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Patent # Description
2018/0214446 SOLID STATE FORMS OF SELEXIPAG
The present disclosure relates to solid state forms of Selexipag, in particular selexipag forms IV and V, and processes for preparation thereof, pharmaceutical...
2018/0214445 ARYL SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS
Disclosed is a compound of Formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein one R.sub.3 is H and...
2018/0214444 Piperazine-Substituted Benzothiophenes For Treatment of Mental Disorders
The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment...
2018/0214443 PHARMACEUTICAL PREPARATION CONTAINING OXYCODONE AND NALOXONE
The invention concerns a storage stable pharmaceutical preparation comprising oxycodone and naloxone for use in pain therapy, with the active compounds being...
2018/0214442 METHODS FOR ATTENUATING OR PREVENTING MU(.mu.)-OPIOID RECEPTOR MEDIATED TOLERANCE AND OPIOID-INDUCED HYPERALGESIA
Methods are provided for attenuating or preventing .mu.-opioid receptor mediated tolerance and opioid-induced hyperalgesia in a subject in need of acute or...
2018/0214441 Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition
Disclosed is the synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and...
2018/0214440 ORAL COMPOSITION
The invention provides an oral composition comprising 4-methyl-8-phenoxy-1-(2-phenylethyl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinoli- ne or a pharmaceutically...
2018/0214439 AZA-CYANOQUINOLINONE PDE9 INHIBITORS
The present invention is directed to azacyanoquinolinone compounds which may be useful as therapeutic agents for the treatment of central nervous system...
2018/0214438 SELECTIVE PFKFB4 INHIBITORS FOR THE TREATMENT OF CANCER
Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and the treatment of cancer are described.
2018/0214437 NEW ALFENTANIL COMPOSITION FOR THE TREATMENT OF ACUTE PAIN
There is provided pharmaceutical compositions for the treatment of pain e.g. short-term pain, which compositions comprise a mixture comprising: (a)...
2018/0214436 PHACETOPERANE FOR TREATING OF ATTENTION DEFICIT HYPERACTIVITY DISORDER
The invention relates to the treatment of an attention deficit hyperactivity disorder (ADHD) with alpha-phenyl(piperidin-2-yl)methanol, or the pharmaceutically...
2018/0214435 ORAL PHARMACEUTICAL DOSAGE FORMS
Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable...
2018/0214434 SEMI-SOLID TOPICAL COMPOSITION CONTAINING PIRFENIDONE AND MODIFIED DIALLYL DISULFIDE OXIDE (M-DDO) FOR...
The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl...
2018/0214433 COMPOSITIONS AND METHODS FOR REDUCING MUSCLE CONTRACTION
Disclosed herein are methods of reducing muscle contraction in a diaphragm or peripheral muscle(s) of a patient sufficient to permit a surgical procedure. The...
2018/0214432 PHARMACEUTICAL COMPOSITION COMPRISING BETAHISTINE
The present disclosure relates to a pharmaceutical composition comprising as active substance betahistine or a pharmaceutically acceptable salt thereof, for...
2018/0214431 Methods of Maintaining, Treating or Improving Cognitive Function
A method of administering an effective amount of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, or a pharmaceutically acceptable salt...
2018/0214430 Selective Inhibitors Of i-NOS For Use Against Viral Infection
The present invention concerns compounds for use in the prevention of viral replication and/or the prevention or treatment of a viral infection, wherein the...
2018/0214429 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0214428 3-(1H-INDOL-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF
7-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0214427 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF
6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0214426 PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF BETA-GLUCURONIDASE
The present invention provides novel pyrazolo[4,3-c]quinoline derivatives exhibiting specifically inhibition activity to microbiota .beta.-glucuronidase,...
2018/0214425 METHODS OF TREATING BLADDER CANCER
The present invention provides methods and compositions for treating bladder cancer, including metastatic bladder cancer and non-muscle-invasive bladder...
2018/0214424 PHARMACEUTICAL COMPOSITIONS COMPRISING 40-O-(2-HYDROXY)ETHYL-RAPAMYCIN
The invention relates to extended release pharmaceutical formulations in form of multiparticulates comprising 40-O-(2-hydroxy)ethyl-rapamycin, to dosage forms...
2018/0214423 PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR DERIVATIVE THEREOF, AND METHOD FOR PRODUCING THE SAME
It is an object of the present invention to provide a pharmaceutical composition which can suppress a reduction in the content of an active ingredient caused...
2018/0214422 SOLID DISPERSIONS COMPRISING TACROLIMUS
A pharmaceutical composition comprising tacrolimus (FK-506) dissolved and/or dispersed in a hydrophilic or water-miscible vehicle to form a solid dispersion or...
2018/0214421 COMPOSITIONS, METHODS AND KITS FOR REDUCING LIPID LEVELS
Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of...
