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Patent # Description
2018/0015192 ULTRAVIOLET B LIGHTING SYSTEM FOR A MOTOR VEHICLE
A UVB lighting system for a motor vehicle includes a printed circuit board including a UVB light source and a map light. A controller operates the system. A...
2018/0015191 DEVICE AND METHOD FOR STERILIZING THERMOPLASTIC CONTAINERS USING A PULSED ELECTRON BEAM AND A MOBILE REFLECTOR
Disclosed is a device and a method for sterilizing thermoplastic containers using a pulsed beam of electrons which is formed of a succession of pulses each...
2018/0015190 STERILIZING METHOD AND APPARATUS
Methods and apparatus for sterilization are presented. An apparatus includes a sterilizing cabinet assembly including a cabinet having an access port and a...
2018/0015189 Method for Virus Clearance
The invention discloses a method for virus clearance of a cell culture medium, comprising the steps of: i) providing a bulk medium portion, comprising amino...
2018/0015188 Methods of Performing Brachytherapy
In one aspect, radioactive nanoparticles are described herein. In some embodiments, a radioactive nanoparticle described herein comprises a metal nanoparticle...
2018/0015187 COMPOUNDS AND COMPOSITIONS FOR TARGETING MACROPHAGES AND OTHER MANNOSE-BINDING C-TYPE LECTIN RECEPTOR HIGH...
Provided are compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of...
2018/0015186 Compositions And Methods For In Vivo Imaging
This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.
2018/0015185 Mice expressing polymorphic low affinity FcgammaR alpha-chains
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a...
2018/0015184 METHOD AND COMPOSITION TO INCREASE RADIATION-INDUCED TUMOR THERAPEUTIC EFFECTS
Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side...
2018/0015183 METHOD AND COMPOSITION TO INCREASE RADIATION-INDUCED TUMOR THERAPEUTIC EFFECTS
Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side...
2018/0015182 Engineered Exosomes for the Delivery of Bioactive Cargo Using Transmembrane Tetraspanins
Engineered exosomes for the delivery of bioactive cargo are provided. The exosomes incorporate a tetraspanin transmembrane anchoring scaffold onto the membrane...
2018/0015181 COMBINATIONS AND MODES OF ADMINISTRATION OF THERAPEUTIC AGENTS AND COMBINATION THERAPY
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising...
2018/0015180 SHORT AND D-AMINO ACID-CONTAINING POLYPEPTIDES FOR THERAPEUTIC CONJUGATES AND USES THEREOF
The present invention relates to short polypeptides (e.g., fewer than 19 amino acids in length) and longer polypeptides (e.g., 19 or more amino acids in...
2018/0015179 ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES
The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.
2018/0015178 ANTI-DLL3 ANTIBODY DRUG CONJUGATES AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
2018/0015177 ANTI-Ly6E ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE
The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.
2018/0015176 ANTIBODY-DRUG CONJUGATES (ADCS) OF KSP INHIBITORS WITH AGLYCOSYLATED ANTI-TWEAKR ANTIBODIES
The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use...
2018/0015175 LIQUID FORMULATION OF LONG ACTING INSULINOTROPIC PEPTIDE CONJUGATE
Provided are a liquid formulation of long-acting insulinotropic peptide conjugate, containing a pharmaceutically effective amount of long-acting insulinotropic...
2018/0015174 SYNTHETIC NANOPARTICLES FOR DELIVERY OF IMMUNOMODULATORY COMPOUNDS
The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer...
2018/0015173 CONJUGATES FOR PROTECTION FROM NEPHROTOXIC ACTIVE SUBSTANCES
The present invention relates to a conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective...
2018/0015172 ENGINEERED RECEPTOR/LIGAND SYSTEM FOR DELIVERY OF THERAPEUTIC AGENTS
Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent to a subject utilizing an engineered ...
2018/0015171 HIGH-DENSITY LIPOPROTEIN, AND DELIVERY OF DRUG TO POSTERIOR SEGMENT OF EYE BY OCULAR INSTILLATION OF SAID...
The purpose of the present invention is to provide a novel system for the delivery of a drug to a posterior segment of the eye. The present invention relates...
2018/0015170 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY
Methods and compositions relating to CDP-taxane conjugates are described herein.
2018/0015169 STABILIZING EXCIPIENTS FOR THERAPEUTIC PROTEIN FORMULATIONS
The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a...
2018/0015168 STABILIZING EXCIPIENTS FOR THERAPEUTIC PROTEIN FORMULATIONS
The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a...
