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Patent # Description
2018/0051104 FLUORINE-CONTAINING BORIC ACID PVB COMPOSITE
A fluorine-containing boric acid PVB composite comprising a condensate of a fluorine-containing alcohol, boric acid and polyvinyl butyral, wherein the...
2018/0051103 OLIGOMER PRODUCTION METHOD AND CATALYST
An oligomer production method and a catalyst, the method comprising a step of co-oligomerizing a polymerizable monomer including ethylene and an .alpha.-olefin...
2018/0051102 PROCESS FOR TRANSITIONING BETWEEN INCOMPATIBLE CATALYSTS
The invention relates to a process for transitioning from a first continuous polymerization reaction in a reactor, for example a gas-phase reactor conducted in...
2018/0051101 MODIFIED CONJUGATED DIENE POLYMER, METHOD FOR PRODUCING MODIFIED CONJUGATED DIENE POLYMER, POLYMER COMPOSITION,...
A modified conjugated diene-based polymer is produced by reacting a conjugated diene-based polymer having an alkali metal or an alkali-earth metal at a...
2018/0051100 Hyaluronic Acid Derivatives
The present disclosure relates to hyaluronic acid derivatives, and in particular, derivatives in which the N-acetyl group of hyaluronic acid has been...
2018/0051099 Processes to Prepare Highly Functional Fiber Products and Products Produced Thereby
Processes to prepare highly functional fiber products from agricultural by-products (e.g., sugar beet pulp, orange peel, apple pulp and other pectin containing...
2018/0051098 MANUFACTURING PROCESS FOR CYCLODEXTRIN DERIVATIVES
A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin...
2018/0051097 PHARMACEUTICAL COMPOSITIONS COMPRISING MODIFIED FUCANS AND METHODS RELATING THERETO
Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases.
2018/0051096 PHYSICALLY MODIFIED SAGO SARCH AND USES OF SAME
The present invention relates to physically modified sago starch which exhibits an increased onset of gelatinization temperature and controlled viscosity...
2018/0051095 NOVEL MULTIVALENT IMMUNOGLOBULINS
The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with...
2018/0051094 ANTIBODY THAT RECOGNISES THE T14 PEPTIDE OF ACHE
The invention relates to antibodies, and in particular, to antibodies used in the diagnosis and treatment of neurodegenerative disorders, such as Alzheimer's...
2018/0051093 NUCLEIC ACIDS AND HOST CELLS EXPRESSING ANTIBODIES CAPABLE OF BINDING TO THE COAGULATION FACTOR XIA AND USES...
The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof,...
2018/0051092 Methods of Treatment by Administering an Anti-BAFFR Antibody Therapeutic Formulation
Anti-BAFFR antibodies are formulated as liquid formulation comprising a high concentration of the antibody active ingredient for delivery to a patient without...
2018/0051091 ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40L
Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are...
2018/0051090 PROCESS OF PRODUCTION WITH CONTROLLED COPPER IONS
The present invention provides a method of cell culture comprising adding a cell-containing seed medium to an initial medium and starting to culture the cell...
2018/0051089 T CELL RECEPTOR KNOCK OUT ENGINEERED IMMUNE CELLS, ENDOWED WITH CHIMERIC ANTIGEN RECEPTORS BINDING TO CD123 FOR...
The present invention relates to a TCR KO--or TCR KO and dCK KO--engineered immune cells expressing a Chimeric Antigen Receptors (CAR) specific for CD123 that...
2018/0051088 ACTRIIB BINDING AGENTS AND USES THEREOF
The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.
2018/0051087 Anti-Inflammatory Polypeptides
This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
2018/0051086 METHOD OF TREATING PRIMARY SCLEROSING CHOLANGITIS
Disclosed is a method for treating a subject having primary sclerosing cholangitis, comprising administering to said subject an effective amount of a humanized...
2018/0051085 NOVEL ANTI-PD-1 CHECKPOINT INHIBITOR ANTIBODIES THAT BLOCK BINDING OF PD-L1 TO PD-1
The present invention concerns compositions and methods of use of anti-PD-1 antibodies comprising CDR sequences corresponding to SEQ ID NO:1 to SEQ ID NO:6....
2018/0051084 COMBINATION OF BETA-ADRENERGIC RECEPTOR ANTAGONISTS AND CHECK POINT INHIBITORS FOR IMPROVED EFFICACY AGAINST CANCER
Provided are methods for prophylaxis and/or therapy of cancer that include administering to an individual in need thereof an effective amount of a...
2018/0051083 BI-SPECIFIC ANTIBODIES AGAINST TIM-3 AND PD-1 FOR IMMUNOTHERAPY IN CHRONIC IMMUNE CONDITIONS
Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as...
2018/0051082 ANTIBODIES DIRECTED AGAINST PROGRAMMED DEATH-1 (PD-1)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a programmed...
2018/0051081 THERAPEUTIC CD47 ANTIBODIES
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to CD47 of multiple mammalian species, block the binding of SIRPalpha and...
2018/0051080 NOVEL T CELL RECEPTORS AND IMMUNE THERAPY USING THE SAME
The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel T cell receptor (TCR)...
