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Patent # Description
2018/0022814 SPECIFIC ANTI-CD38 ANTIBODIES FOR TREATING HUMAN CANCERS
The present disclosure concerns an antibody that specifically binds CD38 which is capable of killing a CD38.sup.+ cell by induction of apoptosis, ...
2018/0022813 ANTIGEN BINDING COMPLEX HAVING AGONISTIC ACTIVITY AND METHODS OF USE
Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or...
2018/0022812 TREATMENT OF AUTOIMMUNE DISORDERS WITH CD154 ANTIBODIES
The present invention relates to a method of treating an autoimmune or inflammatory disease or a neurodegenerative disease with an antibody to CD154.
2018/0022811 Chemokine receptor binding polypeptides
The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of...
2018/0022810 USE OF CXCR3 INHIBITORS FOR PROTECTING AGAINST FETAL WASTAGE
Provided herein are compositions and methods related to reducing the risk of or preventing fetal wastage in a subject using a CXCR3 inhibitor.
2018/0022809 ANTI-PD-L1 ANTIBODIES AND DIAGNOSTIC USES THEREOF
The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same.
2018/0022808 ANTIBODY CONSTRUCT
The present invention relates to an antibody construct comprising at least one antigen binding site specific for ICAM1 and at least one antigen binding site...
2018/0022807 BISPECIFIC BINDING PROTEINS AND USES THEREOF
The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first...
2018/0022806 MARKERS OF ACUTE MYELOID LEUKEMIA STEM CELLS
Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and...
2018/0022805 ANTI-PRE-BCR ANTAGONISTS AND METHODS
This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The...
2018/0022804 HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-Beta)
The disclosure provides compositions and methods for the treatment of ocular conditions associated with angiogenesis comprising administering an antibody that...
2018/0022803 ANTIBODIES TO L-TYPE VOLTAGE GATED CHANNELS AND RELATED METHODS
Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to an extracellular poor loop of an alpha 1a subunit of L-type voltage...
2018/0022802 MONOCLONAL ANTIBODIES TO PROGASTRIN AND THEIR USES
The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and...
2018/0022801 ANTIBODIES TO IL-6 AND USE THEREOF
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of...
2018/0022800 BIOMARKER
The invention relates to methods of treating chronic intestinal inflammation and/or inflammatory bowel disease by administering an antagonist of oncostatin-M...
2018/0022799 METHODS FOR ADMINISTERING ANTI-IL-5 ANTIBODIES
The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and...
2018/0022798 COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth...
2018/0022797 TRANSTHYRETIN ANTIBODIES AND USES THEREOF
The present invention provides compositions comprising anti-transthyretin antibodies. The compositions are particularly useful for diagnosis, prognosis and/or...
2018/0022796 Chimeric and Humanized Anti-Histone Antibodies
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein....
2018/0022795 TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY
The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a...
2018/0022794 ANTI-RHO GTPASE CONFORMATIONAL SINGLE DOMAIN ANTIBODIES AND USES THEREOF
The present invention relates to active form specific anti-Rho GTPase conformational single domain antibodies and their uses in particular in the therapeutic...
2018/0022793 CHEMOREPULSION OF CELLS
The present invention provides compositions and methods of controlling the direction and/or movement of migratory cells. Specifically, the invention is...
2018/0022792 Biological Materials and Uses Thereof
There is provided agents for modulation of a chronic inflammatory response wherein the agent modulates the biological activity of tenascin-C. There is also...
2018/0022791 AGROCHEMICAL COMPOSITIONS COMPRISING ANTIBODIES BINDING TO SPHINGOLIPIDS
This disclosure relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one...
2018/0022790 EQUINE IMMUNOGLOBULIN COMPOSITIONS AND USES FOR TREATING FILOVIRUS-MEDIATED DISEASES
The disclosure provides a composition comprising immunoglobulin from an equine that has been hyper-immunized with a filovirus immunogen. The disclosure further...
2018/0022789 GELATIN PARTICLES, METHOD FOR PRODUCING GELATIN PARTICLES, GELATIN-PARTICLECONTAINING CELLS, METHOD FOR...
Gelatin particles include: gelatin that serves as a main component; and an auxiliary component carried on the gelatin, the gelatin particles being configured...
