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Patent # Description
2017/0369579 HIGH AFFINITY ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR ALPHA 1
High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of...
2017/0369578 REGENERATION OF AGED SATELLITE CELLS
Methods and compositions described herein are useful for rejuvenating skeletal muscle stem cells (i.e., satellite cells), promoting skeletal muscle...
2017/0369577 RECOMBINANT CD74 POLYPEPTIDES
Disclosed are recombinant CD74 polypeptides mutated relative to the naturally occurring CD74 polypeptides with improved properties such as binding of CD74...
2017/0369576 Treatment And Functional Cure Of HIV Infection By Monoclonal Antibodies To CD4 Mediating Competitive HIV Entry...
The present disclosure is directed to compositions and methods for the prevention, treatment, and/or functional cure of HIV infection. One aspect of the...
2017/0369575 SINGLE CHAIN VARIABLE FRAGMENT CD3 BINDING PROTEINS
Disclosed herein are single chain variable fragment CD3 binding proteins with improved binding affinities, and robust aggregation profiles. Also described are...
2017/0369574 AN IMMUNOTOXIN FOR USE IN THE TREATMENT OF LEISHMANIASIS
An immunotoxin for use in the treatment of leishmaniasis A wherein the immunotoxin comprises a portion which is specifically binding to the cellular surface...
2017/0369573 MONOMERIC FC DOMAINS
Monomeric Fc-domains are provided, as well as multimeric and single chain proteins comprising the monomeric Fc-domains. The proteins have utility in the...
2017/0369572 ANTI-CD47 ANTIBODIES AND USES THEREOF
Provided herein are compositions, methods and uses involving antibodies that specifically bind to human CD47. Also provided are uses and methods, such as...
2017/0369571 ANTI SEZ6 ANTIBODIES AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
2017/0369570 COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY
The present invention includes, among other things, .beta.-1,6-glucan linked to an antibody directed to a cell present in a tumor microenvironment. T...
2017/0369569 Anti-Active GIP Antibody
Provide is an anti-active GIP antibody which allows accurate detection of active GIP. The present invention provides an anti-active GIP antibody which binds to...
2017/0369568 INTERFERON ALPHA ANTIBODIES AND THEIR USES
The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological...
2017/0369567 SELECTIVE REDUCTION OF CYSTEINE RESIDUES IN IL-17 ANTIBODIES
The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a...
2017/0369566 BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES
The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions...
2017/0369565 THERAPEUTIC CANINE IMMUNOGLOBULINS AND METHODS OF USING SAME
A method of preparing a canine antibody suitable for use in the therapeutic treatment of a canine is provided. In particular, there is provided immunoglobulins...
2017/0369564 ANTI-VEGF ANTIBODIES
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit...
2017/0369563 SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN
Disclosed herein are single domain serum albumins binding proteins with improved thermal stability, binding affinities, and robust aggregation profiles. Also...
2017/0369562 METHODS FOR TREATING COMPLEMENT-ASSOCIATED DISORDERS
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or...
2017/0369561 GLYPICAN-3-SPECIFIC ANTIBODY AND USES THEREOF
The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression...
2017/0369560 HUMAN ANTI-TAU ANTIBODIES
Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and...
2017/0369559 METHODS OF TREATING ALZHEIMER'S DISEASE
Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild...
2017/0369558 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are...
2017/0369557 NOVEL METHODS OF CONSTRUCTING LIBRARIES COMPRISING DISPLAYED AND/OR EXPRESSED MEMBERS OF A DIVERSE FAMILY OF...
Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the...
2017/0369556 RECOMBINANT CELLS COMPRISING miRNA MIMICS
Disclosed are compositions and methods related to recombinant cells expressing microRNA and an immunoglobulin gene.
2017/0369555 ARTIFICIAL ANTIBODY POLYPEPTIDES
The present invention provides a fibronectin type III (Fn3) molecule, wherein the Fn3 contains a stabilizing mutation. The present invention also provides Fn3...
