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Patent # Description
2017/0355994 ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of...
2017/0355993 MODULATION OF ALTERNATIVE MDM2 SPLICING
Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an...
2017/0355992 FACTOR V/Va-TARGETING APTAMER COMPOSITONS AND METHODS OF USING THE SAME
Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing...
2017/0355991 COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabrotica plant...
2017/0355990 TREATMENT OF SODIUM CHANNEL, VOLTAGE-GATED, ALPHA SUBUNIT (SCNA) RELATED DISEASES BY INHIBITION OF NATURAL...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sodium channel, voltage-gated, alpha subunit...
2017/0355989 RNAI INDUCED HUNTINGTIN GENE SUPPRESSION
The present invention provides for a double stranded RNA comprising a first RNA sequence and a second RNA sequence wherein the first and second RNA sequence...
2017/0355988 MITOCHONDRIAL PHOSPHATE CARRIER TARGETS FOR TREATING SOFT-TISSUE CALCIFICATION
Disclosed herein are compositions and methods for treating soft-tissue calcification by targeting SLC25A24 and/or SLC25A3.
2017/0355987 Inhibitors Of Lactate Transporters For Use In The Treatment Of Inflammatory Diseases
The present invention provides methods and compositions for the treatment of inflammatory diseases such as rheumatoid arthritis using inhibitors of lactate...
2017/0355986 ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds,...
2017/0355985 High Specificity Genome Editing Using Chemically Modified Guide RNAs
The present invention relates to guide RNAs having chemical modifications and their use in CRISPR-Cas systems. The chemically modified guide RNAs have enhanced...
2017/0355984 NUCLEIC ACID SEQUENCING ADAPTERS AND USES THEREOF
High-fidelity, high-throughput nucleic acid sequencing enables healthcare practitioners and patients to gain insight into genetic variants and potential health...
2017/0355983 TWO-CASSETTE REPORTER SYSTEM FOR ASSESSING TARGET GENE TRANSLATION AND TARGET GENE PRODUCT INCLUSION BODY FORMATION
The present invention relates to a dual cassette reporter system capable of assessing target gene translation and target gene product folding. The present...
2017/0355982 GENETIC ENCODING OF CHEMICAL POST-TRANSLATIONAL MODIFICATION FOR PHAGE-DISPLAYED LIBRARIES
The present application provides a method of synthesizing a genetically-encoded chemical modification of a peptide library. A vector in a substrate, such as a...
2017/0355981 METHOD AND REAGENT FOR CONSTRUCTING NUCLEIC ACID DOUBLE-LINKER SINGLE-STRAND CYCLICAL LIBRARY
A method and reagent for constructing a nucleic acid double-linker single-strand cyclic library. The method comprises: breaking a nucleic acid into nucleic...
2017/0355980 DISPLAY LIBRARY PROCESS
Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be...
2017/0355979 CARRIER INCLUDING AMMONIUM OXIDIZING BACTERIA IMMOBILIZED THEREIN AND METHOD FOR PREPARING SAME
Disclosed is a method for preparing the same. The method for preparing a carrier including ammonium oxidizing bacteria immobilized therein includes: preparing...
2017/0355978 RNase H-Based Assays Utilizing Modified RNA Monomers
The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and...
2017/0355977 OPTOGENETIC TOOL FOR RAPID AND REVERSIBLE CLUSTERING OF PROTEINS
A protein construct including a gene encoding a light-sensitive protein fused to at least one of either a low complexity sequence, an intrinsically disordered...
2017/0355976 NITRILASE FROM ARABIS ALPINA, ITS ENCODING GENE, VECTOR, RECOMBINANT BACTERIAL STRAIN AND USES THEREOF
The disclosure provides a nitrilase from Arabis alpina, which belongs to genus Arabis, family brassicaceae. The disclosure further provides the encoding gene,...
2017/0355975 NITRILASE FROM ARABIS ALPINA, ITS ENCODING GENE, VECTOR, RECOMBINANT BACTERIAL STRAIN AND USES THEREOF
The disclosure provides a nitrilase from Arabis alpina, which belongs to genus Arabis, family brassicaceae. The disclosure further provides the encoding gene,...
2017/0355974 FACTOR VII CONJUGATES
The present invention relates to the conjugation of Factor VII polypeptides with heparosan polymers. The resultant conjugates may be used to deliver Factor...
2017/0355973 FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND METHOD FOR ITS PRODUCTION
Disclosed are a modified FIX (factor IX) polypeptide comprising a leucine, cysteine, aspartic acid, glutamic acid, histidine, lysine, asparagine, glutamine or...
2017/0355972 Xylanase Variants and Polynucleotides Encoding Same
The present invention relates to xylanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2017/0355971 NOVEL THERMOPHILE-DERIVED KERATINASE AND USE THEREOF
The present invention relates to a novel thermophile-derived keratinase having keratin decomposition ability. Further, the present invention relates to a...
2017/0355970 MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES
Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3' sugar...
2017/0355969 A METHOD FOR THE ENZYMATIC CONVERSION OF A PHENOL SUBSTRATE INTO A CORRESPONDING CATECHOL PRODUCT
A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a...
