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Patent # Description
2018/0037662 PERTUZUMAB VARIANTS AND EVALUATION THEREOF
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines...
2018/0037661 PERTUZUMAB VARIANTS AND EVALUATION THEREOF
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines...
2018/0037660 PERTUZUMAB VARIANTS AND EVALUATION THEREOF
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines...
2018/0037659 METHODS OF PREPARATION OF CONJUGATES
The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise...
2018/0037658 TREATMENT OF POST-PRANDIAL HYPERINSULINEMIA AND HYPOGLYCEMIA AFTER BARIATRIC SURGERY
The present disclosure relates, in general, to methods of treating or preventing post-prandial hypoglycemia after gastric bypass surgery using a negative...
2018/0037657 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO FLT3 PROTEINS
Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern...
2018/0037656 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a...
2018/0037655 THERAPEUTIC AND DIAGNOSTIC METHODS FOR CANCER
The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of...
2018/0037654 NEW ANTI-HCTLA-4 ANTIBODIES
The invention relates to new anti-hCTLA-4 antibodies that bind to a different epitope than prior art anti-CTLA4 antibodies, methods to produce these antibodies...
2018/0037653 TREATMENT FOR CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
The present disclosure relates to the treatment of chronic lymphocytic leukemia. Monoclonal antibody XmAb5574 is efficacious when administered to patient at...
2018/0037652 Disrupting FC Receptor Engagement on Macrophages Enhances Efficacy of Anti-SIRPalpha Antibody Therapy
Anti-SIRP.alpha. antibodies, including multi-specific anti-SIRP.alpha. antibodies, are provided, as are related compositions and methods. The antibodies of the...
2018/0037651 ANTI- GPRC5D ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND GPRC5D AND CD3, AND USES THEREOF
Provided herein are antibodies that specifically bind to GPRC5D. Also described are related polynucleotides capable of encoding the provided GPRC5D-specific...
2018/0037650 Pain Treatment
A method of managing pain in an individual including the following steps: providing an individual in need of pain management; administering an anti-P2X.sub.7...
2018/0037649 CKAP4-MOLECULAR-TARGETED ANTITUMOR AGENT
Disclosed is to identify a target molecule that is involved in Dkk1-induced hyperproliferation of tumor cells to provide a novel antitumor agent....
2018/0037648 METHODS FOR TREATING MELANOMA
The present invention relates to methods for treating melanoma and other indications by inhibiting leptin activity.
2018/0037647 Cachexia Treatment
Administration of an antibody that specifically binds IL-1.alpha. is useful for treating cachexia and increasing the lifespan of a subject suffering from...
2018/0037646 EPITOPES OF IL-17A AND IL-17F AND ANTIBODIES SPECIFIC THERETO
The present invention relates neutralising epitopes of IL-17A and IL-17F and antibodies which bind those epitopes. The present invention also relates to the...
2018/0037645 IL-17A/F AND IL-23p19 BISPECIFIC ANTIBODIES AND METHODS OF USING THE SAME
The present invention relates to antagonizing the activity of IL-17A, IL-17F and IL-23 using bispecific antibodies that comprise a binding entity that is...
2018/0037644 ANTI-IL-33 ANTIBODIES, COMPOSITIONS, METHODS AND USES THEREOF
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.
2018/0037643 ANTI-INTERLEUKIN ANTIBODY PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE...
Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing...
2018/0037642 CORRECTLY FOLDED ETANERCEPT IN HIGH PURITY AND EXCELLENT YIELD
A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly...
2018/0037641 ANTIBODIES TO TAU
This invention relates to antibodies to tau and methods of use thereof.
2018/0037640 ANTIBODY MOLECULES AND USES THEREOF
This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding...
2018/0037639 PEPTIDE CONSTRUCT HAVING A PROTEASE-CLEAVABLE LINKER
There is provided inter alia a construct suitable for oral administration comprising a first polypeptide and a second polypeptide connected by a labile peptide...
2018/0037638 ANTI-INFECTIVE BINDING PROTEINS THAT BIND AIP2
There is disclosed compositions and methods relating to or derived from anti-AIP2 antibodies. More specifically, there is disclosed fully human antibodies that...
