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Patent # Description
2018/0015091 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)
Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance...
2018/0015090 COMPOUNDS FOR ENHANCING PPARy EXPRESSION AND NUCLEAR TRANSLOCATION AND THERAPEUTIC USE THEREOF
The present invention relates to a novel type of PPAR.gamma. modulator having a pyrimido[5,4-d]pyrimidine main structure. The PPAR.gamma. modulator can enhance...
2018/0015089 METHOD OF TREATING OR PREVENTION OF ATHEROTHROMBOTIC EVENTS IN PATIENTS WITH HISTORY OF MYOCARDIAL INFARCTION
The present disclosure relates to methods for reducing the rate of cardiovascular death, myocardial infarction, or stroke in a patient in recognized need...
2018/0015088 SITE SPECIFIC DOSING OF A BTK INHIBITOR
Disclosed herein are formulations and methods of site specific administration of Compound (I) or a pharmaceutically acceptable salt thereof. Compound (I) is a...
2018/0015087 CONJUGATES OF CEREBLON BINDING COMPOUNDS AND G12C MUTANT KRAS, HRAS OR NRAS PROTEIN MODULATING COMPOUNDS AND...
Conjugates of a cereblon-binding compound and compounds having modulatory activity against G12C mutant KRAS, HRAS or NRAS G12C proteins are provided. Methods...
2018/0015086 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA
The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula I: ...
2018/0015085 CGRP Receptor Antagonists
The disclosures herein relate to novel compounds of formula ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, and their use in...
2018/0015084 Use of Flibanserin in the Treatment of Obesity
The invention relates to compositions for the treatment of obesity and related diseases comprising a) an active substance being not flibanserin, selected from...
2018/0015083 PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES
Disclosed are compounds of Formula 1, ##STR00001## or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined in...
2018/0015082 6-Alkynyl-pyridine Derivatives
6-Alkynyl-pyridine of general formula (I) ##STR00001## their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments...
2018/0015081 Crenolanib for Treating FLT3 Mutated Proliferative Disorders
The present invention relates to the use of crenolanib, in a pharmaceutically acceptable salt form for the treatment of FLT3 mutated proliferative disorders...
2018/0015080 COMPOSITIONS AND METHODS FOR TREATMENT IN PARKINSON'S DISEASE PATIENTS
The invention provides dosage forms and methods for treating Parkinson's Disease, symptoms resulting from Parkinson's Disease, side effects resulting from...
2018/0015079 THERAPEUTIC AGENT FOR BILE DUCT CANCER
The present invention provides a therapeutic agent for bile duct cancer comprising 5-((2-(4-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-- ...
2018/0015078 STABILIZED LIQUID FORMULATIONS CONTAINING PICOSULFATE
Stable liquid formulations containing picosulfate and magnesium citrate are provided. The formulations are useful to treat constipation or for the clearance of...
2018/0015077 COMPOUNDS AND METHODS FOR TREATING HIV INFECTION
Provided herein, inter alia, are methods and compounds for treating an HIV infection.
2018/0015076 METHODS OF INCREASING TONIC INHIBITION AND TREATING SECONDARY INSOMNIA
Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods...
2018/0015075 METHODS AND COMPOSITIONS FOR TREATMENT OF VENOUS MALFORMATION
Methods of treating venous malformation (VM) are described. The described methods may include the steps of administering an mTOR inhibitor and an ABL kinase...
2018/0015074 USE OF MTOR INHIBITORS TO PREVENT AND REGRESS EDHESIONS AND FIBROSIS
Embodiments of the disclosure include preventing or reducing adhesion between two tissues and/or organs in an individual subjected to a procedure and/or...
2018/0015073 COMPOSITIONS AND METHODS FOR TREATING CHRONIC URTICARIA
Disclosed herein are methods of treating conditions, which may be associated with elevated levels of mast cells, basophils, eosinophils, or a combination...
2018/0015072 Tryptophan is a pro-drug for infectious diseases and cancers
The innovation provides compositions and methods for treating infectious diseases and cancers, wherein said, in vitro, in higher active TDO (tryptophan...
2018/0015071 CO-ADMINISTRATION OF ATORVASTATIN AND ETHYL EICOSAPENTAENOIC ACID OR A DERIVATIVE THEREOF
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of...
2018/0015070 METHODS AND COMPOSITIONS FOR UPREGULATING ENDOGENOUS ANTIOXIDANT SYSTEMS
A nutritional supplement for reducing free radical damage is disclosed. The nutritional supplement includes a first vehicle comprising an upregulating compound...
2018/0015069 ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS OR PRECURSORS THEREOF
Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to...
2018/0015068 LACTATE DEHYDROGENASE INHIBITOR AND ANTIEPILEPTIC DRUG CONTAINING THE SAME
The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are...
2018/0015067 COMBINATION THERAPIES
Provided herein are methods of treating and sensitizing cancer comprising administering a glycolytic inhibitor and an oxidative phosphorylation inhibitor.
