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Patent # Description
2018/0030132 METHODS OF TREATMENT USING AN INTERFERON GAMMA INHIBITOR
The invention encompasses methods of treatment of interferon gamma (IFN-.gamma.)-mediated diseases using IFN-.gamma. inhibitors, such as anti-huIFN-.gamma....
2018/0030131 Use of Reslizumab to Treat Moderate to Severe Eosinophilic Asthma
Disclosed herein are methods of treating moderate to severe eosinophilic asthma in a patient comprising administering a therapeutically effective dose of...
2018/0030130 METHOD OF TREATING A LOCALIZED FIBROTIC DISORDER USING AN IL-33 ANTAGONIST
The subject invention provides a method of treating a patient suffering from a localized fibrotic condition which comprises administering to the patient an...
2018/0030129 STEM CELL FACTOR INHIBITOR
Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell...
2018/0030128 TREATMENT OF CANCER WITH ANTI-LAP MONOCLONAL ANTIBODIES
Described herein are compositions and methods relating to LAP-binding agents, including, for example, anti-LAP antibodies, and to their use in methods of...
2018/0030127 ANTI-SERUM ALBUMIN FAB-EFFECTOR MOIETY FUSION CONSTRUCT, AND METHOD OF PREPARING THE CONSTRUCT
The present invention relates to antigen-binding fragment (Fab) and a Fab-effector fusion protein or polypeptide comprising thereof. The Fab of the present...
2018/0030126 IMMUNOREGULATORY STRUCTURES FROM NORMALLY OCCURING PROTEINS
The present invention relates to isolated protein sequences that correspond to cell binding peptides, fragments, neo-structures and/or neo-epitopes of a...
2018/0030125 DEVICE AND METHOD FOR DETECTING A TARGET ANALYTE
A device and method for detecting the presence of a target analyte in a fluid sample are provided. The device can include an inclined capillary tube for...
2018/0030124 METHODS AND COMPOSITIONS FOR ENHANCING ANTI-SSEA4 IMMUNOTHERAPY
A method for treating a tumor by administering an antibody or antibody fragment that binds specifically to stage-specific embryonic antigen 4, and an agent...
2018/0030123 METHOD FOR TREATING A TUMOR WITH BIFUNCTIONAL AGENTS THAT BIND TO TUMOR CARBOHYDRATE ANTIGENS
A method for treating a tumor with at least two bifunctional agents. The bifunctional agents each include a binding domain that specifically binds to...
2018/0030122 BIOMARKERS FOR RHEUMATOID ARTHRITIS
The present invention relates to the diagnosis of autoimmune disorders, more specifically to the diagnosis of rheumatoid disorders, chronic autoimmune...
2018/0030121 ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE
The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides...
2018/0030120 ANTI-SALMONELLA ANTIBODIES AND USES THEREOF
The present disclosure provides anti-Salmonella antibodies or antibody fragments, such as camelid single domain antibodies (VHHs), along with associated...
2018/0030119 HUMAN MONOCLONAL ANTIBODY SPECIFIC FOR THE F PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS (RSV)
This invention is directed to an antibody construct or fragment thereof derived from an RSV-infected human, such that the antibody construct binds with...
2018/0030118 HUMANZIED FILOVIRUS ANTIBODIES AND USES THEREOF
The present disclosure relates to an antibody or antigen-binding portion thereof that binds to a filovirus. The antibody or antigen-binding portion thereof may...
2018/0030117 Synthetic Single Domain Antibody
The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain...
2018/0030116 VARIANTS OF TISSUE INHIBITOR OR METALLOPROTIENASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making...
2018/0030115 COLLAGEN MIMICS
Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly).sub.n, where one of the positions Xaa or Yaa is a bulky,...
2018/0030114 GPR156 Variants And Uses Thereof
The disclosure provides nucleic acids, including cDNA, comprising alterations that encode aspartic acid at a position corresponding to position 533 of the...
2018/0030113 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0030112 NOVEL MINOR HISTOCOMPATIBILITY ANTIGENS AND USES THEREOF
Novel minor histocompatibility antigens (MiHAs) are described. These novel MiHAs were selected based on two features: (i) they are encoded by loci with a minor...
2018/0030111 FC MUTANTS WITH MODIFIED FUNCTIONAL ACTIVITY
Disclosed is to a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a...
2018/0030110 Fully-human T-cell receptor specific for the 369-377 epitope derived from the Her2/Neu (ERBB2) receptor protein.
The present invention relates to compositions and methods for treating HER2/Neu (ERBB2) expressing cancer cells. In some embodiments, the invention includes an...
2018/0030109 TUMOR TARGETED TNF-RELATED APOPTOSIS INDUCING LIGAND FUSION POLYPEPTIDE, METHODS AND USES THEREFOR
Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds...
