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Patent # Description
2017/0342054 COMPOUNDS AND METHODS OF USE THEREOF
Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the...
2017/0342053 CRYSTAL FORMS OF A CCR5 ANTAGONIST
The present disclosure relates to forms of a CCR5 inhibitory compound, (4,6-dimethylpyrimidin-5-yl)(4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromet- ...
2017/0342052 PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
2017/0342051 INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Compounds of formula (I): ##STR00001## wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.3, R.sub.4, R.sub.5, A.sub.1, A.sub.2, T and W are as defined in the...
2017/0342050 SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR...
Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the...
2017/0342049 NOVEL 1,3,5 -TRIAZINE BASED PI3K INHIBITORS AS ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF
The present invention describes heterocyclic compounds of general Formula 1 and their method of preparation thereof. The present invention describes general...
2017/0342048 GDF-8 Inhibitors
Described are GCF-8 inhibitors of the formula (I), ##STR00001## and pharmaceutically acceptable salts thereof, wherein n, R.sup.1, R.sup.2, R.sup.5, R.sup.6, X...
2017/0342047 Cancerous Cell Growth Inhibiting Compounds
The present invention provides a compound of Formula I, II or III or a salt or prodrug or derivative thereof that is useful for skin-whitening by inhibiting...
2017/0342046 Fatty Acid Cysteine-Based Conjugates and Their Use in Treating Medical Disorders
The invention relates to fatty acid cysteine-based conjugates, compositions comprising a fatty acid cysteine-based conjugates, and methods for using such...
2017/0342045 KETAL ESTER COMPOUNDS AND USES THEREOF
The invention describes methods of preparation and compositions of plasticizers. The ketal diester products described are useful as components of polymer...
2017/0342044 ISOFLAVONOID COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer,...
2017/0342043 FUMIGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME
The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of...
2017/0342042 PROCESS FOR PRODUCING POLYVALENT GLYCIDYL COMPOUND
A polyvalent glycidyl compound is produced from a compound having one or more 2-alkenyl ether groups and two or more 2-alkenyl groups using a hydrogen peroxide...
2017/0342041 METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC)
Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including...
2017/0342040 NOVEL COMPOUNDS, SYNTHESIS METHOD THEREOF AND USE OF SAME IN MEDICINE AND IN COSMETICS
Novel compounds, synthesis methods and use of the same in medicine and in cosmetics are disclosed. Also disclosed, are novel compounds and ligands that...
2017/0342039 CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF
The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of...
2017/0342038 A METHOD FOR PREPARING GADOBUTROL
The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production...
2017/0342037 A CRYSTAL FORM OF NEPTINIB di-P-METHYLBENZENESULFONATE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL...
Provided is a composition of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(ethoxy)-6-quinazolinyl]-4-(di- methylamino)-2-butenamide p-toluene sulfonate 1.5...
2017/0342036 SIK INHIBITOR FOR USE IN A METHOD OF TREATING AN INFLAMMATORY AND/OR IMMUNE DISORDER
The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which...
2017/0342035 2-AMINOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
This invention relates to 2-aminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
2017/0342034 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS
The present invention relates to protein-lysine N-methyltransferase SMYD2 (SET and MYND domain-containing protein 2) inhibitors, in particular SMYD2-inhibitory...
2017/0342033 Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use
The present invention is directed to multi-tyrosine kinase inhibitor compounds. The present invention is further directed to compositions comprising those...
2017/0342032 CARBAMATE COMPOUND AND USE THEREOF
A carbamate compound represented by formula (I), wherein, R.sup.1 represents a hydrogen atom or a C1-C3 alkyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each...
2017/0342031 QUENCHER
A quencher is disclosed having a compound represented by the following general formula (1): ##STR00001## wherein R.sub.5 each independently represent a halogen...
2017/0342030 METHOD AND CATALYST FOR SYNTHESISING AZIRIDINE
The present invention relates to methods of synthesizing aziridines including isotopically labelled aziridines, said methods comprising contacting an imine or...
2017/0342029 CATALYTIC OXIDATION OF BUT-3-ENE-1,2-DIOL
The invention concerns a synthesis process of a compound of the following formula (I) or one of the salts thereof, ##STR00001## wherein R represents a COOH,...
2017/0342028 PROCESS FOR PRODUCING METHYL MERCAPTAN FROM DIMETHYL SULFIDE
The present invention generally relates to the manufacture of methyl mercaptan using recycled dimethyl sulfide. In particular, the invention relates to a...
2017/0342027 CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES
The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in...
2017/0342026 ISOPROPOXY-PHENYLGUANIDINE SERIES SALT AND APPLICATION THEREOF IN PREPARING GROWTH PROMOTERS FOR ANIMAL FEED
Isopropoxy-phenylguanidine series salt as shown by the Formula (I) and an application thereof in preparing growth promoters for animal feed, wherein R is...
2017/0342025 ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS
The invention discloses compounds of the formula wherein A, B, X, Y and Z are defined. The compounds of the invention show activity against a range of...
