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Patent # Description
2018/0030537 PUMA, A PRO-APOPTOTIC GENE, AS A NOVEL MOLECULAR BIOMARKER FOR TNFALPHA-INDUCED HUMAN ISLET DAMAGE
p53-upregulated modulator of apoptosis (PUMA) is a biomarker associated with islet cell health. If PUMA is low, islet cells are typically healthy. If PUMA is...
2018/0030536 GENE AND MUTATIONS THEREOF ASSOCIATED WITH SEIZURE AND MOVEMENT DISORDERS
The present invention relates to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give...
2018/0030535 BIOMARKER FOR DIAGNOSIS OF MOYAMOYA DISEASE
Provided are a biomarker composition for the diagnosis of moyamoya disease, including caveolin-1, a kit for the diagnosis of moyamoya disease, a method of...
2018/0030534 BI-DIRECTIONAL SEQUENCING COMPOSITIONS AND METHODS
In some embodiments, methods for obtaining sequence information from a nucleic acid template linked to a support include hybridizing a first primer to a...
2018/0030533 Single Cell Nucleic Acid Detection and Analysis
Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
2018/0030532 Bubble-shaped adaptor element and method of constructing sequencing library with bubble-shaped adaptor element
Provided are an adaptor element in a bubble shape, a method of constructing a sequencing library with such an adapter element. The adaptor element is a hybrid...
2018/0030531 METHODS FOR DETERMINING GENE FUNCTIONS
Disclosed herein are methods, systems and compositions for determining substrate specificity of an enzyme. The disclosed methods, systems and compositions can...
2018/0030530 ENZYME METHOD
The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is...
2018/0030529 PAIRED-END SEQUENCING METHOD
A paired-end sequencing method for sequencing a string of oligonucleotides is disclosed. The method includes preparing a template that includes a substrate...
2018/0030528 METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
2018/0030527 METHODS AND COMPOSITIONS FOR GENERATING AND AMPLIFYING DNA LIBRARIES FOR SENSITIVE DETECTION AND ANALYSIS OF...
The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the...
2018/0030526 HETERO-PORES
The invention relates to hetero-oligomeric pores derived from Msp. The invention also relates to polynucleotide characterisation using the hetero-oligomeric...
2018/0030525 NANOPORE SEQUENCING OF POLYNUCLEOTIDES WITH MULTIPLE PASSES
Disclosed are methods and materials for rereading individual single-stranded DNA or RNA molecules with a nanopore device. A single strand polymer can be passed...
2018/0030524 NUCLEIC ACID SEQUENCING USING TAGS
This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a...
2018/0030523 OLIGONUCLEOTIDE FRAGMENT, AND METHOD AS WELL AS APPLICATION OF SELECTIVE AMPLIFICATION OF VARIANT OF TARGET...
Provided is a method for selective amplification of a variant of a target nucleic acid sequence. Also provided is an oligonucleotide fragment with a particular...
2018/0030522 AMPLIFICATION AND ANALYSIS OF WHOLE GENOME AND WHOLE TRANSCRIPTOME LIBRARIES GENERATED BY A DNA POLYMERIZATION...
The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular...
2018/0030521 Methods and Systems for Solution Based Sequence Enrichment
The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In...
2018/0030520 METHODS AND COMPOSITIONS FOR DETECTING TARGET NUCLEIC ACIDS
The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the...
2018/0030519 METHODS AND SYSTEMS FOR DETECTING TARGET NUCLEIC ACIDS
The present invention provides methods and systems for nucleic acid detection and identification.
2018/0030518 HOST-ASSOCIATED DNA SEQUENCES, PRIMERS, AND PROBES FOR PCR-BASED IDENTIFICATION OF DOG FECAL POLLUTION SOURCES
A method for detecting dog-fecal contamination in a sample, comprising assaying the sample using a nucleotide sequence based genetic assay which comprises...
2018/0030517 Compositions and methods for identifying secretory antibody-bound microbes
The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression...
2018/0030516 Microbiome Diagnostics
A method for determining data related to a microbiome of a human includes isothermally amplifying polynucleotides of at least N different microorganisms...
2018/0030515 Droplet-Based Method And Apparatus For Composite Single-Cell Nucleic Acid Analysis
The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic...
2018/0030514 NON-INVASIVE DIAGNOSIS OF GRAFT REJECTION IN ORGAN TRANSPLANT PATIENTS
The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a...
2018/0030513 SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION OF DNA
A system and method for amplifying and detecting nucleic acids are disclosed. In one embodiment, the system includes: a microfluidic device comprising a...
2018/0030512 CAPSULE ARRAY DEVICES AND METHODS OF USE
This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample...
