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Patent # Description
2018/0037611 ANTI-DENGUE VACCINES AND ANTIBODIES
A Dengue virus Envelope Dimer Epitope (EDE) wherein the EDE: c) spans the polypeptides of a Dengue virus Envelope polypeptide dimer; and/or d) is presented on...
2018/0037610 NOVEL SP-B & SP-C PEPTIDES, SYNTHETIC LUNG SURFACTANTS, AND USE THEREOF
The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including ...
2018/0037609 PHASE TRANSITION BIOPOLYMERS AND METHODS OF USE
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or...
2018/0037608 MODIFIED CYCLOPENTAPEPTIDES AND USES THEREOF
The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein...
2018/0037607 PEPTIDES FOR THE TREATMENT OF MALIGNANT PROLIFERATIVE DISEASES
Synthetic peptides containing chemical modifications having anti-tumor properties are provided. Further provided are pharmaceutical compositions including the...
2018/0037606 METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF
Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation...
2018/0037605 SYNTHETIC PEPTIDES AND ENZYMATIC FORMATION OF INTRACELLULAR HYDROGELS
The invention relates to a peptide that includes a plurality of amino acid residues and an enzymatically cleavable moiety including taurine or hypotaurine, the...
2018/0037604 PROCESS FOR THE PURIFICATION OF RECOMBINANT PROTEINS
A process for the extraction and purification of recombinant proteins, more specifically interferons and insulin, having improved quality and yield. The...
2018/0037603 Capture Purification Processes for Proteins Expressed in a Non-Mammalian System
Methods of purifying proteins expressed in non-mammalian expression systems in a non-native soluble form directly from cell lysate are disclosed. Methods of...
2018/0037602 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Described herein are neuroactive steroids of the Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof; wherein R.sup.1, R.sup.2, R.sup.a, G,...
2018/0037601 Nucleoside-Based Anti-Bacterial and Anti-Protozoan Drugs
The present invention is directed to purine nucleoside analogs of the general formula I or salts and pharmaceutical compositions comprising such compounds and...
2018/0037600 NON-CALORIC SWEETENER
Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
2018/0037599 FIBER-RICH MALTOOLIGOSACCHARIDES HAVING LOW GLUCOSE BIOAVAILABILITY, METHOD OF MANUFACTURE THEREOF AND USE...
The present invention relates to maltooligosaccharides, the content of .alpha.-1,4-glycosidic bonds of which is between 70% and 80% of the total number of...
2018/0037598 METHODS OF MAKING AND USING LIGNIN DERIVATIVES
Materials and methods for preparing reactive lignin and for preparing a bio-based adhesive are described herein.
2018/0037597 CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)...
Crystalline forms of brigatinib, pharmaceutical compositions comprising the same, and methods of their preparation and use of the same are disclosed herein.
2018/0037596 NOVEL BIS (ALKOXYSILYL-VINYLENE) GROUP-CONTAINING SILICON COMPOUND AND PRODUCTION METHOD OF SAME
Provided is an organic silicon compound represented by the following general formula (1) ##STR00001## (wherein R.sup.1 represents either an alkyl group that has ...
2018/0037595 BENZOXABOROLE COMPOUNDS AND USES THEREOF
Compounds whose structure comprises Formula II, or a compound whose structure comprises Formula III wherein X is selected from chloro, fluoro, bromo and iodo,...
2018/0037594 Oxadiazolopyridine Derivates for Use as Ghrelin O-Acyl Transferase (GOAT) Inhibitors
The present invention relates to compounds of general formula I, ##STR00001## wherein the groups R.sup.1, R.sup.2 and n are defined as in claim 1, which have...
2018/0037593 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R.sup.x is an optionally substituted carbocyclyl lower alkyl, or the like] or a...
2018/0037592 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R.sup.x is an optionally substituted carbocyclyl lower alkyl, or the like] or a...
2018/0037591 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R.sup.X is an optionally substituted carbocyclyl lower alkyl, or the like] or a...
