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Patent # Description
2018/0030486 BIOLOGICAL METHODS FOR PREPARING A FATTY DICARBOXYLIC ACID
The technology relates in part to biological methods for producing a fatty dicarboxylic acid and engineered microorganisms capable of such production.
2018/0030485 PRODUCTION METHOD FOR OIL AND FAT
The present invention provides a commercially-viable-level, highly efficient production method for oil and fat that are rich in USU.
2018/0030484 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL,...
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents...
2018/0030483 PROCESS FOR PRODUCTION OF BIO-ALCOHOL
A process of enhanced bio-alcohol production from molasses is provided herein. The process comprises contacting molasses with sodium benzoate, potassium...
2018/0030482 Use of acetaldehyde in the fermentative production of ethanol
The instant invention relates to processes and systems for the fermentative production of ethanol. The ethanol is produced by fermenting a fermentable...
2018/0030481 GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS
The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically...
2018/0030480 NOVEL CHO INTEGRATION SITES AND USES THEREOF
Expression-enhancing nucleotide sequences for eukaryotic expressions systems are provided that allow for enhanced and stable expression of recombinant proteins...
2018/0030479 METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES...
Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided.
2018/0030478 ELIMINATION OF PROLIFERATING CELLS FROM STEM CELL-DERIVED GRAFTS
Provided herein are methods and compositions for a suicide gene approach comprising an expression vector comprising a cell cycle-dependent promoter driving the...
2018/0030477 GENE THERAPY TO IMPROVE VISION
The invention relates to the use of gene therapy vectors to improve vision by introducing into healthy rod photoreceptor cells of a patient suffering from cone...
2018/0030476 NOVEL INTERGENIC ELEMENTS FOR ENHANCING GENE EXPRESSION
The present invention relates to nucleic acid fragments and constructs comprising genomic nucleotide sequences, which are present upstream of Rb1 and p15C that...
2018/0030475 METHODS FOR PRODUCING MODIFIED RED BLOOD CELL COMPOSITIONS, COMPOSITIONS AND USES THEREOF
The present invention encompasses methods for generating JAK2-modified cultured red blood cells (modified cRBCs) expressing a mutant Janus kinase 2 peptide,...
2018/0030474 Methods and Compositions for Selective Regulation of Protein Expression
The invention provides methods and compositions for selectively suppressing the expression of a recombinant protein in a male reproductive tissue of a...
2018/0030473 MUTATED NUCLEOTIDE MOLECULE, AND TRANSFORMED PLANT CELLS AND PLANTS COMPRISING THE SAME
The present invention relates to a method for producing male sterile plant, a mutated nucleotide molecule comprising a nucleotide sequence of the transcription...
2018/0030472 COMPOSITIONS AND METHODS FOR INSECTICIDAL CONTROL OF STINKBUGS
Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula,...
2018/0030471 ENHANCING THE EFFECTIVENESS OF BLENDED REFUGE
The present invention provides a seed blend comprising pesticidal seed and refuge seed, wherein plants grown from the pesticidal seed type do not pollinate or...
2018/0030470 HERBICIDE-RESISTANT PROTEIN, ENCODING GENE AND USE THEREOF
Involved is a herbicide-resistant protein, coding gene and use thereof. The herbicide-resistant protein comprises: (a) a protein consisting of an amino acid...
2018/0030469 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, CONSTRUCT AND PLANTS COMPRISING SAME AND METHODS OF USING SAME FOR...
Provided are isolated polypeptides which are at least 80% homologous to SEQ ID NOs: 496-794, 2898-3645, and 3647-4855, isolated polynucleotides which are at...
2018/0030468 METHOD FOR REGULATING PLANT GROWTH
An object of the present invention is to elucidate the mechanism of plant growth regulation by brassinosteroid and the mechanism of transfer of the BIL1...
2018/0030467 COMPOSITIONS AND METHODS FOR INCREASING PLANT GROWTH AND YIELD USING RICE PROMOTERS
Compositions and methods for improving plant growth are provided herein. Compositions comprise promoter sequences that direct expression of an operably linked...
2018/0030466 POLYNUCLEOTIDES AND POLYPEPTIDES INVOLVED IN PLANT FIBER DEVELOPMENT AND METHODS OF USING SAME
Isolated polynucleotides are provided. Each of the isolated polynucleotides comprise a nucleic acid sequence encoding a polypeptide having an amino acid...
2018/0030465 MODIFICATION OF TRANSCRIPTIONAL REPRESSOR BINDING SITE IN NF-YC4 PROMOTER FOR INCREASED PROTEIN CONTENT AND...
Method of increasing protein content in a eukaryotic cell comprising an NF-YC4 gene comprising modifying the transcriptional repressor binding site; method of...
2018/0030464 SOYBEAN EVENT DP-305423-1 AND COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND/OR DETECTION THEREOF
Compositions and methods related to transgenic high oleic acid/ALS inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides...
2018/0030463 CERTAIN PLANTS WITH "NO SATURATE" OR REDUCED SATURATE LEVELS OF FATTY ACIDS IN SEEDS, AND OIL DERIVED FROM THE...
