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Patent # Description
2018/0016306 MUTANT IMMUNOGLOBULIN K CHAIN VARIABLE REGION-BINDING PEPTIDE
A first immunoglobulin .kappa. chain variable region-binding peptide includes an amino acid sequence of SEQ ID NO: 21 with substitution of one or more amino...
2018/0016305 DAGRS: Directed Antigonists to Cancer Cell Growth Signals
The present invention describes a unique method of treating cancer with the administration of an improved DAGRS.TM. construct which functions as a humanized...
2018/0016304 SELF-ASSEMBLING ULTRASHORT ALIPHATIC DEPSIPEPTIDES FOR BIOMEDICAL APPLICATIONS
The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of ...
2018/0016303 BK CHANNEL-MODULATING PEPTIDES AND THEIR USE
The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca.sup.2+ activated K.sup.+...
2018/0016302 Peptides for Treating Cancer
The invention relates to novel peptides having an HDM-2 targeting sequence that target the human minute binding protein-2. The invention also relates to fusion...
2018/0016301 Synthesis of Beta-Arrestin Effectors
Embodiments disclosed herein provide compounds and methods for preparing Beta-Arrestin Effectors.
2018/0016300 COMPOUNDS, LINKER-DRUGS AND LIGAND-DRUG CONJUGATES
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently,...
2018/0016299 METHODS FOR MAKING ARRAYS FOR HIGH THROUGHPUT PROTEOMICS
Methods to obtain expression systems and proteins in a high-throughput protocol by utilizing mixtures of cells cultured from those transformed with a desired...
2018/0016298 TERPENOID DERIVATIVES
It is intended to provide a novel terpenoid derivative that exhibits anti-inflammatory action and a cytoprotective action by activating the Keap1/Nrf2/ARE...
2018/0016297 CRYSTALLINE FORMS OF S-[4-(3-FLUORO-3-METHYLBUTYRYLOXY)BUT-2-YNYL] ...
The present invention relates to crystalline forms of S-[4-(3-fluoro-3-methylbutyryloxy)but-2-ynyl] ...
2018/0016296 METHOD FOR FULLY AUTOMATED SYNTHESIS OF 16Beta-18F-FLUORO-5Alpha-DIHYDROTESTOSTERONE (18F-FDHT)
The automated synthesis of clinically relevant amounts of 16.beta.-.sup.18F-fluoro-5.alpha.-dihydrotestosterone (.sup.18F-FDHT) using a commercially available...
2018/0016295 TGR5 Modulators and Methods of Use Thereof
The invention relates to compounds of Formula A: ##STR00001## or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators...
2018/0016294 Oligonucleotide Compositions and Methods of Making the Same
The present disclosure provides a solid phase method of making oligonucleotides via sequential coupling cycles including at least one coupling of a...
2018/0016293 Oligonucleotide Compositions and Methods of Making the Same
The present disclosure provides a solid phase method of making oligonucleotides via sequential coupling cycles including at least one coupling of a...
2018/0016292 PROCESS FOR THE PREPARATION OF DIOSMIN
The present invention relates to a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with...
2018/0016291 Rebaudioside Analogs
The present disclosure provides novel compounds that are steviol derivatives. The compounds generally can be characterized by a structure according to Formula...
2018/0016290 PROCESS FOR THE PREPARATION OF SGLT INHIBITOR COMPOUNDS
The present invention DISCLOSES a novel process for preparing sodium glucose transporters 2 (SGLT2) inhibitor compounds of Formula IX. ##STR00001## Wherein, R...
2018/0016289 REDOX-SENSITIVE VESICLES
There is provided a redox-sensitive compound comprising a redox-sensitive organometallic moiety and a phospholipid or modified-phospholipid moiety. The...
2018/0016288 COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS...
Compounds of formula (I) ##STR00001## wherein: Ak.sub.1 represents an alkyl chain, X represents --(CH.sub.2).sub.m--, --CH(R)--, --N(R)--, --CH.sub.2--N(R)--, ...
2018/0016287 METHOD OF STABILIZING IMINO-FUNCTIONAL SILANE
A method of stabilizing imino-functional silane involving adding thereto at least one Bronsted-Lowry base to inhibit, suppress or prevent the addition...
2018/0016286 PROCESS FOR PREPARING SILOXANOLS FROM METAL SALTS OF SILANOLS
Siloxanes which are liquid at 25.degree. C. and 1 bar, have 2% to 12% by weight of silanol groups and are of the formula (1): ...