2018/0030108 NOVEL VOLTAGE-DEPENDENT ION CHANNEL FUSIONS AND METHOD OF USE THEREOF
The present invention relates to novel voltage-dependent ion channel fusion subunits, and to a functional bioluminescence resonance energy transfer (BRET)...
2018/0030107 Pharmaceutical Preparation Comprising Recombinant HcG
The present disclosure describes recombinant human chorionic gonadotropin (hCG) and methods for the production thereof. The recombinant hCG can include...
2018/0030106 INTERLEUKIN-2 EXPRESSION CONSTRUCT USING HUMAN SERIUM ALBUMIN
The present invention relates to an interleukin-2 expression construct for yeast, comprising a methanol oxidase (MOX) promoter; a human serum albumin gene or a...
2018/0030105 Therapeutic Compositions and Methods for Disorders Associated with Neuronal Degeneration
Disclosed are isolated mutant erythropoietin (EPO) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such...
2018/0030104 COMPOSITION AND METHOD FOR AFFECTING THE BINDING OF ANTIGEN-BINDING POLYPEPTIDES TO ANTIGENS
The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two...
2018/0030103 STABLE AMYLOID BETA MONOMERS AND OLIGOMERS
The invention provides monomeric and oligomeric amyloid beta peptide isomers that are resistant towards fibrillogenesis and their use as screening reagents or...
2018/0030102 APPLICATION OF METRNL PROTEIN IN PREPARING HYPOLIPIDEMIC, HYPOGLYCEMIC MEDICINE
The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present...
2018/0030101 NOVEL PROTEINS SPECIFIC FOR PYOVERDINE AND PYOCHELIN
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
2018/0030100 NON-NATURAL SEMAPHORINS 3 AND THEIR MEDICAL USE
The present invention relates to non-naturally occurring, mutated Semaphorin 3 molecules. Particularly, the invention relates to the mutated Semaphorin 3 or...
2018/0030099 Apelin Fusion Proteins and Uses Thereof
The invention provides a fusion protein or polypeptide comprising an apelin peptide fused to a multimerizing component. The invention also provides a fusion...
2018/0030098 NOVEL EGFR BINDING PROTEINS
The present invention relates to new EGFR binding molecules based on ubiquitin muteins (Affilin.RTM.), preferably Affilin molecules having a characteristic...
2018/0030097 EPITOPE-SUBSTITUTED VACCINE FOR USE IN IMPROVING SAFETY AND IMMUNOGENICITY AGAINST DENGUE VIRUSES
Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and...
2018/0030096 RECOMBINANT AAV1, AAV5, AND AAV6 CAPSID MUTANTS AND USES THEREOF
Provided herein are modified recombinant adeno-associated virus (rAAV) capsid proteins, such as modified rAAV1, rAAV5, and rAAV6 capsid proteins, rAAV...
2018/0030095 SILSTATIN COMPOUNDS
The present disclosure relates to Silstatin compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or...
2018/0030094 CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES
Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds,...
2018/0030093 SELF-ASSEMBLING ULTRASHORT ALIPHATIC CYCLIC PEPTIDES FOR BIOMEDICAL APPLICATIONS
The invention relates to cyclic peptides of 3-9 amino acids comprising 2-7 aliphatic and 0-2 polar amino acids that are capable of self-assembling, wherein...
2018/0030092 COMPOUNDS
The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the...
2018/0030091 COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR USE IN VASCULAR INTERVENTION
This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for...
2018/0030090 NON-MEMBRANE DISRUPTIVE P53 ACTIVATING STAPLED PEPTIDES
The present invention relates to non-membrane disruptive and p53 activating stapled peptides, as well as methods of treatment of cancer involving the use of...
2018/0030089 IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions...
2018/0030088 IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions...
2018/0030086 METHODS AND SYSTEMS FOR GENERATING, VALIDATING AND USING MONOCLONAL ANTIBODIES
Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating...
2018/0030085 CRYSTAL FORM OF ABIRATERONE PROPIONATE AND PREPARATION METHOD THEREFOR
The present invention relates to the field of pharmaceutical chemistry, and particularly to a crystal form of Abiraterone propionate and a preparation method...
2018/0030084 DEUTERATED BILE ACIDS
This disclosure relates to deuterated bile acid compositions. A deuterated compound is selected from the disclosed groups of bile acids and their derivatives,...
2018/0030083 DEUTERATED CHENODEOXYCHOLIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND THEREOF
Disclosed are deuterated chenodeoxycholic acid derivatives and pharmaceutical compositions containing the deuterated chenodeoxycholic acid derivatives. In...
2018/0030082 BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTIT- UTED PURINE NUCLEOTIDES FOR HCV...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an...
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