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Patent # Description
2018/0022763 Anti-Viral Compounds
The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of...
2018/0022762 PROCESS FOR PREPARING TRIS[3-(ALKOXYSILYL)PROPYL] ISOCYANURATES
A tris[3-(alkoxysilyl)propyl] isocyanurate from the group of tris[3-(trialkoxysilyl)propyl] isocyanurate, tris[3-(alkyldialkoxysilyl)propyl] isocyanurate and ...
2018/0022761 Si-CONTAINING FILM FORMING PRECURSORS AND METHODS OF USING THE SAME
Mono-substituted TSA precursor Si-containing film forming compositions are disclosed. The precursors have the formula: (SiH.sub.3).sub.2N--SiH.sub.2--X,...
2018/0022760 CONDENSED HETEROCYCLIC COMPOUNDS AND PESTICIDES
To provide novel pesticides, especially insecticides or acaricides. A condensed heterocyclic compound represented by the formula (1) or its salt or an N-oxide...
2018/0022759 COMPOUNDS, COMPOSITIONS AND METHODS
The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
2018/0022758 BICYCLIC HETEROCYCLYL DERIVATIVES AS IRAK4 INHIBITORS
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors,...
2018/0022757 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS
Methods of making compounds of Formula I are disclosed: ##STR00001##
2018/0022756 COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH
Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and...
2018/0022755 BICYCLIC PYRIDINE COMPOUND
The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically a pharmaceutically...
2018/0022754 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2018/0022753 MACROCYCLES AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all...
2018/0022752 FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF
This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising...
2018/0022751 N-SUBSTITUTED 8-[(2,6-DIFLUOROBENZYL)OXY]-2,6-DIMETHYLIMIDAZO[1,2-A]PYRAZIN-3-CARBOXAMI- DE DERIVATIVES AS...
The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides, to processes for their preparation, to their use, alone or in...
2018/0022750 6-HYDROXYBENZOFURANYL- AND 6-ALKOXYBENZOFURANYL-SUBSTITUTED IMIDAZOPYRIDAZINES
The present invention relates to 6-hydroxybenzofuranyl- and 6-alkoxybenzofuranyl-substituted imidazopyridazine compounds of general formula (I) in which R1 and...
2018/0022749 COMPOUNDS AS MODULATORS OF ROR GAMMA
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the variables are defined herein which are suitable for the modulation of...
2018/0022748 9H-PYRROLO-DIPYRIDINE DERIVATIVES
The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their...
2018/0022747 Factor IXa Inhibitors
The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said...
2018/0022746 INDAZOLE AND AZAINDAZOLE SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic...
2018/0022745 ISOQUINILINE AND NAPTHALENE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical...
2018/0022744 BENZOTHIAZOLE AND BENZISOTHIAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic...
2018/0022743 COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES
The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem...
2018/0022742 AUTOTAXIN INHIBITORS
The present invention relates to compounds of formula (I): wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4a, R.sub.4b, R.sub.4C, R.sub.4d, L, A, Q, W and HET are...
2018/0022741 COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions...
2018/0022740 ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION...
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing...
2018/0022739 5-[[4-[[Morpholin-2-yl]Methylamino]-5-(Trifluoromethyl)-2 Pyridyl]Amino]Pyrazine-2-Carbonitrile and Therapeutic...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to ...
2018/0022738 3-SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES
Compounds of the formula I ##STR00001## in which R, W, R.sup.1, R.sup.4, X.sup.1, X.sup.2, X.sup.3, X.sup.4 and q have the meanings indicated in Claim 1, are...
2018/0022737 CRYSTALLINE FORMS OF (S)-5-BENZYL-N-(5-METHYL-4-OXO-2,3,4,5-TETRAHYDROBENZO[b][1,4]OXAZEPIN-3-- ...
Disclosed are novel crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-- yl)-4H-1,2,4-triazole-3-carboxamide, and...
2018/0022736 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF
The present invention relates to the technical field of medicine, and specifically relates to the carboxylic acid compound represented by the chemical formula...
