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Patent # Description
2018/0057485 BACE1 INHIBITORS
The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
2018/0057484 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR
The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition...
2018/0057482 SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS
The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
2018/0057481 SOLID FORMS OF CENICRIVIROC MESYLATE AND PROCESSES OF MAKING SOLID FORMS OF CENICRIVIROC MESYLATE
The invention relates to solid forms of cenicriviroc mesylate, methods of their preparation, pharmaceutical compositions thereof and methods of their use.
2018/0057480 PYRAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous...
2018/0057479 Inhibitors of BCR-ABL Mutants and Use Thereof
Inhibitor compounds of Bcr-Abl and Bcr-Abl mutants including Bcr-Abl T315I mutant protein are disclosed. Compositions comprising the inhibitor compounds and...
2018/0057478 AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME
Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure ...
2018/0057477 HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE
The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT.sub.2) receptor. More particularly the invention...
2018/0057476 PRODUCTION OF MESO-LACTIDE, D-LACTIDE AND L-LACTIDE BY BACK BITING OF POLYLACTIDE
Process for increasingly producing D-Lactide and meso lactide by depolymerizing by back biting polylactide (PLA) said process which comprises: (i)...
2018/0057475 Nitroalkene Trolox Derivatives and Methods of Use Thereof In The Treatment And Prevention of Inflammation...
The present invention is directed to a class of anti-inflammatory, antioxidant nitroalkene compounds used in biological or biochemical applications to reduce...
2018/0057474 2,3-Fluorinated Glycosides as Neuraminidase Inhibitors and Their Use as Anti-Virals
Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for...
2018/0057473 METHOD FOR THE EPOXIDATION OF PROPENE WITH HYDROGEN PEROXIDE
The method for the epoxidation of propene comprises continuously reacting propene with hydrogen peroxide in the presence of a homogeneous epoxidation catalyst...
2018/0057472 DERIVATIVES OF SOBETIROME
Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
2018/0057471 Two-Electron Donating Phenothiazines and Use Thereof
Compounds for use as electrolyte in a non-aqueous redox battery are provided, including an N-substituted phenothiazine compound according to the formula: ...
2018/0057470 COMPOUNDS FOR THERAPEUTIC USE
Chemical entities of Formula (I): ##STR00001## Including enantiomers thereof, wherein R.sup.1 has any of the values described herein, and compositions comprising...
2018/0057469 CRYSTALLINE FORMS OF TYROSINE KINASE INHIBITORS AND THEIR SALTS
The invention relates to various polymorphic forms and amorphous form of sodium 4-((3-(4-cyclo-hexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazo- ...
2018/0057468 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture...
2018/0057467 NOVEL TRIAZOLE DERIVATIVES
The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the...
2018/0057466 TRIAZOLE DERIVATIVES AND THEIR USE AS PDE4 ACTIVATORS
Compounds of Formula (I), which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes, are provided. Methods and uses of these...
2018/0057465 Inhibitors of Necroptosis
The invention relates to novel heterocyclic compounds of Formula (I) which inhibit necroptosis and methods for their use. The compounds may be useful in the...
2018/0057464 PROCESSES FOR PREPARING OLAPARIB
Provided herein are novel processes and methods for making 4-[(3-[(4-cyclopropylcarbonyl)piperazin-1-yl]carbonyl)-4-fluorophenyl]met- hyl(2H)phthalazin-1-one...
2018/0057463 PICOLINAMIDE N-OXIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY
This disclosure relates to picolinamide N-oxides of Formula I and their use as fungicides. ##STR00001##
2018/0057462 Substituted 2-difluoromethyl-nicotin(thio)carboxanilide derivatives and their use as fungicides
The present invention relates to novel substituted 2-difluoromethyl-nicotin(thio)carboxanilides derivatives, to processes for preparing these compounds, to...
2018/0057461 PICOLINAMIDES AS FUNGICIDES
This disclosure relates to picolinamides of Formula I and their use as fungicides. ##STR00001##
2018/0057460 PICOLINAMIDES AS FUNGICIDES
This disclosure relates to picolinamides of Formula I and their use as fungicides. ##STR00001##
2018/0057459 METHOD FOR PRODUCING 2,3-DICHLORO-5-(TRICHLOROMETHYL)PYRIDINE
The present invention relates to a novel process for producing of 2,3-dichloro-5-(trichloromethyl)pyridine by using PCl.sub.5 as chlorinating agent at elevated...
