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Patent # Description
2017/0360817 USE OF AMINOGLYCOSIDE ANALOGS IN THE TREATMENT OF RETT SYNDROME
Compounds, methods and uses of pseudo-trisaccharide aminoglycosides represented by the general formula I: ##STR00001## or a pharmaceutically acceptable salt...
2017/0360816 METHODS FOR TREATING PULMONARY NON-TUBERCULOUS MYCOBACTERIAL INFECTIONS
Provided herein are methods for treating a pulmonary infection in a patient in need thereof for example, a nontuberculous mycobacterial pulmonary infection for...
2017/0360815 COMPOSITIONS AND METHODS FOR PROTECTING AGAINST AIRBORNE PATHOGENS AND IRRITANTS
The present disclosure features methods and compositions for enhancing the ability of the respiratory membranes to filter airborne pathogens and protect a...
2017/0360814 Pain Reliever Composition
An inventive composition including an amount of sugar or sugar alcohol, an amount of alkalizing agent, and an amount of vehicle; whereby the inventive...
2017/0360813 COMPOSITIONS AND METHODS FOR TREATING MEDULLOBLASTOMA
Provided are methods and compositions for treating an individual who has a medulloblastoma. Methods for treating an individual who has a medulloblastoma tumor...
2017/0360812 PHOSPHOLIPID PREPARATIONS FOR THE IMPROVEMENT OF COMMUNICATION SKILLS
The preparation of the present invention was found to be effective for the majority of patients diagnosed with autism. In patients characterized by delayed...
2017/0360811 NOVEL BISPHOSPHONIC ACID DERIVATIVE AND APPLICATION FOR SAME
The novel bisphosphonic acid ester derivatives represented by the following formula (1): Y--Cy--(NH).sub.m--(CH.sub.2).sub.n--C(X)(PO(OR.sup.1)(OR.sup.2)).sub.2 ...
2017/0360810 USE OF DERIVATIVES CONTAINING C-O-P BONDS IN PATIENTS WITH KIDNEY FAILURE
Use of a derivative attaining C-O-P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said...
2017/0360809 VASCULAR CALCIFICATION
The invention relates to the use of a poly(ADP ribose) polymerase (PARP) inhibitor and/or a tetracycline, for treating, preventing or ameliorating medial...
2017/0360808 TOPICAL FORMULATIONS COMPRISING A STEROID
The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are...
2017/0360806 CORTEXOLONE 17ALPHA-BENZOATE FOR USE IN THE TREATMENT OF TUMOURS
The present invention provides certain cortexolone derivatives of formula (I), and the same for use as antitumor active ingredients for the curative or...
2017/0360805 MOTOR-ASSOCIATED NEURODEGENERATIVE DISEASE AND METHODS OF TREATMENT
Disclosed herein are methods and compounds for treating a motor-associated neurodegenerative disease or condition. In some instances, also included herein are...
2017/0360804 C-19 Steroids for Inhibiting Neovascularization
The present invention relates to the field of medicine, particularly to novel uses of C-19 steroid compounds having an androsten-17-(OR.sub.4)-3-one structure...
2017/0360803 METHODS FOR TREATING OR PREVENTING CANCER IN A KRAS-VARIANT PATIENT AND FOR DIAGNOSING RISK OF DEVELOPING...
The invention relates to methods for preventing cancer in a KRAS-variant subject which include administering to the KRAS-variant subject an amount of estrogen...
2017/0360802 Enrichment Method of Ergosterol Peroxide from Sporoderm-Broken Ganoderma Lucidum Spore Powder
The invention provides an enrichment method of Ergosterol peroxide from sporoderm-broken Ganoderma lucidum spore powder, comprising the steps of preparing...
2017/0360801 BROMODOMAIN INHIBITOR AS ADJUVANT IN CANCER IMMUNOTHERAPY
Inhibition of bromodomain proteins in antigen presenting cells is shown herein to be more inflammatory, to display lower expression of the immunosuppressive...
2017/0360800 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is --C(R1)= or...
2017/0360799 AQUEOUS COMPOSITION
A technique is provided for suppressing the crystal precipitation of an aqueous composition containing a halogenated isoquinoline derivative during...
2017/0360798 ANAVEX2-73 AND CERTAIN ANTICHOLINESTERASE INHIBITORS COMPOSITION AND METHOD FOR NEUROPROTECTION
This invention concerns a dosage form comprising a therapeutically neuroprotective amount of A2-73 and a neuroprotective amount of at least one cooperating...
2017/0360797 METHOD FOR TREATING CANCER
The present invention relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy...
2017/0360796 BTK INHIBITOR COMBINATIONS AND DOSING REGIMEN
Disclosed herein are methods and combination dosing regimen of administering a combination of a BTK inhibitor (e.g. ibrutinib) and an anti-CD20 therapeutic...
2017/0360795 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS
Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders.
2017/0360794 JAK INHIBITOR
The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof...
2017/0360793 USE OF ANAGRELIDE FOR TREATING CANCER
The present invention relates to the use of the anti-megakaryocytic agent anagrelide, or a therapeutically active metabolite thereof, in the prevention or...