2018/0037590 SUBSTITUTED QUINOLINES AS PDE-10 INHIBITORS
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one...
2018/0037589 THIENODIAZEPINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION...
The present invention relates to novel thienodiazepine derivatives or pharmaceutically acceptable salts thereof, and a pharmaceutical composition including the...
2018/0037588 INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS
Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
2018/0037587 Substituted Tricyclics and Method of Use
The present invention provides for compounds of formula (I) ##STR00001## wherein X, Y, and R.sup.1 have any of the values defined in the specification, and...
2018/0037586 SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING...
Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating...
2018/0037585 METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS USE THEREOF
Compounds that modulate GluR5 activity and methods of using the same are disclosed.
2018/0037584 AMORPHOUS SUBSTANCE OF IDELALISIB AND PREPARATION METHOD THEREFOR
The present invention relates to an amorphous form of Idelalisib and its methods of preparation. Using a Cu-K.alpha. radiation, the X-ray powder diffraction...
2018/0037583 PURINONE COMPOUNDS AS KINASE INHIBITORS
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition,...
2018/0037582 SUBSTITUTED PYRAZINO[2,2-a]ISOQUINOLINE DERIVATIVES
The present invention relates to compounds of formula of formula I wherein R, R.sup.1, R.sup.2 and L are as described herein, compositions containing compounds...
2018/0037581 HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
Benzodiazepine dimers having a structure represented by ##STR00001## wherein X comprises a heteroaromatic moiety and is as further defined in the application;...
2018/0037580 Substituted pyrazolo[1,5-a]-pyridine-3-carboxamides and use thereof
The present application relates to novel substituted pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for their preparation, to their use, alone or in...
2018/0037579 COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES
Disclosed are methods for the treatment of diseases or conditions of the eye, especially retinopathies, ocular edema and ocular neovascularization....
2018/0037578 METHOD FOR PRODUCING 1,2,4-OXADIAZOLE DERIVATIVE
The invention provides a production method of a 1,2,4-oxadiazole derivative represented by formula (A), which comprises reacting a compound represented by...
2018/0037577 INHIBITORS OF JUN N-TERMINAL KINASE
The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: ##STR00001## or a salt or...
2018/0037576 SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF
The present invention belongs to the field of medicinal chemistry, and relates to substituted pyrimidine compounds as phosphatidylinositol 3-kinase (PI3K)...
2018/0037575 SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS
Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering...
2018/0037574 COMPOUND, COMPOSITION, ORGANIC ELECTROLUMINESCENCE ELEMENT, AND ELECTRONIC DEVICE
A compound has a first structure represented by a formula (1), a second structure represented by a formula (2), a third structure represented by a formula (3),...
2018/0037573 UREA DERIVATIVES AND USES THEREOF
The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
2018/0037572 UREA DERIVATIVES AND USES THEREOF
The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
2018/0037571 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
2018/0037570 TLR7/8 ANTAGONISTS AND USES THEREOF
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists.
2018/0037569 DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS
The present invention relates to novel pyridine derivatives of formula (I): ##STR00001## as A.sub.2B adenosine receptor antagonists and ligands of MT.sub.3 ...
2018/0037568 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or...
2018/0037567 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
Provided are 4'-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of...
2018/0037566 THERAPEUTIC COMPOUNDS AND USES THEREOF
The invention relates to compounds of formula (I) and salts thereof: ##STR00001## wherein R.sup.1-R.sup.3 have any of the values defined in the specification....
2018/0037565 PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with a dialkyl maleate to provide an alkyl...
2018/0037564 HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q is ##STR00002## and...
2018/0037563 PROCESS FOR MAKING BERAPROST
A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer...
2018/0037562 Process for Preparing 5-(Chloromethyl)furfural
Disclosed herein is a process for preparing 5-(chloromethyl)furfural which includes the steps of: subjecting a cellulosic biomass to a pretreatment so as to...
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