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Patent # Description
2017/0342155 METHODS AND COMPOSITIONS RELATING TO ANTI-CCR7 ANTIGEN BINDING PROTEINS
The present invention provides compositions and methods relating to antigen binding proteins against CCR7, including antibodies, nucleic acids, vectors,...
2017/0342154 MODIFIED ANTIBODY CONSTANT REGION
The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated...
2017/0342153 FUSION POLYPEPTIDE INHIBITING VEGF-C, VEGF-D AND/OR ANGIOPOIETIN-2, AND USE THEREOF
A fusion polypeptide capable of binding simultaneously to angiopoietin 2, VEGF-C and VEGF-D; or capable of binding simultaneously to VEGF-C and VEGF-D, and...
2017/0342152 ANTI-GLYCOPROTEIN IIb/IIIa ANTIBODIES
Antibodies and antigen-binding antibody fragments that bind to GPIIb/IIIa and chimeric polypeptides comprising these binding molecules are disclosed. Some of...
2017/0342151 ANTI-CHONDROITIN SULFATE PROTEOGLYCAN 4 ANTIBODIES AND USES THEREOF
Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and...
2017/0342150 METHOD OF TREATING MULTIPLE MYELOMA USING COMBINATION THERAPIES BASED ON ANTI-CS1 ANTIBODIES
Compositions and methods for treating MM are provided herein.
2017/0342149 ANTIBODY THERAPY FOR MODULATING FUNCTION OF INTESTINAL RECEPTORS AND METHODS OF TREATING DIABETES AND OBESITY
The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a...
2017/0342148 ANTI IL-34 ANTIBODIES
The present disclosure relates to novel anti IL-34 antibodies or antigen-binding fragments thereof specifically binding cytokine IL-34 with high affinity, the...
2017/0342147 Antibodies for IL-17C
The present invention provides antibodies or antibody fragments binding to human IL-17C. In particular, it relates to antibodies or antibody fragments that...
2017/0342146 NANOBODIES AGAINST TUMOR NECROSIS FACTOR-ALPHA
The present invention relates to improved Nanobodies.TM. against Tumor Necrosis Factor-alpha (TNF-alpha), as well as to polypeptides comprising or essentially...
2017/0342145 PROTEIN PURIFICATION USING DISPLACEMENT CHROMATOGRAPHY
Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to...
2017/0342144 ENGINEERED ANTI-TGF-BETA ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS
Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-.beta. (TGF.beta.). TGF.beta.-isoform selective antibodies or...
2017/0342143 ANTI-NGF ANTIBODIES AND METHODS USING SAME
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use...
2017/0342142 PEPTIDE-HINGE-FREE FLEXIBLE ANTIBODY-LIKE MOLECULE
The present invention provides an antibody that can bind to targets with greater affinity. A flexible antibody-like molecule having a nonpeptide hinge part...
2017/0342141 USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN...
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody...
2017/0342140 MONOCLONAL ANTIBODY REACTING WITH GLYCOPEPTIDE, AND USE THEREOF
Disclosed is a monoclonal antibody reacting with a glycopeptide, wherein the glycopeptide contains a core fucose moiety and at least 4 contiguous amino acid...
2017/0342139 Methods for Treatment of Refractory Generalized Myasthenia Gravis
The disclosure provides methods of treating myasthenia gravis (MG) in a subject in need thereof by administering to the subject a substance that specifically...
2017/0342138 Method for and use of blocking immunosuppressive functions of pathogens
The present invention provides a method for blocking immunosuppressive functions of pathogens, comprising: applying to an environment where the pathogens exist...
2017/0342137 MONOCLONAL ANTIBODY INHIBITING IMMUNOSUPPRESSIVE FUNCTIONS OF PATHOGENS, ANTIGEN-BINDING FRAGMENT THEREOF, AND...
The present invention relates to a monoclonal antibody that inhibits immunosuppressive functions of pathogens, antigen-binding fragment thereof, and hybridomas...
2017/0342136 MONOCLONAL ANTIBODY AGAINST MURAMYL PEPTIDES IN PREVENTION AND TREATMENT OF IMMUNE-MEDIATED DISEASES
Disclosed are methods of treating an autoimmune or inflammatory disease using a composition comprising an isolated antibody or an antigen-binding fragment or...
2017/0342135 Antibodies With Simultaneous Subsite Specificities To Protein and Lipid Epitopes
Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than...
2017/0342134 RSV G PROTEIN SPECIFIC ANTIBODIES
The invention relates to human isolated, synthetic or recombinant antibodies or functional parts thereof, specific for the RSV G protein. Antibodies specific...
2017/0342133 sc(Fv)2 SITE-DIRECTED MUTANT
To solve the above-mentioned problems, the present inventors introduced site-specific mutations into sc(Fv)2 and examined the stabilizing effects on sc(Fv)2....
