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Patent # Description
2018/0002397 CD33 SPECIFIC CHIMERIC ANTIGEN RECEPTORS
Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from a CD33 monoclonal antibody....
2018/0002393 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related...
2018/0002392 Cytokine Fusion Proteins
The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further...
2018/0002391 GLYPICAN EPITOPES AND USES THEREOF
The present invention relates to epitopes of glypican-1 (GPC-1) and uses thereof.
2018/0002386 NOVEL INSECTICIDAL PROTEINS TOXIC OR INHIBITORY TO HEMIPTERAN PESTS
Nucleotide sequences are disclosed encoding novel, insecticidal TIC4747 and related proteins exhibiting Hemipteran and Lepidopteran inhibitory activity, as...
2018/0002385 Influenza Virus Vaccines And Uses Thereof
Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.
2018/0002379 METHODS AND COMPOSITIONS FOR IDENTIFICATION OF HIGHLY SPECIFIC NUCLEASES
Disclosed herein are methods and compositions for identification of specific DNA binding domains for constructing highly specific nucleases, which allows for...
2018/0002377 A PROCESS FOR PURIFICATION OF CARFILZOMIB
The present invention relates to a process for the purification of Carfiizomib of Formula I that reduces the level of an acetamide impurity of Formula II...
2018/0002374 Non-Denatured Proteins Derived From a Biomass Source
A biomass-derived protein compound has a high concentration of protein and can be made to have a very low concentration of fat and water; even when the biomass...
2018/0002373 Amino Acid and Peptide Conjugates and Uses Thereof
The present invention relates to peptides, and amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by...
2018/0002371 BUFALIN PHOSPHATE PRODRUGS AND METHODS OF USE THEREOF
Bufalin phosphate prodrugs are provided herein, as well as methods for their use as small molecule inhibitors of steroid receptor coactivator (SRC) family...
2018/0002367 Phosphorodiamidate Backbone Linkage for Oligonucleotides
This invention relates to antisense oligonucleotides comprising at least one N3'.fwdarw.P5' phosphorodiamidate linkage (NPN) in the backbone as well as methods...
2018/0002363 SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH
The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.
2018/0002361 ALKANE DEHYDROGENATION PROCESS
Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex. In the dehydrogenation reactions, hydrogen that...
2018/0002360 PHOSPHAZENE COMPOUND CONTAINING ESTER GROUP, PREPARATION METHOD AND USE THEREOF
The present invention relates to a phosphazene compound containing an ester group having a structure of formula (I). The present invention grafts ester groups...
2018/0002359 PHOSPHITE COMPOUND, METHOD FOR PRODUCING THE SAME AND USES THEREOF
The present invention relates to a novel phosphite compound represented by the formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each...
2018/0002358 TRICYCLIC SULFONES AS ROR GAMMA MODULATORS
There are described ROR.gamma. modulators of the formula (I), ##STR00001## and formula (II) ##STR00002## or stereoisomers, tautomers, pharmaceutically acceptable...
2018/0002356 HETEROBICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can...
2018/0002355 BENZOCYCLOOCTENE-BASED AND INDENE-BASED ANTICANCER AGENTS
Benzocyclooctene (fused 6,8 ring system) analogues and corresponding indene (fused 6,5 ring system) analogues function as inhibitors of tubulin polymerization....
2018/0002354 PEROVSKITE CORE-SHELL NANOCRYSTALS
Provided is a nanocrystal comprising a core comprised in a shell, wherein the core comprises a first material of a perovskite structure comprising a first...
2018/0002352 Quinolinyldiamido Transition Metal Complexes, Production and Use Thereof
Quinolinyldiamido transition metal complexes are disclosed for use in alkene polymerization to produce multimodal polyolefins.
2018/0002351 BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to...
2018/0002350 BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the...
2018/0002347 CONDENSED HETEROCYCLIC COMPOUND HAVING CYCLOALKYLPYRIDYL GROUP OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL...
An object of the present invention is to provide and develop novel agricultural and horticultural insecticides in view of the still immense damage caused by...
