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Patent # Description
2017/0349672 FUCOSE-CONTAINING BACTERIAL BIOPOLYMER
The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide...
2017/0349671 PROCESS FOR PRODUCING AN OXIDIZED NANOFIBRILLAR CELLULOSE HYDROGEL
A process for producing an oxidized nanofibrillar cellulose hydrogel is disclosed, wherein the process comprises oxidizing cellulose pulp fibers in the...
2017/0349670 METHOD AND APPARATUS FOR CONTROLLING THE CATALYTIC OXIDATION OF CELLULOSE
A method for controlling the catalytic oxidation of cellulose includes using a heterocyclic nitroxyl compound as catalyst oxidizing cellulose in a reaction...
2017/0349669 MULTISPECIFIC ANTIBODIES
The present invention relates to multispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof.
2017/0349668 OPTIMIZED CROSS-SPECIES SPECIFIC BISPECIFIC SINGLE CHAIN ANTIBODY CONTRUCTS
The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T...
2017/0349667 C-MET ANTIBODY COMBINATIONS
The invention provides a product combination or composition, and also multispecific antibodies comprising two or more antigen-binding sites (as antibodies or...
2017/0349666 COMBINATION THERAPY OF T CELL ACTIVATING BISPECIFIC ANTIGEN BINDING MOLECULES AND PD-1 AXIS BINDING ANTAGONISTS
The present invention generally relates to T cell activating bispecific antigen binding molecules, PD-1 axis binding antagonists, and in particular to...
2017/0349665 ANTI-CD52 ANTIBODIES
Anti-human CD52 antibodies and antigen-binding fragments thereof are provided. Also provided are isolated nucleic acids, recombinant vectors and host cells for...
2017/0349664 METHODS FOR TREATING PROGRESSIVE MULTIPLE SCLEROSIS
The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such...
2017/0349663 METHODS AND COMPOSITIONS FOR CANCER TREATING CONDITIONS RELATING TO OVER EXPRESSIONS OF EPHA2
An anti-EphA2 scFv single-chain antibody binds with high specificity for EphA2 and blocks ephrin binding to Eph-A2. The antibody may be linked with other...
2017/0349662 MODIFIED GLYCOPROTEINS
Modified glycoproteins, and methods of making and using such modified glycoproteins, are described.
2017/0349661 ANTAGONISTIC ANTI-OX40L ANTIBODIES AND METHODS OF THEIR USE
Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system....
2017/0349660 BISPECIFIC ANTIBODIES THAT BIND CD123 AND CD3
The present invention is directed to novel bispecific anti-CD123 x anti-CD3 antibodies.
2017/0349659 WNT SIGNALING AGONIST MOLECULES
Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is...
2017/0349658 ANTI-AXL ANTAGONISTIC ANTIBODIES
Described are antibodies that specifically bind to the Axl protein and inhibit the interaction between Axl and the Axl-ligand, Gas6. Also disclosed are methods...
2017/0349657 BISPECIFIC ANTIBODIES THAT BIND CD20 AND CD3
The present invention is directed to methods of administrating bispecific anti-CD20.times.anti-CD3 antibodies.
2017/0349656 USE OF IL-20 ANTAGONISTS FOR TREATING PANCREATIC CANCER
Methods for treating pancreatic cancer using an IL-20 antagonist, which can be an antibody that binds IL-20 or an IL-20 receptor, thereby blocking the...
2017/0349655 METHODS TO MODULATE LYSINE VARIANT DISTRIBUTION
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the...
2017/0349654 LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME USING DISPLACEMENT CHROMATOGRAPHY
The present invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods...
2017/0349653 METHODS FOR TREATING SPINAL CORD INJURY AND PAIN
Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat spinal cord injury, including promoting axonal regeneration,...
2017/0349652 TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PATIENTS BY AN INHIBITOR OF COMPLEMENT
Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial...
2017/0349651 PREVENTION AND TREATMENT OF SYNUCLEINOPATHIC AND AMYLOIDOGENIC DISEASE
The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of...
2017/0349650 IMMUNOGLOBULINS WITH REDUCED AGGREGATION
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational...
2017/0349649 ANTIBODIES THAT BIND HUMAN PROTEIN TYROSINE PHOSPHATASE beta (HPTPbeta) AND USES THEREOF
Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTP.beta.), and uses thereof.
2017/0349648 Compositions and Methods for Treating and Preventing Staphylococcus Aureus Infections
Antibodies having Fab regions that specifically bind to Staphylococcus aureus protein A are capable of mediating opsinization of Staphylococcus aureus bacteria...
2017/0349647 COMPOSITE COMPRISING ANTIBODY CAPABLE OF BINDING TO INTRANUCLEAR PROTEIN OF INFLUENZA VIRUS
The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a...
