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Patent # Description
2018/0214497 REPLICATION-COMPETENT VESICULAR STOMATITIS VIRUSES
This document provides methods and materials related to vesicular stomatitis viruses. For example, replication-competent vesicular stomatitis viruses, nucleic...
2018/0214496 COMPOSITIONS COMPRISING BACTERIAL STRAINS
The invention provides compositions comprising one or more bacterial strains for treating or preventing visceral hypersensitivity.
2018/0214495 USE OF GRAM NEGATIVE SPECIES TO TREAT ATOPIC DERMATITIS
Pharmaceutical compositions are disclosed that includes a therapeutically effective amount of a purified viable gram negative bacteria and a pharmaceutically...
2018/0214494 METHOD AND COMPOSITION FOR PREVENTING EGG ALLERGY
The present invention provides an egg allergy prevention method to be carried out with respect to a human infant, including: a first administration period...
2018/0214493 Tissue Grafts Composed Of Micronized Placental Tissue And Methods Of Making And Using The Same
Described herein are tissue grafts composed of at least one membrane, where at least one side of the membrane has micronized placental tissue applied it. Also...
2018/0214492 Repair of Peripheral Nerve Injury
The invention relates to methods and compositions for maintaining the pro-regenerative capacity of distal nerve segments following nerve injury.
2018/0214491 COMPOSITIONS AND METHODS FOR EXPANSION OF EMBRYONIC HEMATOPOIETIC STEM CELLS
The present invention relates to methods, kits and compositions for expansion of embryonic hematopoietic stem cells and providing hematopoietic function to...
2018/0214490 METHODS OF TREATING LYSOSOMAL STORAGE DISEASES
Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing...
2018/0214489 MESENCHYMAL STEM CELLS WITH ENHANCED EFFICACY IN TREATMENT OF AUTOIMMUNITY PARTICULARLY RHEUMATOID ARTHRITIS
Disclosed herein are protocols, isolation means, and compositions of matter useful for identifying mesenchymal stem cells possessing enhanced clinical activity...
2018/0214488 METHODS AND COMPOSITIONS FOR STEM CELL TRANSPLANTATION
The present disclosure relates to the field of hematopoietic stem or progenitor cell transplantation. More specifically, methods, compositions and kits for...
2018/0214487 PD-L1 EXPRESSING HEMATOPOIETIC STEM CELLS AND USES
Embodiments disclosed here provide engineered modified hematopoietic stem cells (HSCs), artificially prostaglandin E2 (PGE2)-stimulated HSCs, compositions...
2018/0214486 BONE MARROW DERIVED CD271 PRECURSOR CELLS FOR CARDIAC REPAIR
Methods for the isolation of CD271.sup.+ stem cell populations are important in the prevention or treatment of cardiovascular diseases and repair of cardiac...
2018/0214485 TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES
Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes.
2018/0214484 TUMOR LYSATE LOADED PARTICLES
Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility...
2018/0214483 THERAPEUTIC METHODS INVOLVING MODULATING INFLAMMASOME ACTIVATION OF MYELOID-DERIVED SUPPRESSOR CELLS
In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a...
2018/0214482 METHOD OF ENABLING MUSCLE RELAXATION
A method of application to human skin of a water solution of metallic salts at concentrations from 1 to not more than 10 times the normal concentration found...
2018/0214481 READY TO USE SURFACE DISINFECTANT
This invention relates generally to improved chemical formulations and methods of use that provide for the disinfection of microorganisms and biological...
2018/0214480 PHARMACEUTICAL-GRADE FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME
The present invention discloses pharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which...
2018/0214479 MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA
The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the...
2018/0214478 POLYMERS FOR REVERSING HEPARIN-BASED ANTICOAGULATION
Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding...
2018/0214477 GRANULAR COMPOSITION FOR ORAL ADMINISTRATION
The present invention relates to a granular composition for oral suspension characterized by the presence of an insoluble resin and a silica gel.
2018/0214476 THROMBIN-RESPONSIVE HYDROGELS AND DEVICES FOR AUTO-ANTICOAGULANT REGULATION
The present disclosure relates to a thrombin-responsive closed-loop patch for prolonged heparin delivery in a feedback-controlled manner. The microneedle-based...
2018/0214475 microRNAS FOR THE TREATMENT OF HEART DISEASES
The invention relates to the field of molecular biology and medicine, more specifically the invention is directed towards the treatment, delay and amelioration...
2018/0214474 Methods and Compositions for Selecting siRNA of Improved Functionality
Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize...
2018/0214473 COMPOSITIONS AND METHODS RELATED TO CHARACTERIZING PROVIRAL RESERVOIRS
In some aspects, the invention relates to methods for determining the proportion of intact, hypermutated, deleted, and/or defective proviruses in a sample of...
2018/0214472 CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one antifungal agent or antibacterial agent with at...
