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Patent # Description
2017/0369478 1,3-DIHYDROIMIDAZOLE-2-THIONE DERIVATIVES AS INHIBITORS OF DOPAMINE-BETA-HYDROXYLASE
Compounds of formula I and a method for their preparation are described, where R.sub.1, R.sub.2 and R.sub.3 are the same or different and signify hydrogens,...
2017/0369477 1,3-Dihydroimidazole-2-Thione Derivatives for Use in the Treatment of Pulmonary Arterial Hypertension and Lung...
The present invention relates to compounds of formula I: ##STR00001## for use in treating pulmonary arterial hypertension and associated conditions, where...
2017/0369476 2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS
Compounds within the scope of the present invention have a Formula 1 ##STR00001## or a salt or prodrug thereof, where ring A is selected from cycloaliphatic;...
2017/0369475 Flibanserin Hydrate
The present invention relates to a hydrate of flibanserin, a process for its preparation and to a pharmaceutical composition comprising the hydrate. The...
2017/0369474 COMPOUNDS, COMPOSITIONS AND METHODS OF USE
Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases,...
2017/0369473 PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS
The invention relates to heterocyclic angiotensin II type 2 (AT.sub.2) receptor antagonists of formula (I), and pharmaceutically acceptable salts thereof, ((I)...
2017/0369472 MAP KINASE MODULATORS AND USES THEREOF
The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38.alpha. MAP...
2017/0369471 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
Provided are 5-substituted quinazolinone compounds, for example, of formula (I), and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers,...
2017/0369470 Cyclic Compounds and Uses Thereof
The invention generally relates to substituted benzothiophenyl, substituted benzothiazolyl, substituted indolyl and substituted benzoimidazolyl compounds and,...
2017/0369469 COMPOUNDS, COMPOSITIONS AND METHODS
The disclosed subject matter provides certain polymorphic forms of Compound (I) as well as pharmaceutical compositions comprising Compound (I) or such...
2017/0369468 ANTHROPOD REPELLENT CHEMICALS
Compositions and methods for repelling arthropods. The compositions include a carrier and an arthropod repelling compound, which can be a compound discovered...
2017/0369467 Process for the Preparation of N-Monosubstituted beta-Amino Alcohols
A process is disclosed for the preparation of a compound of formula ##STR00001## and/or an addition salt of a proton acid, wherein R.sup.1 and R.sup.2 ...
2017/0369466 3-[(BENZO[D][1,3]DIOXOLAN-4-YL)-OXY]-3-ARYLPROPYLAMINE TYPE COMPOUNDS AND APPLICATIONS THEREOF
The present invention relates to 3-[(benzo[d][1,3]dioxolan-4-yl)-oxy]-3-arylpropylamine compounds of formula I or pharmaceutically acceptable salts thereof and...
2017/0369465 SOOTHING PRO-PHEROMONAL COMPOSITION FOR MAMMALS
The invention relates to a compound of general formula (I) (in configuration Z or E) and to pro-pheromonal compositions and formulations comprising said...
2017/0369464 Process for Producing 4-Azidosulfonylphthalic Anhydride
The present disclosure provides a process for the production of 4-azidosulfonylphthalic anhydride. In an embodiment, a process is provided and includes...
2017/0369463 ESTERIFICATION OF 2,5-FURAN-DICARBOXYLIC ACID
A method of making a furan dicarboxylate by means of reacting 2,5-furan dicarboxylic acid (FDCA) with an alcohol or mixture of alcohols in a ...
2017/0369462 Modulation of Bacterial Quorum Sensing with Synthetic Ligands
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention...
2017/0369461 PROFLAVOR DELIVERY POWDERS
Provided herein are formulations of plated powders of acetaldehyde precursors. Also provided herein are methods of making and using the powders.
2017/0369460 CARRIER TREATMENT TO IMPROVE CATALYTIC PERFORMANCE OF AN ETHYLENE OXIDE CATALYST
A method for lowering the sodium content of different carriers which may have different physical properties as well as varying degrees of sodium is provided....
2017/0369459 THIADIAZOLYL - OXIMINOACETIC ACID DERIVATIVE COMPOUNDS
Thiadiazolyl-oximinoacetic acid derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds. Compound (1)...
2017/0369458 METHOD FOR PREVENTION OF PREMATURE POLYMERIZATION
The present invention relates to a method for prevention of premature polymerization during the preparation, purification, transportation and storage of a...
2017/0369457 Antibacterial Compounds
The present invention relates to the following compounds for use in the treatment of a bacterial infection ##STR00001## wherein the integers are as defined in...
2017/0369456 SYNTHESIS OF CYCLOPHANES FOR A SELF-ASSEMBLY REACTION
Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or...
2017/0369455 COMBINATION OF UV ABSORBER AND PIGMENT FOR PROTECTION OF SUBSTRATES FROM UV/VIS-RADIATION
A coating composition, which contains one or more compounds (A) according to formula (I) and a pigment (B) having a minimum integrated transmittance within the...
