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Patent # Description
2018/0030081 BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTI- TUTED PURINE NUCLEOTIDES FOR HCV...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an...
2018/0030080 Phosphoramidate nucleoside prodrug for treating viral diseases and cancer, processes for their preparation and...
The present invention pertains to chemotherapeutic agents and their use for treating viral and cancerous diseases. These compounds are inhibitors of HCV NS5B...
2018/0030079 Crystalline Form Of Nicotinamide Riboside
Provided are crystalline forms of nicotinamide riboside, including a Form II of nicotinamide riboside chloride: nicotinamide riboside chloride. Also disclosed...
2018/0030078 A NEW QUINOLINE DERIVATIVE FOR USE IN THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS
The present invention relates to a quinoline derivative of formula (1) or one of its pharmaceutically acceptable salts. The present invention further relates...
2018/0030077 PROCESS FOR PREPARING HIGH-PURITY L-ARABINOSE BY USING ARABIC GUM AS RAW MATERIAL
The present invention discloses a process for preparing L-arabinose from Gum Arabic comprising the steps of catalytical hydrolysis of L-arabinose from gum...
2018/0030076 Crystalline Fosaprepitant Dicyclohexylamine Salt and its Preparation
Dicyclohexylamine salt of fosaprepitant (fosaprepitant DCHA), a process for preparing fosaprepitant DCHA, and a use of fosaprepitant DCHA in the preparation of...
2018/0030075 ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising formula I, or a pharmaceutically acceptable salt or...
2018/0030074 PHOSPHONIUM COMPOUND AND PRODUCTION METHOD THEREFOR
The present invention provides a phosphonium compound of formula (II). Also provided is a method for producing a quaternary phosphonium compound labeled with a...
2018/0030073 NATURAL LIPIDS CONTAINING NON-OXIDIZABLE FATTY ACIDS
Provided herein is technology relating to natural lipids containing non-.beta.-oxidizable fatty acids and particularly, but not exclusively, to compositions...
2018/0030072 HYDRIDOSILAPYRROLES, HYDRIDOSILAAZAPYRROLES, THIASILACYCLOPENTANES, METHOD FOR PREPARATION THEREOF, AND...
Hydridosilapyrroles and hydridosilaazapyrrole are a new class of heterocyclic compounds having a silicon bound to carbon and nitrogen atoms within the ring...
2018/0030071 HYDRIDOSILAPYRROLES, HYDRIDOSILAAZAPYRROLES, THIASILACYCLOPENTANES, METHOD FOR PREPARATION THEREOF, AND...
Hydridosilapyrroles and hydridosilaazapyrrole are a new class of heterocyclic compounds having a silicon bound to carbon and nitrogen atoms within the ring...
2018/0030070 Multivinylaminosilanes as Branching Agents for Functionalized Elastomeric Polymers
Novel polymerizable multivinylaminosilanes which are useful as branching agents for synthetic and natural rubber are described. The compounds can be used in...
2018/0030069 THIENOTHIOPHENE - BORON (DONOR-ACCEPTOR) BASED MATERIALS FOR ORGANIC LIGHT EMITTING DIODES
The present invention discloses new molecules having defined structures of a series of thienothiophene (TT) and boron derivatives, light emitting devices of...
2018/0030068 MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT AND ORGANIC ELECTROLUMINESCENT ELEMENT IN WHICH SAME IS USED
Provided are an organic electroluminescent device (organic EL device) that is improved in luminous efficiency, sufficiently secures driving stability, and has...
2018/0030067 CRYSTAL OF IMIDAZO-OXAZINE, PHARMACEUTICAL COMPOSITION CONTAINING SAID CRYSTAL, AND METHOD FOR PRODUCING SAID...
An object of the present invention is to provide a crystal of trans-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]- ...
2018/0030066 CRYSTAL FORM A OF COMPOUND AND PREPARATION METHOD THEREOF
The present invention relates to crystal form A of a compound. The present invention also discloses a preparation method and a pharmaceutical composition of...
2018/0030065 FLUORESCEIN POLYMER CONJUGATES
This technology relates to fluorescein conjugates including fluorescein conjugates of polymers.
2018/0030064 COMPOUNDS AND COMPOSITIONS AND USES THEREOF
Disclosed are compounds of formula (I): ##STR00001## and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric...
2018/0030063 PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES
The present invention provides compounds of formula (I), ##STR00001## wherein: R.sub.1 is unsubstituted C.sub.1-C.sub.6 alkyl; L.sub.a is substituted or...
2018/0030062 Orvinol and Thevinol Derivatives Useful in the Treatment of Drug and Alcohol Abuse, Depression, Anxiety, or a...
The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the...
2018/0030061 NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHBITORS
The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and...
2018/0030060 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE
The present invention provides a compound having the structure: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each independently H,...
2018/0030059 COELENTERAZINE ANALOGUES
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection...