2018/0022788 METHODS AND COMPOSITIONS BASED ON DIPHTHERIA TOXIN-INTERLEUKIN-3 CONJUGATES
The present invention provides methods for inhibiting interleukin-3 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using...
2018/0022787 VECTORS AND METHODS TO TREAT ISCHEMIA
This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect...
2018/0022786 NOVEL SODIUM CHANNEL BLOCKING PEPTIDES AND THE USE THEREOF
The present invention relates to C-terminal modified Protoxin II peptides that selectively inhibit the Nav1.7 sodium channel; the present invention also...
2018/0022785 PROTEIN EXPRESSION STRAINS
The invention provides an improved host strain for production of desired protein.
2018/0022784 Clostridium Difficile Toxins a and/or B Antigen and Epitope Antibody, and Pharmaceutical Uses Thereof
It is described a Clostridium difficile (C-difficile) toxins A and/or B as a target for therapy, including passive immunotherapy, and particularly prevention...
2018/0022783 NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS THEREOF
In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide...
2018/0022782 VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to...
2018/0022781 POLYPEPTIDES FOR ENGINEERING INTEGRASE CHIMERIC PROTEINS AND THEIR USE IN GENE THERAPY
The present invention relates to polypeptide for engineering integrase chimeric proteins and their use in gene therapy. In particular, the present invention...
2018/0022780 STABILIZATION ADRENOMEDULLIN DERIVATIVES AND USE THEREOF
The invention relates to novel, biologically active, stabilized Adrenomedullin (ADM) compounds. The invention further relates to the compounds for use in a...
2018/0022779 COMPOSITIONS AND METHODS FOR REGULATING ARTERIAL TONE
The present invention provides compositions and methods for regulating arterial tone based on the discovery herein of novel expression and regulation of...
2018/0022777 THERAPEUTIC AGENTS FOR REDUCING PARATHYROID HORMONE LEVELS
Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of...
2018/0022776 IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions...
2018/0022775 PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF
The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical...
2018/0022774 PROCESS FOR THE PREPARATION OF SOFOSBUVIR
The present invention relates to an improved, commercially viable and industrially advantageous process for the preparation of sofosbuvir, which uses reagents...
2018/0022773 1, 1' -BIS(PHOSPHINO)FERROCENE LIGANDS FOR ALKOXYCARBONYLATION
Compound of formula (I) ##STR00001## where R.sup.2, R.sup.4 are each independently selected from --(C.sub.1-C.sub.12)-alkyl, --(C.sub.3-C.sub.12)-cycloalkyl, ...
2018/0022772 1, 1' -BIS(PHOSPHINO)FERROCENE LIGANDS FOR ALKOXYCARBONYLATION
Diastereomer mixture comprising diastereomers of the formulae (I.1) and (I.2) ##STR00001## where R.sup.2, R.sup.4 are each independently selected from ...
2018/0022771 CYMANQUINE COMPOUNDS AND DERIVATIVES THEREOF AND USES THEREOF
Organometallic compounds comprising a chloroquinoline moiety and uses the compounds. The compounds are, for example, manganese or rhenium complexes of a ligand...
2018/0022770 METAL COMPLEXES AND A PROCESS OF PREPARING THEM
A compound of the formula II (I) in which X is substituted pyrrolide with the general structure of (II) in which R.sup.a-R.sup.d are independently selected...
2018/0022769 NOVEL FLUORINE-CONTAINING BISPHOSPHONIC ACID DERIVATIVE AND USE THEREOF
A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an...
2018/0022768 RADIOACTIVE PHOSPHOLIPID METAL CHELATES FOR CANCER IMAGING AND THERAPY
Alkylphosphocholine analogs incorporating a chelating moiety that chelates a radioactive metal isotope are disclosed herein. The alkylphophocholine analogs,...
2018/0022767 Compounds for Treatment of Complement Mediated Disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2018/0022766 ETHER COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2018/0022765 PROCESS FOR THE ALKOXYCARBONYLATION OF ALCOHOLS
The invention relates to a process comprising the following process steps: a) introducing a first alcohol, the first alcohol having 2 to 30 carbon atoms; b)...
2018/0022764 PROCESS FOR THE ALKOXYCARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS WITH MONOPHOSPHINE LIGANDS
The invention relates to a process comprising the following process steps: a) introducing an ethylenically unsaturated compound; b) adding a monophosphine...
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