2018/0015167 CROSSLINKABLE TREHALOSE FOR THE COVALENT INCORPORATION IN HYDROGELS AND METHODS OF USE
Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.
2018/0015166 POLYAPHRONS AND PALPEBRAL ADMINISTRATION THEREOF
Disclosed is a composition for use for topical administration onto the upper and/or lower eyelid of a subject. The composition includes a polyaphron, and the...
2018/0015165 FORMULATIONS FOR THE DELIVERY OF ACTIVE INGREDIENTS
This invention relates generally to in vivo delivery of active ingredient formulations. More particularly, this invention relates to formulations of active...
2018/0015164 A Composition Containing Protective Agent for Singlet Oxygen and A Preparation Method therefor
The Invention relates to a method to utilize the characteristic of a protective agent to incubate singlet oxygen and prolong its lifetime so as to provide...
2018/0015163 CANCER METHODS
A method of treating a patient having a cancer in which HER2, HER4, FGFR1, EPHA2 and/or FGFR3 is upregulated and/or in which HER2, HER4, FGFR1, EPHA2 and/or...
2018/0015162 ANTIBODIES THAT BIND HUMAN C6 AND USES THEREOF
Isolated monoclonal antibodies that bind to human complement component C6 and related antibody-based compositions and molecules are disclosed. Also disclosed...
2018/0015161 Checkpoint Inhibitor and Vaccine Combinations and Use of Same For Immunotherapy
Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject....
2018/0015160 In Vivo Activation of Antigen Presenting Cells for Enhancement of Immune Responses Induced by Virus-Like Particles
The invention relates to the finding that stimulation of antigen presenting cell (APC) activation using substances such as anti-CD40 antibodies or DNA...
2018/0015159 CMV ANTIGENS AND USES THEREOF
The invention relates to a recombinant human cytomegalovirus (CMV) protein dimeric complex comprising CMV gH protein or a complex-forming fragment thereof, and...
2018/0015158 Stable, Spray Dryed, Immunogenic, Viral Compositions
Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, MVA viruses, and baculoviruses which encode...
2018/0015157 Attenuated Pasteurella Multocida Vaccines & Methods of Making & Use Thereof
The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains,...
2018/0015156 POLYMER PARTICLES AND USES THEREOF
The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalised polymer particles, processes...
2018/0015155 COMBINATION OF PROTEIN FORMS FOR HORNFLY VACCINATION
Thrombostasin is an anti-clotting protein found in saliva of Haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on...
2018/0015154 Radiohalogenated Agents for in Situ Immune Modulated Cancer Vaccination
A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an ...
2018/0015153 COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION
The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the...
2018/0015152 Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway
The present invention provides compositions and methods for treating or preventing a disease or disorder associated with endothelial activation, inflammation...
2018/0015151 METHODS AND COMPOSITIONS FOR IMPROVED COGNITION
Provided herein are klotho polypeptide compositions and methods for improving cognitive function in an individual comprising treatment of with klotho...
2018/0015150 THERAPEUTIC INTERVENTION GUIDANCE SYSTEM FOR ATOPIC ECZEMA AND A METHOD OF PROVIDING THERAPEUTIC INTERVENTION...
A therapeutic intervention guidance system for atopic eczema includes a device measuring a skin surface moisture level and a Trans-Epidermal Water Loss (TEWL)...
2018/0015149 COLLAGEN III COMPOSITION AND USES
The invention includes methods of suppressing cancer metastasis and local recurrence in a subject. In one aspect, the method comprises removing the tumor by...
2018/0015148 DRUG FOR INHIBITING ADIPOSE CELL DIFFERENTIATION AND INSULIN RESISTANCE
The present invention provides use of endostatin or a functional variant thereof in the preparation of a medicament for treating dietary obesity, non-alcoholic...
2018/0015147 MATRIX IN BALL FORM AS A CELL CARRIER
The invention relates to a matrix in ball form comprising cross-linked fibrinogen, the matrix being free from fibrin, as well as to a method for preparing such...
2018/0015146 THERAPEUTIC AGENT PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG...
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many...
2018/0015145 VESICLES COMPRISING EPIDERMAL GROWTH FACTOR AND COMPOSITIONS THEREOF
The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also...
2018/0015144 AGONISTS OF THE NOGO-A S1PR PATHWAY FOR THE TREATMENT OF GLIOBLASTOMA
The invention relates to the use of an extracellular domain of Nogo selected from Nogo-A delta 20 and Nogo-66 for the treatment of glioblastoma, particularly...
2018/0015143 METHODS TO TREAT ALLERGIC CONDITIONS
Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits...
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