2018/0002344 HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are heteroaryl compounds with estrogen receptor modulation activity or function having the Formula I, II, and III structures: ##STR00001## ...
2018/0002343 HETEROCYCLIC INHIBITORS OF MONOCARBOXYLATE TRANSPORTERS
The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a...
2018/0002342 MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B
The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization...
2018/0002341 ASYMMETRIC SYNTHESIS OF FUNAPIDE
This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or...
2018/0002339 TRICYCLIC HETEROCYCLES AS ANTICANCER AGENTS
Tricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity,...
2018/0002336 IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS
The present invention relates to substituted imidazopyridazine derivatives of Formula (I) ##STR00001## wherein the variables have the meaning defined in the...
2018/0002333 ETHYNYL DERIVATIVES
The present invention relates to compounds that may be used for the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism,...
2018/0002331 5,7-Dihydro-Pyrrolo-Pyridine Derivatives
The present invention provides, in part, compounds of Formula I: ##STR00001## or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the...
2018/0002329 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY
A compound of formula (I') or (I'') or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including...
2018/0002328 SUBSTITUTED IMIDAZO[1, 2-A]PYRIDIN-2-YLAMINE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
Provided herein are substituted imidazo[1,2-a]pyridin-2-ylamine compounds, for example, of formula (A), and pharmaceutical compositions thereof; and methods of...
2018/0002327 HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
2018/0002326 PRODUCTION METHOD OF THIAZOLE DERIVATIVE
Provided is a production method of a thiazole derivative represented by the formula (I), which has an adenosine A.sub.2A receptor antagonistic action and is...
2018/0002325 OXATHIAZOLE THIAZOLIUM HSP 70 INHIBITORS
Provided herein are compounds of formula (I) which are, inter alia, useful allosteric inhibitors of Hsp70. The compounds and methods provided are useful for...
2018/0002324 METHODS AND AGENTS FOR TREATING DISEASE
The present invention provides compounds having the general structural formula (I) [formula should be inserted here] and pharmaceutically acceptable...
2018/0002323 AZOLINE COMPOUNDS SUBSTITUTED BY A CONDENSED RING SYSTEM
Compounds of formula I are provided herein, as well as the use of these compounds for controlling invertebrate pests. Plant propagation material and...
2018/0002322 BICYCLIC COMPOUND
Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: ##STR00001## wherein each symbol is as...
2018/0002321 SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE
Disclosed are compounds of formula (I) wherein A is CH or N, B is CR or N; and D is CR; R represents hydrogen, OH or NH.sub.2; R1 and R2, independently of each...
2018/0002319 MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY
This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. ##STR00001##
2018/0002317 CRYSTALLINE SALT FORM OF (S)-(2-(6-CHLORO-7-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)-2-METHYLPYRROLIDIN-1-- ...
The invention relates to a crystalline form of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-- ...
2018/0002313 ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS...
Compounds of formula (I): ##STR00001## wherein Het, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.8, R.sub.9, T, p, p', q, and q' are as defined in the description. ...
2018/0002311 PROCESS FOR PREPARING AN ANTI-CANCER AGENT, ...
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine...
2018/0002310 CRYSTALLINE FORMS OF EFINACONAZOLE
The present invention provides crystalline forms of efinaconazole, including crystalline efinaconazole forms designated herein as Form A, Form B and Form C,...
2018/0002308 TRICYCLIC SPIRO COMPOUND
A medicinal agent for the prevention and/or treatment of diseases caused by EP.sub.4 receptor activation. A compound having antagonistic activity against the...
2018/0002306 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE
The present disclosure provides edible compositions comprising a flavor-grade sweet taste modulator or a combination of flavor-grade sweet taste modulators or...
2018/0002305 PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES
Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their...
2018/0002304 PREPARATION OF FURFURAL USING MIXED SOLVENTS
Processes for the preparation of furfural from a xylose containing feedstock and more particularly to an elevated temperature conversion of a xylose containing...
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