2017/0360792 ORGANIC COMPOUNDS
The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for...
2017/0360791 PHARMACEUTICAL COMPOSITIONS FOR INCREASING THE BIOAVAILABILITY OF POORLY SOLUBLE DRUGS
Pharmaceutical compositions comprising poorly soluble compounds, such as BCS class II or class IV drugs (e.g. amuvatinib), are provided. The pharmaceutical...
2017/0360790 KINASE INHIBITOR PRODRUG FOR THE TREATMENT OF CANCER
Compositions containing and methods of administering TH-4000 are useful in treatment of cancer alone or in combination with other anti-cancer agents.
2017/0360789 FAS Inhibitors and Methods Associated Therewith
The present invention relates to compounds, compositions and methods comprising nanoparticles (NP) that are based on hyaluronic acid (HLA) that have been...
2017/0360788 SMALL MOLECULE INHIBITORS OF EGFR AND PI3K
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or...
2017/0360787 COMPOSITIONS AND METHODS FOR REDUCTION OF AMYLOID-BETA LOAD
The present invention relates to methods and compositions for modulating levels of amyloid-.beta. peptide (A.beta.) exhibited by non-neuronal (i.e.,...
2017/0360786 Protein Kinase C Inhibitors and Uses Thereof
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and...
2017/0360785 PYRIMIDINE FGFR4 INHIBITORS
Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.
2017/0360784 TRIZOL-1-OL ANALOGS ANTI-RETROVIRAL LATENCY DRUGS
In one aspect, the invention relates to triazol-1-ol compounds, analogs thereof, compositions comprising same, and methods of using same, alone or in...
2017/0360783 Methods for Treating HCV
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as...
2017/0360782 PHARMACOTHERAPY FOR PREVENTING OR TREATING GLAUCOMA
A pharmacotherapy is provided for preventing glaucoma or preventing or treating ocular hypertension, the pharmacotherapy providing potent intraocular...
2017/0360781 PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND AS...
[Problem] Provided is a pharmaceutical composition for treating various types of cancer in which mitochondrial Complex I is involved, particularly colorectal...
2017/0360780 PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND AS...
[Problem] Provided is a pharmaceutical composition for treating multiple myeloma. [Means for Solution] The inventors of the present invention conducted ...
2017/0360779 PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND AS...
[Problem] Provided is a pharmaceutical composition for treating lung cancer in which mitochondrial Complex I is involved, particularly non-small cell lung...
2017/0360778 Methods for Treating a Cytomegalovirus Infection
The present disclosure provides a method for inhibiting cytomegalovirus (CMV) replication in a cell infected with CMV, the method comprising contacting the...
2017/0360777 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)-PHENYL]PIPERAZINE AS A COMPOUND With COMBINED SEROTONIN REUPTAKE, 5-HT3 AND...
1-[2-(2,4-dimethylphenylsulphanyl)phenyl)]piperazine exhibits potent activity on SERT, 5-HT.sub.3 and 5-HT.sub.1A and may as such be useful for the treatment...
2017/0360776 COMPOSITIONS AND METHODS COMPRISING BUPROPION OR RELATED COMPOUNDS FOR SUSTAINED DELIVERY OF DEXTROMETHORPHAN
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2017/0360775 GLUTAMATE AGENTS IN THE TREATMENT OF MENTAL DISORDERS
Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an...
2017/0360774 BUPROPION AS A MODULATOR OF DRUG ACTIVITY
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2017/0360773 COMPOSITIONS AND METHODS FOR INCREASING THE METABOLIC LIFETIME OF DEXTROMETHORPHAN AND RELATED PHARMACODYNAMIC...
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2017/0360772 PHARMACEUTICAL COMPOSITIONS
Methods and compositions are provided which comprise effective amounts of an analgesic to treat a subject, including reducing or eliminating an adverse effect...
2017/0360771 TREATING POSTOPERATIVE NAUSEA AND VOMITING
Methods, compositions, systems, and packaging are disclosed for reducing postoperative nausea and/or vomiting (PONV) in a human patient in need of general...
2017/0360770 EFFICACY OF ANTI-HLA-DR ANTIBODY DRUG CONJUGATE IMMU-140 (hL243-CL2A-SN-38) IN HLA-DR POSITIVE CANCERS
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an anti-HLA-DR antibody or antigen-binding antibody fragment. The...
2017/0360769 INJECTABLE ANTICANCER COMPOSITION FOR LOCAL ADMINISTRATION CONTAINING SUSPENSION OF QUININE SALT
Disclosed herein is an injectable anticancer composition for local administration, which contains a suspension of quinine hydrochloride. The anticancer...
2017/0360768 Novel Regimens of Tafenoquine for Prevention of Malaria in Malaria-Naive Subjects
Methods of prevention of symptomatic malaria in a malaria-naive, G6PD-normal human subject comprising administering to the human subject a compound of Formula...
2017/0360767 MULTI-LAYER NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITION
The invention provides a multi-layered pharmaceutical composition comprising two or more formulations with varying properties. In some embodiments, the...
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