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| Patent # | Description |
|---|---|
| 2017/0342155 |
METHODS AND COMPOSITIONS RELATING TO ANTI-CCR7 ANTIGEN BINDING PROTEINS The present invention provides compositions and methods relating to antigen binding proteins against CCR7, including antibodies, nucleic acids, vectors,... |
| 2017/0342154 |
MODIFIED ANTIBODY CONSTANT REGION The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated... |
| 2017/0342153 |
FUSION POLYPEPTIDE INHIBITING VEGF-C, VEGF-D AND/OR ANGIOPOIETIN-2, AND
USE THEREOF A fusion polypeptide capable of binding simultaneously to angiopoietin 2, VEGF-C and VEGF-D; or capable of binding simultaneously to VEGF-C and VEGF-D, and... |
| 2017/0342152 |
ANTI-GLYCOPROTEIN IIb/IIIa ANTIBODIES Antibodies and antigen-binding antibody fragments that bind to GPIIb/IIIa and chimeric polypeptides comprising these binding molecules are disclosed. Some of... |
| 2017/0342151 |
ANTI-CHONDROITIN SULFATE PROTEOGLYCAN 4 ANTIBODIES AND USES THEREOF Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and... |
| 2017/0342150 |
METHOD OF TREATING MULTIPLE MYELOMA USING COMBINATION THERAPIES BASED ON
ANTI-CS1 ANTIBODIES Compositions and methods for treating MM are provided herein. |
| 2017/0342149 |
ANTIBODY THERAPY FOR MODULATING FUNCTION OF INTESTINAL RECEPTORS AND
METHODS OF TREATING DIABETES AND OBESITY The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a... |
| 2017/0342148 |
ANTI IL-34 ANTIBODIES The present disclosure relates to novel anti IL-34 antibodies or antigen-binding fragments thereof specifically binding cytokine IL-34 with high affinity, the... |
| 2017/0342147 |
Antibodies for IL-17C The present invention provides antibodies or antibody fragments binding to human IL-17C. In particular, it relates to antibodies or antibody fragments that... |
| 2017/0342146 |
NANOBODIES AGAINST TUMOR NECROSIS FACTOR-ALPHA The present invention relates to improved Nanobodies.TM. against Tumor Necrosis Factor-alpha (TNF-alpha), as well as to polypeptides comprising or essentially... |
| 2017/0342145 |
PROTEIN PURIFICATION USING DISPLACEMENT CHROMATOGRAPHY Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to... |
| 2017/0342144 |
ENGINEERED ANTI-TGF-BETA ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-.beta. (TGF.beta.). TGF.beta.-isoform selective antibodies or... |
| 2017/0342143 |
ANTI-NGF ANTIBODIES AND METHODS USING SAME The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use... |
| 2017/0342142 |
PEPTIDE-HINGE-FREE FLEXIBLE ANTIBODY-LIKE MOLECULE The present invention provides an antibody that can bind to targets with greater affinity. A flexible antibody-like molecule having a nonpeptide hinge part... |
| 2017/0342141 |
USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT
PHOTOPHOBIA OR LIGHT AVERSION IN... The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody... |
| 2017/0342140 |
MONOCLONAL ANTIBODY REACTING WITH GLYCOPEPTIDE, AND USE THEREOF Disclosed is a monoclonal antibody reacting with a glycopeptide, wherein the glycopeptide contains a core fucose moiety and at least 4 contiguous amino acid... |
| 2017/0342139 |
Methods for Treatment of Refractory Generalized Myasthenia Gravis The disclosure provides methods of treating myasthenia gravis (MG) in a subject in need thereof by administering to the subject a substance that specifically... |
| 2017/0342138 |
Method for and use of blocking immunosuppressive functions of pathogens The present invention provides a method for blocking immunosuppressive functions of pathogens, comprising: applying to an environment where the pathogens exist... |
| 2017/0342137 |
MONOCLONAL ANTIBODY INHIBITING IMMUNOSUPPRESSIVE FUNCTIONS OF PATHOGENS,
ANTIGEN-BINDING FRAGMENT THEREOF, AND... The present invention relates to a monoclonal antibody that inhibits immunosuppressive functions of pathogens, antigen-binding fragment thereof, and hybridomas... |
| 2017/0342136 |
MONOCLONAL ANTIBODY AGAINST MURAMYL PEPTIDES IN PREVENTION AND TREATMENT
OF IMMUNE-MEDIATED DISEASES Disclosed are methods of treating an autoimmune or inflammatory disease using a composition comprising an isolated antibody or an antigen-binding fragment or... |
| 2017/0342135 |
Antibodies With Simultaneous Subsite Specificities To Protein and Lipid
Epitopes Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than... |
| 2017/0342134 |
RSV G PROTEIN SPECIFIC ANTIBODIES The invention relates to human isolated, synthetic or recombinant antibodies or functional parts thereof, specific for the RSV G protein. Antibodies specific... |
| 2017/0342133 |
sc(Fv)2 SITE-DIRECTED MUTANT To solve the above-mentioned problems, the present inventors introduced site-specific mutations into sc(Fv)2 and examined the stabilizing effects on sc(Fv)2.... |
| 2017/0342132 |
