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Patent # Description
2018/0021348 Hypotensive lipid-containing biodegradable intraocular implants and related implants
Biocompatible intraocular implants include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide...
2018/0021347 COMPOSITION FOR THE TREATMENT OF HEPATIC VENO-OCCLUSIVE DISEASE
The present invention provides a composition comprising a prostacyclin analogue, derivative or a pharmaceutically acceptable salt thereof, for use in...
2018/0021346 NOVEL GLP-1 RECEPTOR MODULATORS
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic...
2018/0021345 AUTOTAXIN INHIBITORS
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments...
2018/0021344 METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME
Provided are immediate or prolonged administration of certain potassium ATP (K.sub.ATP) channel openers, optionally in combination with growth hormone, to a...
2018/0021343 BURN OINTMENT FOR PROMOTING TISSUE REGENERATION AND SKIN GROWTH, AND PREPARATION METHOD THEREFOR
A burn ointment for promoting tissue regeneration and skin growth comprises the following raw materials (pts. wt): cephalosporin (5-15), gentamicin (5-15),...
2018/0021342 CRYSTALLINE FORM OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRI- ...
A novel crystalline form of (S)--N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyri- midin-3-yl)-3-hydroxypyrrolidine-1-carboxamide,...
2018/0021341 ACC INHIBITOR COMBINATION THERAPY FOR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
The present invention provides methods of treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease using an ACC...
2018/0021340 METHODS AND COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF ABNORMAL BONE FORMATION IN A SOFT TISSUE
Provided herein are methods and compositions for the treatment and/or prevention of abnormal bone formation in a soft tissue. In certain embodiments, the...
2018/0021339 METHOD FOR TREATING LIVER DISEASES OF VARIOUS ORIGINS
The invention relates to medicine, in particular to gastroenterology, and lies in the field of treatment of liver diseases of various origins. For this...
2018/0021338 FLUOROCYCLOPENTENYLCYTOSINE METHODS OF USE
The disclosed subject matter provides methods using and kits comprising a compound of formula (I) ##STR00001## or a hydrate, a solvate, or a pharmaceutically...
2018/0021337 SALT OF A PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE COMPOUND
The present invention relates to a pharmaceutically acceptable acid addition salt of: (i) ...
2018/0021336 IMIDAZOLIDINEDIONE DERIVATIVES
The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as...
2018/0021335 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds...
2018/0021334 USE OF ERGOT ALKALOIDS AS AN ANTHELMINTIC AGENT
Methods for preventing, inhibiting or treating parasitic flatworm infection in a vertebrate are provided that include administering an effective amount of a...
2018/0021333 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF EBOLA VIRUS DISEASE
The invention relates to methods and pharmaceutical compositions for the treatment of Ebola Virus Disease. In particular the present relates to a method of...
2018/0021332 PHARMACEUTICAL COMPOSITIONS COMPRISING ...
The invention relates to pharmaceutical compositions comprising N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl- ...
2018/0021331 HDAC1,2 INHIBITORS AND METHODS OF USING THE SAME
Disclosed herein are methods for treating a cancer and a method for sensitizing a cancer to a chemotherapeutic agent. Each method administers an agent that...
2018/0021330 PHARMACEUTICAL FORMULATION CONTAINING OPIOID AGONIST, OPIOID ANTAGONIST AND GELLING AGENT
Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of an opioid analgesic, an opioid antagonist and one or...
2018/0021328 NICOTINE SALT WITH META-SALICYLIC ACID AND APPLICATIONS THEREIN
The present disclosure relates generally to the field of nicotine delivery. The disclosure teaches a nicotine meta-salicylate. More specifically, the...
2018/0021327 TREATMENT OF CORNEAL NEOVASCULARIZATION
There is provided inter alia a compound which is an NK-1 receptor antagonist for use in the treatment or prevention of CNV. There is also provided a compound...
2018/0021326 Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts...
Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts...
2018/0021325 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such...
2018/0021324 ILOPERIDONE FOR THE TREATMENT OF SCHIZOPHRENIA
Aspects of the invention relate generally to the treatment of schizophrenia in an individual and, more specifically, to the treatment of an individual with...
2018/0021323 FLIP - A SELECTIVE MOLECULAR TARGET OF SENESCENT CELLS
The present invention relates to modulators of FLIP protein and their method of use in the treatment and prevention of diseases and pathologies related to...
2018/0021322 1-ARYLALKYL-4-ACYLAMINOPIPERIDINE COMPOUNDS
The present invention provides a compound of the formula: ##STR00001## wherein ring Z is a 5-, 6- or 7-membered ring; R.sup.1 is C.sub.1-10 alkyl, C.sub.1-10...
