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Patent # Description
2018/0021449 ANTISENSE CONJUGATES FOR DECREASING EXPRESSION OF DMPK
The disclosure provides novel conjugates comprising antisense oligonucleotides that hybridize to a DMPK transcript and a 3E10 antibody or binding fragment...
2018/0021448 Conjugates of Cell Binding Molecules with Cytotoxic Agents
A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R.sup.1, R.sup.2, R.sup.3,...
2018/0021447 Lipid Nanoparticle Compositions and Methods of Making and Methods of Using the Same
Lipid nanoparticle formulations, methods of making, and methods of using same are disclosed.
2018/0021446 SYSTEMS FOR STABILIZING AND DELIVERING ACTIVE AGENTS
A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an...
2018/0021445 USE OF P97 AS AN ENZYME DELIVERY SYSTEM FOR THE DELIVERY OF THERAPEUTIC LYSOSOMAL ENZYMES
The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient...
2018/0021444 MULTI-ARM POLYMER PRODRUGS
Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of...
2018/0021443 LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOL DRUG CONJUGATES HAVING IMPROVED DRUG BIOLOGICAL ACTIVITY
Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are...
2018/0021442 LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOL DRUG CONJUGATES HAVING IMPROVED DRUG BIOLOGICAL ACTIVITY
Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are...
2018/0021441 HYPERBRANCHED POLYMERS AND POLYPLEXES AND DNA OR RNA DELIVERY SYSTEMS INCLUDING THE SAME
A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least...
2018/0021440 BISPECIFIC ANTIBODY CAPABLE OF BEING COMBINED WITH IMMUNE CELLS TO ENHANCE TUMOR KILLING CAPABILITY, AND...
The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a...
2018/0021439 OLIGOSACCHARIDE CONJUGATES AND METHODS OF USE
There is provided a method of detecting in a sample the presence of an anti-M and/or anti-A and/or anti-C/Y antibody, the method comprising contacting the...
2018/0021438 MEDICATION DISPENSING SYSTEM
A method for delivering therapeutics includes infusing a hydrogel with cannabis; and contacting the hydrogel infused with cannabis into a human which causes...
2018/0021437 MICROSTRUCTURE USING CROSS-LINKED HYALURONIC ACID HYDROGEL, AND METHOD FOR PRODUCING SAME
The present invention provides microstructures using crosslinked hyaluronic acid hydrogels and the method for preparing the same. The present invention for...
2018/0021436 ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED Ph EFFECT
Disclosed are compressed tablets containing atazanavir sulfate and an acidifying agent, optionally with another active agent, e.g., anti-HIV agents, and...
2018/0021435 HYPOTONIC HYDROGEL FORMULATIONS FOR ENHANCED TRANSPORT OF ACTIVE AGENTS AT MUCOSAL SURFACES
Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic,...
2018/0021434 TOPICAL PHARMACEUTICAL COMPOSITION BASED ON SEMIFLUORINATED ALKANES
The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are...
2018/0021433 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0021432 COMBINATIONS OF INECALCITOL WITH AN ANTI-CD38 AGENT AND THEIR USES FOR TREATING CANCER
The present invention concerns combinations of inecalcitol with an anti-CD38 agent such as daratumumab, MOR 202 or isatuximab for the treatment of cancer, such...
2018/0021431 METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including...
2018/0021430 SELECTIVE TARGETING OF THE CD40L/MAC-1 INTERACTION BY SMALL PEPTIDE INHIBITORS AND ITS USE FOR THE TREATMENT OF...
The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of...
2018/0021429 ANTICANCER AGENTS OR ANTIMETASTATIC AGENTS USING FSTL1 AND COMBINATION DRUG THEREOF
The present invention provides an anti-FSTL1 antibody or a fragment or functional equivalent thereof, wherein the antibody recognizes an epitope in a region...
2018/0021428 RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPS)
The present invention is generally related to virus-like particles (VLPs) comprising rabies virus (RV) glycoproteins (G proteins) and methods for making and...
2018/0021427 H3 INFLUENZA A VIRUS
The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
2018/0021426 Combination Purified Inactivated Vaccine for Flaviviruses
Disclosed herein are immunogenic compositions comprising one or more inactivated dengue viruses and one or more inactivated non-dengue flaviviruses and methods...
2018/0021425 CYTOMEGALOVIRUS-BASED VACCINE EXPRESSING EBOLA VIRUS GLYCOPROTEIN
A recombinant herpesvirus-based vector comprising a nucleic acid sequence encoding a heterologous antigen and a promoter for controlling the expression of the...
2018/0021424 LIPOSOMAL ADJUVANT COMPOSITIONS
The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a...
