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Patent # Description
2018/0194862 BISPECIFIC BINDING PROTEINS
The present disclosure provides bispecific proteins that bind to two antigens, as well as their compositions, uses, and methods of making.
2018/0194861 IgM- or IgE-Modified Binding Proteins and Uses Thereof
Engineered binding proteins comprising a modified constant region, such as an IgG constant region modified to contain a CH2 domain from an IgM, a CH2 domain...
2018/0194860 STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN THE Fc DOMAIN
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc...
2018/0194859 Linked Dual Antibodies Conjugated at a Hinge Region
There is disclosed methods for derivatizing and conjugating two hinge-containing antibody molecules. There is further disclosed derivatized and conjugated...
2018/0194858 BINDING MOLECULES SPECIFIC FOR CD73 AND USES THEREOF
The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical...
2018/0194857 MONOCLONAL ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR (TFPI)
Isolated monoclonal antibodies that bind to specific epitopes of human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding...
2018/0194856 FUSION PROTEINS WHICH BIND TO HUMAN FC RECEPTORS
The invention relates to fusion proteins which bind to human Fc-receptors. The fusion proteins are initially produced as monomers, and are capable of assembly...
2018/0194855 ANTI-OX40 ANTIBODIES AND THEIR USES
The present disclosure provides novel anti-OX40 antibodies, compositions including the antibodies, nucleic acids encoding the antibodies, and methods of making...
2018/0194854 Endoglin Antibodies
The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One...
2018/0194853 IL2RBETA/COMMON GAMMA CHAIN ANTIBODIES
Anti-CD122 and/or .gamma.c antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses...
2018/0194852 CHIMERIC THERAPEUTIC ANTI - CD37 ANTIBODIE HH1
The present invention relates to chimeric or humanized antibodies derived from the mouse monoclonal antibody HH1. The applications of the present invention...
2018/0194851 4-1BB BINDING MOLECULES
The present disclosure provides isolated binding molecules that bind to human 4-1BB, nucleic acid molecules encoding an amino acid sequence of the binding...
2018/0194850 ANTAGONISTIC ANTI-TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY ANTIBODIES
Antagonistic TNFR superfamily polypeptides, such as antibodies and antigen-binding fragments thereof, and the use of these polypeptides to inhibit the...
2018/0194849 AGONISTIC TNF RECEPTOR BINDING AGENTS
The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different...
2018/0194848 COMPOSITIONS COMPRISING RANK/RANKL ANTAGONISTS AND RELATED COMPOUNDS FOR TREATING PAIN
Disclosed herein are methods of treating pain using RANK/RANKL antagonists.
2018/0194847 CD154 BINDING POLYPEPTIDE AND USE THEREOF
Disclosed is a CD154 binding polypeptide that specifically recognizes CD154. The polypeptide according to the present disclosure effectively inhibits the...
2018/0194846 COMPOSITIONS AND METHODS FOR INCREASING MUSCLE GROWTH
This disclosure is in the field of anti-Activin receptor IIB (ActRIIB) antibodies. In particular, it relates to the use of said antibodies for treating muscle...
2018/0194845 MONOCLONAL ANTIBODIES AGAINST HER2
Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are...
2018/0194844 METHODS OF TREATING FGFR3 RELATED CONDITIONS
Provided herein are biomarkers and therapies for the treatment of pathological conditions, such as cancer, and method of using FGFR3 antagonists. In...
2018/0194843 IMMUNOGLOBULIN FORMULATION AND METHOD OF PREPARATION THEREOF
A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate...
2018/0194842 ANTI-CD3 ANTIBODIES AND METHODS OF USE THEREOF
The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully...
2018/0194841 METHODS FOR TUMOR TREATMENT USING CD3XCD20 BISPECIFIC ANTIBODY
The present invention relates to a method (dosage regimen) for administering a CD3.times.CD20 bispecific antibody to a human patient, comprising (a)...
2018/0194840 COVALENT DIABODIES AND USES THEREOF
The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological...
2018/0194839 ANTI-IL-17A ANTIBODIES AND THEIR USE IN TREATING AUTOIMMUNE AND INFLAMMATORY DISORDERS
The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine...
2018/0194838 METHOD FOR TREATING CANCER METASTASIS AND COMPOSITION THEREOF
The present invention is related to a method for treating cancer metastasis and composition thereof. By using an IL-35 antagonist, cancer metastasis can be...
2018/0194837 COMPOSITIONS AND METHODS FOR TREATING CANCER
One aspect of the invention provides a method for treating a cancer including administering to a subject in need of such treatment a composition including a...
2018/0194836 PREVENTION OF METASTASIS AND RECURRENCE AFTER PRIMARY CANCER TREATMENT
There is provided methods for inhibiting metastasis or recurrence of a cancer in a patient after a primary treatment of the patient, and compositions for same....
2018/0194835 USE OF VEGF ANTAGONIST IN TREATING CHORIORETINAL NEOVASCULAR AND PERMEABILITY DISORDERS IN PAEDIATRIC PATIENTS
The present invention relates to the use of a VEGF antagonist in the treatment of chorioretinal neovascular or permeability disorders in children. In...
