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Patent # Description
2018/0216116 ANTISENSE OLIGOMERS AND CONJUGATES TARGETING PCSK9
The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a...
2018/0216115 Compositions and Methods for Inhibiting Expression of the PCSK9 Gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense...
2018/0216114 XANTHINE DEHYDROGENASE (XDH) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting a xanthine dehydrogenase (XDH) gene, and methods of using such...
2018/0216113 METHODS FOR REDUCING PROTEOTOXICITY
The present disclosure provides methods of reducing protein misfolding and/or aggregation in a cell. The present disclosure provides methods of treating...
2018/0216112 PROCESS FOR INDUCING RESISTANCE TO DIPHTHERIA TOXIN IN HUMAN CELLS, PRODUCTS AND USES THEREOF
Process for inducing resistance to diphtheria toxin in a human cell, wherein the process is carried out in vitro and/or in vivo in a rodent xenografted with a...
2018/0216111 ANTISENSE-INDUCED EXON2 INCLUSION IN ACID ALPHA-GLUCOSIDASE
The present disclosure relates to antisense oligomers and related compositions and methods for inducing exon inclusion as a treatment for glycogen storage...
2018/0216110 Novel Paratransgenic System for the Biocontrol of Disease-Transmitting Mosquitos
The inventive technology relates to novel paratransgenic strategies for the control of pathogens. The inventive technology may specifically include a novel...
2018/0216109 MICRORNA-328 ANTI-SENSE COMPOSITION AND THERAPEUTIC USE
The present invention is directed to anti-sense microRNA-328 in a form of oligodeoxyribonucleotides, or locked nucleic acid (LNA)-modified, and ...
2018/0216108 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions,...
2018/0216107 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided...
2018/0216106 OLIGONUCLEOTIDES MATCHING COL7A1 EXON 73 FOR EPIDERMOLYSIS BULLOSA THERAPY
Antisense oligonucleotides capable of preventing or reducing exon 73 inclusion into the human COL7A mRNA are characterized in various ways: (a) the...
2018/0216105 BIOLOGICAL CONTROL OF COLEOPTERAN PESTS
Disclosed are double stranded RNA molecules that are toxic to coleopteran insects. In particular, interfering RNA molecules that capable of interfering with...
2018/0216104 HSD17B13 Variants And Uses Thereof
Provided are compositions related to HSD17B13 variants, including isolated nucleic acids and proteins related to variants of HSD17B13, and cells comprising...
2018/0216103 Methods and Compositions for Enrichment of Target Polynucleotides
High-fidelity, high-throughput nucleic acid sequencing enables healthcare practitioners and patients to gain insight into genetic variants and potential health...
2018/0216102 Methods for Obtaining Information from Single Cells Within Populations Using DNA Origami Nanostructures Without...
Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha...
2018/0216101 MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and...
2018/0216100 MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and...
2018/0216099 MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and...
2018/0216098 Synthon Formation
This disclosure provides, among other things, a composition comprising: a 5' exonuclease; a strand-displacing polymerase; and optionally a single strand DNA...
2018/0216097 SYSTEM FOR CONTINUOUS MUTAGENESIS IN VIVO TO FACILITATE DIRECTED EVOLUTION
A system for continuous mutagenesis to facilitate directed evolution, the system including DNA polymerases carrying the novel K54E point mutation, and other...
2018/0216096 CARBON DIOXIDE FIXATION VIA BYPASSING FEEDBACK REGULATION
Genetically engineered cells and methods are presented that allow for the production of various value products from CO.sub.2. Contemplated cells have a CBB...
2018/0216095 COMPOSITIONS OF ADENOSINE DEAMINASE-2 (ADA2), VARIANTS THEREOF AND METHODS OF USING SAME
Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are...
2018/0216094 REVERSAL AGENTS FOR FXIa INHIBITORS
The disclosure provides compositions and methods for counteracting the effects of direct activated Factor XI (FXIa) inhibitors in a subject by administering a...
2018/0216093 HETEROMERS COMPRISING ANTIBODY DOMAIN FUSION PROTEINS
The present invention pertains to fusion constructs of dimeric proteins, wherein the portions of the protein are fused to either to the CH1 domain of the CL...
2018/0216092 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS
The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one...
2018/0216091 NOVEL SOLUBLE SORTASE A
Herein is reported a polypeptide comprising the amino acid sequence of SEQ ID NO: 38 as sole Listeria monocytogenes derived polypeptide and its use in...