2018/0214471 COMPOSITION FOR PREVENTING AND TREATING OSTEOPOROSIS, COMPRISING DIHYDROPHASEIC ACID 3-O-B-D-GLUCOPYRANOSIDE...
The present invention relates to a compound of dihydrophaseic acid 3'-O-beta-D-glucopyranoside for the prevention and treatment of osteoporosis. It was found...
2018/0214470 NEW EFFECTIVE AMINOGLYCOSIDE ANTIBIOTIC FOR MULTIDRUG-RESISTANT BACTERIA
A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof,...
2018/0214469 ANTICANCER COMPOSITION AND USE THEREOF
A composition for inhibiting a liver tumor in an organism is disclosed. The composition includes an activator being ...
2018/0214468 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF
The invention relates to the treatment or prevention of renal impairment and/or complications using a SGLT-2 inhibitor, for example in patients diagnosed with...
2018/0214467 GLP-1 SECRETAGOGUE
An object of the present invention is to provide a GLP-1 secretagogue which is an incretin hormone-related drug relatively inexpensive, excellent in safety,...
2018/0214466 USE OF GINSENOSIDE M1 FOR TREATING IGA NEPHROPATHY
The present invention provides a method of treating a subject afflicted with IgA nephropathy (IgAN) comprising administering to the subject an amount of...
2018/0214465 THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic...
2018/0214464 METHODS OF TREATING RETROVIRAL INFECTIONS AND RELATED DOSAGE REGIMES
The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention...
2018/0214463 USE OF PHYTIC ACID OR THE SALTS THEREOF, ALONE OR COMBINED WITH B6 VITAMERS, FOR PREVENTING THE FORMATION OF...
The invention relates to the use of phytate or any of the salts thereof for preventing the formation of advanced glycation end-products (AGE), toxic products...
2018/0214462 BLOOD-BRAIN-BARRIER PERMEABILITY MODULATORS AND USES THEREOF
Provided are compositions which include N-methyl-d-aspartate receptor (NMDA-R) antagonists. Moreover, provided are methods for reducing the permeability of the...
2018/0214460 TABLET
The present invention provides a tablet showing high stability of the active ingredients (potassium-competitive acid blocker and acetylsalicylic acid) and...
2018/0214459 LIQUID POLYMER DELIVERY SYSTEM FOR EXTENDED ADMINISTRATION OF DRUGS
Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active...
2018/0214458 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME
The present invention relates to 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells,...
2018/0214457 USE OF CYMANQUINE COMPOUNDS AS ANTIMALARIAL AGENTS
Organometallic compounds comprising a chloroquinoline moiety for use in the prophylaxis and treatment of malaria. The compounds can be manganese or rhenium...
2018/0214456 ORBIT AZINE-FUMARATE, HYDRATE, CRYSTAL FORM AND PREPARATION METHOD THEREFOR
The invention relates to the field of pharmaceutical chemistry, particularly relates to an orbit azine-fumarate, a hydrate, a crystal form, and a preparation...
2018/0214455 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE
Provided in some embodiments are compounds of Formula A, as defined herein, that modulate the activity of 5-HT2C receptor. Also provided in some embodiments...
2018/0214454 ANTIBIOTIC SOLUTION AND METHOD OF INJECTION TO PREVENT OPHTHALMIC INFECTIONS
A method of preventing post-operative endophthalmitis involves injecting an antibiotic solution into the anterior segment of the eye during surgery, the...
2018/0214453 RIVAROXABAN PHARMACEUTICAL COMPOSITIONS
A rivaroxaban immediate release tablet comprising a non-ionic surfactant obtainable by using a dry process (i.e. no solvent is used during the manufacturing of...
2018/0214452 COMPOSITION FOR PREVENTION OR TREATMENT OF INTRACTABLE EPILEPSY COMPRISING mTOR INHIBITOR
Provided is a use of the prophylaxis, amelioration or therapy of intractable epilepsy, for example, Focal Cortical Dysplasia (FCD).
2018/0214451 Combination
The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method...
2018/0214450 TREATMENT OF KIDNEY DISEASES ASSOCIATED WITH ELEVATED AVP
Disclosed are methods for treating kidney disease including autosomal dominant polycystic kidney disease (ADPKD) in a subject, comprising the step of...
2018/0214449 CANCER THERAPY USING JAK INHIBITOR IN COMBINATION WITH MAPK INHIBITORS
Provided herein are new therapeutic regimens for treatment of cancer with a combination of a JAK inhibitor and an inhibitor targeting the MAPK pathway,...
2018/0214448 METHOD OF DIAGNOSING AND TREATING SKIN NECROPTOSIS DISEASE COMPRISING RIP3-MLKL PATHWAY BLOCKER
The present invention relates to methods of preventing or treating skin necroptosis diseases, including administering to subjects receptor-interacting protein...
2018/0214447 PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF
The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI)...
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