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Patent # Description
2018/0028664 COMPOSITIONS AND METHODS FOR DELIVERY OF AGENTS
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo...
2018/0028663 SODIUM BICARBONATE IN SITU CONVERSION DRIVEN TRANSDERMAL DELIVERY OF AMINE DRUG
Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.
2018/0028662 Method for Suppressing Bitterness of Quinoline Derivative
The present invention provides a method for suppressing bitterness of a quinoline derivative.
2018/0028661 PRODUCTION OF ARTIFICIAL TISSUES COMPRISING MAGNETIC PARTICLES
The invention is comprised in the field of biomedicine, and more specifically, the field of tissue engineering. The invention specifically relates to the use...
2018/0028660 DRUG COMBINATIONS COMPRISING A DGAT INHIBITOR AND A PPAR-AGONIST
The present invention relates to combinations of a DGAT inhibitor and a peroxisome proliferator-activator receptor (PPAR) agonist or a prodrug thereof. The...
2018/0028659 COMPOSITIONS AND METHODS COMPRISING ENERGY ABSORBING MATERIALS FOR FOLLICULAR DELIVERY
The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a...
2018/0028658 ANTIBODY-DRUG CONJUGATES FOR REDUCING THE LATENT HIV RESERVOIR
Disclosed herein are antibody-drug conjugates having the general formula A-L-D, wherein A represents a neutralizing antibody specific for human ...
2018/0028657 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0028656 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0028655 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0028654 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0028653 Syringe Containing Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0028652 PHARMACEUTICAL FORMULATION
The current invention relates to a new pharmaceutical formulation, in particular to a pharmaceutical formulation comprising a protein, more particularly an...
2018/0028651 COMBINATION THERAPY FOR TREATMENT OF CORONARY ARTERY DISEASE
An effective combined dose of an anti-CD47 agent and an anti-TNF agent is administered to the subject in a dose and for a period of time effective to...
2018/0028650 METHODS OF PREVENTING SECONDARY INFECTIONS
A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises...
2018/0028649 SYNTHETIC GLUCOPYRANOSYL LIPID ADJUVANTS
Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: ##STR00001## or a pharmaceutically...
2018/0028648 COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about...
2018/0028647 MODIFICATIONS OF THERAPEUTIC AGENTS FOR ENHANCED DELIVERY TO TARGET SITES
Compositions of a modulator of cell metabolism, typically targeting cellular glycolysis, preferably with a targeting moiety, attached directly or indirectly to...
2018/0028646 POLYELECTROLYTE MULTILAYERS ASSEMBLED FROM IMMUNE SIGNAL COMPOUNDS
Immune-polyelectrolyte multilayers (iPEMs) that can be made entirely from immune signal compounds are provided. iPEMs are formed from first layer of a first...
2018/0028645 HUMAN CYTOMEGALOVIRUS RNA VACCINES
The disclosure relates to HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
2018/0028644 THERMAL INACTIVATION OF ROTAVIRUS
Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the...
2018/0028643 ZIKA VIRUS VACCINES USING VIRUS-LIKE PARTICLES
A flavivirus virus-like particle and methods of making and using that particle, and antibodies raised to a plurality of those particles, are provided.
2018/0028642 CHLAMYDIA-ACTIVATED B CELL PLATFORMS AND METHODS THEREOF
Disclosed herein is a Chlamydia-activated B cell (CAB) platform. Also disclosed is a method of enhancing a population of B cells, comprising exposing said B...
2018/0028641 MULTIPLE VARIANTS OF MENINGOCOCCAL PROTEIN NMB1870
Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting ...
2018/0028640 PROTEINS COMPRISING MRSA PBP2A AND FRAGMENTS THEREOF, NUCLEIC ACIDS ENCODING THE SAME, AND COMPOSITIONS AND...
Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising...
2018/0028639 Compositions and Methods for Treatment of Cancer
Here we show that SEG/SEI presented from a HLA-DQ8 (HLA-DQB*0302 and HLA-DQA*0301) platform prevent the de novo outgrowth (vaccination) of Lewis lung carcinoma...
2018/0028638 CHOLERA TOXIN CHIMERA AND ITS USE AS A STAPH VACCINE
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present...
2018/0028637 Toxoid, Compositions and Related Methods
The disclosure relates to generally to the field of toxin inactivation. More specifically, it relates to clostridial toxins, methods of inactivating these...
2018/0028636 METHODS AND COMPOSITIONS FOR EMERGENCY POST-INFECTION TREATMENT OF ANTHRAX
Compositions effective for treating or preventing an anthrax infection in a subject in need thereof and recombinant proteins included in the compositions are...
