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Patent # Description
2017/0369529 CELL PENETRATING PEPTIDES
Provided herein are cell penetrating peptides optionally including a cargo moiety linked thereto.
2017/0369528 CO-CRYSTAL OF CARFILZOMIB WITH MALEIC ACID AND PROCESS FOR THE PREPARATION OF PURE CARFILZOMIB
Aspects of the present application relates to co-crystal of carfilzomib with maleic acid, process for the preparation of co-crystal of carfilzomib with maleic...
2017/0369527 METHOD FOR AFFINITY PURIFICATION
The invention relates to a method of immunoaffinity purification which comprises the use of a binding agent which binds to an epitope that it is present at...
2017/0369526 BONE PROTEIN EXTRACTION WITHOUT DEMINERALIZATION
Embodiments of the invention relate generally to protein extraction and, more generally, to bone protein extraction methods that do not require ...
2017/0369525 SITE-SPECIFIC CONJUGATION THROUGH GLYCOPROTEINS LINKAGE AND METHOD THEREOF
A method for specific linkage to a glycoprotein includes obtaining a glycoprotein having a monoglycan or diglycan attached thereto; producing a reactive...
2017/0369524 In-situ Solvent Recycling Process for Solid Phase Peptide Synthesis at Elevated Temperatures
An improvement in of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high...
2017/0369523 TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE...
Template-fixed .beta.-hairpin peptidomimetics of the general formula ##STR00001## wherein Z is a template-fixed chain of 8 .alpha.-amino acid residues which,...
2017/0369522 3.ALPHA.-ETHYNYL, 3.BETA.-HYDROXY-5.ALPHA.-PREGNAN-20-OXIME FOR USE IN THE TREATMENT OF CNS DISORDERS
The invention relates to 3.alpha.-ethynyl, 3.beta.-hydroxy, 5.alpha.-pregnan-20-oxime or a pharmaceutically acceptable salt thereof, which compounds and/or...
2017/0369521 PROCESS FOR THE PREPARATION OF ESTETROL
The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3, 15a, 16a, 1713-tetraol (estetr-01), via a silyl enol ether...
2017/0369520 Adenosine receptor activation reagent and the uses of thereof
The present invention relates to application of N(6)-(2-hydroxyethyl)-adenosine (HEA) and its derivatives as an adenosine A.sub.1 receptor agonist in...
2017/0369519 METHODS FOR THE STEREOSELECTIVE PREPARATION OF APIOSE DERIVATIVES FROM ALLYLIC ALCOHOL COMPOUNDS AND ALLENE...
The present invention relates to a method for the stereoselective preparation of apiose derivatives from allylic alcohol compounds and allene compounds using...
2017/0369518 LIQUID-LIQUID EXTRACTION OF DMF
The present invention relates to a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate...
2017/0369517 COMPOSITIONS, METHODS AND SYSTEMS FOR DERIVATION OF USEFUL PRODUCTS FROM AGRICULTURAL BY-PRODUCTS
Embodiments of the present invention report compositions, systems and methods for obtaining xylo-oligosaccharide-rich extracts from agricultural by-product...
2017/0369516 Oxidized Lipids and Methods of Use Thereof
The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of...
2017/0369515 LIGAND COMPOUND, CATALYST SYSTEM FOR OLIGOMERIZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING THE SAME (As...
The present disclosure relates to a ligand compound, a catalyst system for oligomerization, and a method for olefin oligomerization using the same. The...
2017/0369514 Method Of Producing Organohalosilanes
A method for producing an organohalosilane, the method comprising: reacting an organic compound comprising a halogen-substituted or unsubstituted aromatic...
2017/0369513 SILICON OLIGOMER AND PRODUCTION METHOD THEREFOR
An object of the present invention is to provide a silicon oligomer having a novel function that has not been achieved by a conventional condensation product...
2017/0369512 APPARATUS AND CONTINUOUS FLOW PROCESS FOR PRODUCTION OF BORONIC ACID DERIVATIVES
A process for a continuous production of a boronic acid derivative based on a Matteson boronic ester homologation and an apparatus of performing the process...
2017/0369511 HETEROCYCLIC COMPOUNDS AND USES THEREOF
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods...