2018/0022735 MODULATORS OF THE P70S6 KINASE FOR USE IN THE TREATMENT OF BRAIN DISORDERS AND TRIPLE-NEGATIVE BREAST CANCER
The invention provides compounds for use in the treatment of a disease or condition selected from brain disorders and triple-negative breast cancer, the...
2018/0022734 SUNITINIB PRODRUG AND PHARMACEUTICAL COMPOSITION
The present invention provides a Sunitinib prodrug having formula I, wherein R.sub.12, R.sub.13 are selected from the group consisting of H, C.sub.1-C.sub.6...
2018/0022733 BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS
The present invention is directed to benzoimidazole compounds of the formula: ##STR00001## and enantiomers, diastereomers, racemates, and pharmaceutically ...
2018/0022732 COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO RET
Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using...
2018/0022731 2-(PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES AS RET INHIBITORS
Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using...
2018/0022730 SMALL-MOLECULE INHIBITORS TARGETING DISCOIDIN DOMAIN RECEPTOR 1 AND USES THEREOF
Compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic...
2018/0022729 Antioxidants and Methods to Maximize Performance
A method of preventing or reducing the level of degradation of an organic substrate is described, wherein a composition is formed that includes the organic...
2018/0022728 Glutarimide Derivatives, Use Thereof, Pharmaceutical Composition Based Thereon and Methods for Producing...
A compound having the following formula: ##STR00001## or a pharmaceutically acceptable salt thereof. A medicament or pharmaceutical composition contains the...
2018/0022727 THERAPEUTIC COMPOUNDS AND USES THEREOF
The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically...
2018/0022726 MUSCARINIC AGONISTS
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and/or M.sub.4 receptor and which are useful in the treatment of...
2018/0022725 Process for the Preparation of 4-Phenyldibenzothiophene
The invention relates to a novel method for the preparation of 4-phenyldibenzo[b,d]thiophene which can be conducted in one pot up to the thiophene ring...
2018/0022724 KETAL COMPOUNDS AND USES THEREOF
Various esterified alkyl ketal ester or hydroxyalkyl ketal ester products are useful as components of organic polymer compositions. The ketal esters are...
2018/0022723 NOVEL COMPOUNDS FOR THE TREATMENT OF HEPATITIS C
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity...
2018/0022722 Compounds for Stabilizing Ryanodine Receptors from Aberrant Levels of Calcium Release
Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods...
2018/0022721 CONTINUOUS HYDROGENATION OF LEVULINIC ACID
The invention relates to a continuous or repetitive batch process for the hydrogenation of levulinic acid (LA) or esters thereof to at least gamma ...
2018/0022720 METHOD FOR FABRICATING TITANIUM-CONTAINING SILICON OXIDE MATERIAL AND APPLICATION OF THE SAME
A method for fabricating a titanium-containing silicon oxide material and an application of the same are disclosed. The method needn't use a template but...
2018/0022719 COMPOUNDS FOR USE IN IMAGING, DIAGNOSING AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM OR OF TUMORS
This invention relates to novel compounds suitable for labelling or already labelled by .sup.18F, methods of preparing such a compound, compositions comprising...
2018/0022718 UNSYMMETRICAL BENZOTHIADIAZOLE-BASED MOLECULAR COMPLEXES
A molecular complex comprising ##STR00001## wherein X1 and X2 are independently selected from the group consisting of: H, Cl, F, CN, alkyl, alkoxy, ester,...
2018/0022717 METHOD OF PRODUCING BENZO[1,2-B:4,5-B']DITHIOPHENE AND BENZOTHIADIAZOLE-BASED MOLECULAR COMPLEXES
A method of forming a molecular complex. The method proceeds by reacting 5-chloro-2,1,3-benzothiadiazole with N-bromosuccinimide to produce ...
2018/0022716 POLYMERIZABLE COMPOUND AND OPTICAL ISOMER
The present invention provides a polymerizable compound having high storage stability without causing crystal precipitation when added to a polymerizable...
2018/0022715 N2-(3,4-DIMETHYLPHENYL)-6-((4-(P-TOLYL)PIPERAZIN-1-YL)METHYL)-1,3,5-TRIAZI- NE-2,4-DIAMINE
The compound N.sup.2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-- triazine-2,4-diamineor a pharmaceutically acceptable salt of said ...
2018/0022714 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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