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Patent # Description
2018/0201694 CHITIN DERIVATIVES, METHOD FOR PRODUCTION AND USES THEREOF
The present disclosure relates to chitin derivatives of Formula (I), its isomers, prodrugs and pharmaceutically acceptable salts thereof. The present...
2018/0201693 BISPECIFIC AND MULTISPECIFIC ANTIBODIES AND METHOD FOR ISOLATION OF SUCH
Bispecific and multispecific antibodies having differentially modified light chains, that allows for isolation of the bispecific or multispecific antibodies...
2018/0201692 ANTI-HER2 ANTIBODY VARIANTS
The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains...
2018/0201691 THERAPEUTIC AND DIAGNOSTIC TARGET FOR CANCER COMPRISING DLL3 BINDING REAGENTS
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of cancer, such as lung cancer, pancreatic cancer and...
2018/0201690 ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR
The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are...
2018/0201689 Antibody Fusion Protein and Preparation Method and Use Thereof
The present invention provides an antibody fusion protein, comprising an antitumor antigen-specific antibody or a Fab fragment thereof, a single domain...
2018/0201688 NOVEL ANTI-PRESEPSIN ANTIBODY
The present invention provides methods and compositions for determining sepsis in an individual. Specifically, the present invention provides for antibodies of...
2018/0201687 ANTIBODIES HAVING SPECIFICITY TO MYOSIN 18A AND USES THEREOF
The present disclosure relates to antibodies having specificity to myosin 18A and uses thereof. In particular, the present disclosure relates to an antibody...
2018/0201686 RAPID CLEARANCE OF ANTIGEN COMPLEXES USING NOVEL ANTIBODIES
The present invention relates to rapid clearance molecules that bind target antigens and Fc.gamma.RIIb with increased affinity as compared to parent molecules,...
2018/0201685 METHODS FOR USE OF MIXED MULTIFUNCTIONAL SURFACES FOR REDUCING AGGREGATE CONTENT IN PROTEIN PREPARATIONS
Methods for reduction of aggregate levels in antibody and other protein preparations comprising the steps of treatment with an organic multivalent cation...
2018/0201684 B7-H1, A NOVEL IMMUNOREGULATORY MOLECULE
The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid...
2018/0201683 CELL LINE 3M
The present invention provides, inter alia, an isolated cell line, 3M as well as methods for making such a cell line and methods of using such a cell line,...
2018/0201682 SOLUBLE AND STABLE HETERODIMERIC TCR
Disclosed are a heterodimeric TCR containing artificial interchain disulfide bond between the variable region of .alpha. chain and the constant region of...
2018/0201681 ANTI-CD83 ANTIBODIES AND USE THEREOF
The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis or prognosis.
2018/0201680 SINGLE AGENT ANTI-PD-L1 AND PD-L2 DUAL BINDING ANTIBODIES AND METHODS OF USE
The present invention is based, in part, on the identification of novel antibodies that have binding affinity for both PD-L1 and PD-L2 and methods of using same.
2018/0201679 HUMANIZED ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those...
2018/0201678 ANTIBODY MOLECULES WHICH BIND CD79
The present disclosure relates to antibody molecules comprising a binding domain specific to CD79, said binding domain comprising SEQ ID NO: 1, 2, 3 or 4,...
2018/0201677 ANTI-CD47 ANTIBODIES AND METHODS OF USE
Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain...
2018/0201676 METHODS AND COMPOSITIONS FOR MODULATING LILR PROTEINS
The present invention is directed to methods and compositions for modulating LILR for treatment of cancer and inhibition of metastasis.
2018/0201675 ANTIBODIES TO IL-6 AND USE THEREOF
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of...
2018/0201674 Methods of Using IL-1beta Compounds
This invention relates to methods employing IL-1 beta-ligand/IL-1 receptor disrupting compounds, such as IL-1 beta antibodies or IL-1 receptor antibodies, in...
2018/0201673 TREATMENT OF PRURITUS
The present invention provides a method using IL-17 antagonistic antibodies for treating pruritus.
2018/0201672 ANTAGONISTS FOR INTERLEUKIN-17 RECEPTOR B (IL-17RB) AND ITS LIGAND IL-17B FOR CANCER THERAPY
Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its...
2018/0201671 VEGF-BINDING MOLECULES
VEGF-binding molecules, preferably VEGF-binding immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing...
2018/0201670 ANTI-TRANSTHYRETIN ANTIBODIES
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases...
2018/0201669 Humanized Antibodies That Recognize Alpha-Synuclein
The present application discloses humanized 9E4 antibodies. The antibodies bind to human alpha synuclein and can be used for immunotherapy of Lewy body disease.
2018/0201668 In vivo Imaging using Anti-IL-6 Antibodies
The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab 1 antibody or antibody fragment having binding specificity for...
2018/0201667 ANTIBODY FOR DETERMINING SEX OF SPERM, AND USE THEREOF
Provided are an antibody for sexing sperms and use thereof, and more particularly, a composition for and a method of sexing sperms by using the antibody, and a...
