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Patent # Description
2017/0334958 PROTEIN SCAFFOLDS FOR ANTIBODY MIMICS AND OTHER BINDING PROTEINS
Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such...
2017/0334957 PLANT PROMOTER AND 3'UTR FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a Zea mays...
2017/0334956 PLANT PROMOTER AND 3'UTR FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a Zea mays...
2017/0334955 VARIANTS OF GAL2 TRANSPORTER AND THEIR USES
The present invention relates to polypeptides which are Gal2 variants comprising at least one amino acid substitution at a position corresponding to M435, and...
2017/0334954 Mutated Immunoglobulin-Binding Polypeptides
An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO:...
2017/0334953 MOSQUITOCIDAL XENORHABDUS, LIPOPEPTIDE AND METHODS
Provided is a bacterial strain which produces a family of mosquitocidal toxins, Xenorhabdus MT, on deposit with the American Type Culture Collection, PTA-6826,...
2017/0334952 METHODS AND KITS FOR THE DIAGNOSIS OF CANCER THROUGH DETECTION OF HUMAN ENDOGENOUS RETROVIRUS ENV (HERV-WL)
The present invention relates to methods and kits for diagnosis of cancer in a subject by detecting human endogenous retrovirus env (HERV-WL) polypeptides.
2017/0334951 IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF
This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a...
2017/0334950 SUBSTRATES FOR FLT3 KINASE AND USES THEREOF
The invention provides kinase substrates and methods comprising their use.
2017/0334949 REAGENT KIT AND METHOD FOR REMOVING BACTERIAL ENDOTOXIN IN BIOLOGICAL PRODUCT
Disclosed are a reagent kit for removing a bacterial endotoxin in a biological product, a method for using the reagent kit for removing the bacterial endotoxin...
2017/0334948 LIGANDS FOR ANTIBODY AND FC-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMOTOGRAPHY IV
The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a...
2017/0334947 AFFINITY SEPARATION MATRIX FOR FAB REGION-CONTAINING PEPTIDE
The objective of the present invention is to provide an affinity separation matrix having excellent adsorption performance and binding capacity to a peptide...
2017/0334946 OXOLUPENE DERIVATIVES
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid...
2017/0334945 EXTENDED BETULINIC ACID ANALOGS
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid...
2017/0334944 NEUROACTIVE 19-ALKOXY-17(20)-Z-VINYLCYANO-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT...
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically...
2017/0334943 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF
6-aryl-9-glycosidpurines of general formula I ##STR00001## and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts...
2017/0334942 DERIVATIVES OF URIDINE 5'-CYCLOPHOSPHATE USEFUL TO TREAT HEPATITIS C VIRAL INFECTIONS
Some embodiments of the present invention include nucleoside 5'-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such...
2017/0334941 2',2'-DIHALO NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow...
2017/0334940 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS
An Embodiment of the invention relates to a compound of the general formula. The compound of formula is suitable for use in a method for treating a disorder...
2017/0334939 MODULAR ASSEMBLY OF METAL-ORGANIC SUPER-CONTAINERS INCORPORATING CALIXARENES
A new strategy to design container molecules is presented. Sulfonylcalix[4]arenes, which are synthetic macrocyclic containers, are used as building blocks that...
2017/0334938 ALVOCIDIB PRODRUGS HAVING INCREASED BIOAVAILABILITY
Compounds having the following structure (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein one of R.sup.1,...
2017/0334936 ANTHRACENE-9, 10-DIONE DIOXIME COMPOUND PRODRUGS AND THEIR USES
Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures;...
2017/0334935 PROCESS FOR PURIFYING MONOOCTYLIN TRICHLORIDE
The present invention provides a process for producing monooctyltin trichloride comprising very low levels of dioctyltin and trioctyltin compounds, said...
