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Patent # Description
2018/0030031 COMPOUNDS CONTAINING CARBON-CARBON LINKER AS GPR120 AGONISTS
The present invention relates to compound of Formula (I) containing carbon-carbon linker, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a...
2018/0030030 AMIDE COMPOUND
[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating chronic...
2018/0030029 PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine.dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide...
2018/0030028 SYNTHESIS AND RESOLUTION OF NICOTINE
The present disclosure generally relates to methods of preparing nicotine and resolving R,S nicotine to enrich the (S)(-) enantiomer. The method may comprise...
2018/0030027 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the...
2018/0030026 INHIBITORS OF THE KYNURENINE PATHWAY
The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase,...
2018/0030025 METHOD FOR MANUFACTURING LACTIDE
A method for producing lactide including the steps of: providing a solution of lactic acid in a volatile organic solvent, subjecting the solution to an...
2018/0030024 Recovery of tocopherols/tocotrienols, glycerine, sterols and fatty acid esters from vegetable oil distillate...
A process for recovering tocotrienols/tocopherols from vegetable oil distillate comprising the steps of esterifying the vegetable oil distillate with an...
2018/0030023 RECOVERY OF MONOMER FROM POLYURETHANE MATERIALS BY DEPOLYMERIZATION
Methods for recovering monomers from polymers, such as polyurethanes (including thermoset polyurethanes) include heating the polymer to depolymerize the...
2018/0030022 NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS
The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat...
2018/0030021 NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT
The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
2018/0030020 4,6-DIFLUORODIBENZOFURAN DERIVATIVES
4,6-difluorodibenzofuran derivatives of the formula I ##STR00001## the preparation thereof, the use thereof as components in liquid-crystalline media and...
2018/0030019 SUBSTITUTED BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C
Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
2018/0030018 MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount...
2018/0030017 BENZOFURANS SUBSTITUTED WITH PRIMARY BENZAMIDE AS HCV INHIBITORS
Compounds of Formula (I), including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
2018/0030016 BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C
Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
2018/0030015 CONTINUOUS CARBONYLATION PROCESSES
Provided are processes for monitoring and maintaining continuous carbonylation of epoxides or lactones. Processes include measuring parameters affecting the...
2018/0030014 INTEGRATED METHODS FOR CHEMICAL SYNTHESIS
The integrated processes herein provide improved carbon efficiency for processes based on coal or biomass gasification or steam methane reforming. Provided are...
2018/0030013 MANUFACTURING METHOD FOR COMPOUND HAVING N,N-BIS(2-HYROXY-3-CHLOROPROPYL)AMINO GROUP
A method efficiently and safely manufactures, on an industrial scale, a compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group. (1) an amine compound...
2018/0030012 METHOD FOR THE EPOXIDATION OF AN OLEFIN WITH HYDROGEN PEROXIDE
In the method for the epoxidation of an olefin, the olefin is continuously reacted with hydrogen peroxide in a mixed reactor in the presence of a water soluble...
2018/0030011 METHOD FOR THE EPOXIDATION OF AN OLEFIN WITH HYDROGEN PEROXIDE
Epoxidation of an olefin is carried out by continuously reacting the olefin with hydrogen peroxide in the presence of a water soluble epoxidation catalyst,...
2018/0030010 METHOD FOR THE EPOXIDATION OF AN OLEFIN WITH HYDROGEN PEROXIDE
Epoxidation of an olefin is carried out by continuously reacting the olefin with hydrogen peroxide in the presence of a homogeneous epoxidation catalyst in a...
2018/0030009 METHOD FOR PREPARING FORMAMIDE COMPOUND
Disclosed is a method for preparing a formamide compound, the method uses carbon dioxide, hydrogen and an amine compound as raw materials and a transition...
2018/0030008 PROCESS FOR THE PREPARATION OF VORTIOXETINE
Disclosed herein a process for the isolation of intermediate of Vortioxetine in a solid state form and an improved, commercially viable and industrially...
2018/0030007 ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
The present disclosure relates to compounds of formula I that are useful as modulators of .alpha.7 nAChR, compositions comprising such compounds, and the use...
2018/0030006 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME
The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
2018/0030005 TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma...
The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X.sup.1, X.sup.2,...
