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Patent # Description
2018/0208598 PYRROLO[2,3-d]PYRIMIDINE COMPOUND OR SALT THEREOF
Provided are a novel compound or a salt thereof, and a pharmaceutical composition comprising the same, which selectively and strongly inhibit JAK3, exhibit an...
2018/0208597 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES
The invention relates to new compounds of formula (I) that are useful in medicine, specifically in treating or preventing cancerous diseases in a mammal, to...
2018/0208596 Solid Forms and Formulations of Imidazopyrazine Compound
In some embodiments, the invention relates to crystalline solid forms, including hydrates, polymorphs, and salt forms, of ...
2018/0208595 SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
Substituted 4-azaindoles as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for...
2018/0208594 PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of...
2018/0208593 4-Azaindole Derivatives
4-Azaindole derivatives which are modulators of muscarinic acetylcholine receptor (mAChR) M1 and which may be effective for the prevention or disease modifying...
2018/0208592 BENZOQUINOLONE INHIBITORS OF VMAT2
The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof. ##STR00001##
2018/0208591 SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these...
2018/0208590 NOVEL COMPOUNDS HAVING ESTROGEN RECEPTOR ALPHA DEGRADATION ACTIVITY AND USES THEREOF
The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of...
2018/0208589 LMP7 INHIBITORS
The present disclosure provides compounds that are Large Multifunctional Protease 7 (LMP7) inhibitors and are therefore useful for the treatment of diseases...
2018/0208588 HETEROCYCLIC COMPOUNDS AND USE THEREOF
Heterocyclic compounds of Formula (I) shown herein. Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. Further...
2018/0208587 TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE
The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions,...
2018/0208586 COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCERS AND OTHER MEDICAL CONDITIONS
There are provided compounds, their preparation and their use in the treatment of medical conditions including cancers and immune disorders. ##STR00001##
2018/0208585 2-ARYLAMINO PYRIDINE, PYRIMIDINE OR TRIAZINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
The present disclosure relates to 2-arylamino pyridine, pyrimidine, or triazine derivatives, and the preparation method and use thereof. The 2-arylamino...
2018/0208584 1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS
Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases...
2018/0208583 OXIME ESTER PHOTOINITIATORS
Compounds of the formulae (I) or (II) ##STR00001## wherein X is ##STR00002## A is O, S, NR.sub.5 or CR.sub.16R.sub.17; R.sub.1 is for example hydrogen or...
2018/0208582 COMPOUNDS, COMPOSITIONS, AND METHODS
The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or...
2018/0208581 ANILINE PYRIMIDINE DERIVATIVES AND USES THEREOF
The present disclosure relates to aniline pyrimidine derivatives or pharmaceutically acceptable salts thereof as EGFR inhibitors, specifically relates to...
2018/0208580 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an...
2018/0208578 INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers,...
2018/0208577 Compounds and Methods of Use
This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with...
2018/0208576 NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11.beta.-HSD1) inhibitors and the use thereof to prevent...
2018/0208575 TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF
The invention relates to compounds of formula IA ##STR00001## and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of...
2018/0208574 PRO-DRUGS AND RELATED METHODS
The invention relates to Pro-drugs, comprising red-ox-sensitive cleavage sites. The compounds may be utilized in medical practice for targeting of si RNA,...
2018/0208573 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF
Disclosed are compounds, for example, compounds of formula (I), (Formula (I) wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y', and E are as described herein,...
2018/0208572 PRODRUGS OF TETRAHYDROCANNABINOL, COMPOSITIONS COMPRISING PRODRUGS OF TETRAHYDROCANNABINOL AND METHODS OF USING...
Described herein are .DELTA..sup.9-THC prodrugs, methods of making .DELTA..sup.9-THC prodrugs, formulations comprising .DELTA..sup.9-THC prodrugs and methods...
2018/0208571 Method for Obtaining Vitamin E, Sterols and/or Terpenes From Oily or Fatty Mixtures of Biological Origin
Disclosed is a continuous process for concentrating or separating of vitamin E, sterols and/or terpenes from oily or fatty mixtures of biological origin...
