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Patent # Description
2018/0016356 THERMOSET FOAMS, AND METHOD FOR MANUFACTURING SAME FROM REDUCING SUGARS AND AMINES
A process for manufacturing a solid thermoset foam includes the following successive stages: (a) providing an expandable and thermosetting composition...
2018/0016355 SOLVENT-BASED PROCESSES FOR PRODUCING NANOCELLULOSE, AND COMPOSITIONS AND PRODUCTS PRODUCED THEREFROM
The present invention provides a process for producing a nanocellulose material, comprising: fractionating a lignocellulosic biomass feedstock in the presence...
2018/0016354 DOMAIN-EXCHANGED ANTIBODY
The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2-CH3,...
2018/0016353 METHOD FOR OBTAINING HIGH-YIELD, STABLE EXPRESSION CELL CLONES AND ANTIBODY MOLECULES OBTAINED THEREBY
Provided is a method for obtaining high-yield, stable expression cell clones from myeloma cell lines in a protein-free culture medium. The method is used for...
2018/0016352 TARGETING CONSTRUCTS FOR DELIVERY OF PAYLOADS
Disclosed are targeting constructs for targeting a target site, including a molecule or complex of interest. The targeting constructs comprise a polymer chain...
2018/0016351 ANTIBODIES COMPRISING SEQUENCES FROM CAMELIDAE TO HIGHLY CONSERVED TARGETS
The present invention is concerned with antigen binding polypeptides, and in particular conventional antibodies derived from camelid species, that specifically...
2018/0016350 METHOD FOR DECREASING IMMUNOGENICITY
A method for decreasing the immunogenicity of antibody variable domains is disclosed.
2018/0016349 CONJUGATED ANTI-CD38 ANTIBODIES
Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed...
2018/0016348 HUMAN NEUTRALIZING ANTIBODIES BINDING TO INFLUENZA NEURAMINIDASE
Influenza neuraminidase (NA)-binding human antibodies, which are capable of neutralizing at least one influenza A virus strain containing NA of the N1 subtype,...
2018/0016347 STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN THE Fc DOMAIN
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc...
2018/0016346 BISPECIFIC ANTIBODY BINDING TO TRAILR2 AND PSMA
The present invention is related to a bispecific antibody or an antibody fragment thereof comprising an antigen binding domain that binds to a TRAILR2, and an...
2018/0016345 LIGHT INHIBITORS FOR SCLERODERMA AND SKIN FIBROTIC DISEASE TREATMENT
Methods of treating inflammatory conditions, disease and disorders of skin are provided. Methods include, for example, contacting or administering a sufficient...
2018/0016344 Multivalent Molecules Comprising DR5-Binding Domains
The present invention is directed to multivalent DR5-Binding Molecules that comprise Binding Domain(s) of anti-DR5 antibodies, and particularly Binding...
2018/0016343 METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-4R ANTAGONIST
The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise...
2018/0016342 INTERLEUKIN-6 RECEPTOR BINDING POLYPEPTIDES
The invention relates to amino acid sequences that are directed against and/or that can specifically bind to IL-6 receptor, compounds or constructs that...
2018/0016341 Antibody Therapeutics That Bind CD123
There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies. More specifically, there is disclosed fully human antibodies...
2018/0016340 Monoclonal Antibodies for Enhancing or Inhibiting Insulin-Like Growth Factor 1 (IGF-1)
The present invention provides an antibody or antigen-binding fragment thereof that binds .alpha..sub.v.beta..sub.3 integrin, as well as methods of use in the...
2018/0016339 SOLUBLE MIC NEUTRALIZING MONOCLONAL ANTIBODY FOR TREATING CANCER
Described herein are compositions and methods relating to antibodies that bind soluble MIC (sMIC), e.g. for the treatment of MIC-positive cancers.
2018/0016338 ANTI CEACAM1 ANTIBODIES AND METHODS OF USING SAME
A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.
2018/0016337 CAR IMMUNE CELLS TO TREAT CANCERS
A chimeric antigen receptor (CAR) that binds to CEACAM6, an epitope or fragment thereof, or a variant thereof.
2018/0016336 ANTIBODIES AGAINST TIM3 AND USES THEREOF
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also...
2018/0016335 SIGNALLING SYSTEM
The present invention relates to a chimeric antigen-receptor (CAR) signalling system comprising; (i) a targeting component comprising an antigen-binding...
2018/0016334 FCRN ANTIBODIES AND METHODS OF USE THEREOF
The present invention features antibodies that have high binding affinity to human neonatal Fc receptor (FcRn). These anti-FcRn antibodies are useful, e.g., to...