2018/0030004 ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS
This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such...
2018/0030003 TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
The present invention relates to novel tricyclic compounds which can bind to FXR and act as modulators of the FXR, or a stereoisomer, a geometric isomer, a...
2018/0030002 Process for preparing substituted phenylisoxazoline derivatives
The present invention relates to a process for preparing substituted phenylisoxazoline derivatives.
2018/0030001 NEW TRIAZINE COMPOUNDS AS PHOTOSTABILIZING AGENTS
Disclosed are triazine compounds of formula (I): ##STR00001## wherein X, R, A and B are as defined in the description as photostabilising agents against...
2018/0030000 AZOLE DERIVATIVES FOR CORROSION MITIGATION
Anticorrosion compounds and compositions can be used in methods for preventing metal corrosion. More specifically, the method comprises contacting an...
2018/0029999 Preparation Method for 1-substituted-1H-1,2,3-triazole 4-carboxylic acid
Provided is a preparation method for 1-substituted-1H-1, 2, 3-triazole-4-carboxylic acid. 1-Substituted-4, 5-dibromo-1H-1,2,3-triazole is added to an...
2018/0029998 METHOD FOR PREPARING PROSTACYCLIN RECEPTOR AGONIST
The present invention relates to preparation methods of a prostacyclin receptor agonist of ...
2018/0029997 QUINAZOLINONE ANTIBIOTICS
A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall...
2018/0029996 BICYCLIC QUINAZOLINONE DERIVATIVES
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, ...
2018/0029995 PYRIDAZINONE AND PYRIDONE COMPOUNDS
The invention relates to pyridazinone and pyridone compounds having formula (I) or (I'), and pharmaceutically acceptable salts, hydrates, and solvates thereof ...
2018/0029994 PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF ELUXADOLINE
The invention relates to an improved process for preparing [(S)-1-(4-phenyl-1-H-imidazol-2-yl)-ethyl]-amine. The process involves formation of the novel...
2018/0029993 METHOD FOR PRODUCING OPTICALLY ACTIVE VALERIC ACID DERIVATIVE
A method for producing a compound (4), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific...
2018/0029992 HEAT-RESISTANT ALIPHATIC-CHAIN SATURATED HYDROCARBON HAVING ION PAIRS AT BOTH ENDS, AND COMPOSITION USING SAME
An aliphatic-chain saturated hydrocarbon including an aliphatic hydrocarbon chain which is saturated and has an ion pair at each end of the aliphatic...
2018/0029991 AMIDE COMPOUND AND THE PREPARATION METHOD AND USE THEREOF
The present invention belongs to the field of fungicides, and relates to an amide compound and the preparation method and use thereof. The amide compound is as...
2018/0029989 STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND
Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-meth- oxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid...
2018/0029988 COMPOUNDS FOR INHIBITING C-MYC/MAX/DNA COMPLEX FORMATION
Disclosed are novel compounds of specific chemical structures having inhibitory activity on c-Myc/Max/DNA complex formation or pharmaceutically acceptable...
2018/0029987 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM
The present invention is directed to new crystalline forms of Pitavastatin hemicalcium salt, referred to hereinafter as polymorphic Forms A, B, C, D, E and F,...
2018/0029986 POLYMORPHIC FORMS OF THE SODIUM SALT OF 4-TERT- BUTYL ...
Disclosed are novel polymorphic solvated and desolvated forms of the sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesul- ...
2018/0029985 PHARMACEUTICALLY ACTIVE COMPOUNDS
The invention is directed to compounds of general formula (I), and pharmaceutical compositions containing such compounds. The compounds and compositions have...
2018/0029984 PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the...
2018/0029983 COMPOUND, ORGANIC ELECTROLUMINESCENT ELEMENT MATERIAL, ORGANIC ELECTROLUMINESCENT ELEMENT, AND ELECTRONIC DEVICE
Disclosed herein is a compound represented by formula (1): A-L-B, wherein: A is a group represented by formula (1-A); B is a group represented by formula...
2018/0029982 METHODS OF PRODUCING MOLINDONE AND ITS SALTS
The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of...
2018/0029981 Process for Making Beta 3 Agonists and Intermediates
The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions: ##STR00001##
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