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Patent # Description
2018/0051306 Enzymatic Hydrolysis with Hemicellulolytic Enzymes
The invention relates to processes of closing an observed gap in sugar yield between pure batch hydrolysis and a multi-stage hydrolysis containing a continuous...
2018/0051305 ENZYMATIC ACTIVITY OF LYTIC POLYSACCHARIDE MONOOXYGENASE
The present invention is in the area of enzymes for (hemi-)cellulose degradation and/or modification, more in particular the degradation and/or modification of...
2018/0051304 Method for Producing DHA-Containing Glyceride-Containing Composition
A method for producing a composition containing a DHA-containing glyceride, including a step of obtaining a composition containing a DHA-containing glyceride,...
2018/0051303 THE MICRBE TRANSFORMANT FOR WEIGHT LOSS AND LIPID REDUCTION, THE METHOD FOR CONSTRUCTING THE TRANSFORMANT, AND...
It discloses a transformant for weight loss and lipid reduction, which is obtained by recombining and substituting human oxyntomodulin gene into thymidylate...
2018/0051302 BIS-ALKOXYL AMIDE ALKYL CATIONIC PEPTIDE LIPIDS, SYNTHESIS METHOD THEREOF, AND APPLICATION THEREOF
A bis-alkoxyl amide alkyl cationic peptide lipid has a chemical structure as below: ##STR00001## wherein the bis-alkoxyl amide alkyl cationic peptide lipid is...
2018/0051301 INDUCTION OF PACEMAKER-LIKE CELLS FROM CARDIOMYOCYTES
Disclosed are compositions and methods relating to the cardiac conduction system. Compositions, methods for converting cardiac tissue to an induced-sinoatrial...
2018/0051300 SELF-COMPLEMENTARY PARVOVIRAL VECTORS, AND METHODS FOR MAKING AND USING THE SAME
The teachings herein are generally directed to a method of enhancing the genetic stability of parvovirus vectors. The stability of conventional ss or dsAAV...
2018/0051299 COMPOSITIONS AND METHODS FOR TREATING DISEASES
The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of...
2018/0051298 EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION
Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease...
2018/0051297 COMPOSITIONS AND SYSTEMS FOR CONFERRING DISEASE RESISTANCE IN PLANTS AND METHODS OF USE THEREOF
Compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins...
2018/0051296 MUTATED ALLENE OXIDE SYNTHASE 2 (AOS2) GENES
Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the...
2018/0051295 METHODS AND COMPOSITIONS FOR SHORT STATURE PLANTS THROUGH MANIPULATION OF GIBBERELLIN METABOLISM TO INCREASE...
The present disclosure provides compositions and methods for altering gibberellin (GA) content in corn or other cereal plants. Methods and compositions are...
2018/0051294 MICROORGANISMS ENGINEERED TO USE UNCONVENTIONAL SOURCES OF NITROGEN
Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and...
2018/0051293 GENETIC CONTROL OF CELL SIZE
Described herein are mutant cyanobacterial cell populations that have a smaller mean cell length than wild type cyanobacterial cell populations of the same...
2018/0051292 CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen...
2018/0051291 MUTANT MICROORGANISM PRODUCING L-ASPARTIC ACID DERIVATIVES, AND METHOD FOR PRODUCING L-ASPARTIC ACID...
The present invention relates to a mutant organism having the ability to produce aspartic acid derivatives, wherein a gene encoding the glyoxylate shunt...
2018/0051290 Splice Switching Oligomers for TNF Superfamily Receptors and Their Use in Treatment of Disease
Methods and compositions are disclosed for controlling expression of TNF receptors (TNFR1 and TNFR2) and of other receptors in the TNFR superfamily using...
2018/0051289 THERAPEUTICS AND METHODS OF TREATING FATTY LIVER DISEASE
A method of treating a condition in a mammal comprising administering a pharmacologically effective amount of a therapeutic, wherein the therapeutic one of...
2018/0051288 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FILOVIRUS INFECTIONS
The present invention relates to methods and pharmaceutical compositions for the treatment of filovirus infections. In particular, the present invention...
2018/0051287 COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D
The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of...
2018/0051286 TREATMENT OF DELTA-LIKE 1 HOMOLOG (DLK1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO DLK1
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Delta-like 1 homolog (DLK1), in particular, by...
2018/0051285 CATIONIC LIPID
The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid...
2018/0051284 INHIBITORS OF MIR-17-92 CLUSTER FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA AND OTHER MALIGNANCIES
The present invention refers to inhibitors of the miR-17-92 cluster and to their use as medicaments, in particular in the treatment of multiple myeloma and...
2018/0051283 COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION
Disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Also disclosed herein are methods for reducing expression...
2018/0051282 ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
2018/0051281 GUIDE RNA WITH CHEMICAL MODIFICATIONS
The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated...
2018/0051280 MATERIALS AND METHODS FOR THE SYNTHESIS OF ERROR-MINIMIZED NUCLEIC ACID MOLECULES
The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first...