2017/0334934 Macrocyclic picolinamides as fungicides
This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. ##STR00001##
2017/0334933 SURFACE TREATMENT AGENT AND NOVEL COMPOUND
A surface treatment agent including a compound (.alpha.) is provided. The compound (.alpha.) has one or more M-OH groups and/or groups capable of forming M-OH...
2017/0334932 CHIMERIC COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros...
2017/0334931 2,3-Dihydro-Thiazolo[3,2-A]Pyridin-5-One Derivatives, Intermediates Thereof, and Their Use as Antibacterial Agents
The disclosure relates to certain novel substituted ring-fused thiazolino 2-pyridines of Formula I, to processes for preparing such compounds, to their use in...
2017/0334930 BACE1 INHIBITORS
The present invention provides a compound of formula (I), having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
2017/0334929 DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including...
2017/0334928 Purification of Rapamycin Derivatives Using Temperature Induced Phase Separation
The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also...
2017/0334927 Nitroimidazole Compound, Preparation Method Therefor And Use Thereof In Drug Manufacturing
A nitroimidazole compound represented by general formula (I) or an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a preparation...
2017/0334926 PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS
The present invention is directed to a process for preparing Substituted Indole Compounds of Formula (I): wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as...
2017/0334925 Thienopyranones as Kinase and Epigenetic Inhibitors
The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral...
2017/0334924 Spirocyclic Heterocyclic Compounds Useful As HIV Integrase Inhibitors
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R.sup.1,...
2017/0334923 OPIOID RECEPTOR MODULATORS
The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1...
2017/0334922 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as...
2017/0334921 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2017/0334920 FUSED HETEROARYL PYRIDYL AND PHENYL BENZENESUFLONAMIDES AS CCR2 MODULATORS FOR THE TREATMENT OF INFLAMMATION
Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in...
2017/0334919 2-((4-AMINO-3-(3-FLUORO-5-HYDROXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1 -YL)METHYL)-3-(2-(TRIFLUORO-MET...
The present invention relates inter alia to a compound of formula (I) ##STR00001## and to compositions comprising the same and to the use of the compounds and to...
2017/0334918 BMP Inhibitors and Methods of Use Thereof
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation,...
2017/0334917 PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE
The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in...
2017/0334916 SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
The invention provides substituted pyrazolo[1,5-a]pyrimidine and related organic compounds, compositions containing such compounds, medical kits, and methods...
2017/0334915 NEW PYRAZOLOPYRIMIDINE DERIVATIVES AS NIK INHIBITORS
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
2017/0334914 DUAL SELECTIVE PI3 DELTA AND GAMMA KINASE INHIBITORS
The present invention relates to dual delta (.delta.) and gamma (.gamma.) PI3K protein kinase modulators, methods of preparing them, pharmaceutical ...
2017/0334913 Methods Of Preparing Carbocyclic Nucleosides
The present disclosure provides methods of preparing carbocyclic nucleosides, in particular, Prurisol.TM. ((-) ...
2017/0334912 Purine Diones As Wnt Pathway Modulators
The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R.sup.1,...
2017/0334911 N-SUBSTITUTED BETA-CARBOLINIUM COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS
The present invention relates to the N-substituted beta-carbolinium compounds of general formula A and formulae I and II wherein, R.sub.1 and R.sub.2 groups...
2017/0334910 FORMS OF METHYL {4,6-DIAMINO-2-[1 (2-FLUOROBENZYL)-1H-PYRAZOLO[3-4-B]PYRIDINO-3-YL]PYRIMIDINO-5-YL}METHYL ...
This present invention relates to forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimi- dino-5-yl}methylcarbamate...
2017/0334909 SYNTHESIS OF A COMPOUND THAT MODULATES KINASES
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## or a salt thereof, active on the receptor protein kinases...
2017/0334908 NOVEL HIGH PENETRATION DRUGS AND THEIR COMPOSITIONS THEREOF FOR TREATMENT OF PARKINSON DISEASES
One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of...
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