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Patent # Description
2018/0201996 GENOTYPING BY NEXT-GENERATION SEQUENCING
Provided herein is technology relating to genotyping and particularly, but not exclusively, to methods for genotyping one or more organisms by genome sequencing.
2018/0201995 METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLING
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample...
2018/0201994 BALANCED CAPTURE PROBES AND METHODS OF USE THEREOF
Capture probe libraries can be used to enrich a region of interest in a sequencing library for high-depth sequencing. The capture probes within the capture...
2018/0201993 NANOPORE SEQUENCING METHODS
Methods are provided for sequencing of nucleic acid templates using nanopores. A polymerase-nucleic acid complex having a strand displacing polymerase is...
2018/0201992 METHODS AND SYSTEMS FOR GENERATION AND ERROR-CORRECTION OF UNIQUE MOLECULAR INDEX SETS WITH HETEROGENEOUS...
The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index...
2018/0201991 Systems and Methods for Sequencing T Cell Receptors and Uses Thereof
Disclosed herein are methods and systems that can reconstruct, extract, and/or analyze TCR sequences using short reads. The methods and systems can be applied...
2018/0201990 Kit, apparatus, and method for detecting chromosome aneuploidy
A kit, an apparatus, and a method for detecting chromosome aneuploidy. The method comprises: sequencing the peripheral blood cell-free DNA of a pregnant woman...
2018/0201989 OXIDANT AND USE THEREOF
Provided is an oxidant including a hypervalent iodine compound which has iodobenzene micelle-incarcerated by a surfactant as a basic structure and is hydrophobic.
2018/0201988 METHOD FOR DESIGNING PRIMER, PRIMER, PRIMER SET, DNA AMPLIFICATION METHOD, AND ANALYSIS METHOD
A method for designing a primer supplied to a PCR reaction includes a primer designing step of defining a 5'-end-side base sequence of the primer so as to...
2018/0201987 COMPENSATION FOR SPECTRAL CROSSTALK IN MULITPLEX NUCLEIC ACID AMPLIFICATION
A method includes performing a nucleic acid amplification of a nucleic acid sample using a detection probe, wherein the nucleic acid amplification occurs over...
2018/0201986 NUCLEIC ACID DETECTION KIT AND NUCLEIC ACID DETECTION METHOD USING NANOPARTICLES
The present invention relates to a nucleic acid detection kit and a nucleic acid detection method, which use nanoparticles. More specifically, the present...
2018/0201985 METHODS, COMPOSITIONS, KITS, AND USES FOR ANALYSIS OF NUCLEIC ACIDS COMPRISING REPEATING A/T-RICH SEGMENTS
Described herein are methods, compositions, kits, and uses thereof for analysis of nucleic acid segments comprising a repeating A/T-rich segment, wherein the...
2018/0201984 MAGNETIC BASE FOR COLLECTION AND RELEASE OF PARAMAGNETIC PARTICLES
Provided herein are devices, systems, and methods for magnetic purification of sample components. In particular, provided herein are device bases, systems, and...
2018/0201983 IMAGE DIFFERENTIATED MULTIPLEX ASSAYS FOR MULTIPLEX DETECTION OF DNA MUTATIONS
Provided herein are methods and kits for detecting the presence of DNA mutations in the KRAS, BRAF, CTNNB1, and APC genes. The methods and kits employ...
2018/0201982 DISPOSABLE SENSOR
A biosensor comprising a swellable biologically sensitive element comprising a nucleic acid probe and a physicoelectrical transducer associated with the...
2018/0201981 COUMARIN COMPOUNDS AND THEIR USES AS FLUORESCENT LABELS
The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides...
2018/0201980 METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE
The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of...
2018/0201979 GENETIC TESTING FOR PREDICTING RESISTANCE OF ACINETOBACTER SPECIES AGAINST ANTIMICROBIAL AGENTS
The invention relates to a method of determining an infection of a patient with Acinetobacter species potentially resistant to antimicrobial drug treatment, a...
2018/0201978 APPARATUS FOR HIGH THROUGHPUT CHEMICAL REACTIONS
Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise...
2018/0201977 NUCLEIC ACID PRESERVATION SOLUTION AND METHODS OF MANUFACTURE AND USE
Disclosed is nucleic acid preserving compositions and methods of manufacturing and using the same. Compositions include a carrier, a chaotropic agent, a...
2018/0201976 METHODS AND TRANSPOSON NUCLEIC ACIDS FOR GENERATING A DNA LIBRARY
A method for the generation of DNA fragmentation library based on a transposition reaction in the presence of a transposon end with an engineered cleaveage...
2018/0201975 METHOD AND COMPOSITION USING A QUATERNARY AMMONIUM COMPOUND
A method of determining of the presence or absence of a target RNA component in a sample, the method comprising steps of: (a) contacting the sample with a...
2018/0201974 SAMPLE PREPARATION FOR NUCLEIC ACID AMPLIFICATION
Presented herein are methods and compositions for targeted amplification of DNA and sample identification. The methods are particularly useful in validation...
2018/0201973 Improved Detection of Methylated DNA
The present invention is based on the discovery of sensitive and specific methylation detection by a) controlling excessive DNA degradation prior to conversion...
2018/0201972 ENHANCED THROUGHPUT MINERAL COATINGS FOR OPTIMIZATION OF STEM CELL BEHAVIOR
Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell...
