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Patent # Description
2018/0208648 GDF11 BINDING PROTEINS AND USES THEREOF
Binding proteins that specifically bind to GD-F11 prodomain complex are disclosed. In some embodiments, antibodies that specifically bind to GDF11 prodomain...
2018/0208647 VEGF-SPECIFIC ANTAGONISTS FOR ADJUVANT AND NEOADJUVANT THERAPY AND THE TREATMENT OF EARLY STAGE TUMORS
Disclosed herein are methods of treating benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of...
2018/0208646 ANTI-LAMININ4 ANTIBODIES SPECIFIC FOR LG4-5
The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin .alpha.4. The antibodies can preferentially stain...
2018/0208645 Compositions and Methods for Treating Cancer with Anti-Mesothelin Immunotherapy
Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen...
2018/0208644 ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER'S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME
The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or...
2018/0208643 ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen...
2018/0208642 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TARGETING PEPTIDE-ELASTIN FUSION POLYPEPTIDES AND THEIR...
Disclosed is a fusion polypeptide for inhibiting neovascularization, including a peptide specifically binding to vascular endothelial growth factor (VEGF)...
2018/0208641 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0208640 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0208639 CTLA-4 Variants
Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for...
2018/0208638 T CELL RECEPTORS
The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide GLYDGMEHL (SEQ ID NO: 1) derived from the MAGE-A10 protein....
2018/0208637 METHODS OF IDENTIFYING, ISOLATING AND USING ODORANT AND AROMA RECEPTORS
Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and...
2018/0208636 BINDING-TRIGGERED TRANSCRIPTIONAL SWITCHES AND METHODS OF USE THEREOF
The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the ...
2018/0208635 COMPOUNDS FOR INDUCING TISSUE FORMATION AND USES THEREOF
The present disclosure provides peptides, or variants or analogs thereof, with between 8 and 30 amino acids, having growth factor receptor-binding capability,...
2018/0208634 Recoverin as a Fusion Protein Tag to Improve Expression, Solubility and Purification of Proteins
Herein presented is a new, versatile fusion protein tool (tag) to improve the solubility and purification of proteins. Particularly, the fusion tag is the...
2018/0208633 Peptide Compounds and Methods of Production and Use Thereof
Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of...
2018/0208632 MUTANT LYSENIN PORES
The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.
2018/0208631 PESTICIDAL TOXIN PROTEINS ACTIVE AGAINST LEPIDOPTERAN INSECTS
Disclosed herein are nucleotide sequences encoding an insecticidal protein exhibiting Lepidopteran inhibitory activity, as well as novel insecticidal proteins...
2018/0208630 FUSION PROTEINS AND METHODS FOR STIMULATING PLANT GROWTH, PROTECTING PLANTS, AND IMMOBILIZING BACILLUS SPORES...
The present invention is generally directed to fusion proteins containing a targeting sequence that targets the fusion protein to the exosporium of a Bacillus...
2018/0208629 COMPOSITION FOR PREVENTING MYCOPLASMA SPP. INFECTION
The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention...
2018/0208628 NEW SPECIES OF TOBAMOVIRUS
The present invention provides a new species of tobamovirus and its use to identify plants comprising resistance against the virus.
2018/0208627 HYDROCARBON-STAPLED POLYPEPTIDES FOR ENHANCEMENT OF ENDOSOME-LYSOSOMAL DEGRADATION
The present invention relates to a Beclin 1-UVRAG complex structure which reveals a tightly packed coiled coil assembly with Beclin 1 and UVRAG residues...
2018/0208626 IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF
This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a...
2018/0208625 METHOD FOR PREVENTING, IMPROVING, OR TREATING INFLAMMATORY BOWEL DISEASE
Pyrrolidine carboxamido derivatives, optical isomers thereof, and salts thereof that are able to prevent, improve, and/or treat inflammatory conditions,...
