIAL FOR REDUCING THE NEUROTOXICITY OF AMYLOSPHEROID, AND...
In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid...
2017/0327535 AFFINITY SEPARATION MATRIX FOR PURIFYING PROTEIN CONTAINING IMMUNOGLOBULIN K CHAIN VARIABLE REGION
An affinity separation matrix includes a water-insoluble base material; and a ligand that is immobilized on the water-insoluble base material, wherein the...
2017/0327534 SEPARATION MATRIX
The invention relates to a separation matrix comprising at least 11 mg/ml Fc-binding ligands covalently coupled to a porous support, wherein: a) the ligands...
2017/0327533 METHOD FOR SPECIFIC CLEAVAGE OF C Alpha-C BOND AND SIDE CHAIN OF PROTEIN AND PEPTIDE, AND METHOD FOR...
The present invention provides a method for specifically cleaving a C.alpha.-C bond of a peptide backbone and/or a side chain of a protein and a peptide, and a...
2017/0327532 METHODS, COMPOSITIONS, AND KITS USING HETEROGENEOUS CATALYSTS
Described herein are methods, compositions and kits utilizing heterogeneous metal catalysts for the preparation of cycloaddition compounds, such as triazoles...
2017/0327531 6.ALPHA.-ALKYL-6,7-DIONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR MODULATORS
The invention relates to compounds of formula (I), wherein R.sup.1, R.sup.2, Y, R.sup.4 and R.sup.5b are as defined herein. The compounds are intermediates in...
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