2018/0201971 AN INVENTION RELATING TO A MICROBIOLOGICAL TESTING APPARATUS
The abstract particularly describes the nature of this invention and the manner in which it is to be performed:-- 1. Specific process and apparatus developed ...
2018/0201970 SYSTEM AND METHOD FOR MEASURING SULPHITE IN FOOD SAMPLES USING AN AMPEROMETRIC BIOSENSOR AND THE USE OF SAID...
A system for measuring sulphite in food samples is provided using a biosensor, a method for determining sulphite in food samples using the biosensor, and the...
2018/0201969 RECOMBINANT HUMAN ADA2 AND ADA2 FUSION PROTEINS AND METHODS FOR TREATING ADA2 DEFICIENCIES
The present invention is directed to isolated recombinant human ADA2 proteins, ADA2 biologically active fragments, and ADA2 fusion proteins. The proteins of...
2018/0201968 Azidomethyl Ether Deprotection Method
The invention relates to a method of converting an azidomethyl ether substituent to a free hydroxyl group. The invention also relates to methods of nucleic...
2018/0201967 METHOD OF PRODUCING RNA FROM CIRCULAR DNA AND CORRESPONDING TEMPLATE DNA
The present invention is concerned with a method of producing a target RNA using a circular DNA, wherein said method does not comprise a step of linearizing...
2018/0201966 METHOD FOR THE SYNTHESIS OF PENTOSTATIN
The present invention relates to a method for the stereo-selective production of pentostatin comprising an enzymatic transglycosylation reaction between...
2018/0201965 METHOD FOR PRODUCING GALACTOOLIGOSACCHARIDES FROM LACTOSE
Methods are disclosed for the enzymatic preparation of galactooligosaccharide (GOS) from lactose using two different microbial lactase enzymes to maximize the...
2018/0201964 THERMOPHILIC AND THERMOACIDOPHILIC BIOPOLYMER-DEGRADING GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
2018/0201963 TRANSAMINASE BIOCATALYSTS
The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
2018/0201962 GENERATION OF ACYL ALCOHOLS
Methods, compositions, and cells for generating acyl alcohols. Compositions comprising acyl alcohols. Methods of cleaving acyl amino acids and/or acyl alcohols...
2018/0201961 PRODUCTION OF POLYHYDROXYALKANOATES WITH A DEFINED COMPOSITION FROM AN UNRELATED CARBON SOURCE
Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an R-specific enoyl-CoA hydratase gene, a...
2018/0201960 MICROORGANISM HAVING ENHANCED PRODUCTIVITY OF LACTIC ACID AND A PROCESS FOR PRODUCING LACTIC ACID USING THE SAME
The present invention relates to Saccharomyces sp. capable of producing lactic acid with a decreased activity of pyruvate decarboxylase (PDC) and increased...
2018/0201959 PRODUCTION OF D-SORBITOL BY HYDROGENATION
The present invention relates to a novel and inventive process for the production of sorbitol from D-sucrose.
2018/0201958 GLUCOSE METABOLISM WITH MOLECULAR PURGE VALVE
Provided is an engineered pathway that can function in a cell-free system, cellular system or a combination thereof to convert a sugar to a chemical or biofuel.
2018/0201957 METHODS FOR SUSTAINING THE VIABILITY OF MICROORGANISMS DURING A CESSATION OF SYNGAS FLOW AND PROCESSES FOR...
The methods are disclosed for sustaining a population of microorganisms in an aqueous fermentation broth used in a process to convert syngas to alcohol when...
2018/0201956 SYSTEMS AND METHODS FOR ONE-SHOT GUIDE RNA (ogRNA) TARGETING OF ENDOGENOUS AND SOURCE DNA
Engineered nucleic acids encoding genome editing system components are provided, as are engineered RNA-guided nucleases that include inserts encoded in part by...
2018/0201955 TARGETED INTEGRATION INTO THE PPP1R12C LOCUS
Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a...
2018/0201954 PSEUDOTYPING OF RETROVIRAL VECTORS, METHODS FOR PRODUCTION AND USE THEREOF FOR TARGETED GENE TRANSFER AND HIGH...
The invention relates to the pseudotyping of retroviral vectors with heterologous envelope proteins derived from the Paramyxoviridae family, genus...
2018/0201953 COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS
Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as...
2018/0201952 GENE THERAPY METHODS
The present invention generally provides improved gene therapy vectors, cell-based compositions, and methods of using the same in methods of gene therapy. The...
2018/0201951 COMPOSITIONS, SYSTEMS AND METHODS FOR CELL THERAPY
Disclosed herein are compositions and methods for cell therapy comprising an engineered cell. The present invention is directed to a composition for treating a...
2018/0201950 Erysiphe Necator Resistance Providing Genes in Vitis Vinifera
Provided herein are Erysiphe necator resistance conferring genes, plants, plant parts and seeds comprising the present resistance providing genes and the use...
2018/0201949 HPPD-INHIBITOR HERBICIDE TOLERANCE
This invention relates generally to the detection of genetic differences among soybeans. More particularly, the invention relates to soybean quantitative trait...
2018/0201948 DROUGHT TOLERANT PLANT SYSTEM
A drought resistant plant system, including transgenic plants, methods of conferring drought resistance on a plant, and methods of cultivating a plant.
2018/0201947 NOVEL GENE FOR INCREASING PLANT BIOMASS AND USE THEREFOR
An object of the present invention is to identify a novel gene that effectively increases plant biomass and to provide said gene as well as techniques...
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