2018/0030058 Crystal of 5-( (2-(6-amino)-9H-purin-9-yl) ethyl) amino) pentan-1-o1
The present invention provides a new crystal form of 5-((2-(6-amino)-9H-purin-9-yl)ethyl)amino)pentan-1-ol, which has a relatively better effect in selectively...
2018/0030057 SUBSTITUTED IMIDAZO[1,5-a]PYRAZINES AS CGRP RECEPTOR ANTAGONISTS
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which arc CGRP-receptor antagonists. The...
2018/0030056 BENZOFURANS SUBSTITUTED WITH BICYCLIC SECONDARY BENZAMIDE AS HCV INHIBITORS
Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
2018/0030055 3,3-DIFLUORO-PIPERIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS
Disclosed are chemical entities of Formula (I): wherein X, Y, Z, R.sup.1, R.sup.3, R.sup.4 and R.sup.5 are defined herein, as NR2B subtype selective receptor...
2018/0030054 NOVEL INHIBITOR OF FLT3 KINASE AND USE THEREOF
Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate,...
2018/0030053 TETRACYCLIC PYRIDONE COMPOUNDS AS ANTIVIRALS
The invention provides compounds of Formula (I) ##STR00001## as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions...
2018/0030052 USE OF TETRAMIC ACID DERIVATIVES AS NEMATICIDES
Use of a tetramic acid compound according to formula (I) or (I') with a second nematicide as a treatment for crop plants to combat and control nematodes in the...
2018/0030051 SOLID FORMS OF A COMPOUND MODULATING KINASES
Solid forms of the compound, [5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-(6-triflu- oromethyl-pyridin-3-ylmethyl)-amine HCl salt (Compound...
2018/0030050 Protein Kinase C Inhibitors and Uses Thereof
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and...
2018/0030049 PREPARATION METHOD FOR PRAZIQUANTEL AND INTERMEDIATE COMPOUNDS THEREOF
Disclosed is a preparation method for praziquantel and intermediates thereof. The method includes: obtaining a target product praziquantel by using...
2018/0030048 COMPOUNDS AND METHODS TO SUPPRESS AUTOIMMUNE RESPONSE
A composition and method for treating autoimmune disease includes administering an effective amount of an aryl hydrocarbon receptor (AhR) ligand. The AhR...
2018/0030047 COMPOUNDS FOR THEIR USE AS DRUGS FOR THE TREATMENT AND/OR THE PREVENTION OF INFECTION(S) CAUSED BY...
Disclosed are compounds of the following formula I: ##STR00001## wherein: m represents an integer being equal to 0, 1, 2, 3, 4, 5 or 6, X represents a simple...
2018/0030046 NOVEL COMPOUNDS AND METHODS OF TREATING OR AMELIORATING AN IL-1R-MEDIATED DISEASE OR DISORDER USING SAME
The present invention provides compounds useful for treating or preventing an IL-1R-mediated disease or disorder. In certain embodiments, the disease or...
2018/0030045 SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8,...
2018/0030044 SELECTIVE BACE1 INHIBITORS
The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof. ##STR00001##
2018/0030043 NOVEL PROCESS FOR THE PREPARATION OF 1,3-THIAZOL-5-YLMETHYL [(2R,5R)-5- CARBAMOYL) AMINO] ...
The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-t- ...
2018/0030042 Methods, Compounds, and Compositions for the Treatment of Angiotensin-Related Diseases
Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders,...
2018/0030041 CONDENSATION PRODUCT OF 1-AMINO-2-PROPANOL AND FORMALDEHYDE AND THE USE THEREOF FOR REDUCING THE AMOUNT OF...
Disclosed is a storage-stable condensation product prepared from 1-amino-2-propanol and formaldehyde in a molar ratio in the range from 1:2.0 to 1:3.1. The...
2018/0030040 SELECTIVE HDAC1 AND HDAC2 INHIBITORS
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or...
2018/0030039 PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR...
Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention...
2018/0030038 Polymorphic Forms of Afatinib Dimaleate
The present disclosure relates to amorphous and crystalline forms of 2-butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]7-[[(3S)-tetrahydro-3-furanyl]oxy]-6- ...
2018/0030037 HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the groups R.sub.1, Cy and Y are defined herein, which are suitable for the...
2018/0030036 Factor IXa Inhibitors
The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said...
2018/0030035 AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY
A compound having the structure according to formula III ##STR00001## wherein: X is NH or S; R.sup.1 is H or (1C-4C)alkyl; R.sup.2 is (1C-4C)alkyl, phenyl or a...
2018/0030034 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS
A compound of formula I ##STR00001## wherein A, X, Y, Z, R.sub.1 and R.sub.24 are described herein. The compounds are useful as inhibitors of potassium channel...
2018/0030033 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the...
2018/0030032 COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO RET
Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using...
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