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Patent # Description
2017/0369883 MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION
Disclosed herein are antisense compounds and methods for decreasing HBV mRNA, DNA and protein expression. Such methods, compounds, and compositions are useful...
2017/0369882 FULLY STABILIZED ASYMMETRIC SIRNA
Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient...
2017/0369881 RNA Targeting in Alpha-Synucleinopathies
Therapies and assays to screen for small molecules that can have therapeutic use in the control of neurodegenerative diseases such as Parkinson's and other...
2017/0369880 COMPOSITIONS COMPRISING ALTERNATING 2'-MODIFIED NUCLEOSIDES FOR USE IN GENE MODULATION
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is...
2017/0369879 METHODS FOR TREATMENT OF ALPORT SYNDROME
Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified...
2017/0369878 MICRORNA COMBINATIONS FOR ANTI-CANCER THERAPEUTICS
Described herein are methods and compositions of combinations of microRNAs that enhance the sensitivity of cancer cells to chemotherapeutic agents or reduce...
2017/0369877 REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to...
2017/0369876 EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.
2017/0369875 EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.
2017/0369874 RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 ANTI-TRYPSIN DEFICIENCIES
The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin...
2017/0369873 PARENTAL RNAI SUPPRESSION OF CHROMATIN REMODELING GENES TO CONTROL COLEOPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of...
2017/0369872 REVERSIR TM COMPOUNDS
The present invention relates, in general to agents that modulate the pharmacological activity of conjugated siRNAs.
2017/0369871 INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF
Disclosed herein are methods, composition and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA, wherein the...
2017/0369870 METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive...
2017/0369869 EXPRESSION AND SECRETION SYSTEM
The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic...
2017/0369868 METHOD FOR ENGINEERING IMMUNOGLOBULINS
The present invention relates to a method for engineering an immunoglobulin comprising a variable domain and at least one modification in at least two...
2017/0369867 MIRAC PROTEINS
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are...
2017/0369866 COMPOSITIONS AND METHODS FOR EFFICIENT GENE EDITING IN E. COLI USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS IN...
Compositions and methods are provided for genome modification of a target sequence in the genome of an Escherichia coli cell. The methods and compositions...
2017/0369865 ACOUSTOPHORESIS DEVICE WITH DUAL ACOUSTOPHORETIC CHAMBER
An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates...
2017/0369863 GENETICALLY MODIFIED PHENYLPYRUVATE DECARBOXYLASE, PROCESSES TO PREPARE, AND USES THEREOF
Modification of the amino acid sequence of a phenylpyruvate decarboxylase from Azospirillum brasilense produces a novel group of phenylpyruvate decarboxylases...
2017/0369862 PREPARATION OF FACTOR XA DERIVATIVES
The present disclosure provides methods for manufacturing a fXa derivative protein at large scale leading to high yield of highly pure protein product. The...
2017/0369861 MUTATED FACTOR X POLYPEPTIDES AND USES THEREOF FOR THE TREATMENT OF HAEMOPHILIA
The present invention relates to mutated factor (FX) polypeptides and uses thereof for the treatment of haemophilia. In particular, the present invention...
2017/0369860 Endoglucanase Variants and Polynucleotides Encoding Same
The present invention relates to endoglucanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2017/0369859 METHODS OF COMBINED BIOPROCESSING AND RELATED MICROORGANISMS, THERMOPHILIC AND/OR ACIDOPHILIC ENZYMES, AND...
A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus...
2017/0369858 GENE CONSTRUCT ENCODING MUTANT THIOESTERASE, MUTANT THIOESTERASE ENCODED THEREBY, TRANSFORMED HOST CELL...
Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of...
2017/0369857 NUCLEOTIDE TRANSIENT BINDING FOR SEQUENCING METHODS
Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the...
2017/0369856 DNA POLYMERASES AND RELATED METHODS
Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a...
2017/0369855 SYSTEMS AND METHODS FOR GENOME MODIFICATION AND REGULATION
The present invention provides methods of systems and methods of site specific methylation.
2017/0369854 A METHOD FOR A LARGE SCALE VIRUS PURIFICATION
Methods of producing and purifying viruses using density gradient ultracentrifugation. The methods are suitable for large scale production, and for viruses...