2017/0355968 BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS
The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the...
2017/0355967 AMADORIASE HAVING ENHANCED DEHYDROGENASE ACTIVITY
Provided are an amadoriase that is less likely to be influenced by oxygen concentration and a method and a reagent kit for measurement of HbA1c using such...
2017/0355966 ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells...
2017/0355965 NON-VIRAL IPSCS INDUCING METHOD, COMPOSITIONS, KITS AND IPSCS
The present invention relates to a non-viral iPSCs induction method as well as the compositions, kits and iPSCs obtained therefrom. More specifically, the...
2017/0355964 Delta133P53Beta and Delta133P53Gamma Isoforms Are Biomarkers of Cancer Stem Cells
The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on...
2017/0355963 DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage...
2017/0355962 METHODS OF REPROGRAMMING CELLS
The present invention provides methods of reprogramming cells, for example, directly reprogramming a somatic cell of a first cell type into a somatic cell of a...
2017/0355961 METHOD OF ISOLATING CELLS FROM A TISSUE IN A MAMMAL
Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture...
2017/0355960 IMMORTALIZED STEM CELL, COMPOSITIONS, PREPARATIONS AND USES THEREOF
The purpose of the present invention is to provide immortalized stem cells, which produce a growth factor capable of regenerating various kinds of tissues that...
2017/0355959 METHODS FOR MOBILISING POPULATIONS OF STEM CELLS
The invention provides a method for mobilising haematopoietic stem and progenitor cells (HSPC) and/or mesenchymal stem cells (MSC) in a subject, the method...
2017/0355958 MODULATION OF SH2B3 TO IMPROVE RED BLOOD CELL PRODUCTION FROM STEM CELLS AND/OR PROGENITOR CELLS
Disclosed herein are methods for producing red blood cells (RBCs) from a population of stem cells and/or progenitor cells. In at least one of the stem cells or...
2017/0355957 IMPROVED METHOD FOR THE GENERATION OF GENETICALLY MODIFIED CELLS
The invention provides a method for the improved generation of genetically modified cells in vitro, in order to obtain a population of effector cells with...
2017/0355956 COMPOSITIONS FOR INCREASING SURVIVAL OF MOTOR NEURON PROTEIN (SMN) LEVELS IN TARGET CELLS AND METHODS OF USE...
Compositions for altering splicing activity of the DcpS gene and increasing SMN protein expression in target cells are provided. Also disclosed are methods of...
2017/0355955 DEVICE AND METHOD FOR SELECTING EUKARYOTIC CELLS IN A TRANSPORTATION CHANNEL BY ALTERING THE EUKARYOTIC CELLS...
The device can be used for the in vitro selection of eukaryotic cells, and in particular sperm cells (SP). It comprises a transportation channel (100),...
2017/0355954 Aligned and Electrospun Piezoelectric Polymer Fiber Assembly and Scaffold
A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least...
2017/0355953 METHOD FOR PRODUCING WNT PROTEIN AND METHOD FOR STORING WNT PROTEIN
Provided is a novel method for producing a Wnt protein, which method comprises (1) a step of performing affinity purification targeting afamin to obtain a Wnt...
2017/0355952 COSMETIC COMPOSITION FOR IMPROVING CONDITION OF SKIN, CONTAINING CELL CULTURE MEDIUM, EPIDERMAL GROWTH FACTOR...
The present invention relates to: a cosmetic composition for improving the condition of the skin, containing, as active ingredients, a cell culture medium, an...
2017/0355951 Mosquito Salivary Gland Extraction Device and Methods of Use
A device and method of use for augmenting the extraction of salivary glands from Plasmodium-infected mosquitoes, where the sporozoite stage of Plasmodium...
2017/0355950 SYSTEMS FOR DISSOCIATION OF BIOLOGICAL TISSUES
Provided herein is technology relating to processing biological samples and particularly, but not exclusively, to systems and apparatuses for dissociating...
2017/0355949 OBSERVATION APPARATUS
It is possible to observe imaging subjects, such as cells or the like, without causing an increase in the apparatus size. Provided is an observation apparatus...
2017/0355948 PROBE
A probe assembly and a method of manufacturing a probe assembly. In one aspect there is a method of manufacturing a probe assembly comprising providing an...
2017/0355947 CROSS-SCALE MODELING OF BIOREACTOR CULTURES USING RAMAN SPECTROSCOPY
Aspect of the disclosure relate to methods of assessing a bioreactor culture that involve determining a culture parameter of the manufacturing-scale bioreactor...
2017/0355946 ACCORDION AIR LOOP BIOREACTOR
Disclosed herein are bioreactors that include a vessel with sides and a bottom, at least one opening in the vessel connected to a means for introducing a gas,...
2017/0355945 Microfluidic Device for Three Dimensional and Compartmentalized Coculture of Neuronal and Muscle Cells, with...
The present subject matter provides a microfluidic device that enables the precise and repeatable three dimensional and compartmentalized coculture of muscle...
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