2017/0342132 SECRETION OF HEME-CONTAINING POLYPEPTIDES
This disclosure provides for methods and compositions for the expression and secretion of heme-containing polypeptides.
2017/0342131 SECRETION OF HEME-CONTAINING POLYPEPTIDES
This disclosure provides for methods and compositions for the expression and secretion of heme-containing polypeptides.
2017/0342130 GELATIN PURIFICATION
Described is an improved method of removing lipopolysaccharide from an aqueous medium comprising gelatin and lipopolysaccharides, said method comprising the...
2017/0342129 Protein Comprising a Collagen Domain of CCBE1 and Uses Thereof
The invention relates among others to a protein comprising a fragment of 30-240 amino acids of Collagen and calcium-binding EGF domain-containing protein 1...
2017/0342128 METHOD FOR PRODUCING MONOMERIC AND MULTIMERIC MOLECULES AND USES THEREOF
Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide...
2017/0342127 FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF USING THEREOF
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions...
2017/0342126 HLA-DR BINDING PEPTIDES AND THEIR USES
The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor...
2017/0342125 NOVEL PEPTIDES, COMBINATION OF PEPTIDES AS TARGETS AND FOR USE IN IMMUNOTHERAPY AGAINST GALLBLADDER CANCER AND...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0342124 Universal Immune Receptor Expressed by T Cells for the Targeting of Diverse and Multiple Antigens
The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune...
2017/0342123 IMMUNOTHERAPY AGAINST ERBB-3 RECEPTOR
The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More...
2017/0342122 Novel Oxyntomodulin Derivatives and Pharmaceutical Composition For Treating Obesity Comprising The Same
The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native...
2017/0342121 GLUCAGON/GLP-1 AGONISTS FOR THE TREATMENT OF OBESITY
This disclosure provides GLP-1/glue agon agonist peptides for the treatment of metabolic diseases, e.g., obesity.
2017/0342120 USE OF RELAXIN TO TREAT ATRIAL FIBRILLATION
Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial...
2017/0342119 CONSTRUCTION AND CHARACTERIZATION OF MULTIMERIC IL-15-BASED MOLECULES WITH CD3 BINDING DOMAINS
The invention features soluble fusion protein complexes comprising at least two soluble fusion proteins. For example, the first fusion protein is an anti-CD3...
2017/0342118 METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA
Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for...
2017/0342117 GHRELIN SPLICE VARIANT FOR TREATING NEURONAL DAMAGE,NEURODEGENERATIVE DISEASE, PARKINSONS DISEASE, ALZHEIMERS...
The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereat: or a ghrelin splice variant-like compound for the...
2017/0342116 TREATMENT OF ISCHEMIA
A system, including methods and compositions, for treatment of ischemia.
2017/0342115 NOVEL RHTB PROTEIN VARIANTS AND THE METHOD OF PRODUCING O-PHOSPHOSERINE USING THE SAME
The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export ...
2017/0342114 NOVEL RHTB PROTEIN VARIANTS AND THE METHOD OF PRODUCING O-PHOSPHOSERINE USING THE SAME
The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export ...
2017/0342113 RECOMBINANT H7 HEMAGGLUTININ AND USE THEREOF
A recombinant H7 hemagglutinin derived from Chinese hamster ovary (CHO) cell. The recombinant H7 hemagglutinin includes a H7 hemagglutinin domain, a GCN4-pII...
2017/0342112 VACCINES AND VACCINE COMPONENTS FOR INHIBITION OF MICROBIAL CELLS
The invention encompasses components from microbial cells which are useful for antibody production, including peptides, polypeptides comprising these peptides,...
2017/0342111 Markers for the Diagnosis of Celiac Disease
The invention relates to isolated antibodies that bind to specific peptides and to their use in the diagnosis of celiac disease.
2017/0342110 GLYCOPEPTIDES AND USES THEREOF
The present disclosure provides a compound of Formula I or its stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure...
2017/0342109 Natural IGM Antibodies and Inhibitors Thereof
The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.
2017/0342108 CELL PENETRATING STAPLED PEPTIDE, MANUFACTURING METHOD THEREFOR, AND USE THEREOF
The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical...
2017/0342107 MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF
Certain embodiments of the invention provide a compound of formula (I): R.sup.1--C(.dbd.O)--W--X--Y--Z--N(R.sup.2).sub.2 (I) or a salt thereof, wherein R.sup.1,...
2017/0342106 METHOD OF MAKING PRODRUGS AND TARGETED THERAPEUTIC COMPOUNDS
Provided is a method for making the compound of Formula 1. Various compounds utilized in that method are also provided, as are methods of making those...
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