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Patent # Description
2018/0201644 PEPTIDE PURIFICATION USING MIXED-PHASE SOLID PHASE EXTRACTION MATERIAL
The present invention relates to a method of purifying peptides and/or polypeptides, said method comprising or consisting of: (a) loading a sample comprising...
2018/0201643 OXYSTEROLS AND METHODS OF USE THEREOF
Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R.sup.1,...
2018/0201642 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide...
2018/0201641 Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods Related Thereto
Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further...
2018/0201640 4-METHYLUMBELLIFERONE DERIVATIVES FOR TREATMENT FOR IMMUNE MODULATION
This disclosure presents 4-MUG derivatives (e.g., 4-MUG ester prodrugs) that reduce or prevent HA synthesis. In some embodiments, the 4-MUG derivatives of the...
2018/0201639 ICARISIDE COMPOUND, PREPARATION METHOD THEREOF, AND APPLICATION THEREOF
An icariside compound as shown in Formula I wherein the compound is a natural chemical component in the traditional Chinese herbal epimedium or a chemically...
2018/0201638 METALLOCENE COMPOUND AND PREPARATION METHOD THEREFOR
A preparation method for a metallocene compound is provided. The method includes: stirring at least one compound I among compounds expressed by the following...
2018/0201637 SUBSTITUTED LEAD HALIDE PEROVSKITE INTERMEDIATE BAND ABSORBERS
Lead halide perovskites have proven to be a versatile class of visible light absorbers that allow rapid access to the long minority carrier lifetimes and...
2018/0201636 CHEMICAL VAPOR DEPOSITION RAW MATERIAL INCLUDING DINUCLEAR RUTHENIUM COMPLEX AND CHEMICAL DEPOSITION METHOD...
The present invention relates to a chemical vapor deposition raw material for producing a ruthenium thin film or a ruthenium compound thin film by a chemical...
2018/0201635 POLYMERIZED OILS & METHODS OF MANUFACTURING THE SAME
Embodiments of the present invention provide a method, comprising obtaining a lecithin-containing material, in some aspects derived from a crude refining...
2018/0201634 DEHYDROGENATIVE SILYLATION, HYDROSILYLATION AND CROSSLINKING USING PYRIDINEDIIMINE COBALT CARBOXYLATE CATALYSTS
A process for producing a silylated product comprises reacting a mixture comprising (a) an unsaturated compound containing at least one unsaturated functional...
2018/0201633 ORGANOSILICON COMPOUNDS HAVING (METH)ACRYLATE GROUPS AND A PROCESS FOR PREPARATION THEREOF
(Meth)acrylate-functionalized silicon compounds are easily prepared by the reaction of a (meth)acryloyl-functionalized chlorosilane with an organosilicon...
2018/0201632 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME
A polycyclic compound is represented by Formula 1, ##STR00001## where X.sub.1, X.sub.2, L, R.sub.1 to R.sub.8, and a to d are as defined in the specification.
2018/0201631 POLYMER WITH ALTERNATING PHENYLENE SILICON AND SILOXANE STRUCTURE AND METHOD OF PRODUCING PRECURSOR OF THE SAME
A polymer with alternating phenylene silicon and siloxane structure and a method of producing a precursor of the same are introduced to develop an autonomous...
2018/0201630 Bridged Bis(Indenyl) Transitional Metal Complexes, Production, and Use Thereof
The present disclosure relates to bridged metallocene catalysts that include at least one indenyl ligand substituted at the 2-position with a C.sub.3-C.sub.10...
2018/0201629 SEPARATION OF METAL-ORGANIC FRAMEWORKS
A method of separating a metal organic framework (MOF) from a solution and associated apparatus. The method comprises: providing a MOF containing solution;...
2018/0201628 Boron-Containing Diacylhydrazine Compounds
The present disclosure provides boron-containing diacylhydrazines having Formula I: ##STR00001## and the pharmaceutically acceptable salts and solvates thereof,...
2018/0201627 ORGANOBORON COMPOUNDS AND METHODS OF MAKING ORGANOBORON COMPOUNDS
Embodiments of the present disclosure provide for methods of making an organoboron compound, organoboron compounds, and the like.
2018/0201626 METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
2018/0201625 New molecules for isolation of polyribosomes, ribosomes, uses and kits thereof
Molecules of general Formula (I): able to bind to native polyribosomes engaged in active protein synthesis. The disclosure relates also to the use of the...
2018/0201624 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2018/0201623 N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
The present invention relates to compounds of formula I: ##STR00001## in which p, q, Y.sub.1, Y.sub.2, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b,...