SECRETION OF HEME-CONTAINING POLYPEPTIDES This disclosure provides for methods and compositions for the expression and secretion of heme-containing polypeptides. |
| 2017/0342131 |
SECRETION OF HEME-CONTAINING POLYPEPTIDES This disclosure provides for methods and compositions for the expression and secretion of heme-containing polypeptides. |
| 2017/0342130 |
GELATIN PURIFICATION Described is an improved method of removing lipopolysaccharide from an aqueous medium comprising gelatin and lipopolysaccharides, said method comprising the... |
| 2017/0342129 |
Protein Comprising a Collagen Domain of CCBE1 and Uses Thereof The invention relates among others to a protein comprising a fragment of 30-240 amino acids of Collagen and calcium-binding EGF domain-containing protein 1... |
| 2017/0342128 |
METHOD FOR PRODUCING MONOMERIC AND MULTIMERIC MOLECULES AND USES THEREOF Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide... |
| 2017/0342127 |
FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF
USING THEREOF The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions... |
| 2017/0342126 |
HLA-DR BINDING PEPTIDES AND THEIR USES The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor... |
| 2017/0342125 |
NOVEL PEPTIDES, COMBINATION OF PEPTIDES AS TARGETS AND FOR USE IN
IMMUNOTHERAPY AGAINST GALLBLADDER CANCER AND... The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates... |
| 2017/0342124 |
Universal Immune Receptor Expressed by T Cells for the Targeting of
Diverse and Multiple Antigens The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune... |
| 2017/0342123 |
IMMUNOTHERAPY AGAINST ERBB-3 RECEPTOR The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More... |
| 2017/0342122 |
Novel Oxyntomodulin Derivatives and Pharmaceutical Composition For
Treating Obesity Comprising The Same The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native... |
| 2017/0342121 |
GLUCAGON/GLP-1 AGONISTS FOR THE TREATMENT OF OBESITY This disclosure provides GLP-1/glue agon agonist peptides for the treatment of metabolic diseases, e.g., obesity. |
| 2017/0342120 |
USE OF RELAXIN TO TREAT ATRIAL FIBRILLATION Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial... |
| 2017/0342119 |
CONSTRUCTION AND CHARACTERIZATION OF MULTIMERIC IL-15-BASED MOLECULES WITH
CD3 BINDING DOMAINS The invention features soluble fusion protein complexes comprising at least two soluble fusion proteins. For example, the first fusion protein is an anti-CD3... |
| 2017/0342118 |
METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for... |
| 2017/0342117 |
GHRELIN SPLICE VARIANT FOR TREATING NEURONAL DAMAGE,NEURODEGENERATIVE
DISEASE, PARKINSONS DISEASE, ALZHEIMERS... The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereat: or a ghrelin splice variant-like compound for the... |
| 2017/0342116 |
TREATMENT OF ISCHEMIA A system, including methods and compositions, for treatment of ischemia. |
| 2017/0342115 |
NOVEL RHTB PROTEIN VARIANTS AND THE METHOD OF PRODUCING O-PHOSPHOSERINE
USING THE SAME The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export ... |
| 2017/0342114 |
NOVEL RHTB PROTEIN VARIANTS AND THE METHOD OF PRODUCING O-PHOSPHOSERINE
USING THE SAME The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export ... |
| 2017/0342113 |
RECOMBINANT H7 HEMAGGLUTININ AND USE THEREOF A recombinant H7 hemagglutinin derived from Chinese hamster ovary (CHO) cell. The recombinant H7 hemagglutinin includes a H7 hemagglutinin domain, a GCN4-pII... |
| 2017/0342112 |
VACCINES AND VACCINE COMPONENTS FOR INHIBITION OF MICROBIAL CELLS The invention encompasses components from microbial cells which are useful for antibody production, including peptides, polypeptides comprising these peptides,... |
| 2017/0342111 |
Markers for the Diagnosis of Celiac Disease The invention relates to isolated antibodies that bind to specific peptides and to their use in the diagnosis of celiac disease. |
| 2017/0342110 |
GLYCOPEPTIDES AND USES THEREOF The present disclosure provides a compound of Formula I or its stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure... |
| 2017/0342109 |
Natural IGM Antibodies and Inhibitors Thereof The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders. |
| 2017/0342108 |
CELL PENETRATING STAPLED PEPTIDE, MANUFACTURING METHOD THEREFOR, AND USE
THEREOF The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical... |
| 2017/0342107 |
MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF Certain embodiments of the invention provide a compound of formula (I): R.sup.1--C(.dbd.O)--W--X--Y--Z--N(R.sup.2).sub.2 (I) or a salt thereof, wherein R.sup.1,... |
| 2017/0342106 |
METHOD OF MAKING PRODRUGS AND TARGETED THERAPEUTIC COMPOUNDS Provided is a method for making the compound of Formula 1. Various compounds utilized in that method are also provided, as are methods of making those... |
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