2018/0208624 Protein Separations Using An Acrylamide Containing Filter
Novel compositions for removing impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions...
2018/0208623 CRYSTALLINE SOLVATE FORMS OF A PHARMACEUTICAL
Described herein are solid state 17.alpha.-ethynylandrost-5-ene-3.beta.,7.beta.,17.beta.-triol including amorphous and crystalline forms and specific...
2018/0208622 STABLE CRYSTALLINE FORM OF REGADENOSON
The present invention provides crystalline Form S of regadenoson which is substantially free of residual organic solvent and having an X-ray powder diffraction...
2018/0208621 NUCLEOTIDES FOR THE TREATMENT OF CANCER
The present application relates to novel nucleoside derivatives of formula (I) as claimed in claim 1, pharmaceutical compositions comprising the compounds,...
2018/0208620 TUNICAMYCIN RELATED COMPOUNDS WITH ANTI-BACTERIAL ACTIVITY
Tunicamycin related compounds having an acyl chain double bond reduced and/or having an acyl chain double bond and an uracil ring double bond reduced are...
2018/0208619 SYNTHESES, ACTIVITIES, AND METHODS OF USE OF DIHYDRONICOTINAMIDE RIBOSIDE DERIVATIVES
Disclosed is a compound of formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and are as defined herein. Also disclosed are methods for increasing...
2018/0208618 NOVEL SUGAR DERIVATIVE GELATORS
A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): ##STR00001## wherein R.sub.1 is a linear or branched...
2018/0208617 TUNGSTEN PRECURSOR, AND METHOD FOR DEPOSITING TUNGSTEN-CONTAINING FILM COMPRISING SAME
The present invention relates to a tungsten precursor compound to which a substituent is bonded so as to obtain thermal stability and a tungsten-containing...
2018/0208616 DINITROSYL IRON COMPLEX, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL COMPRISING THE...
Disclosed herein are novel compounds of formula (I) and (II), each of which may serve as a reagent to deliver nitric oxide (NO) and a therapeutic agent to...
2018/0208615 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A metal tetradentate complex is disclosed in which an imidazole moiety is used as a linker in the ligand. The complex is useful as an emitter or other...
2018/0208614 CRYSTAL OF CYCLIC PHOSPHONIC ACID SODIUM SALT AND METHOD FOR MANUFACTURING SAME
An object of the present invention is to provide a crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and...
2018/0208613 PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS
Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are...
2018/0208612 PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS
Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are...
2018/0208611 METHOD FOR PREPARING INORGANIC/ORGANIC HYBRID PEROVSKITE COMPOUND FILM
The present invention relates to a method for preparing an inorganic/organic hybrid perovskite compound film, and a structure for a solar cell and,...
2018/0208610 COMPOSITIONS HAVING ADHESION PROPERTIES
Compositions of matter that have adhesion properties. The presence of a large number of silanols on the molecules described herein creates a solubility or...
2018/0208609 BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the...
2018/0208608 HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS
The present invention provides, in part, heterocyclic spiro compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for...
2018/0208607 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
2018/0208606 HISTONE DEACETYLASE INHIBITORS
This invention relates to generally inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
2018/0208605 Substituted Aza Compounds as IRAK-4 Inhibitors
The present invention provides substituted aza compounds of formula (I) or (II) and pharmaceutically acceptable salts thereof, and their use to inhibit IRAK-4...
2018/0208604 FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound...
2018/0208603 HETEROCYCLIC THIOSEMICARBAZONE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated...
2018/0208602 NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.9, Y, W, m, n, p and q are as defined herein,...
2018/0208601 BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.9, Y, W, m, n, p and q are as defined herein,...
2018/0208600 BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF
The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as...
2018/0208599 Novel polymorphs of ponatinib hydrochloride
Novel crystalline ponatinib hydrochloride forms designated Form alpha and Form beta are disclosed. Form alpha is characterized by data selected from an XRPD...
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