2017/0369510 TRICYCLIC DLK INHIBITORS AND USES THEREOF
The invention relates to compounds of formula (I) and salts thereof: ##STR00001## wherein ring A and R.sup.1-R.sup.2 have any of the values defined in the ...
2017/0369509 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a...
2017/0369508 COMPOUND FOR USES IN OPTICAL AND ELECTROOPTICAL DEVICES
A compound having the following formula: ##STR00001## which can also be embedded into a conjugated oligomeric of polymeric backbone, is proposed for optical and...
2017/0369507 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is...
2017/0369506 N-(2-(2-AMINO-6-SUBSTITUTED-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]OXAZIN-8a- (8H)-YL)-THIAZOL-4-YL) AMIDES
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds...
2017/0369505 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Disclosed herein are tricyclic compounds, including pyrimido[4',5':4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-4-amine, ...
2017/0369504 NOVEL METHOD FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATES USED THEREIN
The present invention provides a novel method for preparing a thienopyrimidine compound of Formula 1, which is a selective inhibitor of tyrosine kinase...
2017/0369503 OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE
This invention provides compounds having the structure ##STR00001## which may be used for the treatment of tumors.
2017/0369502 ANTIVIRAL COMPOUNDS
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
2017/0369501 KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATIONS
The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them, ...
2017/0369500 CONFORMATIONALLY RESTRICTED 4-SUBSTITUTED-2,6-DIMETHYLFURO[2,3-d]PYRIMIDINES AS ANTI-TUMOR AGENTS
The present invention provides conformationally restricted 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidine compounds and pharmaceutical compositions comprising...
2017/0369499 PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME
Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: ##STR00001## or a pharmaceutically...
2017/0369498 TRICYCLIC GYRASE INHIBITORS
Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as...
2017/0369497 IMIDAZOPYRAZINES AS LSD1 INHIBITORS
The present invention is directed to imidazo[1,2-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof, which are LSD1 inhibitors...
2017/0369496 PYRAZOLO[3,4-D]PYRIMIDIN DERIVATIVE AND ITS USE FOR THE TREATMENT OF LEISHMANIASIS
The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-IH-pyrazolo- [3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamide having the ...
2017/0369495 MOLECULAR ISOTOPIC ENGINEERING
The present invention relates to molecular isotopic engineering. The present invention relates to a method or process for preparing a target compound of a...
2017/0369494 DRUG FOR TREATING DISORDERS OF CORNEAL EPITHELIUM
A new agent for the treatment of a corneal epithelium disorder, which acts directly on corneal epithelial cells, is provided. Disclosed is an agent for the...
2017/0369493 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
2017/0369492 1,3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES AND ANALOGUES USEFUL IN THE TREATMENT OR PREVENTION OF DIABETES...
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Q, X.sup.4, X.sup.5, X.sup.6, X.sup.7, R.sup.1,...
2017/0369491 COMPOUNDS AND METHODS FOR TARGETING HSP90
Described herein are compounds that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may include...
2017/0369490 FLUORINATED TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID DERIVATIVES AND USES THEREOF
The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to...
2017/0369489 CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a...
2017/0369488 TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES AS LSD1 INHIBITORS
The present invention is directed to [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-a]pyrazine derivatives of Formula I, or a pharmaceutically...
2017/0369487 IMIDAZOPYRIDINES AND IMIDAZOPYRAZINES AS LSD1 INHIBITORS
The present invention is directed to imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof,...
2017/0369485 HETEROCYCLIC INHIBITORS OF GLUTAMINASE
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the...
2017/0369484 IMINOTHIADIAZINE DIOXIDES BEARING AN AMINE-LINKED SUBSTITUENT AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): or a tautomers thereof, and...
2017/0369483 ARYL SULFONAMIDES
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of...
2017/0369482 DERIVATIVES OF 5-PHENYL- OR 5-HETEROARYLATHIAZOL-2-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA...
The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IIIa), (III), or (IV) can increase cystic...
2017/0369481 Bicyclic PKM2 Activators
Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the...
2017/0369480 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
The present disclosure is directed to disclosed compounds that increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in...
2017/0369479 CYCLIC COMPOUNDS SUBSTITUTED BY A CONDENSED RING SYSTEM
Compounds of formula I ##STR00001## defined herein are provided. Uses of these compounds for controlling invertebrate pests, protecting plant propagation...
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