2018/0216090 COMPOSITIONS AND METHODS COMPRISING LG12-CLADE PROTEASE VARIANTS
The present disclosure provides LG12-clade enzyme variants, compositions comprising these enzyme variants, and method of using these enzymes and compositions,...
2018/0216089 Polypeptides Having Beta-Xylosidase Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having beta-xylosidase activity and polynucleotides encoding the polypeptides. The invention also...
2018/0216088 Engineered CRISPR-Cas9 Nucleases
Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
2018/0216087 Enhanced hAT Family Transposon-Mediated Gene Transfer and Associated Compositions, Systems and Methods
This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
2018/0216086 Cellobiose Phosphorylase
The invention relates to a cellobiose phosphorylase, which catalyzes, among other things, the synthesis of cellobiose from glucose 1-phosphate and glucose. The...
2018/0216085 MUTATED GENES FOR THE CATALYTIC PROTEIN OF OPLOPHORUS LUCIFERASE AND USE THEREOF
Luciferases which are different from those known heretofore have been desired. A luciferase mutant comprising an amino acid sequence in which at least one...
2018/0216084 HSD17B13 VARIANTS AND USES THEREOF
Provided are compositions related to HSD17B13 variants, including nucleic acid molecules and polypeptides related to variants of HSD17B13, and cells comprising...
2018/0216083 ENGINEERED PREPHENATE DEHYDROGENASES AND AROGENATE DEHYDROGENASES AND METHODS OF USING THE SAME
The invention generally relates to engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same. More specifically, the...
2018/0216082 LIVE ATTENUATED ARKANSAS SEROTYPE INFECTIOUS BRONCHITIS VIRUS VACCINE
Attenuated isolates of the Arkansas serotype of infectious bronchitis virus (IBV), including the IBV isolate ArkGA p60 deposited at the ATCC under Patent...
2018/0216081 NOVEL ADENOVIRUS
There is provided adenoviral vectors encoding a mycobacterial antigen derived from a chimp adenovirus, and to related aspects.
2018/0216080 SALMON GILL POXVIRUS
The present document is directed to a new poxvirus infecting salmon. The present document further discloses the genomic sequence of this double-stranded DNA...
2018/0216079 GENERATION OF HUMAN iPS CELLS BY A SYNTHETIC SELF-REPLICATIVE RNA
The disclosure provides methods and compositions useful for obtaining induced stem cells, methods of making and use thereof.
2018/0216078 SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential....
2018/0216077 DIFFERENTIATION OF HUMAN IPS CELLS TO HUMAN ALVEOLAR TYPE II VIA DEFINITIVE ENDODERM
The present invention relates to compositions and methods for generating populations of tissue precursor cells from pluripotent cells, and preferably induction...
2018/0216076 Methods and Compositions for Producing Pancreatic Beta Cells
Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell...
2018/0216075 COMPOSITE BINDER MATERIAL, CELL AGGREGATE, CELL ACCUMULATION METHOD, CELL PRESERVATION METHOD AND METHOD OF...
Provided is a composite binder material, a cell aggregate, a cell accumulation method, a cell preservation method, and a method of manufacturing a composite...
2018/0216074 METHODS AND USES FOR EX VIVO TISSUE CULTURE SYSTEMS
The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device...
2018/0216073 IMMUNO-ONCOLOGY MESODERMAL PROGENITOR (IOMP) CELL
The invention relates to immuno-oncology mesodermal progenitor (ioMP) cells and their use in therapy.
2018/0216072 BIOPRESERVED STEM CELLS ON MICROCARRIERS
Disclosed herein are compositions and methods involving stem cells biopreserved on microcarriers, which can be thawed and expanded, all while maintaining their...
2018/0216071 CELLULAR CULTURE MEDIUM FREE FROM SERUM
The present invention relates to a cell culture medium, in particular for culturing autologous fibroblasts, for use in aesthetic medicine for skin ...
2018/0216070 METHOD FOR OBTAINING HUMAN BROWN/BEIGE ADIPOCYTES
The present invention concerns a method of producing brown/beige adipocytes from white adipose tissue cells and/or mesenchymal stem cells, in particular from...
2018/0216069 COMPOSITIONS AND METHODS FOR REGULATING NK CELL ACTIVITY
The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to...
2018/0216068 CD34+CD41DIM MEGAKARYOCYTES PROGENITORS AND USES THEREOF FOR PRODUCING PROPLATELET-BEARING MKS AND/OR PLATELETS
The invention relates to a method of producing CD34+CD4.sup.dim megakaryocyte (MK) progenitor cells, and substantially pure cell population of megakaryocyte...
2018/0216067 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or...
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