2017/0369554 COMPOSITIONS AND METHODS FOR ENHANCING COAGULATION FACTOR VIII FUNCTION
Factor VIII variants and methods of use thereof are disclosed.
2017/0369553 METHOD FOR PREPARING TNFR-FC FUSION PROTEIN CONTAINING TARGET CONTENT OF IMPURITIES
The present invention relates to a method for preparing a TNFR-Fc fusion protein mixture comprising a target content of hydrophobic chromatogram peak 3, and to...
2017/0369552 FUSION PROTEIN COMPRISING A LIGAND BINDING DOMAIN OF VEGF AND PDGF
Fusion proteins containing a PDGF binding portion, a VEGF binding portion, and an Fc antibody region are described. Also described are nucleic acids encoding...
2017/0369551 METHODS OF TREATING IgA NEPHROPATHY AND HENOCH-SCHONLEIN PURPURA NEPHRITIS USING A B-CELL ACTIVATING FACTOR...
Provided herein are methods, compositions, and kits for treating IgA nephropathy and Henoch-Schonlein purpura nephritis using BAFF inhibitors, including...
2017/0369550 Cell
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an...
2017/0369549 METHODS OF TREATMENT USING CTLA4 MUTANT MOLECULES
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or...
2017/0369548 INSULIN ANALOGUES WITH SELECTIVE SIGNALING PROPERTIES AND REDUCED MITOGENICITY
A two-chain insulin analogue contains Aspartic Acid at position B10 and penta-fluoro-Phenylalanine at position B24, optionally Histidine or Glutamic Acid at...
2017/0369547 CYSTEINE VARIANTS OF INTERLEUKIN-11 AND METHODS OF USE THEREOF
Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
2017/0369546 BMP PEPTIDES AND METHODS OF USE
The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors....
2017/0369545 MET RECEPTOR AGONIST PROTEINS
Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote...
2017/0369544 PROTEOLYTIC DIGESTION OF CARDIAC TROPONIN I
A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the...
2017/0369543 METHODS AND REAGENTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION
The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and...
2017/0369542 HUMAN NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (HNGAL) MUTEINS THAT BIND HEPCIDIN AND NUCLEIC ACID ENCODING SUCH
The present invention relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Hepcidin, which proteins preferably are...
2017/0369541 METHODS TO PRODUCE ROD-DERIVED CONE VIABILITY FACTOR (RDCVF)
The invention is related to methods of producing rod-derived cone viability factor (RdCVF). This invention also relates to the treatment of an ocular disease...
2017/0369540 NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES CONFERRING MODULATED PLANT CHARACTERISTICS
The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides able confer the trait of modulated plant size,...
2017/0369539 MODIFIED CRY1CA TOXINS USEFUL FOR CONTROL OF INSECT PESTS
The subject invention concerns Bacillus thuringiensis modified Cry1Ca insecticidal toxins and the polynucleotide sequences which encode these toxins. Uses in...
2017/0369538 DIG-305 INSECTICIDAL CRY TOXINS
DIG-305 insecticidal protein toxins, polynucleotides encoding such toxins, and transgenic plants that produce such toxins are disclosed. Also disclosed are...
2017/0369537 ENHANCED PROTEIN EXPRESSION
The present invention relates in general to bacterial cells having a genetic alteration that results in increased expression of a protein of interest and...
2017/0369536 Compositions and Methods Related to Protein A (SpA) Variants
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium....
2017/0369535 PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The...
2017/0369534 THERAPEUTIC HPV18 VACCINES
Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
2017/0369533 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising...
2017/0369532 CYTOMEGALOVIRUS ANTIGENS AND USES THEREOF
This disclosure provides modified cytomegalovirus (CMV) gL proteins and complexes comprising gL proteins. The modified gL proteins remain intact and are able...
2017/0369531 MU OPIOID RECEPTOR AGONIST ANALOGS OF THE ENDOMORPHINS
The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain....
2017/0369530 MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
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