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Patent # Description
2018/0057586 ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF
The present application relates to antibodies that specifically bind to hepcidin and methods of using the antibodies. Another aspect relates to antibodies...
2018/0057585 TREATING VASCULAR DISEASE AND COMPLICATIONS THEREOF
Administration of an antibody that specifically binds IL-1.alpha. is useful for reducing the chance or severity of a major adverse clinical event occurring in...
2018/0057584 IL-17 ANTIBODY FORMULATION
The present invention provides pharmaceutical formulations for anti-IL-17 antibodies. These anti-IL-17 antibody pharmaceutical formulations can be used to...
2018/0057583 ANTI-IL-25 ANTIBODIES AND USES THEREOF
The present invention provides antibodies that bind to human interleukin-25 (IL-25) and methods of using the same. According to certain embodiments, the...
2018/0057582 METHODS OF TREATMENT OF EOSINOPHILIC BRONCHITIS WITH AN ANTI-IL-5 ANTIBODY
The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and...
2018/0057581 ANTIBODIES TARGETING M-CSF
This disclosure generally relates to antibodies or antibody fragments which specifically bind to M-CSF. In particular antibodies and antibody fragments are...
2018/0057580 ANTI-GREMLIN-1 (GREM1) ANTIBODIES AND METHODS OF USE THEREOF FOR TREATING PULMONARY ARTERIAL HYPERTENSION
The present invention provides anti-Gremlin-1 (GREM1) antibodies, and antigen-binding fragments thereof, as well as methods of use of such antibodies, or...
2018/0057579 ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous...
2018/0057578 Antibodies Specific for TGF-Beta
The present disclosure relates, in general, to materials and methods for antibodies specific for transforming growth factor beta (TGF.beta.), including...
2018/0057577 Split Inteins, Conjugates and Uses Thereof
Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
2018/0057576 COMPLEMENT FACTOR Bb ANTIBODIES
The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the...
2018/0057575 COMPOSITIONS AND METHODS OF USE FOR DETERMINATION OF HE4a
The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker...
2018/0057574 ANTI-HISTONE THERAPY IN ACUTE KIDNEY INJURY
Acute kidney injury (AKI) is often associated with damage to remote organs, such as lungs or heart. AKI induces kidney tubular necrosis as well as NETosis,...
2018/0057573 MZB1, A NOVEL B CELL FACTOR, AND USES THEREOF
The marginal zone (MZ) and B1 subsets of B cells, which differ from conventional follicular (FO) B cells both developmentally and functionally, are involved in...
2018/0057572 ANTIBODY BINDING A LINEAR EPITOPE OF HUMAN P53 AND DIAGNOSTIC APPLICATIONS THEREOF
The invention relates to an anti-human p53 antibody suitable for specifically binding a linear epitope which is exposed only in a conformationally altered...
2018/0057571 METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS
The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the...
2018/0057569 THERAPEUTIC USE OF SPECIFIC LIGAND IN MSRV ASSOCIATED DISEASES
A ligand includes each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ...
2018/0057568 REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE
The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition....
2018/0057567 Multispecific Antibodies Facilitating Selective Light Chain Pairing
Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be...
2018/0057566 O-Linked Glycoforms Of Polypeptides And Method To Manufacture Them
The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX,...
2018/0057565 STABILIZED POLYPEPTIDE INSULIN RECEPTOR MODULATORS
Provided herein are stapled or stitched polypeptides comprising an alpha-helical segment, wherein the polypeptide binds to the insulin receptor, and wherein...
2018/0057564 ANTAGONISTS OF IL-20 FAMILY OF CYTOKINES AND THEIR USE
Methods for blocking the activity of the IL-20 family of cytokines in a mammal having a disorder-mediated by one or more of the IL-20 family of cytokines...
2018/0057563 METHODS FOR EXPANDING IMMUNE CELLS
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the...
2018/0057562 UNIVERSAL ANTIBODY-MEDIATED BIOSENSOR
A universal antibody-mediated biosensor is provided that comprise a biosensor cell line stably expressing a novel chimeric fusion protein that can be used to...
2018/0057561 PD-L1 AND PD-L2-BASED FUSION PROTEINS AND USES THEREOF
Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1...
2018/0057560 COMBINED T CELL RECEPTOR GENE THERAPY OF CANCER AGAINST MHC I AND MHC II-RESTRICTED EPITOPES OF THE TUMOR...
The present invention relates to the field of immunotherapy, in particular adoptive T cell therapy or T cell receptor (TCR) gene therapy of cancer. The...