2018/0030510 NUCLEIC ACID AMPLIFICATION REACTION METHOD AND NUCLEIC ACID AMPLIFICATION REACTION REAGENT
A nucleic acid amplification reaction method includes performing thermal cycling for amplifying a nucleic acid for a reaction solution containing a primer and...
2018/0030509 NUCLEIC ACID AMPLIFICATION REACTION METHOD, REAGENT, AND METHOD OF USING REAGENT
A nucleic acid amplification reaction method includes a heating step of heating a reaction solution containing a reverse transcriptase, a polymerase, a primer,...
2018/0030508 NUCLEIC ACID AMPLIFICATION REACTION METHOD, REAGENT SET, AND METHOD OF USING REAGENT SET
A nucleic acid amplification reaction method includes a thermal cycling step of performing thermal cycling for amplifying a nucleic acid for a reaction...
2018/0030507 METHOD AND APPARATUS RELATING TO TREATMENT OF A BLOOD SAMPLE FOR SEQUENCING OF CIRCULATING TUMOUR CELLS
A method of detecting mutations in a CTC genome that uses a negative selection step to remove a proportion of non-CTCs from a blood sample. The negative...
2018/0030506 Method for Constructing Nucleic Acid Molecule
The present invention provides a method for constructing a single-stranded nucleic acid molecule for nucleic acid sequencing by means of a nanopore sequencer,...
2018/0030505 USE OF APTAMERS IN PROTEOMICS
The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a...
2018/0030504 HIGHLY-MULTIPLEXED FLUORESCENT IMAGING
Provided herein is a method and system for analyzing a sample. In some embodiments the method makes use of a plurality of capture agents that are each linked...
2018/0030503 OXIDIZED GLUTATHIONE ASSAY
The present invention provides an assay for detection of oxidized glutathione (GSSG).
2018/0030502 Regulation of Autophagy and Cell Survival
Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering...
2018/0030501 GENETICALLY ENGINEERED GAS VESICLE GENE CLUSTERS, GENETIC CIRCUITS, VECTORS, PROKARYOTIC CELLS, COMPOSITIONS,...
Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a...
2018/0030500 ENRICHMENT AND SELECTIVE CULTURE OF MYCOBACTERIA
A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a...
2018/0030499 ELECTRODE AND MANUFACTURING METHOD THEREOF, ENZYME SENSOR, GLUCOSE SENSOR AND IN-VIVO COMPONENT MEASURING DEVICE
In a hydrogen peroxide electrode 100 used as a working electrode 30 of an enzyme sensor 20, an intermediate layer 101 containing particles and a retentive...
2018/0030498 FAD-DEPENDENT GLUCOSE DEHYDROGENASE
An object of the present invention is to construct a more excellent glucose sensor, and to provide GDH more suitable for the glucose sensor. Provided is...
2018/0030497 MULTIPLE-USE RENEWABLE ELECTROCHEMICAL SENSORS BASED ON DIRECT DRAWING OF ENZYMATIC INKS
Methods, systems, and devices are disclosed for providing a portable enzymatic-ink dispensing system. The system includes an enzymatic-ink including one or...
2018/0030496 METHODS AND COMPOSITIONS FOR EXPRESSION OF POLYPEPTIDES IN A CELL
Disclosed herein are vector systems for expression of polypeptides in eukaryotic cells; and methods of obtaining high-level expression of polypeptides in a...
2018/0030495 Cell Culture Medium And Methods For Enhancing Recombinant Antibody Purity
This invention relates to a novel cell culture medium and methods to enhance recombinant antibody purity using the cell culture medium disclosed herein. The...
2018/0030494 Low Sequence Bias Single-Stranded DNA Ligation
The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence...
2018/0030493 NUCLEIC ACID AMPLIFICATION REACTION METHOD, NUCLEIC ACID AMPLIFICATION REACTION REAGENT, AND METHOD OF USING...
A nucleic acid amplification reaction method includes performing thermal cycling for amplifying a nucleic acid for a reaction solution containing a template...
2018/0030492 FUNGAL CELLS AND FERMENTATION PROCESSES
The present invention provides an isolated fungal cell that is capable of producing one or more biomass-degrading enzymes and that exhibits increased or...
2018/0030491 METHODS FOR STARCH HYDROLYSIS
The presently disclosed subject matter provides a process for starch liquefaction using at least two classes of .alpha.-amylase enzymes, wherein the starch...
2018/0030490 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2018/0030489 Fiber-Containing Carbohydrate Composition
A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a...
2018/0030488 DEHYDROGENASE-CATALYSED PRODUCTION OF FDCA
The invention relates to a cell expressing a polypeptide having 5-hydroxymethyl-2-furancarboxylic acid dehydrogenase activity, as well as to a cell expressing...
2018/0030487 Methods for Making L-Glufosinate
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The...
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