2017/0342024 MONOFUNCTIONAL OR MULTIFUNCTIONAL URETHANE ACRYLATE OLIGOMERS WITHOUT ISOCYANATES
The present invention relates to an acrylated and/or methacrylated urethane oligomer obtained by reaction of a specific polyamine a) with a cyclic carbonate...
2017/0342023 ISOCYANATE COMPOUND MANUFACTURING METHOD
By reacting 3-methyl-2-methoxymethylaniline, etc. with a phosgene compound in the presence of a tertiary amine at 10.degree. C. to 14.degree. C. in at least...
2017/0342022 PROCESSES FOR THE DIAZOTIZATION OF 2,5-DICHLOROANILINES
The present disclosure relates, in general, to processes for converting 2,5-dichloroaniline compounds to the corresponding 2,5-dichlorobenzenediazonium...
2017/0342021 RAS-INHIBITING INDENYL ACETAMIDE COMPOUNDS, COMPOSITIONS, AND USES
Disclosed are compounds, for example, compounds of formula (I), wherein R, R.sub.0 R.sub.1-R.sub.8, n, X, Y, Y.sup.1, and E are as described herein,...
2017/0342020 MODULATORS OF THE EIF2ALPHA PATHWAY
Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2.alpha. phosphorylation, the Integrated Stress...
2017/0342019 PROCESS FOR THE REDUCTIVE AMINATION AND SELECTIVE HYDROGENATION OF SUBSTRATES CONTAINING A SELECTED HALOGEN
Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed...
2017/0342018 PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF
Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and...
2017/0342017 CARBONATE ESTER PURIFICATION METHOD, CARBONATE ESTER SOLUTION PRODUCTION METHOD, AND CARBONATE ESTER...
A carbonate ester purification apparatus including a first distillation column in which an alcohol and a first solution containing a carbonate ester and...
2017/0342016 METHOD OF MANUFACTURING BHCD AND DERIVATIVES THEREOF
The present disclosure provides a method of manufacturing bis(2-hydroxyethyl) cyclohexane-1,4-dicarboxylate (BHCD) and derivatives thereof. The method includes...
2017/0342015 PROCESS FOR CONTINUOUSLY PREPARING DI-C1-3-ALKYL SUCCINATES
The invention relates to a process for continuously preparing di-C.sub.1-3-alkyl succinates by reacting succinic acid with an C.sub.1-3-alkanol in the presence...
2017/0342014 SURFACE TREATED CARBON CATALYSTS PRODUCED FROM WASTE TIRES FOR FATTY ACIDS TO BIOFUEL CONVERSION
A method of making solid acid catalysts includes the step of sulfonating waste tire pieces in a first sulfonation step. The sulfonated waste tire pieces are...
2017/0342013 ALPHA-HALOTETRAMETHYCYCLOHEXANONE, A METHOD FOR THE PREPARATION THEREOF, AND A METHOD FOR THE PREPARATION OF A ...
The present invention provides a method for the preparation of a sex pheromone of Obsucure Mealy bug (OMB), (plus/minus) (2,3,4,4-tetramethycyclopentyl)methyl...
2017/0342012 Rh/WxC Heterogeneous Catalyst for Preparing Acetic Acid by Carbonylation Reaction
This invention relates to a catalyst used in a carbonylation of methanol using carbon monoxide to acetic acid, and more particularly to a heterogeneous...
2017/0342011 METHYLENE BETA-DIKETONE MONOMERS, METHODS FOR MAKING METHYLENE BETA-DIKETONE MONOMERS, POLYMERIZABLE...
The present teachings are directed at polymers, polymeric compositions, polymerizable compositions, and articles including a 1,1-disubstituted alkene monomers...
2017/0342010 ALLYL ALCOHOL HYDROFORMYLATION PROCESS
The present disclosure relates to a method of using homogenous rhodium-BIPHEPHOS catalysts comprising for the hydroformylation of an allyl alcohol. In some...
2017/0342009 METHOD OF PREPARING 1,3-BUTADIENE AND METHYL ETHYL KETONE FROM 2,3-BUTANEDIOL USING ADIABATIC REACTOR
Disclosed is a method of preparing 1,3-butadiene and methyl ethyl ketone from 2,3-butanediol, including: a) providing a plurality of adiabatic reactors, which...
2017/0342008 NOVEL METHOD FOR CATALYTIC DEHYDRATION OF GLYCEROL TO ACROLEIN
A novel method for catalytic dehydration of glycerol to acrolein is provided. A fixed bed reactor is used, which is placed in a microwave unit. The feedstock...
2017/0342007 PROCESS FOR THE PREPARATION OF OSPEMIFENE AND FISPEMIFENE
Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent...
2017/0342006 METHOD FOR EFFICIENT CO2 DEGASIFICATION
A method including acidifying a solution including dissolved inorganic carbon; vacuum stripping a first amount of a carbon dioxide gas from the acidified...
2017/0342005 Oxygenate Synthesis and Homologation
The invention relates to processes for oxygenate synthesis and homologation, to equipment and materials useful in such processes, and to the use of such...
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