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Patent # Description
2018/0193352 HETEROARYLDIAZEPINE DERIVATIVES AS RSV INHIBITORS
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## These compounds are...
2018/0193351 Form C of Avibactam Sodium
The present invention relates to crystalline form C of avibactam sodium and to a process for its preparation. The invention also concerns a pharmaceutical...
2018/0193350 TREATMENT OF NUT MIDLINE CARCINOMA
Disclosed herein is a method of treating nuclear protein in testis (NUT) midline carcinoma (NMC) in a subject in need thereof, comprising administering an...
2018/0193349 USE OF SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES FOR TREATING LYMPHOMAS
Described herein are pharmaceutical combinations and compositions comprising a) a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or a salt thereof, and b) one...
2018/0193348 Medicament for Treating Peripheral Neuropathies
The invention provides a pharmaceutical composition for treating atopic dermatitis of a human that is induced by Herpes simplex virus (HSV), said ...
2018/0193347 TOFACITINIB ORAL SUSTAINED RELEASE DOSAGE FORMS
The present invention relates to oral sustained release formulations of tofacitinib and pharmaceutical acceptable salts thereof. The formulations described...
2018/0193346 PHARMACEUTICAL COMBINATIONS
The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely ...
2018/0193345 INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS
Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders...
2018/0193344 Nanocarriers And Their Processing For Diagnostics And Therapeutics
The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic...
2018/0193343 IMIDAZO-PYRAZINYL DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate...
2018/0193342 COMBINATION THERAPY FOR TREATMENT OF HEMATOLOGICAL CANCERS AND SOLID TUMORS
Provided herein are methods for treating, preventing, and/or managing hematological cancers and solid tumors using combination therapy of ...
2018/0193341 DNA-PK INHIBITORS
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said...
2018/0193340 TREATMENT OF SEXUAL DYSFUNCTION
The present invention describes novel methods for the treatment of sexual dysfunction.
2018/0193339 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING DRY EYE DISEASES, CONTAINING IMATINIB AS ACTIVE INGREDIENT
The present invention relates to a composition for preventing or treating dry eye syndrome or eye diseases caused by dry dyes, containing imatinib as an active...
2018/0193338 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula I: ##STR00001## where R.sup.1, R.sup.2a, R.sup.2b, and R.sup.3-R.sup.6 are as defined in the...
2018/0193337 Methods of Blocking the CXCR-4/SDF-1 Signaling Pathway With Inhibitors of Bruton's Tyrosine Kinase
In some embodiments, the present invention relates to novel small molecule inhibitors that block the CXCR4-SDF-1 signaling pathway by directly inhibiting the...
2018/0193336 SPRAY DRY FORMULATIONS
Disclosed herein are compounds, compositions, methods and formulations therefor, for preventing and treating proliferative diseases associated with aberrant...
2018/0193335 COMPOSITIONS, FORMULATIONS, PACKAGED PHARMACEUTICALS, AND METHODS OF USING HEDGEHOG PATHWAY MODULATORS FOR THE...
Compositions, formulations, packaged pharmaceuticals, and methods of treatment by the sensitization of resistant tumors are provided. The compositions comprise...
2018/0193334 PHARMACEUTICAL COMPOSITION OF VORTIOXETINE OR SALT THEREOF, AND PREPARATION METHOD THEREFOR
Provided are a pharmaceutical composition of an amorphous vortioxetine or a salt thereof, and a preparation method therefor. The pharmaceutical composition...
2018/0193333 TRANSDERMAL DELIVERY SYSTEM
The invention relates to a method of treating pain in a patient by applying a transdermal therapeutic system for the transdermal administration of...
2018/0193332 LOW-TEMPERATURE STABLE OPIOID ANTAGONIST SOLUTIONS
The present invention relates to pharmaceutical compositions comprising an opioid antagonist, PG, and an isotonicity agent. The pharmaceutical compositions are...
2018/0193331 Systems and Methods for Treating an Opioid-Induced Adverse Pharmacodynamic Response
Disclosed in certain embodiments is a method of treating or preventing an opioid induced adverse pharmacodynamic response comprising administering to a patient...
2018/0193330 ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS
Derivatives of 1,2,3,4-tetrahydroisoquinoline (THIQ) having the general formula A-(CH.sub.2).sub.n--B are provided, wherein A is THIQ or a substituted...
2018/0193329 METHODS OF TREATING CANCER PATIENTS WITH FARNESYLTRANSFERASE INHIBITORS
The present invention relates to the field of molecular biology and cancer biology. Specifically, the present invention relates to methods of treating a...
2018/0193328 USE OF LAQUINIMOD TO DELAY HUNTINGTON'S DISEASE PROGRESSION
The subject invention provides methods of treating or delaying disease progression in a subject afflicted with Huntington's disease (HD) comprising...