2018/0028634 METHOD FOR PROLONGING AND ENHANCING ANTI-TUMOR VACCINE RESPONSE
A method for treating a tumor includes administering (i) a vaccine that contains stage-specific embryonic antigen 4 conjugated to a carrier, (ii) an antibody...
2018/0028633 CHIMERIC ANTIGEN RECEPTOR COMBINATION THERAPY FOR TREATING TUMORS
A method for treating a tumor in a subject by administering at least three of the following treatment modalities: (i) an antibody, (ii) T cells bearing a first...
2018/0028632 METHOD OF TREATING TUMORS WITH NK AND NKT CELLS EXPRESSING ANTI-SSEA4 CHIMERIC ANTIGEN RECEPTORS
Two methods for treating a tumor are disclosed. The first method includes (i) obtaining NK cells or NKT cells from a subject, (ii) transducing the NK cells or...
2018/0028631 ANTI-SSEA4 CHIMERIC ANTIGEN RECEPTORS AND THEIR USE FOR TREATING CANCER
A chimeric antigen receptor containing (i) a single chain Fv that specifically binds to stage-specific embryonic antigen 4 and (ii) an endodomain from...
2018/0028630 COMPOSITIONS AND METHODS FOR THERAPEUTIC ANTI-CANCER VACCINATION
An immunogenic composition that includes a glycoconjugate containing a fusion protein composed of an immunoglobulin gamma Fc domain fused to a tumor-associated...
2018/0028629 IMMUNOGENIC/THERAPEUTIC GLYCAN COMPOSITIONS AND USES THEREOF
The present disclosure encompasses immunogenic/therapeutic compositions including Globo series antigens (SSEA-4, Globo H or SSEA-3) glycoconjugates and...
2018/0028628 USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER
The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor...
2018/0028627 TREATMENT VACCINE FOR PROSTATE CANCER
A method of treating prostate cancer by intradermally injecting a person with a composition comprising (a) a recall antigen and (b) prostate specific antigen...
2018/0028626 IMMUNOTHERAPEUTIC VACCINE AND ANTIBODY COMBINATION THERAPY
The present invention relates to a combination product, composition(s) and kit of parts comprising at least (i) a therapeutic vaccine and (ii) one or more...
2018/0028625 ADMINISTRATION OF PLANT EXPRESSED ORAL TOLERANCE AGENTS
Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is other complicated by pathogenic antibody responses,...
2018/0028624 Injection Paradigm For Administration Of Botulinum Toxins
Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a...
2018/0028623 USE OF PERTUSSIS TOXIN AS A THERAPEUTIC AGENT
The present application relates to the use of pertussis toxin, and its derivatives, analogs, salts and pharmaceutical equivalents. In one embodiment, the...
2018/0028622 TREATMENT OF OSTEOPOROSIS
A pharmaceutical composition for use in the treatment of osteoporosis by oral administration of the composition is provided herein. The composition comprises...
2018/0028621 METHODS OF INDUCING INDOLAMINE 2,3 - DIOXYGENASE (IDO)
A composition and method for using a composition, the composition having at least two compounds, each of which induces indolamine 2,3-dioxygenase, for the...
2018/0028620 Composition for Controlled Ovarian Stimulation
Preparations including FSH, for example recombinant FSH, for use in the treatment of infertility.
2018/0028619 LKKTET AND/OR LKKTNT PEPTIDE COMPOSITIONS WHICH ARE LYOPHILIZED OR IN A FORM CAPABLE OF BEING LYOPHILIZED
A composition including a peptide agent including amino acid sequence LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2], a conservative variant thereof, or a...
2018/0028618 COMPOSITIONS AND METHODS FOR TREATING OBESITY AND HYPERPHAGIA
The present disclosure is directed to the treatment of diseases or conditions characterized by the buildup of fatty tissue, or hyperphagia, such as...
2018/0028617 METHODS OF TREATING MILD BRAIN INJURY AND POST-TRAUMATIC STRESS DISORDER
The present disclosure provides methods for treating Post-Traumatic Stress Disorder (PTSD) and other neurological disorders in a subject, comprising...
2018/0028616 TARGETED HUMAN-INTERFERON FUSION PROTEINS
This disclosure relates to a modified .alpha.-helical bundle cytokine, with reduced activity via an .alpha.-helical bundle cytokine receptor, wherein the...
2018/0028615 COMPOSITIONS AND METHODS USING IL-8 TO IMPROVE MILK PRODUCTION AND REPRODUCTIVE HEALTH IN MAMMALS
The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The...
2018/0028614 USE OF INTERLEUKIN-22 IN THE TREATMENT OF FATTY LIVER DISEASE
The present invention relates to use of interleukin-22 (IL-22) for treating fatty liver disease by decreasing the levels of transaminases. The use of IL-22 in...
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