2018/0016285 Boron-Containing Small Molecules
This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds,...
2018/0016284 NOVEL POLYMORPHS
The invention relates to a polymorphic forms of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-- ...
2018/0016282 INHIBITORS OF HISTONE DEACETYLASE
The present invention relates to compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U,...
2018/0016281 HIV INHIBITING BICYCLIC PYRIMIDINE DERIVATIVES
HIV replication inhibitors of formula ##STR00001## N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof,...
2018/0016280 PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS
Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating...
2018/0016279 SUBSTITUTED PYRAZOLYLPYRAZOLE DERIVATIVE AND USE OF SAME AS HERBICIDE
Provided is a compound capable of effectively control worst weeds of higher leaf stages that present practical problems. A specific pyrazolylpyrazole...
2018/0016278 Imidazo[1,2-a]quinoxalines and Derivatives Thereof for the Treatment of Cancer
The invention relates to imidazo[1,2-a]quinoxaline compounds of formula (I) for the treatment of cancer, the pharmaceutical compositions comprising said...
2018/0016277 DEUTERATED TIC10
This invention relates to novel imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one compounds, and pharmaceutically acceptable salts thereof. This invention also...
2018/0016276 FLUORINATED 3-(2-OXO-3-(3-ARYLPROPYL)IMIDAZOLIDIN-1-YL)-3-ARYLPROPANOIC ACID DERIVATIVES
The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated ...
2018/0016275 NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF...
A compound according to Formula Ia: ##STR00001## wherein Cy, L.sub.1, G, and R.sup.1 are as described herein. The present invention relates to novel compounds...
2018/0016274 AUTOTAXIN INHIBITORY COMPOUNDS
The present invention relates to compounds of formula I, wherein A.sub.1, A.sub.2, A.sub.3, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, L, Ar and Q...
2018/0016273 2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES
The invention relates to novel compounds of the formula (I) ##STR00001## in which the R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, A.sup.1, A.sup.2, A.sup.4 and n have...
2018/0016272 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES
Compound of formula (I), processes for their production and their use as pharmaceuticals. ##STR00001##
2018/0016271 FLUORINATED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS INHIBITORS OF BROMODOMAIN CONTAINING PROTEINS
A novel class of fluorinated derivatives of Formula (I) have been prepared and found to be useful in the treatment of cancers and other disorders related...
2018/0016270 DIAZA-BENZOFLUORANTHRENE COMPOUNDS
Disclosed are a series of diaza-benzofluoranthrene compounds. The present invention particularly relates to a compound represented by formula (I), ...
2018/0016269 NOVEL COMPOUNDS AND USES THEREOF
The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of...
2018/0016268 Novel Flavone Based EGFR Inhibitors and Process for Preparation Thereof
The present invention discloses a novel EGFR inhibitor compound of formula (1), process for preparation thereof and methods of treating abnormal cell growth in...
2018/0016267 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
Compounds of formula I defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention...
2018/0016266 KAPPA OPIOID AGONISTS AND USES THEREOF
Provided are compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2018/0016265 AMINOESTER DERIVATIVES
Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or...
2018/0016264 SALT FORMS OF 4-CYANO-N-(2-(4,4-DIMETHYLCYCLOHEX-1-EN-1-YL)-6-(2,2,6,6-TETRAMETHYLTETRA- ...
The present disclosure discusses salt forms of 4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetra- ...
2018/0016263 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula (I); and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel....
2018/0016262 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases...
2018/0016261 NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases...
2018/0016260 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2018/0016259 QUINAZOLINE INHIBITORS OF ACTIVATING MUTANT FORMS OF EPIDERMAL GROWTH FACTOR RECEPTOR
The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof: ##STR00001## Formula (I) which possess inhibitory activity...
2018/0016258 2-(2,4,5-SUBSTITUTED ANILINE) PYRIMIDINE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Disclosed are a 2-(2,4,5-substituted aniline) pyrimidine derivative, a pharmaceutical composition and a use thereof. The pharmaceutical composition comprises a...
2018/0016257 Glutarimide Derivatives, Use Thereof, Pharmaceutical Composition Based Thereon and Methods for Producing...
A method for preparing a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, by heating of dicarboxylic acid monoamide of formula...
2018/0016256 Glutarimide Derivatives, Use Thereof, Pharmaceutical Composition Based Thereon and Methods for Producing...
A medicament or pharmaceutical composition for the treatment of respiratory syncytial virus, which is a compound having the following formula: ##STR00001## ...
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