2018/0193327 PROPHYLACTIC LEUKOTRIENE INHIBITOR AND IMPLANT DISPLACEMENT THERAPY FOR PREVENTION AND TREATMENT OF CAPSULAR...
A method of treating or preventing capsular contracture in a patient resulting from surgical insertion of a silicone breast implant in a surgically created...
2018/0193326 OPHTHALMIC COMPOSITION
Provided herein is an ophthalmic composition. In some embodiments, the ophthalmic composition includes a low concentration of an ophthalmic agent for treatment...
2018/0193325 METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in...
2018/0193324 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE
The invention is a method of treating osteoarthritis or normalizing a condition of osteoarthritis comprising administering to an animal or a human in need...
2018/0193323 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of...
2018/0193322 THIENOPYRIDINE DERIVATIVE FOR THE TREATMENT OF HEPATITIS C INFECTIONS
The present invention relates to methods of treatment of hepatitis C using prasugrel. The methods of the present invention can be used in patients with...
2018/0193321 INDOLOTRYPTOLINE ANTICANCER AGENTS
Indolotryptoline compounds of the general structure: ##STR00001## are disclosed. In these compounds R.sup.1 is chosen from hydrogen, halogen and OH; R.sup.2 is...
2018/0193320 ANYHYDROUS COMPOSITIONS OF mTOR INHIBITORS AND METHODS OF USE
Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR...
2018/0193319 REGIMEN FOR SUPPRESSING ORGAN REJECTION
The present invention relates to a method of suppressing organ rejection in a patient receiving an organ transplant by initiating oral treatment with a...
2018/0193318 NOVEL METHODS FOR TREATING CANCER
The invention provides thiazole-substituted indolin-2-ones as inhibitors of cancer stem cell pathway kinases (CSCPK) and related kinases, and methods of using...
2018/0193317 Angiotensin II Receptor Antagonist for the Prevention or Treatment of Systemic Diseases in Cats
A method is described for the treatment of systemic diseases in cats. A composition is administered to a cat, where the composition includes a therapeutically...
2018/0193316 DRUG COMPOSITIONS
Described herein are pharmaceutical compositions including a proton pump inhibitor and an antiparasitic drug. In some embodiments, the compositions can be...
2018/0193315 SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE
Compounds having a structure of Formula (IX): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2a,...
2018/0193314 AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof, wherein: "Z", R.sup.1 and R.sup.2 are defined...
2018/0193313 GLUCOCORTICOID RECEPTOR MODULATORS TO TREAT PANCREATIC CANCER
Methods and compositions for treating a subject hosting a non-ACTH-secreting pancreatic tumor are disclosed. The methods include administering to the subject a...
2018/0193312 NUTRACEUTICAL COMPOSITION AND DOSING REGIMEN
The present invention is a nutraceutical formulation, intended for oral administration, comprising co-administered if not co-formulated melatonin together with...
2018/0193311 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS
The present invention provides controlled release dosage formulations of compounds having the Formula: ##STR00001## or pharmaceutically acceptable salts thereof,...
2018/0193310 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION
A method for inhibiting biofilm formation by bacteria on a surface or disrupting existing biofilm on a surface, including contacting the surface or existing...
2018/0193309 USE OF INDOLE COMPOUNDS FOR FAT REDUCTION AND SKIN AND SOFT TISSUE TIGHTENING
The present invention relates to indole compounds and compositions and uses thereof, including uses of the indole compounds and compositions for the reduction...
2018/0193308 POLYMORPHIC FORMS OF ST-246 AND METHODS OF PREPARATION
Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocy- cloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as...
2018/0193307 METHODS TO MITIGATE INJURY FROM RADIATION EXPOSURE
Mitigating radiation induced injury to a mammal that has been exposed to radiation by administering a pharmaceutically effective amount of a composition...
2018/0193306 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF MUSCULAR DISORDERS AND BONE DISORDERS
The present invention relates to compounds and compositions and their applications as pharmaceuticals for treating, preventing, or reversing injury to skeletal...
2018/0193305 CROMOLYN COMPOSITIONS FOR TREATMENT OF CHRONIC COUGH DUE TO IDIOPATHIC PULMONARY FIBROSIS
The disclosure provides a method of treating chronic cough in a subject having idiopathic pulmonary fibrosis (IPF) comprising administering to the subject a...
2018/0193304 PHYTOTERPENOID FACILITATION OF THERAPEUTIC ONSET AND EFFICACY OF SUBLINGUAL CANNABINOID ADMINISTRATION
A cannabis plant extract based formulation to aid in stabilizing the therapeutic efficacy of cannabinoid containing treatments in patients affected with...
2018/0193303 NOVEL COMPOUNDS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that...
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