2018/0037637 PROBIOTICS, SECRETORY IgA AND INFLAMMATION
Probiotics and ways to increase their effectiveness are provided. One embodiment of the present invention relates to a combination of probiotics with SIgA and...
2018/0037636 STRUCTURED VIRAL PEPTIDE COMPOSITIONS AND METHODS OF USE
The invention provides structurally constrained viral peptides for use as therapeutic and vaccination agents, and for the production of antibodies for use in a...
2018/0037635 RECOMBINANT HUMAN ANTIBODIES FOR THERAPY AND PREVENTION OF POLYOMAVIRUS-RELATED DISEASES
Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of...
2018/0037634 ENGINEERED POLYPEPTIDES AND USES THEREOF
Polypeptides, such as antibody molecules and fusion proteins, comprising an Fc region, are disclosed. The polypeptides can be used to treat, prevent, and/or...
2018/0037633 MONOVALENT ANTIGEN BINDING PROTEINS
The present invention relates to monovalent antigen binding proteins with a CH1-CL domain exchange, methods for their production, pharmaceutical compositions...
2018/0037632 Compositions and Methods for Diagnosis and Treatment of Cancer
The present invention relates to the diagnosis and treatment of cancerous diseases, in particular cancerous diseases expressing Seprase (Fap-alpha; fibroblast...
2018/0037631 BISPECIFIC EGFR/IGFIR BINDING MOLECULES
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and...
2018/0037630 Chimeric Antigen Receptors
Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a...
2018/0037629 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0037628 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0037626 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer,...
2018/0037625 USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified...
2018/0037624 MOLECULES THAT SELECTIVELY ACTIVATE REGULATORY T CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
This invention provides for a fusion protein between an IL2.alpha..beta..gamma. Selective Agonist protein (IL2 Selective Agonist) and a IgG Fc protein using a...
2018/0037623 METHODS AND COMPOSITIONS USING KLOTHO VARIANT POLYPEPTIDES
The present disclosure is directed to compositions and methods related to an alpha sKlotho variant or fragment, in which 1 to up to about 20 amino acids have...
2018/0037622 METHODS FOR TREATING REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
2018/0037621 COMPOSITIONS AND METHODS FOR ENHANCING AN IMMUNE RESPONSE
The disclosure features compounds comprising an antigen portion, a soluble Major Histocompatibility Complex (MHC) molecule portion (e.g., all or an...
2018/0037620 ETV2 AND USES THEREOF
Described herein is a method for producing a chimeric non-human animal expressing a human ETV2 gene comprising: a) generating an ETV2 null non-human animal...
2018/0037619 NOVEL PROTEINS SPECIFIC FOR PYOVERDINE AND PYOCHELIN
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
2018/0037618 NOVEL PROTEINS SPECIFIC FOR PYOVERDINE AND PYOCHELIN
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
2018/0037617 METHODS AND COMPOSITIONS FOR TREATING AND/OR PREVENTING A DISEASE OR DISORDER ASSOCIATED WITH ABNORMAL LEVEL...
The present invention relates to methods and compositions for treating and/or preventing a disease or disorder associated with abnormally high level of the...
2018/0037616 TUBERCULOSIS VACCINE COMPOSITIONS AND RELATED METHODS
Compositions and methods directed to ESAT-6 variants which serve as vaccines for the prevention and prophylactic treatment of TB.
2018/0037615 MICROORGANISM WITH ENHANCED L-LYSINE PRODUCIBILITY AND METHOD FOR PRODUCING L-LYSINE USING THE SAME
The present disclosure relates to a novel modified RNA polymerase sigma factor A (SigA) polypeptide; a polynucleotide encoding the same; a microorganism...
2018/0037614 IMMUNOASSAYS FOR DIFFERENTIAL DETECTION OF CLOSTRIDIUM DIFFICILE
Ultrasensitive and quantitative assays for detecting toxins of Clostridium difficile, which may involve digital ELISA, are provided. Also provided herein are...
2018/0037613 PEPTIDES AND USES THEREOF
The invention provides a series of peptide signals which, when linked to a polypeptide of interest (POI), ensure that said polypeptide is secreted in high...
2018/0037612 VACCINES FOR PREVENTING MENINGOCOCCAL INFECTIONS
The present invention stems from the finding that the interaction between the .beta.2 adrenoceptor (.beta.2AP) and type IV pilus-associated proteins initiates...
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