2018/0214420 Methods for treating hyperuricemia in patients with gout using halofenate or halofenic acid and a second...
Disclosed herein are pharmaceutical compositions, methods and kits for lowering the serum uric acid level of a subject and for the treatment of a condition...
2018/0214419 COMPOUNDS, COMPOSITIONS, AND METHODS OF INCREASING CFTR ACTIVITY
The present disclosure features compounds such as those having the Formulae (I) and (II), which can increase cystic fibrosis transmembrane conductance...
2018/0214418 MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or...
2018/0214417 METHOD FOR TREATING HEPATIC ENCEPHALOPATHY
A method of treating or preventing type C Hepatic Encephalopathy in a human patient diagnosed with cirrhosis by administering a composition containing at least...
2018/0214416 TREATMENT FOR WOLFRAM SYNDROME AND OTHER ENDOPLASMIC RETICULUM STRESS DISORDERS
The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of...
2018/0214415 TREATMENT METHOD UTILIZING PYRROLIDINE-2, 5-DIONE DERIVATIVES AS IDO1 INHIBITORS
Uses of compound of Formula I: ##STR00001## or pharmaceutically acceptable enantiomers, salts, solvates or prodrugs thereof are described. The compounds of...
2018/0214414 COMPOSITIONS AND METHODS FOR TREATING ESTROGEN-RELATED MEDICAL DISORDERS
Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of...
2018/0214413 Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans
The present technology is directed to modulators of nuclear receptor activity, specifically to the modulation of NR2F6 activity and NR2F6 utilizing compounds,...
2018/0214412 IMMEDIATE RELEASE CANNABINOID FORMULATIONS
The present invention relates to immediate release pharmaceutical compositions comprising one or more natural or synthetic cannabinoids, and one or more...
2018/0214411 COMPOSITION COMPRISING SATIETY-INDUCING PARTICLES
The invention provides a pharmaceutical or food composition comprising ingestible particles with a water-swellable or water-soluble polymeric material a lipid...
2018/0214410 Development of Dietary Therapy in Cancer
The invention provides new compositions or combinations thereof for the treatment of cancer. More specifically, the invention provides compositions or...
2018/0214409 COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTER IN THE TREATMENT OF NEOPLASMS
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such...
2018/0214408 PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA AND USE OF SAME
The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions...
2018/0214407 Compositions for Treating Conditions Associated with Dry Eye and Methods for Using Same
This invention relates to methods for improving the quality of the meibum composition of the meibomian glands to enhance or improve the lipid layer of the tear...
2018/0214406 OMEGA-3 AND/OR OMEGA-6 FATTY ACID(S) IN IMPAIRED SPHINGOLIPID METABOLISM
An application of omega-3 and/or omega-6 fatty acid(s) for the therapeutic treatment of the human or animal body in the case of an impaired sphingolipid...
2018/0214405 Methods of Treating Neurodevelopmental Diseases and Disorders
The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of...
2018/0214404 ORAL NOURISHING COMPOSITION AND METHODS THEREOF
The present invention discloses oral compositions for nourishment a mammalian subject which comprises steviol glycoside, citric acid monohydrate, monosodium...
2018/0214403 Sequelae of Cardiopulmonary Bypass-Induced Pulmonary Injury
A method for administering citrulline to a patient during surgery without filtration of the hemolysis to reduce the uncoupling of eNOS enzyme dimer that leads...
2018/0214402 COMPOSITIONS AND METHODS FOR TREATING CANCER
The invention provides compositions and methods to treat a hyperproliferative disorder with phenyl butyric acid (PBA) or a pharmaceutically acceptable salt...
2018/0214401 METHOD FOR TREATING SCARS WITH ADAPALENE 0.3%
A method is described for treating a scar with an effective amount of adapalene or salts thereof, which is administrated to the patient in need thereof....
2018/0214400 THE USE OF KAURANES COMPOUNDS IN THE MANUFACTURE OF MEDICAMENT FOR TREATMENT OF CADIAC HYPERTROPY AND PULMONARY...
The invention relates novel pharmaceutical use of kaurane compounds of formula (I) in treating and preventing cardiac hypertrophy and myocardium remodeling....
2018/0214399 Use of short chain fatty acids for the treatment and prevention of diseases and disorders
The invention relates to compositions and methods that include short chain fatty acids (SCFAs), related therapeutic compounds, and other compounds, including...
2018/0214398 TOPICAL COMPOSITIONS FOR PAIN RELIEF, MANUFACTURE AND USE
The present invention relates to TRPV1 selective agonist compositions including a capsaicinoid, a surfactant and an extended release agent, and to methods of...
2018/0214397 TOPICAL COMPOSITIONS FOR PAIN RELIEF, MANUFACTURE AND USE
The present invention relates to TRPV1 selective agonist compositions including a capsaicinoid, a surfactant and an extended release agent, and to methods of...
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