2018/0201666 TAU-BINDING ANTIBODIES
The present invention relates to Tau-binding antibodies and binding fragments thereof.
2018/0201665 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND PCSK9
The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins...
2018/0201664 APOA-1 FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS
Compositions and methods relating to ApoA-1 fusion polypeptides are disclosed. The fusion polypeptides include a first polypeptide segment corresponding to an...
2018/0201663 METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTORS...
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40...
2018/0201662 PEPTIDE FOR PROMOTING CELL MIGRATION AND/OR SKIN WOUND HEALING, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME,...
The present disclosure provides a peptide for promoting cell migration and/or skin wound healing, including an IL-6-derived peptide, which is designed within...
2018/0201661 MODIFIED NATURAL KILLER CELLS AND NATURAL KILLER CELL LINES HAVING INCREASED CYTOTOXICITY
NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production...
2018/0201660 ANTI-ANGIOGENIC VEGF-AX ISOFORM
A VEGF-Ax polypeptide, as well as a smaller Ax polypeptide, both having anti-angiogenic activity that can be used for treating or preventing angiogenesis are...
2018/0201659 BMP-4 PEPTIDES AND METHOD OF USE
The invention relates to truncated BMP-4 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-4...
2018/0201658 SELECTIVE MCL-1 BINDING PEPTIDES
Provided herein are stabilized peptides that bind Mcl-1. Also provided are compositions containing these polypeptides and methods of using such peptides in the...
2018/0201657 LIGHT-ACTIVATED, CALCIUM-GATED POLYPEPTIDE AND METHODS OF USE THEREOF
The present disclosure provides a light-activated, calcium-gated polypeptide; and a system comprising: a) the light-activated, calcium-gated polypeptide; and...
2018/0201656 Proteins and nucleic acids useful in vaccines targeting Pseudomonas Aeruginosa
Disclosed are immunogenic proteins from Pseudomonas aeruginosa as well as nucleic acids, vectors and transformed cells useful for expression of the proteins....
2018/0201655 ALLOPHYCOCYANIN ALPHA-SUBUNIT EVOLVED LABELING PROTEINS (smURFPs)
The invention provides evolved red-shifted smURFPs. In some embodiments, the smURFPs are characterized by a) increased Fluorescence of smURFP as compared to...
2018/0201654 PEPTIDE INHIBITORS OF HAUSP DEUBIQUITINASE
Two vIRF4 (Kaposi's-sarcoma-associated-herpesvirus vIRF4) peptides, vif1, corresponding to aa202-216 of vIRF4, and vif2, corresponding to aa220-236 of vIRF4,...
2018/0201653 POLYPEPTIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF
The invention discloses a polypeptide compound and a preparation method and application thereof. The polypeptide compound has a structural formula as follows:...
2018/0201652 CATIONIC PEPTIDOPOLYSACCHARIDES WITH EXCELLENT BROAD- SPECTRUM ANTIMICROBIAL ACTIVITIES AND HIGH SELECTIVITY
The disclosure provides cationic peptidopolysaccharides of Formula I: which has a bacterial peptidoglycan-mimetic structure, and shows outstanding broad...
2018/0201651 PHARMACEUTICAL COMPOSITION THAT IS ANTICANCER AND SUPPRESSES CANCER METASTASIS, CONTAINING, AS ACTIVE...
The present invention relates to a pharmaceutical composition that is anticancer and suppresses cancer metastasis, containing a fusion peptide as an active...
2018/0201650 CONOTOXIN PEPTIDE K-CPTX-BTL05, PREPARATION METHOD THEREFOR, AND USES THEREOF
Provided are a conotoxin peptide .kappa.-CPTx-btl05 and a derivative polypeptide. The amino acid sequence of the conotoxin peptide is indicated by SEQ ID NO:...
2018/0201649 NOVEL CELL-PENETRATING COMPOSITIONS AND METHODS USING SAME
The invention includes an isolated transport peptide, which crosses the cell membrane of a cell and/or binds to a target cell. The invention also includes a...
2018/0201648 HYDROGEL-FORMING PEPTIDES
Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a .beta..sup.3- or .beta..sup.2-homo...
2018/0201647 Peptoid
The invention relates to peptoids, derivatives and analogues thereof, and to methods of chemically synthesising such compounds. The invention relates to mixed...
2018/0201646 NEW BICYCLIC LIPOLANTIPEPTIDE, PREPARATION AND USE AS ANTIMICROBIAL AGENT
The invention relates to a new bicyclic lipolantipeptide, representing a new class of lantipeptide, and salts thereof, their preparation from a culture of a...
2018/0201645 COMPOSITION FOR IMPROVING MEMORY, LEARNING ABILITY, AND COGNITIVE ABILITY
There is provided a composition for improving memory, learning ability, and cognitive ability. It has been confirmed that a peptide having a C-terminal region...
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