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Patent # Description
2018/0028512 DONEPEZIL TRANSDERMAL DELIVERY SYSTEM
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of...
2018/0028511 S1P MODULATING AGENTS
Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
2018/0028510 PREVENTION AND TREATMENT OF THROMBOSIS IN MEDICALLY ILL PATIENTS
Provided herein are methods for preventing and treating thrombosis in medically ill patients by administering to the patient a therapeutically effective amount...
2018/0028509 SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): ##STR00001## and pharmaceutically acceptable salts or prodrug thereof,...
2018/0028508 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2018/0028507 3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY
The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said...
2018/0028506 Methods of Preventing the Occurrence of Cardiovascular Events
The present invention relates to pharmacological interventions with pemafibrate for cardiovascular diseases and adverse cardiovascular events. In addition, the...
2018/0028505 Methods of Preventing Cardiovascular Events in Residual Risk Dyslipidemic Populations
The present invention provides pharmacological interventions for the treatment of dyslipidemia, and to the reduction of residual risk of cardiovascular disease...
2018/0028504 Dosage Regimen, Medication Dispensing Package and Uses Thereof for the Treatment of Major Depressive Disorder
This invention provides an oral dosage regimen for the treatment of depression, a pharmaceutically acceptable medication dispensing package containing multiple...
2018/0028503 Dosage Regimen, Medication Dispensing Package and Uses Thereof for the Treatment of Major Depressive Disorder
This invention provides an oral dosage regimen for the treatment of depression, a pharmaceutically acceptable medication dispensing package containing multiple...
2018/0028502 N-carbamoylated urethane for treating a neuroinflammatory disease
There is provided a composition for treating a neuroinflammatory disease comprising a N-carbamoylated urethane compound which has an effect of inhibiting the...
2018/0028501 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Disclosed herein are thieno[3,2-e][1,2,4]triazolo[1,5-a]pyridin-6-amine, thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridin-3-amine, and ...
2018/0028500 New Azabenzimidazole Derivatives as Agonists of the AMP-Activated Protein Kinase
The present invention relates to compounds of general formula I, wherein the group R.sup.1, X and Y are defined as in claim 1, which have valuable ...
2018/0028499 5HT AGONISTS FOR TREATING DISORDERS
Provided, inter alia, are methods for treating an epilepsy disorder using a 5HT receptor agonist, or a pharmaceutically acceptable salt thereof.
2018/0028498 A PHARMACEUTICAL COMPOSITION FOR THE PARENTERAL ADMINISTRATION OF MELATONIN, AND A PROCESS FOR ITS PREPARATION
The present invention relates to pharmaceutical compositions for the parenteral administration of melatonin in the form of sterile aqueous solutions, provided...
2018/0028497 PANOBINOSTAT DOSAGES FOR MULTIPLE MYELOMA
Treatment of multiple myeloma with a combination of panobinostat and bortezomib at specified doses adjusted for safety.
2018/0028496 COMPOSITION COMPRISING A PHOTOSENSITIVE COMPOUND IN A POLYMERIC NANOPARTICLE, AND A METHOD OF USING THE COMPOSITION
Embodiments of a composition comprising a photosensitive compound and a polymer nanoparticle are disclosed herein. The composition may further comprise a...
2018/0028495 USES OF INDOLINONE COMPOUNDS
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are...
2018/0028494 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF INFLAMMATORY EAR DISEASES, METHOD FOR PRODUCING SAME AND METHOD FOR...
A pharmaceutical composition having an analgesic, anaesthetic and antiseptic action, a method for producing the pharmaceutical composition and a method for...
2018/0028493 INHIBITORS OF INDUCED MMP-1 PRODUCTION
The present invention provides methods and compositions of prophylaxis for, or for treating, chronic obstructive pulmonary disease (COPD), cancer, arthritis,...
2018/0028492 COMPOUNDS AND COMPOSITIONS AND USES THEREOF
Compounds of formula I: ##STR00001## are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric...
2018/0028491 METHODS OF DIAGNOSING AND TREATING ALZHEIMER'S DISEASE WITH S-EQUOL
The present invention provides a method for diagnosing or determining the risk of developing Alzheimer's disease and for treating Alzheimer's disease with...
2018/0028490 Methods Of Treating Diarrhea And Promoting Intestinal Health In Non-Human Animals
Methods of treating neonatal and young non-human animals suffering from diarrhea, and/or symptoms thereof, by administering to an animal in need thereof a...
2018/0028489 STABLE CANNABINOID FORMULATIONS
The present invention is generally directed to substantially pure cannabidiol, stable cannabinoid pharmaceutical formulations, and methods of their use.
2018/0028488 TREATING AND/OR PREVENTING INSULIN-RESISTANCE RELATED WEIGHT GAIN
Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).
2018/0028487 DERMATOLOGICAL FORMULATIONS OF 2-(2-ETHOXY-2-OXOETHYL)(METHYL)AMINO-2-OXOETHYL ...
Disclosed herein are dermatological formulations comprising low-impurity TOFA prodrug 2-(2-ethoxy-2-oxoethyl)(methyl)amino-2-oxoethyl ...