2018/0051279 METHODS OF IDENTIFYING BIOLOGICALLY ACTIVE RANDOM PEPTIDES IN PLANTS AND LIBRARIES OF PLANTS EXPRESSING...
The present disclosure provides methods and systems for identifying biologically active random peptides (BARPs) in plants. The present disclosure also provides...
2018/0051278 DE NOVO SYNTHESIZED NUCLEIC ACID LIBRARIES
Disclosed herein are methods for the generation of nucleic acid libraries encoding for gRNA sequences. The gRNAs encoded by methods described herein may be...
2018/0051277 PROTECTION OF BARCODES DURING DNA AMPLIFICATION USING MOLECULAR HAIRPINS
Described herein are approaches for the improved detection, identification, and/or quantification of target nucleic acids. These approaches provide a means of...
2018/0051276 NOVEL METHODS FOR DISPLAYING CYCLIC PEPTIDES ON BACTERIOPHAGE PARTICLES
The present invention relates to methods for displaying cyclic peptides on the surface of bacteriophage particles and collections thereof.
2018/0051275 METHOD FOR PURIFYING VIRAL VECTORS
The invention relates to methods of purifying viral vectors from cell culture. In particular, the invention relates to a method of purifying a supernatant...
2018/0051274 METHOD OF COLLECTING A NUCLEIC ACID(S)
A method of collecting a nucleic acid(s) from a biological sample includes step a) mixing an aluminum oxide support with a water-soluble neutral polymer...
2018/0051273 SYSTEM AND METHOD FOR DNA EXTRACTION
A portable device for extracting DNA from a sample comprising a tissue with a plurality of cells. The device includes an opening configured to receive the...
2018/0051272 IMMOBILIZED PROTEASE WITH IMPROVED RESISTANCE TO CHANGE IN EXTERNAL ENVIRONMENT
The present invention provides a highly active protease that can be used in sample preparation for mass spectrometry of a protein and has excellent stability...
2018/0051271 NON-AQUEOUS ENZYME-POLYMER CONJUGATE SOLUTIONS AND RELATED METHODS
An enzyme-polymer conjugate shows increased activity and molecular dissolution in non-aqueous solvents enabling enzyme mediated catalysis in non-aqueous...
2018/0051270 HEPARINASES OBTAINED FROM SPHINGOBACTERIUM DAEJEONENSE, PREPARATION THEREFOR AND APPLICATION THEREOF
Heparinases SDhep I and SDhep II obtained from a bacterium Sphingobacterium daejeonense are heparin enzymes that have not been reported. The enzymes were...
2018/0051269 COMPOSITIONS AND METHODS COMPRISING VARIANT MICROBIAL PROTEASES
The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using...
2018/0051268 Alpha-amylase Variants With Altered Properties
The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and...
2018/0051267 TAL EFFECTOR-MEDIATED DNA MODIFICATION
Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; "TALENS") are provided.
2018/0051266 TAL EFFECTOR-MEDIATED DNA MODIFICATION
Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; "TALENS") are provided.
2018/0051265 TRANSPOSASE POLYPEPTIDES AND USES THEREOF
Transposase polypeptides and polynucleotides are provided, which have a high activity in mammalian cells. Methods for engineering cells, such as chimeric...
2018/0051264 NEW POLYPEPTIDE HAVING A POLYESTER DEGRADING ACTIVITY AND USES THEREOF
The present invention relates to a new isolated polypeptide comprising an amino acid sequence having at least 75%, 80%, 85%, 90%, 95%, 99% or 100% identity to...
2018/0051263 MATERIALS AND METHODS FOR CHARACTERIZING AND USING A 3-KETOACYL-ACYL CARRIER PROTEIN (ACP) SYNTHASE III...
A mutant Bacillus subtilis, which does not express a functional KASIIIA and/or KASIIIB, and method of making; a mutant Rhodospirillum rubrum, which does not...
2018/0051262 MESSENGER UNA MOLECULES AND USES THEREOF
This invention provides a range of translatable messenger UNA (mUNA) molecules. The mUNA molecules can be translated in vitro and in vivo to provide an active...
2018/0051261 METHOD OF PRODUCING A POLYPEPTIDE OR VIRUS OF INTEREST IN A CONTINUOUS CELL CULTURE
Described herein is a chemostat-like continuous cell culture system that combines certain advantages of perfusion open systems and chemostat open systems to...
2018/0051260 Method for Producing Stem Cell Clones Suitable for Induction of Differentiation into Somatic Cells
Provided is a method for producing a stem cell clone, which comprises the steps of: (i) introducing into stem cells an exogenous gene associated with induction...
2018/0051259 CELL FATE CONVERSION OF DIFFERENTIATED SOMATIC CELLS INTO GLIAL CELLS
The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into...
2018/0051258 EX VIVO PROLIFERATION OF EPITHELIAL CELLS
The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.
2018/0051257 METHODS FOR GENERATING ALVEOLAR TYPE II CELLS
A method for generating alveolar type II (AT II) cells or lung epithelial cells is disclosed. The method comprises a two-step differentiation protocol to...
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