2018/0016333 PHARMACEUTICAL FORMULATIONS FOR ANTI-TNF-ALPHA ANTIBODIES
The present invention relates to aqueous stable antibody compositions suitable for long term storage, in particular comprising antibodies against Tumor...
2018/0016332 COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth...
2018/0016331 METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES
Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating...
2018/0016330 Antibodies Specific for Hyperphosphorylated Tau and Methods of Use Thereof
The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological ...
2018/0016329 Humanized Antibodies That Recognize Alpha-Synuclein
The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy...
2018/0016328 ANTI-TAU CONSTRUCTS
The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at...
2018/0016327 A Combination of Two or More Anti-C5 Antibodies and Methods of Use
The present invention provides a combination of two or more isolated or purified anti-C5 antibodies, wherein the isolated or purified anti-C5 antibodies bind...
2018/0016326 ANTIBODIES THAT BIND PEPTIDOGLYCAN RECOGNITION PROTEIN 1
Disclosed herein is a method for identifying TREM-1's ligand and antibodies, or fragments thereof, which are capable of modifying the function of TREM-1's...
2018/0016325 ANTI-WALL TEICHOIC ANTIBODIES AND CONJUGATES
The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
2018/0016324 Anti-Zika Virus Antibodies and Methods of Use
The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions...
2018/0016323 BINDING MOLECULES DIRECTED AGAINST INFLUENZA HEMAGGLUTININ AND USES THEREOF
Monomeric and multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said...
2018/0016322 ANTIBODIES SPECIFIC TO GLYCOPROTEIN (GP) OF EBOLAVIRUS AND USES FOR THE TREATMENT AND DIAGNOSIS OF EBOLA VIRUS...
The present invention relates to antibodies or fragments thereof that specifically bind to glycoprotein (GP) of Ebola virus, and to their use for treating and...
2018/0016321 METHOD OF PRODUCING COLLAGEN FROM HYDROLYZED EGG MEMBRANE
A method of producing collagen from hydrolyzed egg membrane includes combining 95% ethanol, cold water, a bacterial pH neutral protease and/or an alkaline...
2018/0016320 METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY
The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses...
2018/0016319 Acylated Glucagon Analogues
The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral pH, to the...
2018/0016318 Novel Fatty Acid Modified Urocortin-2 Analogs for the Treatment of Diabetes and Chronic Kidney Disease
The present invention provides a compound or a pharmaceutically acceptable salt of the Formula: ...
2018/0016317 COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES AND DISORDERS
The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a...
2018/0016316 SUPERKINES AND SYNTHEKINES: REPURPOSED CYTOKINES WITH NEW AND ENHANCED SIGNALING ACTIVITIES
Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for...
2018/0016315 ERYTHROPOIETIN-DERIVED SHORT PEPTIDE AND ITS MIMICS AS IMMUNO/INFLAMMATORY MODULATORS
The present disclosure provides isolated stabilized EPO-derived peptides and their mimics that protect against tissue damage in subjects having diverse forms...
2018/0016314 TREATMENT OF DISEASE VIA TRANSCRIPTION FACTOR MODULATION
Disclosed herein are methods of treatment of various disease states in which an individual in need thereof if administered one or more therapeutic agents...
2018/0016313 MODIFIED DKK2 PROTEIN, NUCLEIC ACID ENCODING THE SAME, PREPARATION METHOD THEREOF, AND USE THEREOF
Provided are a modified DKK2 polypeptide according to an aspect, a nucleic acid encoding the same, a preparation method thereof, and use thereof. Accordingly,...
2018/0016312 NOVEL PROTEINS SPECIFIC FOR ANGIOGENESIS
The present disclosure provides hNGAL muteins that bind Ang-2 and can be used in various application including pharmaceutical applications, for example, to...
2018/0016311 PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME
Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY (SEQ ID NO: 1),...
2018/0016310 FUSION PROTEINS OF SUPERFOLDER GREEN FLUORESCENT PROTEIN AND USE THEREOF
The present disclosure pertains to methods of producing recombinant peptides that contain between 10 and 200 amino acid residues using novel carrier proteins...
2018/0016309 NOVEL BT TOXIN RECEPTORS AND METHODS OF USE
The disclosure relates to Bt toxin resistance management. One embodiment relates to the isolation and characterization of polynucleotides and polypeptides...
2018/0016308 HUMAN ALPHA-DEFENSIN 5 VARIANT AND USES THEREOF
A human .alpha.-defensin 5 variant is obtained by adding amino acid residues at C-terminal of .alpha.-defensin 5 and then being modified to link an aliphatic...
2018/0016307 GRIFFITHSIN MUTANTS
The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors,...
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