2018/0028486 DOCETAXEL ALBUMIN NANOPARTICLE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF
The present invention relates to a docetaxel albumin nanoparticle pharmaceutical composition, a preparation method therefor, and a use thereof for...
2018/0028485 JUICE BEVERAGE FOR PREVENTION AND TREATMENT OF RENAL STONES
Described are edible citrate-rich compositions, including natural juice beverages fortified with natural occurring citrates and synthesized citrate sources...
2018/0028484 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea
The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug...
2018/0028483 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are...
2018/0028482 CHLOROGENIC ACID COMPOSITION AND METHOD FOR ITS USE IN THE TREATMENT OF ALZHEIMER'S DISEASE
The invention provides compositions comprising chlorogenic acid and methods for their use and manufacture in the treatment of Alzheimer's disease. The...
2018/0028481 DENTAL COMPOSITION AND USE
Use of a composition for the prevention, amelioration and/or treatment of conditions, disorders and/or diseases associated with senescence and/or inflammation...
2018/0028480 METHODS OF REDUCING OR PREVENTING OXIDATIVE MODIFICATION OF MEMBRANE POLYUNSATURATED FATTY ACIDS
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of...
2018/0028479 MEDIUM CHAIN FATTY ACIDS AND THEIR TRIGLYCERIDES FOR TREATING ANXIETY
The present invention provides a medium chain fatty acid (MCFA) for use in treating and/or preventing anxiety.
2018/0028478 ANTIVIRAL COMPOSITIONS DIRECTED AGAINST THE NUCLEOPROTEIN OF INFLUENZA VIRUSES
Pharmaceutical compositions for the treatment of a viral infection by a type-A influenza virus are provided. The compositions include a compound having the...
2018/0028477 TREATMENT OF CARDIAC REMODELING AND OTHER HEART CONDITIONS
The present disclosure provides novel methods for treating cardiac remodeling and heart conditions using specific compounds, as well as compositions, and...
2018/0028476 STABLE DOSAGE FORMS OF LEVOMILNACIPRAN
The present invention relates to stable dosage forms of levomilnacipran and pharmaceutically acceptable salts thereof. Processes for the preparation of these...
2018/0028475 COMBINATIONS OF IRS/STAT3 DUAL MODULATORS AND ANTI-CANCER AGENTS FOR TREATING CANCER
Provided is a treatment of cancer using a dual modulator of Insulin Receptor Substrate (IRS) and signal transducer and activator of transcription 3 (Stat3), as...
2018/0028474 METHODS FOR THE BIOSYNTHESIS OF TAURINE OR HYPOTAURINE IN CELLS
The present invention describes an approach to increase taurine or hypotaurine production in prokaryotes. More particularly, the invention relates to genetic...
2018/0028473 NUTRIENTS SOLUTIONS
The present invention relates to dietary supplements, medical foods, and pharmaceutical compositions comprising an aqueous solution of salt of choline, wherein...
2018/0028472 TAMPER-RESISTANT DOSAGE FORM COMPRISING A POLYETHYLENE GLYCOL GRAFT COPOLYMER
A tamper-resistant, oral pharmaceutical dosage form comprising a pharmacologically active ingredient having psychotropic action and a polyethylene glycol graft...
2018/0028471 CONTINUOUS LOCAL SLOW-RELEASE OF THERAPEUTICS FOR HEAD AND NECK PROBLEMS AND UPPER AERODIGESTIVE DISORDERS
The invention features formulations for the local delivery of therapeutically effective doses of curcumin to treat head and neck disorders and upper...
2018/0028470 CURCUMIN-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS FOR FABRICATING THEREOF
Pharmaceutical compositions are described, the compositions consisting essentially of aqueous emulsions of a therapeutically effective quantity of a...
2018/0028469 Fine Dry Particulate Retinoid Active Agent Compositions and Topical Formulations Including the Same
Fine dry particulate retinoid compositions suitable for use in topical formulations, as well as methods of making the same, are provided. In the dry...
2018/0028468 SUSTAINED RELEASE DRUG DELIVERY DEVICES
Sustained release drug delivery devices including scaffolds comprising combinations of anti-connexin, anti-gap junction, anti-hemichannel and/or other agents,...
2018/0028467 TRANSDERMAL DELIVERY SYSTEMS WITH PHARMACOKINETICS BIOEQUIVALENT TO ORAL DELIVERY
A method for delivering a therapeutic agent to a subject from a transdermal delivery system is described, where the therapeutic agent (i) has a half-life in...
2018/0028466 MEMANTINE TRANSDERMAL DELIVERY SYSTEMS
Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer,...
2018/0028465 TRANSDERMAL THERAPEUTIC SYSTEM WITH AN OVERTAPE COMPRISING TWO ADHESIVE LAYERS
The present invention relates to a transdermal therapeutic system for administration of an active ingredient and a process for the preparation thereof. The...
2018/0028464 ADHESIVE PATCH
Provided is an adhesive patch capable of exerting excellent tackiness when the adhesive patch is attached to the skin and having a low incidence of detachment...
2018/0028463 TRANSDERMAL FORMULATION AND DELIVERY METHOD OF LOW SOLUBILITY OR UNSTABLE UNIONIZED NEUTRAL DRUGS BY IN SITU...
Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.
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