2017/0369454 18F-LABELED TRIAZOLE CONTAINING PSMA INHIBITORS
The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of...
2017/0369453 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates...
2017/0369452 Catalysis of Diketopiperazine Synthesis
Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of .epsilon.-amino...
2017/0369451 METHODS FOR PREPARING FUSED BICYCLIC 2, 4-DIAMINOPYRIMIDINE DERIVATIVES
The present disclosure is directed to improved methods useful for the preparation of, for example, ...
2017/0369450 ANTIBACTERIAL COMPOUNDS HAVING BROAD SPECTRUM OF ACTIVITY
The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.
2017/0369449 KINASE INHIBITORS FOR THE TREATMENT OF DISEASE
The invention relates to compounds and their use in the treatment of disease. Novel irreversible inhibitors of wild-type and mutant forms of EGFR, FGFR, ALK,...
2017/0369448 COMPOUNDS FOR AFFINITY CHROMATOGRAPHY AND FOR EXTENDING THE HALF-LIFE OF A THERAPEUTIC AGENT
Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum...
2017/0369447 COMPOUNDS USEFUL AS MODULATORS OF TRPM8
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species...
2017/0369446 MONOCYCLIC HETEROARYL COMPOUNDS
This invention relates to compounds of the general formula: ##STR00001## in which the variable groups are as defined herein, and to their preparation and use.
2017/0369445 a-KETOACYLIC ISONIAZID COMPOUNDS, PROCESS FOR PRODUCING SAID COMPOUNDS, USE OF THE COMPOUNDS IN THE TREATMENT...
The instant invention relates to compounds of formula I ##STR00001## wherein: R is selected from H, Me or Cl, and R' is selected from: H, NH.sub.2,...
2017/0369444 INHIBITORS OF HISTONE DEMETHYLASES
Compounds of the form in which Q is selected from --COOH--CH.dbd.NR.sup.12, --W, --CH.sub.2NHR.sup.13, --CH=0 and --CH(OR.sup.17).sub.2 capable of modulating...
2017/0369443 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2017/0369442 METHOD FOR PREPARING 4-CYANOPIPERIDINE HYDROCHLORIDE
The present invention describes a novel method for preparing 4-cyanopiperidine hydrochloride.
2017/0369441 PIPERIDINE DERIVATIVES AS HDAC1/2 INHIBITORS
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders...
2017/0369440 PROCESS FOR THE PRODUCTION OF 2-[4-(CYCLOPROPANECARBONYL)PHENYL]-2-METHYL-PROPANENITRILE
A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile is described. This compound can be used for the production of...
2017/0369439 CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE SAME, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE...
A condensed cyclic compound represented by Formula 1: ##STR00001## wherein in Formula 1 groups and variables are the same as described in the specification.
2017/0369438 METHOD FOR PRODUCING PYRROLE DERIVATIVE, AND INTERMEDIATE THEREOF
The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity,...
2017/0369437 Process for Preparing Alpha-Carboxamide Pyrrolidine Derivatives
The invention relates to a novel process for preparing .alpha.-carboxamide pyrrolidine derivatives, in particular (2S, ...
2017/0369436 METHODS FOR IMPROVED PRODUCTION OF VITAMINS D2 AND D3
It is an object of the present invention to provide methods for producing vitamin D that gives improved yields and reduced side product contamination. In...
2017/0369435 COMPOUNDS FOR THE TREATMENT OF MTOR PATHWAY RELATED DISEASES
The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present...
2017/0369434 HYDROXY METHIONINE ANALOG FORMULATIONS SUITABLE FOR SPECIALTY CHEMICAL APPLICATIONS
Formulations comprising hydroxy methionine analog and having low levels of sulfate ions and bisulfate salts, processes for preparing the formulations,...
2017/0369433 Beta Lactamase Inhibitors
A compound which is a thienolate of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R.sup.1, R.sup.3, Ring A1, n and Ring A2 are as...
2017/0369432 PREPOLYMERS EXHIBITING RAPID DEVELOPMENT OF PHYSICAL PROPERTIES
Hydroxyl-containing bis(alkenyl) ethers can be incorporated into the backbone of polythioether prepolymers and can be used as curing agents in thiol-terminated...
2017/0369431 HYDRAZINYL AND AMINOOXY COMPOUNDS AND THEIR METHODS OF USE
The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate,...
2017/0369430 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND...
The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphoric acid and carboxylic acid derivatives, in particular the...
2017/0369429 METHOD FOR PREPARING HIGH-PURITY SULFONAMIDE COMPOUND, AND INTERMEDIATE OF SULFONAMIDE COMPOUND
The present invention discloses a method for preparing a high-purity sulfonamide compound and an intermediate of the sulfonamide compound. The method comprises...
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