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Patent # Description
2017/0335008 USE OF SEMAPHORIN-4D INHIBITORY MOLECULES IN COMBINATION WITH AN IMMUNE MODULATING THERAPY TO INHIBIT TUMOR...
Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of Plexin-B1-expressing cancer cells in a subject, comprising...
2017/0335007 ANTI-CD39 ANTIBODIES AND USES THEREOF
The present disclosure relates generally to anti-CD39 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
2017/0335006 CD83 BINDING PROTEINS AND USES THEREOF
An isolated or recombinant CD83 binding protein may include an antigen binding domain, wherein the antigen binding domain binds specifically to CD83 or a cell...
2017/0335005 Anti-Endoglin Antibodies and Uses Thereof
The present application relates to compositions of humanized and deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates...
2017/0335004 FN14-BINDING PROTEINS AND USES THEREOF
The present invention provides an isolated or recombinant Fn14-binding protein comprising an antigen binding do main, wherein the antigen binding domain binds...
2017/0335003 BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC
The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector comprising a recombinant polynucleotide encoding DsbC...
2017/0335002 HIV ANTIBODY THERAPY AS TREATMENT SUBSTITUTE
This invention relates to the use of antibody therapy as a treatment substitute, or for treatment interruption, to treat HIV-1 infected patients. Specifically,...
2017/0335001 Detection of EphA3 as a Marker of the Presence of a Solid Tumor
The invention provides methods and compositions for detecting non-hematopoietic, non-tumor EphA3-expressing cells in cancer patients and for monitoring the...
2017/0335000 ANTIBODIES TO VLA-1
Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are...
2017/0334999 METHODS OF TREATING CONDITIONS WITH ANTIBODIES THAT BIND B7-H4
Provided herein are embodiments relating to therapeutic applications of B7-H4 antibodies.
2017/0334998 CHIMERIC ANTIGEN RECEPTOR (CAR) WITH ANTIGEN BINDING DOMAINS TO THE T CELL RECEPTOR BETA CONSTANT REGION
The present disclosure relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta constant region...
2017/0334997 SINGLE CHAIN VARIABLE FRAGMENT CD3 BINDING PROTEINS
Disclosed herein are single chain variable fragment CD3 binding proteins with improved binding affinities, and robust aggregation profiles. Also described are...
2017/0334996 FUSION PROTEINS CONTAINING RECOMBINANT CYTOTOXIC RNASES
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly,...
2017/0334995 ANTIBODY MOLECULES FOR CANCER TREATMENT
The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules;...
2017/0334994 COMPOSITIONS AND METHODS FOR TREATING CLOSTRIDIUM DIFFICILE INFECTION
Clostridium difficile is the most common hospital acquired pathogen in the United States, and infection is in many cases fatal. Toxins A and B are its major...
2017/0334993 TREATMENT OF PEDIATRIC BCP-ALL PATIENTS WITH AN ANTI-KIR ANTIBODY
This disclosure provides a method for treating a pediatric subject afflicted with acute B cell precursor leukemia (BCP-ALL) comprising administering to the...
2017/0334992 BISPECIFIC MOLECULE BINDING TLR9 AND CD32 AND COMPRISING A T CELL EPITOPE FOR TREATMENT OF ALLERGIES
A molecule or molecule complex capable of binding to TLR9 and to CD32 comprising at least one epitope of at least one antigen, its production and its use a...
2017/0334991 ANTI-CLDN CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE
Provided herein are novel anti-CLDN chimeric antigen receptors and methods of using the same to treat proliferative disorders.
2017/0334990 VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING AGENTS AND USE THEREOF
The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a...
2017/0334989 ANTIBODIES TO NTB-A
Anti-NTB-A antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments...
2017/0334988 BAK BINDING PROTEINS
The present disclosure provides Bak binding proteins that change the conformation of Bak and uses thereof.
2017/0334987 ANTI-ACTH ANTIBODIES AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the...
2017/0334986 ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
2017/0334985 ANTI-IL-13/IL-17 BISPECIFIC ANTIBODIES AND USES THEREOF
The invention provides anti-IL-13/IL-17 bispecific antibodies, in particular, anti-IL13/IL17 AA, AF and FF antibodies and methods of using the same, including...
2017/0334984 HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 8 (IL-8)
Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or...
2017/0334983 SEQUENCES DIRECTED AGAINST HEPATOCYTE GROWTH FACTOR (HGF) AND POLYPEPTIDES COMPRISING THE SAME FOR THE...
The present invention relates to biological materials against HGF and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods...
2017/0334982 Inflammatory Disease Treatment Composition Including Anti-Myosin Regulatory Light-Chain Polypeptide Antibody
Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for...