2018/0021321 Methods of Treating Apoptosis and Altering Programmed Cell Death
In one aspect, a method of altering programmed cell death includes administering to an individual in need thereof a therapeutically effective amount of...
2018/0021320 Method of Preventing or Treating Hearing Loss
The present invention relates to methods of preventing or treating hearing loss and methods of preventing or inhibiting hair cell degeneration or hair cell...
2018/0021319 COMPOSITIONS AND METHODS FOR TREATING GASTROINTESTINAL INFECTIONS
The invention described herein provides compositions and methods for treating or preventing Helicobacter pylori infection.
2018/0021318 PIPERIDINE DERIVATIVES AS HUMAN PAPILLOMA VIRUS INHIBITORS
The present disclosure is directed to antiviral compounds directed against the papilloma virus, to pharmaceutical compositions containing them, to their...
2018/0021317 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER AND METHOD USING THEREOF
Provided are a pharmaceutical composition for preventing or treating cancer and a method of preventing or treating cancer using the same. Cancer may be...
2018/0021316 CHEMICAL COMPOUNDS
The specification relates to compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, to processes and intermediates used for their...
2018/0021315 METHODS OF TREATING HEARING DISORDERS
The present disclosure provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of...
2018/0021314 THERAPEUTIC AGENT FOR MEIBOMIAN DYSFUNCTION
A method for treatment of meibomian gland dysfunction in a mammalian subject, the method involving administering to the mammalian subject an eye drop...
2018/0021313 Methazolamide for the treatment of cancer
The present invention relates to methods of using methazolamide to treat pancreatic cancer. Pancreatic cancer can be treated by administering to a patient in...
2018/0021312 BENZOISOXAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic...
2018/0021311 TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS
The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme...
2018/0021310 MEBENDAZOLE POLYMORPH FOR TREATEMENT AND PREVENTION OF TUMORS
Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of...
2018/0021309 SIGMA LIGANDS FOR POTENTIATING THE ANALGESIC EFFECT OF OPIOIDS AND OPIATES IN POST-OPERATIVE PAIN AND...
The invention refers to a combination comprising a sigma ligand of formula (I) and an opioid or opiate for use in the prevention and/or treatment of pain...
2018/0021308 TOPICAL LIQUID COMPOSITION COMPRISING MELATONIN
The present invention relates to a novel melatonin-based formulation, particularly a topical liquid composition of melatonin (or analog thereof) suitable for...
2018/0021307 Combination Treatment
The present invention relates and the combination of lacosamide and brivaracetam for the preparation of a fixed dose combination that is useful in the...
2018/0021306 INHIBITION OF YAP FOR BREAKING TUMOR IMMUNE TOLERANCE
Yes-associated protein (Yap), a downstream co-activator of the Hippo pathway, is highly expressed in the Treg cell subset, and is critical to maintain its...
2018/0021305 KETOROLAC FOR THE TREATMENT OF CANCER
Methods of treating cancer, including PAR-4 implicated cancers or renal cell carcinoma, using ketorolac are disclosed herein. Ketorolac can be administered as...
2018/0021304 COMPOSITION COMPRISING CEBRANOPADOL IN A DISSOLVED FORM
The present invention relates to a composition comprising cebranopadol in dissolved form and oral dosage forms comprising said composition. The invention...
2018/0021303 BKCA CHANNEL ACTIVATOR FOR TREATING MUSCULAR DISORDER
The present invention relates to BKCa activators for use in the treatment of a muscular disorder, or for controlling spasticity or tremors, for example,...
2018/0021302 PTGDR-1 AND/OR PTGDR-2 ANTAGONISTS FOR PREVENTING AND/OR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS
The present invention concerns a PTGDR-1 antagonist, a PTGDR-2 antagonist, a dual PTGDR-1/PTGDR-1 antagonist, or a combination of PTGDR-1 antagonist and...
2018/0021301 AEROSOL FORMULATION FOR COPD
The stable aerosol solution formulations comprising glycopyrronium chloride are useful for administration to patients with COPD and other respiratory conditions.
2018/0021300 FORMULATION FOR SOFT ANTICHOLINERGIC ANALOGS
Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from...
2018/0021299 PHOSPHODIESTERASE 4 INHIBITORS FOR COGNITIVE AND MOTOR REHABILITATION
The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an...
2018/0021298 A METHOD FOR IMPROVING FEED DIGESTIBILITY AND GROWTH PERFORMANCE
The invention provides a method for improving growth performance animals. In particularly, the inventors of the invention found that the addition of a...
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