2018/0194834 METHODS AND COMPOSITIONS FOR TREATING ULCERS
The present disclosure provides compositions and methods for treating or preventing ulcers in subjects having low red blood cell levels and/or hemoglobin...
2018/0194833 AGENTS, USES AND METHODS FOR THE TREATMENT OF SYNUCLEINOPATHY
The invention relates to combinational treatment using a monoclonal anti-alpha-synuclein antibody and an additional medicament. The antibodies can be used for...
2018/0194832 TAU-BINDING ANTIBODIES
The present invention relates to Tau-binding antibodies and binding fragments thereof.
2018/0194831 METHODS AND COMPOSITIONS RELATING TO ANTI-NUCLEOLIN RECOMBINANT IMMUNOAGENTS
Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind nucleolin (NCL). Also disclosed are treating...
2018/0194830 MULTIMERIC POLYPEPTIDES OF HLA-G INCLUDING AT LEAST TWO ALPHA3 DOMAINS AND PHARMACEUTICAL USES THEREOF
Multimeric polypeptides and pharmaceutical uses thereof; multimers of alpha3 peptides of an HLA-G antigen and methods of producing such multimers,...
2018/0194829 POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF FOR TREATMENT OF IMMUNE RELATED DISORDERS AND CANCER
This invention relates to LY6G6F, VSIG10, TMEM25 and LSR proteins, which are suitable targets for immunotherapy, treatment of cancer, infectious disorders,...
2018/0194828 ACTRIIB ANTAGONISTS AND DOSING AND USES THEREOF
In certain aspects, the present invention provides compositions and methods for promoting hone growth and increasing bone density, as well as for the treatment...
2018/0194827 INSULIN-INCRETIN CONJUGATES
Disclosed herein are insulin agonist peptides conjugated to a glucagon analog wherein the insulin/glucagon conjugate is targeted to liver tissues upon...
2018/0194826 PEPTIDE PHARMACEUTICALS FOR INSULIN RESISTANCE
Described herein are methods of syntheses and therapeutic uses of covalently modified peptides and/or proteins. The covalently modified peptides and/or...
2018/0194825 Combination Immunotherapy
The invention is based on the disclosure provided herein that secondary lymphoid organ chemokine (SLC) inhibits the growth of syngeneic tumors in vivo. Thus,...
2018/0194824 MUSCLIN PEPTIDES AND METHODS OF USE THEREOF
In certain embodiments, the present invention provides a musclin peptide and methods of increasing muscle growth, performance, resistance to injury and/or...
2018/0194823 PEPTIDES AND COMPOSITIONS FOR TREATMENT OF JOINT DAMAGE
The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions...
2018/0194822 DISRUPTION OF THE INTERACTION BETWEEN AMYLOID BETA PEPTIDE AND DIETARY LIPIDS
The present invention relates to methods of treating neurodegenerative disorders associated with Alzheimer's disease (AD), Parkinson's disease (PD) and...
2018/0194821 REGULATORS OF NFAT
Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a...
2018/0194820 ANTI-INFLAMMATORY COMPOUNDS AND METHODS OF USE
Methods of treating or inhibiting inflammation in a subject include administering an anti-inflammatory protein to the subject. In some embodiments, the protein...
2018/0194819 NOVEL BINDING PROTEINS BASED ON DI-UBIQUITIN MUTEINS AND METHODS FOR GENERATION
The present invention refers to new binding proteins based on di-ubiquitin modified in 12, 13, or 14 positions selected from positions R42, I44, H68, V70, R72,...
2018/0194818 CHLOROTOXIN VARIANTS, CONJUGATES, AND METHODS FOR THEIR USE
Chlorotoxin variants, chlorotoxin variant conjugates, compositions that include the chlorotoxin variants or conjugates, and methods for using the chlorotoxin...
2018/0194817 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES, CONDITIONS OR PROCESSES CHARACTERIZED BY ABERRANT...
The described invention provides compositions and methods for treating asthma, a disease, condition or pathologic process whose progression is characterized by...
2018/0194816 FLUORESCENT PROTEIN
A photo-switching fluorescent protein of a type in which wavelengths for switching fluorescence on and off and wavelength for fluorescence excitation are all...
2018/0194815 GLUTEN-DERIVED FLAME RETARDANT MATERIALS
A process of forming a gluten-derived flame retardant material includes forming an amine-functionalized flame retardant molecule that includes an aryl halide...
2018/0194814 Method for reconstructing Aspergillus niger to increase citrate production
The invention discloses a method for increasing citrate production from genome reconstructed Aspergillus niger. The method is to insert a gene of low affinity...
2018/0194813 COMPOSITIONS AND METHODS FOR CONTROLLING PLANT PESTS
Novel insecticidal proteins that are toxic to lepidopteran pests are disclosed. The DNA encoding the insecticidal proteins can be used to transform prokaryotic...
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