2017/0369853 FORMULATION OF SUGAR SOLUTIONS FOR CONTINUOUS ULTRACENTRIFUGATION FOR VIRUS PURIFICATION
The present invention provides a method for purification of a virus or virus antigen comprising providing a virus preparation and centrifugation of said virus...
2017/0369852 NOVEL LACTOBACILLUS BREVIS BACTERIOPHAGE LAC-BRP-1 AND USE THEREOF FOR INHIBITING LACTOBACILLUS BREVIS...
The present invention relates to a Siphoviridae bacteriophage Lac-BRP-1 that is isolated from the nature and can kill Lactobacillus brevis cells specifically,...
2017/0369851 ARTIFICIAL OVARY
Artificial ovaries comprising porous three-dimensional scaffolds are provided. Also provided are ink compositions and methods for printing the scaffolds. The...
2017/0369850 METHOD FOR INDUCING T CELLS FOR IMMUNOCYTOTHERAPY FROM PLURIPOTENT STEM CELLS
Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of: (1) providing Rag 1 and/or Rag 2 gene knockout human...
2017/0369849 COMPOSITIONS AND METHODS FOR BIOENGINEERED TISSUES
The present disclosure provides methods for producing bioengineered tissue along with an apparatus and other relevant compositions employed in generation thereof.
2017/0369848 ENGINEERING MESENCHYMAL STEM CELLS USING HOMOLOGOUS RECOMBINATION
Methods are provided herein for genetically modifying a mesenchymal stem cell, differentiating these cells and using these cells in screening and in treating...
2017/0369847 TISSUES CONTAINING SEMICONDUCTOR NANOMATERIALS AND METHODS OF PREPARING AND USING THE SAME
Provided herein are tissues containing semiconductor nanomaterials and methods of preparing and using the same.
2017/0369846 METHOD FOR SORTING CARDIOMYOCYTES
An object of the present invention is to provide a novel method for sorting cardiomyocytes. Another object of the present invention is to provide a method for...
2017/0369845 METHODS FOR ISOLATION OF PLATELETS
Provided herein are methods for the isolation of platelets, for example, isolation of platelets from umbilical cord blood. In certain embodiments, presented...
2017/0369844 Separating Composite Liquids
Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane...
2017/0369843 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or...
2017/0369842 DIFFERENTIATION OF PRIMATE PLURIPOTENT STEM CELLS TO HEMATOPOIETIC LINEAGE CELLS
The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides...
2017/0369841 METHOD FOR MODIFYING T CELL POPULATION
Provided is a method for increasing the proportion of memory T cells in a T cell population, said method comprising a step of adding a modulator for the...
2017/0369840 DIRECT CONVERSION OF CELLS TO CELLS OF OTHER LINEAGES
Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods,...
2017/0369839 ISOLATED HUMAN LUNG PROGENITOR CELLS AND USES THEREOF
Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such...
2017/0369838 LONG-TERM CELL-CULTIVATION USING POLYIMIDE POROUS MEMBRANE AND CELL-CRYOPRESERVATION METHOD USING POLYIMIDE...
The invention relates to a long term cell culturing method and a cell culturing apparatus and kit that employ a porous polyimide film. The invention further...
2017/0369837 FEED MEDIA
The invention provides stable feed media containing pyruvate and methods for stabilizing feed media by adding pyruvate. The invention further provides methods...
2017/0369836 SERUM-FREE MEDIUM FOR FULL SUSPENSION CULTURE OF MDCK CELLS AND PREPARATION METHOD OF SERUM-FREE MEDIUM
The present invention discloses a serum-free medium for full suspension culture of MDCK cells and a preparation method of the serum-free medium. The serum-free...
2017/0369835 METHOD OF REMOVING DNA FROM BIOTECHNOLOGICAL PRODUCTS
The present invention relates to a method for degrading DNA in a sample obtained by microbial fermentation or bio-transformation, comprising treating the...
2017/0369834 CRYOPROTECTIVE COMPOSITIONS AND USES THEREOF
The invention pertains to compositions for preserving biological material or active molecules, particularly microorganisms, and their uses.
2017/0369833 CELL CULTURE CONTAINER, AUTOMATIC CELL CULTURE APPARATUS, LIQUID CONTAINER, ROBOT HAND, AND ROBOT SYSTEM
A bottle includes a body, a cap mounted to a cap neck of the body. The cap has an outer peripheral portion which is provided with a protrusion. Around the cap,...
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