2018/0051079 BCR-Complex-Specific Antibodies and Methods of Using Same
This invention relates to chimeric and humanized antibodies that specifically bind the BCR complex, and particularly chimeric and humanized antibodies to the...
2018/0051078 METHODS OF TREATING INFLAMMATORY BOWEL DISEASE WITH IFN-GAMMA THERAPY
The present invention describes methods for treating inflammatory disorders of the gastrointestinal tract, including but not limited to Inflammatory Bowel...
2018/0051077 COMBINATION THERAPY OF ANTIBODIES ACTIVATING HUMAN CD40 AND ANTIBODIES AGAINST HUMAN PD-L1
The present invention relates to a pharmaceutical product for the treatment of a proliferative disease, comprising the combination of an antibody, or an...
2018/0051076 NOVEL ANTI-TNFalpha BINDING COMPOUNDS AND USES THEREOF
The present invention is directed to novel Anti-TNF.alpha. antibody binding compounds and methods of using the same. Anti-TNF.alpha. antibody binding compounds...
2018/0051075 ANTI-TGF-BETA ANTIBODY FOR THE TREATMENT OF FANCONI ANEMIA
The present invention provides methods of treating, preventing or delaying the onset of bone marrow failure in Fanconi Anemia patients comprising administering...
2018/0051074 METHODS TO ENHANCE CELL-MEDIATED IMMUNITY
This disclosure provides a method for enhancing cell-mediated immunity in individuals with disorders such as cancer or infection that involves administering an...
2018/0051073 ANTI-TAU ANTIBODIES
The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of the tau...
2018/0051072 ANTI-AMYLOID-BETA ANTIBODIES
The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of the...
2018/0051071 ANTIBODY HIGHLY SPECIFICALLY RECOGNIZING TURN STRUCTURE AT 22- AND 23-POSITIONS IN AMYLOID BETA
Provided is an antibody or an immunologically reactive fragment thereof which targets exclusively an A.beta. having a specific turn structure of A.beta. (a...
2018/0051070 Novel VISTA-Ig constructs and the use of VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3)...
2018/0051069 COMPOSITIONS AND METHODS FOR TREATING ALLERGIC INFLAMMATION
Compositions and methods are provided that relate to inhibiting and/or reducing glycosylation of IgE for the treatment of allergic and atopic disorders. These...
2018/0051068 CalA BINDING AGENTS, CalA PEPTIDES AND METHODS OF USE
Embodiments disclosed herein relate to compositions comprising extracellular thaumatin domain proteins, or portions thereof (e.g., CalA polypeptides, or...
2018/0051067 MODIFIED VON WILLEBRAND FACTOR HAVING IMPROVED HALF-LIFE
The invention relates to a modified VWF molecule for use in the treatment of a blood coagulation disorder.
2018/0051066 MODIFIED CHIMERIC POLYPEPTIDES WITH IMPROVED PHARMACOKINETIC PROPERTIES
The present invention provides VEGF antagonists with improved pharmacokinetic properties. According to certain embodiments, a fusion polypeptide capable of...
2018/0051065 CODON OPTIMIZATION FOR TITER AND FIDELITY IMPROVEMENT
The invention provides methods for producing a protein in a cell free protein synthesis system such that the protein does not contain an asparagine (Asn or N)...
2018/0051064 NEUROPILIN-1 SPECIFIC BINDING PEPTIDE, FUSION PROTEIN FUSED WITH SAME, AND USE THEREOF
A peptide that binds specifically to neuropilin-1 (NRP1) without binding to neuropilin-2 (NRP2) is provided. A fusion protein, a fusion antibody, ...
2018/0051063 TREATMENT WITH HUMAN GROWTH HORMONE ANALOGUES
The present invention concerns an improved therapeutic regimen for GHD therapy. In particular, the invention concerns methods for bolus dose administration of...
2018/0051062 ALKALINE PH-MODIFIED EDIBLE CASEIN-BASED FILMS AND COATINGS, AND METHOD FOR THE MAKING THEREOF
Improved casein-based films are produced by adjusting the pH of a film-production suspension. The film-production suspension may contain a casein source, a...
2018/0051061 Anti-Microbial Peptides and Coatings
Antimicrobial peptides and methods of use are provided.
2018/0051060 CELL-PERMEABLE (ICP)-SOCS3 RECOMBINANT PROTEIN AND USES THEREOF
The present invention relates to providing improved cell-permeable (iCP)-SOCS3 recombinant protein and uses thereof. Preferably, the iCP-SOCS3 recombinant...
2018/0051059 Controlled Gene Expression Methods
Methods and compositions for controlling gene expression are disclosed.
2018/0051058 LIGHT-ACTIVATED CHIMERIC OPSINS AND METHODS OF USING THE SAME
Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively...
2018/0051057 CYANOBACTERIA HAVING IMPROVED PHOTOSYNTHETIC ACTIVITY
This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria, that have a reduced amount of a light harvesting protein (LHP)...
2018/0051056 SYNTHETIC MINIATURE PROTEIN SCAFFOLDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING SAME
Synthetic miniature protein scaffolds are described herein, as are compositions comprising same. Methods for the preparation of the synthetic miniature protein...
2018/0051055 TOLL-LIKE RECEPTOR 2 LIGANDS AND METHODS OF MAKING AND USING THEREOF
Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of...
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