2018/0208570 BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL...
The design and synthesis of a novel bis-furan scaffold tailored for high efficiency at inhibiting transthyretin amyloid formation is reported. In vitro results...
2018/0208569 LIQUID PHASE SELECTIVE OXIDATION TO EPOXIDES WITH MOLECULAR OXYGEN
The present disclosure relates to a method for effecting catalytic selective oxidation in liquid phase comprising a perfluorinated solvent and an olefinic...
2018/0208568 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their...
2018/0208567 PROCESS FOR MAKING HYDROXYETHYL PIPERAZINE COMPOUNDS
The present invention relates to an improved process for making hydroxyethyl piperazine compounds especially mono-hydroxyethyl piperazine. The improvement...
2018/0208566 Deuterated Meclizine
This invention relates to deuterated forms of meclizine, and pharmaceutically acceptable salts or hydrates thereof. This invention also provides compositions...
2018/0208565 METHODS OF CHEMICAL SYNTHESIS OF SUBSTITUTED 10H-PHENOTHIAZINE-3,7-DIAMINE COMPOUNDS
The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of...
2018/0208564 1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS
Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases...
2018/0208563 THERMODYNAMICALLY STABLE CRYSTAL MODIFICATION OF ...
Thermodynamically stable crystal modification of 2-chloro-3-(methylsulfanyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromet- hyl)benzamide A thermodynamically...
2018/0208562 Selective Sulfonation of Benzodiazepine Derivatives
The invention relates to novel methods of preparing cell-binding agent-cytotoxic agent conjugates, wherein the cytotoxic agent is an imine-containing cytotoxic...
2018/0208561 QUINOXALINE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF
A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) ##STR00001## wherein L is NR.sup.8 or O; R.sup.1, R.sup.2,...
2018/0208560 Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
The present invention relates to compounds of formula I, ##STR00001## wherein the groups R, R.sup.1, R.sup.2, R.sup.3, m and n are defined herein, which have...
2018/0208559 PROCESS FOR THE PREPARATION OF 3-HALOALKYLPYRAZOLES
A process for the preparation of a compound of formula IX: ##STR00001## wherein R.sup.1 is difluoromethyl, and R.sup.3 is methyl or ethyl.
2018/0208558 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM
The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron...
2018/0208557 PHENYL-CYANOQUINOLINONE PDE9 INHIBITORS
The present invention is directed to phenylcyanoquinolinone compounds which may be useful as therapeutic agents for the treatment of central nervous system...
2018/0208556 Method for Preparing Pimavanserin
Provided is a method for preparing pimavanserin including reacting an intermediate compound represented by Formula (II) with ...
2018/0208555 METHOD OF SYNTHESIS OF AN IONIZABLE CATIONIC LIPID
What is described is a method of synthesis of the compound of formula 1A, ##STR00001## or a salt thereof, wherein R.sub.3 is a linear or branched alkene of 1, ...
2018/0208554 Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof
Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.
2018/0208553 A PROCESS FOR PRODUCING TAURINE
The present application provides a process for preducing taurine, comprising the steps as follows: (a) mixing isethionic acid with taurine salt solution until...
2018/0208552 UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF
The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be...
2018/0208551 METHOD FOR PRODUCING ORGANIC UREA AND THE ORGANIC UREA AND AUS32 THEREBY OBTAINED
A method for producing organic urea is provided that, by mixing and reacting liquid ammonia (NH.sub.3) and gaseous carbon dioxide (CO.sub.2) through the steps...
2018/0208550 METHOD FOR PRODUCING A CYCLIC ISOCYANATE
The present invention relates to a process for preparing a cyclic isocyanate (B) from a composition (Z) which comprises at least one component (A) which has at...
2018/0208549 NEW TYPE OF ANTIVIRAL COMPOUND
Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral...
2018/0208548 HIGH PURITY HCN FROM ACRYLONITRILE CO-PRODUCTION
Disclosed is a process for co-manufacture of ACRN and HCN with improved HCN selectivity and reduced solids formation in a shared product recovery section.
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