2017/0334981 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF INHIBIT DNA REPAIR
Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by...
2017/0334980 ANTI-PROPERDIN ANTIBODIES AND USES THEREOF
This invention relates to selective inhibition of the alternative pathway (AP) of the complement system using an anti-properdin antibody. Specifically, the...
2017/0334979 SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN
Disclosed herein are single domain serum albumins binding proteins with improved thermal stability, binding affinities, and robust aggregation profiles. Also...
2017/0334978 METHOD FOR THE TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS
The invention is in the field of methods and preparations for medical treatments, in particular the treatment of idiopathic pulmonary fibrosis (IPF). The...
2017/0334977 Targeting Apolipoprotein E (APOE) in Neurologic Disease
Methods for treating neurologic diseases, e.g., amyotrophic lateral sclerosis (ALS) and multiple sclerosis, by modulating the APOE-TGFbeta pathway. The methods...
2017/0334976 ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF
The present invention provides anti-C1q antibodies and methods of using the same.
2017/0334975 POLYCLONAL ANTIBODIES SPECIFIC FOR SEROGROUP X OF N. MENINGITIDIS AND USES THEREOF IN DIAGNOSIS
Polyclonal antibodies specific for serogroup X of N. meningitidis and uses thereof in diagnosis. The present invention is directed to polyclonal antibodies,...
2017/0334974 COMPOSITION AND METHODS BASED ON NEUTRALIZING ANTIBODIES DELIVERED INTRANASALLY FOR ENHANCED THERAPEUTIC EFFICACY
The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly...
2017/0334973 NON-HUMAN PRIMATE-DERIVED PAN-EBOLA AND PAN-FILOVIRUS MONOCLONAL ANTIBODIES DIRECTED AGAINST ENVELOPE GLYCOPROTEINS
The disclosure provides non-human primate-derived binding molecules, e.g., antibodies or antigen-binding fragments thereof, that can bind to orthologous...
2017/0334972 HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and...
2017/0334971 Alpha-1-Antitrypsin (A1AT) Fusion Proteins and Uses Thereof
The invention relates to MIC-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a MIC-1 protein or an analogue...
2017/0334970 Generating Targeted Sequence Diversity in Proteins
Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or...
2017/0334969 METHOD FOR PRODUCING HIGH-CONCENTRATION COLLAGEN FOR USING AS MEDICAL MATERIAL
Disclosed is a method of producing high-concentration collagen for use as a medical material, including: washing tissue of a mammal; subjecting the washed...
2017/0334968 CHIMERIC ANTIGEN RECEPTORS (CAR) TO SELECTIVELY TARGET PROTEIN COMPLEXES
Chimeric antigen receptor (CAR) constructs are provided that are able to selectively bind to specific protein complexes, such as HER 1/HER3 heterodimer...
2017/0334967 TREATMENT OF CANCER USING GFR ALPHA-4 CHIMERIC ANTIGEN RECEPTOR
The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the ...
2017/0334966 ANTI-TUMOR ANTIBODY-TUMOR SUPPRESSOR FUSION PROTEIN COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT OF CANCER
The present invention is directed to methods and compositions for treating cancer, including, hematologic malignancies, such as B-cell malignancies, with...
2017/0334965 SFRP5-DERIVED PEPTIDE FRAGMENT AND COSMETIC COMPOSITION FOR SKIN WHITENING CONTAINING SAME
Provided is a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), i.e., a peptide fragment selected from the group consisting of the peptides as...
2017/0334964 Ligand
The present invention provides a variant proliferation-inducing ligand (APRIL), which has a higher binding affinity to BCMA than wild-type APRIL; and/or...
2017/0334963 IDENTIFICATION AND USE OF NOVOPEPTIDES FOR THE TREATMENT OF CANCER
Compositions, methods, systems, apparatus and/or articles of manufacture are disclosed for reducing the susceptibility of a population and/or members thereof...
2017/0334962 FcRn-TARGETED ANTIGEN FUSION PROTEINS
The invention disclosed herein generally relates to fusion proteins for use alone or as adjuvants or antigen delivery vehicles for vaccines.
2017/0334961 MASP ISOFORMS AS INHIBITORS OF COMPLEMENT ACTIVATION
The present invention relates to novel ficolin-associated polypeptides, and polypeptides derived from these ficolin-associated polypeptides for the use in the...
2017/0334960 METHODS AND COMPOSITIONS FOR DELIVERING INTERLEUKIN-1 RECEPTOR ANTAGONIST
Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1...
2017/0334959 PROTOXIN-II VARIANTS AND METHODS OF USE
The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
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