2018/0021423 METHODS AND COMPOSITIONS FOR ATTENUATED CHLAMYDIA AS VACCINE AND VECTOR
The present invention provides Chlamydia organisms and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for...
2018/0021422 A VACCINE FOR USE AGAINST SUBCLINICAL LAWSONIA INFECTION IN A PIG
The present invention pertains to a vaccine comprising non live Lawsonia intracellularis antigen and a pharmaceutically acceptable carrier for use in a method...
2018/0021421 ATTENUATED VACCINES TO PROTECT AGAINST TICK-BORNE EHRLICHIA SPECIES INFECTIONS
Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also...
2018/0021420 METHODS AND COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE TO EGFRVIII
The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a...
2018/0021419 PEPTIDE MIXTURE
There is disclosed a peptide mixture suitable for eliciting an immune response. It comprises a first and a second peptide, each corresponding to a fragment of...
2018/0021418 ENGINEERED T CELLS AND USES THEREFOR
Lipocalin muteins specific to a predetermined antigen can be transduced into a T cell to bring therapeutic benefits to patients in need. In one example, a...
2018/0021417 ADJUVANT COMPOSITIONS COMPRISING A NON-IONIC ISOTONICITY AGENT
The present invention relates to an aqueous adjuvant composition comprising a TLR-4 agonist and a saponin in a liposomal formulation and a non-ionic...
2018/0021416 TREATMENT OF DISEASES RELATED TO HYPERACTIVITY OF THE COMPLEMENT SYSTEM
Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the...
2018/0021415 A METHOD FOR IMPROVING FEED DIGESTIBILITY IN BOVINE ANIMALS
The invention relates to the use of at least one bacterial amylase in combination with a mixture of at least two essential oil compounds selected from the...
2018/0021414 METHODS OF REGULATING UPTAKE AND TRANSCELLULAR TRANSPORT OF LEUKOCYTES AND THERAPEUTICS
Methods for controlling and regulating engulfment, uptake and/or transcellular transport at a stage following initial engagement of an agent to the endothelium...
2018/0021413 MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES
The present application provides materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing...
2018/0021411 Composition and Method for Improving Sleep Duration and Quality
An intervention for sleep disorders comprises: collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or...
2018/0021410 METHODS FOR INCREASING PERFORMANCE CHARACTERISTICS IN OFFSPRING
Provided herein are methods for altering a characteristic of an offspring or a litter. The method can include administering an effective amount of a...
2018/0021409 Pharmaceutical Composition
The present invention provides liquid compositions comprising albiglutide or a variant thereof, a buffering agent, at least one saccharide and/or at least one...
2018/0021408 Fusion Proteins Containing Insulin-Like Growth Factor-1 and Epidermal Growth Factor and Variants Thereof and...
Fusion proteins comprising cytokines, particularly insulin-like growth factor-1 (IGF-1) and variants thereof, epidermal growth factor (EGF), and other ligands...
2018/0021407 TNFRSF-BINDING AGENTS AND USES THEREOF
Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The...
2018/0021406 PHARMACEUTICAL REMOVAL OF VASCULAR AND/OR NEURONAL EXTENSIONS FROM A DEGENERATING DISC
The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the...
2018/0021405 NUTRITIONAL APPROACH TO THE CONTROL OF ANEMIA, DIABETES AND OTHER DISEASES OR CONDITIONS AND PREVENTION OF...
Nutritional products, compositions, pharmaceutical preparations and methods of use are disclosed for the prevention, suppression and treatment of anemia and/or...
2018/0021404 METHODS AND COMPOSITIONS FOR TREATING GLAUCOMA
Provided are methods and compositions for treating an ocular disease associated with increased intraocular pressure using a therapeutically effective amount of...
2018/0021403 Combination Therapy
The present invention relates to a combination comprising a proteasome inhibitor and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety. In...
2018/0021402 MODULATORS OF COMPLEMENT ACTIVITY
The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing...
2018/0021401 COMPOSITIONS AND METHODS FOR TREATMENT OF INTRACELLULAR DAMAGE AND BACTERIAL INFECTION
Pre-implantation factor (PIF) may be used to treat intracellular damage. Aspects of the invention are directed to a method of treating intracellular damage...
2018/0021400 Princess Lite
Princess lite is a cream used to treat and manage breast health. It has been effective in dissolving cyst and tumors, benign and malignant, in the breast and...
2018/0021399 COMPOSITION AND USE THEREOF IN MANUFACTURE OF PRODUCT FOR IMPROVING INTESTINAL FUNCTION
The present invention relates to the technical field of health care products, in particular to a composition and use thereof in the manufacture of a product...
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