2018/0015066 DRUG COMPLEXES COMPRISING ALPHA-FETOPROTEIN
Compositions which comprise a hydro-phobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a...
2018/0015065 METHODS OF TREATING UREA CYCLE DISORDERS
The present disclosure provides novel methods for determining an effective dosage of a PAA prodrug and for treating a UCD that incorporate body surface area...
2018/0015064 METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS
The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods...
2018/0015063 ANTIVIRAL TREATMENTS
The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
2018/0015062 PPAR-alpha Activator, Pharmaceutical Composition, Food and Drink, Food Additive, Supplement and Method of...
The invention provides a novel PPAR.alpha. activator, a pharmaceutical composition, a food or a drink, a food additive, a supplement and a method of producing...
2018/0015061 ANTIMICROBIAL-ANTIBIOFILM COMPOSITIONS AND METHODS OF USE THEREOF
Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the...
2018/0015060 HEALING TOPICAL COMPOSITION
There are provided, inter alia, novel stabilized compositions for treating skin conditions wherein a therapeutically effective dosage of sulfur compound is...
2018/0015059 ALL-NATURAL ENTERIC SOFT CAPSULES
Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the...
2018/0015058 METHODS OF THERAPEUTIC MONITORING OF PHENYLACETIC ACID PRODRUGS
The present disclosure provides methods for adjusting the dosage of PAA prodrugs (e.g., HPN-100, PBA) based on measurement of PAA and PAGN in plasma and...
2018/0015057 ERR ALPHA AND ERR GAMMA ARE ESSENTIAL COORDINATORS OF CARDIAC METABOLISM AND FUNCTION
Provided herein are methods and kits for increasing cardiac contraction, increasing mitochondrial activity, and/or increasing oxphos activity. Such methods...
2018/0015056 PHARMACEUTICAL COMPOSITION FOR INHIBITING GROWTH OF CANCER STEM CELLS, CONTAINING ALDEHYDE INHIBITOR AND...
The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a...
2018/0015055 METHOD FOR SHORTENING ANTI-INFECTIVE THERAPY DURATION IN SUBJECTS WITH INFECTION
Methods of shortening the duration of anti-infective therapy and increasing the effectiveness of anti-infective drugs in subjects with infection are present....
2018/0015054 Method of Maintaining the Anti-Depressant Effect of Ketamine With Lithium
Disclosed herein is method for maintaining the anti-depressant effect of ketamine by administering lithium to patients that respond to ketamine treatment.
2018/0015053 STABLE TRIENTINE FORMULATIONS
Provided are pharmaceutical dosage forms comprising (i) trientine or a pharmaceutically acceptable salt of trientine, in a (ii) sealed packaging. The sealed...
2018/0015052 DESIGN, SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXMIER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY
The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically,...
2018/0015050 ANESTHETIC BANDAGE
A bandage for delivering an anesthetic through a patient's skin at the site of a hypodermic injection prior to the administration of the hypodermic injection...
2018/0015049 ADHESIVE PATCH
Disclosed is an adhesive patch having a support and an adhesive agent layer laminated on the support, wherein the support consists of spunlace nonwoven fabric,...
2018/0015048 Methods of Delivering a Health Care Active by Administering Personal Health Care Articles Comprising a Filmament
A method of delivering a health care active having the steps of administering to a mammal in need of a health benefit or a treatment for a health condition a...
2018/0015047 MAGNETIC PARTICLE-BASED SUBSTANCE REMOVAL FROM TISSUE
Provided herein are methods and compositions for removal of a substance using magnetic nanoparticles comprising a tagging element capable of targeting the...
2018/0015046 ENTERIC SOFT CAPSULE COMPOSITIONS
Described herein are enteric soft capsules comprising gastric resistant polymers and gelatin and methods for manufacturing the same. The enteric soft capsules...
2018/0015045 COMPOSITION FOR ENTERIC HARD CAPSULE AND METHOD FOR PRODUCING ENTERIC HARD CAPSULE
A composition for an enteric hard capsule by taking advantage of conventionally unknown thermal gelation characteristics of a neutralized aqueous solution of...
2018/0015044 Multi-Compartment Capsule
A method of making a capsule comprising a plurality of compartments, the method comprising: initiating extrusion of a filament solution through a filament...
2018/0015043 TABLET AND METHOD OF PREPARING THE SAME
Disclosed is a method for preparing a tablet. The method can improve the compressibility of the active ingredients and produce tablets of uniform quality,...
2018/0015042 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OBESITY
The present invention relates to a layered pharmaceutical composition comprising: a first layer of sustained-release bupropion or its pharmaceutically...
2018/0015041 PROCESS FOR FORMING ACTIVE DOMAINS DISPERSED IN A MATRIX
Disclosed are processes for forming compositions comprising small domains of an active agent and a matrix material, and methods of using them.
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