2018/0057458 LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2018/0057457 Chemical Process for Preparing Pyrimidine Derivatives and Intermediates Thereof
The present disclosure relates to a method of synthesizing 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-[2-(propa- ...
2018/0057456 DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND...
Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical...
2018/0057455 COMPOUNDS USEFUL AS IMMUNOMODULATORS
The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and...
2018/0057454 PROCESS FOR PREPARATION OF ISOSULFAN BLUE
Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, ...
2018/0057453 Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons
Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions...
2018/0057452 Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons
Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions...
2018/0057451 Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons
Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions...
2018/0057450 NITRILEOXIDE COMPOUND
The present invention provides a compound of the formula (I): ##STR00001## wherein, A is R.sup.6(R.sup.7).sub.s, N, O, S, or --NR.sup.5--; R.sup.6 is an s-valent...
2018/0057449 CARBAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES
The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or...
2018/0057448 Structural requirements of histone deacetylase inhibitors: C4-modified saha analogs display dual HDAC6/HDAC8...
A compound having formula I for histone deacetylase inhibition is provided: ##STR00001## or a pharmaceutically acceptable salt or hydrate thereof wherein R is ...
2018/0057447 METHYL MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION CONTAINING SAME
The purpose of the present invention is to provide a cooling agent composition containing a novel methyl menthol derivative having no undesirable feeling of...
2018/0057446 BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS
Provided herein are compounds of the formulas: (I) wherein: n, X.sub.2, R.sub.3, R.sub.3', R.sub.4, R.sub.4', R.sub.5, R.sub.5', R.sub.6, and R.sub.6' are as...
2018/0057445 SYNTHESIS OF N-VINYL CARBOXYLIC ACID AMIDES
Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for...
2018/0057444 AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS
In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the...
2018/0057443 MECHANOCHEMICAL SYNTHESIS OF IPTYCENES
Methods for mechanochemically synthesizing compositions comprising bridged bicyclic-based compounds such as iptycene-based compounds are generally provided. In...
2018/0057442 3-OXO-3-(ARYLAMINO)PROPANOATES, A PROCESS FOR THEIR PREPARATION, AND THEIR USE IN PREPARING PYRROLIDINONES
Disclosed are compounds of Formula I, including all stereoisomers and salts thereof, ##STR00001## wherein Q.sup.1, Q.sup.2 and R are as defined in the...
2018/0057441 GAS PHASE PRODUCTION OF ALKYL ALKANOATES
An alkane-containing stream is reacted to produce an alkene, which is carbonylated to produce an alkyl alkanoate, e.g., methyl propanoate, by a gas phase...
2018/0057440 METHOD FOR SYNTHESIZING NOVEL COMPOUNDS DERIVED FROM 3-HYDROXY-CYCLOPENTYL ACETIC ACID
The present invention relates to compounds of formula (I): ##STR00001## in which R1 is a hydrogen atom, a phenyl radical, or a straight or branched, saturated or...
2018/0057439 Process For The Sustainable Production Of Acrylic Acid
A process for the production of organic acids having at least three carbon atoms comprises the steps of forming an amount of carbon monoxide and reacting the...
2018/0057438 PROCESS FOR PRODUCING 2-ETHYLHEXANAL HELPING TO IMPROVE YIELD
A process for producing 2-ethylhexanal involves performing reaction using a reaction tank equipped with a gas-introducing mixer having extracting, exhausting,...
2018/0057437 METHOD FOR SYNTHESIZING OPTICALLY ACTIVE CARBONYL COMPOUNDS
The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral...
2018/0057436 NOVEL ALDEHYDE COMPOUNDS AND THEIR USE IN PERFUME COMPOSITIONS
The present invention is directed to novel aldehyde compounds and a method of improving, enhancing or modifying a fragrance formulation through the addition of...
2018/0057435 EFFICIENT CATALYST FOR THE FORMATION OF POLYARYL HYDROCARBONS SUITABLE AS PRECURSORS FOR POLYDENTATE...
The disclosure relates to the efficient preparation of aromatic hydrocarbons useful as intermediates for di-, tri-, tetra- and poly-dentate organophosphorus...
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