The subject invention provides "no sat" canola oil. The subject invention also provides seeds that can be used to produce such oils. Plants that produce these...
2018/0030462 PROTEIN EXPRESSION SYSTEMS
The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in...
2018/0030461 CITRUS TRISTEZA VIRUS BASED VECTORS FOR FOREIGN GENE/S EXPRESSION
Disclosed herein are viral vectors based on modifications of the Citrus Tristeza virus useful for transfecting citrus trees for beneficial purposes. Included...
2018/0030460 ENGINEERING OF HYDROCARBON METABOLISM IN YEAST
The present invention relates to the development of genetically engineered yeasts that can produce hydrocarbons in a controllable and economic fashion. More...
2018/0030459 GENE ENGINEERING YEAST HAVING SACCHARIFICATION FUNCTION, METHOD OF PREPARING SAME, AND APPLICATION OF SAME
A gene engineering yeast having a saccharification function, a method of preparing same, and an application of same, a nucleotide sequence for encoding glucose...
2018/0030458 E. COLI-BASED PRODUCTION OF BETA-LACTAMASE
The invention relates to, in part, improved methods for the production of beta-lactamase using Escherichia coli (E. coli) cells. High yield production of...
2018/0030457 PROTEIN EXPRESSION ENHANCER SEQUENCES AND USE THEREOF
The present invention provides nucleic acid and protein sequences that enhance the expression of fusion proteins by host cells, and in particular bacterial...
2018/0030456 ENHANCED PROTEIN EXPRESSION
The present invention relates in general to nucleic acids and bacterial cells having a genetic alteration that result in increased expression of a protein of...
2018/0030455 INHIBITION OF SEMA3A IN THE PREVENTION AND TREATMENT OF OCULAR HYPERPERMEABILITY
Described herein is a method of preventing or treating ocular vascular hyperpermeability including macular edema, in a subject comprising inhibiting Sema3A...
2018/0030454 RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION...
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond...
2018/0030453 METHOD FOR IMPROVING LEARNING
The invention is directed to a method for improving learning and/or memory (e.g., auditory, visual, somatosensory or motor) in adults and children of an age...
2018/0030452 TARGETING OLIGONUCLEOTIDES AND USES THEREOF TO MODULATE GENE EXPRESSION
Aspects of the invention provide single stranded oligonucleotides for modulating expression of genes based on targeting of low abundance non-coding RNA...
2018/0030451 METHODS FOR TREATING AGING AND SKIN DISORDERS USING NUCLEIC ACIDS TARGETING TYR OR MMP1
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal...
2018/0030450 Antisense Oligonucleotides (ODN) Against SMAD7 and Uses Thereof in Medical Field
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological...
2018/0030449 REPLICATION CAPABLE rAAV VECTORS ENCODING INHIBITORY siRNA AND METHODS OF THEIR USE
In some embodiments, an antiviral vector is provided. The antiviral vector includes a replication competent adeno-associated virus (AAV) and an inhibitory...
2018/0030448 Pharmaceutical Composition Consisting Of RNA Having Alkali Metal As Counter Ion And Formulated With Dications
A biologically active RNA-alkali metal-dication formulation, a pharmaceutical composition containing the complexes, and methods of producing the same. The...
2018/0030447 FUNCTIONAL LIGANDS TO RICIN
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2018/0030446 APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS
The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
2018/0030445 COMPOSITIONS AND METHODS USING CAPSIDS RESISTANT TO HYDROLASES
Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and...
2018/0030444 MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS HAVING NON-NUCLEOTIDE BASED CLEAVABLE LINKERS
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides...
2018/0030443 NON-IONIC, LOW OSMOLAR CONTRAST AGENTS FOR DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AND TREATMENT OF DISEASE
Disclosed are compositions comprising an antisense oligonucleotide and a non-ionic, low-osmolar contrast agent. Also disclosed are methods of delivering an...
2018/0030442 MICRORNA THERAPY FOR PANCREATIC CANCER
Methods for inhibiting pancreatic cancer cell migration and invasion are disclosed herein. Further, methods for inhibiting autophagy are disclosed. More...
2018/0030441 SIRNA COMPOUNDS COMPRISING TERMINAL SUBSTITUTIONS
The invention relates to modified siRNA compounds which down-regulate target gene expression, to pharmaceutical compositions comprising such compounds and to...
2018/0030440 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING MICRORNA AS ACTIVE INGREDIENT
The present invention relates to a pharmaceutical composition for treatment of cancer, which comprises, as an active ingredient, one or more miRNAs selected...
2018/0030439 OLIGONUCLEOTIDE THERAPY FOR LEBER CONGENITAL AMAUROSIS
Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The ...
2018/0030438 MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES
The present application provides materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing...
2018/0030437 ACYL-AMINO-LNA AND/OR HYDROCARBYL-AMINO-LNA OLIGONUCLEOTIDES
A single stranded oligonucleotide containing two or more acyl-amino-LNA or hydrocarbyl-amino-LNA nucleotide monomers, in which other nucleotide monomers can be...
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