2018/0057559 INSULIN ANALOGUES WITH A GLUCOSE-REGULATED CONFORMATIONAL SWITCH
A two-chain insulin analogue contains an A chain modified by (i) a monomeric glucose-binding element at or near its N terminus and (ii) a B chain modified by...
2018/0057558 Synthesis of GLP-1 Peptides
Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.
2018/0057557 METHODS AND COMPOSITIONS OF A FOLLICLE STIMULATING HORMONE RECEPTOR IMMUNORECEPTOR OR CHIMERIC ANTIGEN RECEPTOR
The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression...
2018/0057556 CYCLIC GALANIN-ANALOGS AND USES THEREOF
The invention generally relates to the field of medicine and pharmacology. More particularly, it relates to novel analogs of galanin, and the use thereof in...
2018/0057555 TARGETING OF CYTOKINE ANTAGONISTS
The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule....
2018/0057554 FIBROBLAST GROWTH FACTOR (FGF) 1 MUTANTS AND METHODS OF USE TO REDUCE BLOOD GLUCOSE
The present disclosure provides FGF1 mutant proteins, which include an N-terminal deletion, point mutation(s), or combinations thereof. In some examples, the...
2018/0057553 CONJUGATE AND USE THEREOF
A technique is provided which enables simple and low-cost purification of biologically active proteins by means of a conjugate of a target substance capturing...
2018/0057552 A PEPTIDE OR COLLECTION OF PEPTIDES DERIVED FROM AMYLOID PRECURSOR PROTEIN
The present invention relates to a peptide or collection of peptides derived from amyloid precursor protein (APP). The present invention also relates to uses...
2018/0057551 ALZHEIMER ABETA PEPTIDE BINDING POLYPEPTIDE
The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid .beta. (A.beta.) peptides (in the following referred...
2018/0057550 METHODS AND COMPOSITIONS FOR REGENERATING TISSUES
Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein...
2018/0057549 SAXATILIN-FC FUSION PROTEIN AND USE THEREOF
The present invention relates to a saxatilin derivative having an increased half life and a use thereof. The saxatilin derivative of the present invention has...
2018/0057548 IMPROVED SILK FIBERS
Methods and compositions are provided for improved proteinaceous block copolymer fibers based on long repeat units having molecular weight of greater than...
2018/0057547 DIAGNOSTIC AND THERAPEUTIC EPITOPE, AND TRANSGENIC PLANT
A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent...
2018/0057546 MINIMIZED CYANOBACTERIAL MICROCOMPARTMENT FOR CARBON DIOXIDE FIXATION
A fusion chimeric protein is described herein that can assemble a functional carboxysome core, which is able to fix carbon by taking atmospheric carbon dioxide...
2018/0057545 EVOLUTION OF BT TOXINS
The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure...
2018/0057544 MULTIVALENT CD20-BINDING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT EFFECTOR REGIONS AND ENRICHED COMPOSITIONS...
The present invention provides multivalent CD20-binding molecules, and compositions thereof, such as enriched compositions comprising large proportions of...
2018/0057543 PYOLYSIN METHODS AND COMPOSITIONS
Methods for improved cultivation media and culture conditions for Trueperella pyogenes are disclosed herein. Also disclosed are improved methods for the...
2018/0057542 THERAGNOSTIC PARTICLES
The present invention provides viral-based nanoparticles for therapeutic and diagnostic use, and methods for making and using the nanoparticles. Specifically,...
2018/0057541 SENECAVIRUS A ANTIGENS AND METHODS OF USE
A Senecavirus A polypeptide generally includes at least a portion of 151-434 of SEQ ID NO:1, amino acids 435-673 of SEQ ID NO:1, or amino acids 674-937 of SEQ...
2018/0057540 SIMIAN ADENOVIRUS NUCLEIC ACID-AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF
The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated...
2018/0057539 MULTIMERIZATION OF RECOMBINANT PROTEIN BY FUSION TO A SEQUENCE FROM LAMPREY
The present invention relates to polymerized recombinant proteins, to recombinant nucleic acids coding for the polymerized recombinant proteins, to expression...
2018/0057538 POTENT AND HIGHLY SOLUBLE PEGYLATED COMPSTATIN PEPTIDES
The disclosure provides for highly soluble PEGylated compstatin peptides, which exhibit high binding affinities for complement and therapeutic efficacy in...
2018/0057537 ANG (1-7) DERIVATIVE OLIGOPEPTIDES AND METHODS FOR USING AND PRODUCING THE SAME
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment,...
2018/0057536 SELECTIVE DELIVERY MOLECULES AND METHODS OF USE
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells...
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