2018/0201622 Fused Bicyclic Heteroaromatic Derivatives as Kinase Inhibitors
A series of fused bicyclic heteroaromatic derivatives of formula (IA) or (IB), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase...
2018/0201621 COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME AND ELECTRONIC DEVICE THEREOF
Provided are a compound represented by Formula 1, and an organic electric element comprising a first electrode, a second electrode, and an organic material...
2018/0201620 Selective Modulators of the Activity of the GPR55 Receptor: Chromenopyrazole Derivatives
The present invention relates to a family of chromenopyrazole derivatives of formula (I): ##STR00001## which have the ability to modulate the receptor of the...
2018/0201619 CDK INHIBITORS
Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
2018/0201618 CDK INHIBITORS
Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
2018/0201617 CDK Inhibitors
Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
2018/0201616 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3 -diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly...
2018/0201615 PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF
To provide a novel compound having a HER2 inhibitory effect and having a cytostatic effect. It is also intended to provide a medicament useful in the...
2018/0201614 BICYCLIC COMPOUNDS
Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer...
2018/0201613 FUSED QUINOLINE COMPUNDS AS PI3K/mTOR INHIBITORS
The present invention relates to the compounds of formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient,...
2018/0201612 SENSOR COMPOUNDS AND ASSOCIATED METHODS AND DEVICES
Methods of detecting a non-explosive analyte can include exposing a sensor compound to a non-explosive analyte and displaying a change in the sensor compound...
2018/0201611 Respiratory formulations and compounds for use therein
The present invention relates to respiratory formulations comprising a compound of formula (I): ##STR00001## and use of said compounds and compositions in...
2018/0201610 COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS
Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific...
2018/0201609 INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS
The present invention provides indazole and aza indazole compounds of formula (I) or (II) and pharmaceutically acceptable salts thereof, and their use to...
2018/0201608 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES
Compounds, and compositions, methods, and uses thereof, are described herein for treating neurodegenerative diseases and disorders. In particular, vasopressin...
2018/0201607 HETEROCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY
The present invention provides a compound having a TrkA inhibitory activity or a pharmaceutically acceptable salt thereof. The present invention relates to a...
2018/0201606 METHOD OF INHIBITING DYRK1B
The present invention relates to a DYRK1B inhibitor for use in the treatment of cancer, wherein in said cancer and/or in cells of said cancer the hedgehog...
2018/0201605 MEGLUMINE SALT FORMULATIONS OF 1-(5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
The meglumine salt of 1-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid (compound (1)) and pharmaceutically acceptable formulations...
2018/0201604 COMPOUNDS AND THEIR USE AS BACE1 INHIBITORS
The present invention relates to compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein X, Y, Z,...
2018/0201603 SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
2018/0201602 VICINAL PRIMARY DIAMINES ASSOCIATED WITH METAL AND/OR FREE RADICAL CHELATION MOTIFS, AND ACTIVE AGAINST...
The invention relates to compounds of Formula I: ##STR00001## or the salts thereof, as well as the use thereof in the pharmaceutical, cosmetic or agrofood industry.
2018/0201601 PROCESS FOR PREPARING APALUTAMIDE
The present invention provides efficient, economical, and environmentally friendly processes for synthesizing apalutamide and intermediates thereof. Also...
2018/0201600 NITROGEN-CONTAINING HETEROCYCLES AS PESTICIDES
The present application relates to novel heterocyclic compounds, to processes and intermediates for the preparation thereof, and their use for controlling...
2018/0201599 METHOD FOR PRODUCING 2,3,5-TRIMETHYL BENZOQUINONE BY OXIDATION OF 2,3,6-TRIMETHYLPHENOL
The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the...
2018/0201598 ANTIMICROBIAL AND CYTOTOXIC COMPOUNDS AND METHODS FOR TREATING CANCER, A BACTERIAL INFECTION, AND/OR A FUNGAL...
Small molecules and methods of treating cancer, a bacterial infection, and/or a fungal infection. The small molecules are chromenone derivatives. They have...
2018/0201597 METHOD FOR PRODUCING 2-ACETYL-4H,9H-NAPHTHO[2,3-B]FURAN-4,9-DIONE
The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production....
2018/0201596 FURAN-2,5-DICARBOXYLIC ACID PURGE PROCESS
Disclosed is an oxidation process to produce a crude carboxylic acid product carboxylic acid product. The process comprises oxidizing a feed stream comprising...
2018/0201595 SILVER IMPREGNATION METHOD FOR PRODUCING ETHYLENE OXIDE CATALYST WITH ENHANCED CATALYTIC ABILITY
A method for producing a catalyst effective in the oxidative conversion of ethylene to ethylene oxide, the method comprising: (i) impregnating a porous...
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