2017/0349646 COMPOSITE COMPRISING ANTIBODY CAPABLE OF BINDING TO INTRANUCLEAR PROTEIN OF INFLUENZA VIRUS
The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a...
2017/0349645 NOVEL METHOD FOR EFFICIENT PURIFICATION OF HUMAN SERUM ALBUMIN
The present invention describes a simple purification process for recombinant human serum albumin. The process results in highly purified protein with limited...
2017/0349644 FACTOR VIII WITH EXTENDED HALF-LIFE AND REDUCED LIGAND-BINDING PROPERTIES
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising...
2017/0349643 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and...
2017/0349641 Chiral Substituted Amyloid Beta Peptides
Aspects of the present disclosure include amyloid .beta. (A.beta.) peptides. In certain aspects, the A.beta. peptides include a chiral substitution at an...
2017/0349640 MICRODYSTROPHIN PEPTIDES AND METHODS FOR TREATING MUSCULAR DYSTROPHY USING THE SAME
According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal...
2017/0349639 WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS
The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related...
2017/0349638 COMPANION DIAGNOSTIC TOOL FOR PEPTIDOMIMETIC MACROCYCLES
The present invention provides diagnostic tools, systems, and methods for detecting wild type p53 and p53-associated mutations for the treatment of disease...
2017/0349637 EXPRESSION CONSTRUCTS AND METHODS OF GENETICALLY ENGINEERING METHYLOTROPHIC YEAST
Methods and materials for genetically engineering methylotrophic yeast are provided.
2017/0349636 BREAD QUALITY PROTEIN AND METHODS OF USE
An isolated protein that is highly abundant in the seed of wheat varieties with desirable breadmaking qualities is provided. Associated promoters and promoter...
2017/0349635 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING PLANT YIELD AND/OR...
Provided are isolated polypeptides which are at least 80% homologous to SEQ ID NOs: 182-184, 186-202, 204-216, 219-223, 225, 227-232, 235-236, 238, 240-260,...
2017/0349634 COMPOSITIONS AND METHODS FOR TREATMENT OF CYTOMEGALOVIRUS
The present disclosure provides compositions and methods useful for treating HCMV infection. As described herein, the compositions and methods are based on...
2017/0349633 CONSTRUCTION METHOD FOR RECOMBINANT VACCINE HAVING ANTI-CERVICAL CANCER CELL ACTIVITY AND APPLICATION THEREOF
The present invention provides a fusion protein comprising an HPV cancer-causing protein segment, a coding sequence thereof and an application thereof in...
2017/0349632 QUINOLIUM CONJUGATES OF CYCLOSPORIN
The present invention relates to conjugates of cyclosporin with quinolium mitochondrial targeting groups, and their therapeutic uses.
2017/0349631 COMPSTATIN AND ANALOGS THEREOF FOR EYE DISORDERS
The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration...
2017/0349630 AGONISTS OF GUANYLATE CYCLASE AND THEIR USES
This invention provides novel guanylate cyclase C (GC-C) agonists and their therapeutic use. The agonists may be used either alone or in combination with one...
2017/0349629 Angiotensin-1-Receptor Antagonists
In one aspect, this disclosure features compounds of formula (I) or a pharmaceutically acceptable salt thereof: AA1-Arg-Val-AA4-AA5-His-Pro-AA8-OH (I), in...
2017/0349628 Synthesis of Cell Penetrating Peptides for Drug Delivery and Stem Cell Applications
The present invention provides a novel cell penetrating peptide that transports proteins into cells and/or into nuclei and a pharmaceutical containing the...
2017/0349627 COMPOSITION CONTAINING NITROGEN HETEROCYCLIC HEXAPEPTIDE PRECURSOR AND PREPARATION METHOD AND APPLICATION THEREOF
Disclosed is a preparation method of a composition containing a nitrogen heterocyclic hexapeptide precursor, composition A and B containing a nitrogen...
2017/0349626 CHROMATOGRAPHY DEVICE AND METHOD FOR FILTERING A SOLUTE FROM A FLUID
A chromatography device for removing a solute from a fluid is provided. The device has a first plate having an inlet and a first channel. The first channel...
2017/0349625 MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES
The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the...
2017/0349624 PRO-DRUG FORMING COMPOUNDS
Various prodrug compounds having the general structure: Active agent-(acid)-(linker)-SO.sub.2NR.sub.1R.sub.2 are described herein. Compounds having this...
2017/0349623 NUCLEIC ACID COMPLEX, METHOD FOR FORMING NUCLEIC ACID HYBRIDIZATION, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID...
A nucleic acid complex includes a single-stranded nucleic acid and a cross-linked double-stranded nucleic acid including the first nucleic acid strand linked...
2017/0349622 NOVEL HYBRID GALACTOSIDE INHIBITOR OF GALECTINS
The present invention relates to a compound of the general formula (1). The compound of formula (1) is suitable for use in a method for treating a disorder...
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