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Patent # Description
2018/0215813 ANTI-CGRP COMPOSITIONS AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the...
2018/0215812 PEPTIDES AND BINDING PARTNERS THEREFOR
The invention provides a peptide obtainable from C. albicans as well as variants and fragments thereof, and labelled forms of these. The peptide is immunogenic...
2018/0215811 ANTIBODY BINDING AGENTS THAT BIND ACINETOBACTOR AND USES THEREOF
Presented herein, in certain embodiments, are compositions comprising antibody binding agents that specifically bind to A. baumannii and inhibit and/or block...
2018/0215810 ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS
The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids...
2018/0215808 ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS
The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids...
2018/0215807 DETECTION OF CHO-MIF CONTAMINATIONS
The invention concerns a detection method to enable the detection of complexes formed between antibodies and antigen which is endogenous to the production cell...
2018/0215806 TUMOR-SELECTIVE CTLA-4 ANTAGONISTS
Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular...
2018/0215805 THERAPEUTIC AND DIAGNOSTIC AGENTS
Provided herein is an isolated tumour necrosis factor receptor (TNFR) polypeptide capable of binding to TNF, or a TNF-binding fragment thereof, wherein the...
2018/0215804 REDUCTION OF INFLAMMATORY DISEASE SYMPTOMS BY SHORT PEPTIDES THAT INHIBIT SIGNALING THROUGH CD28
The present disclosure relates to a method for the treatment of a non-pathogen associated inflammatory disorders in a subject in need thereof, comprising...
2018/0215803 DIAGNOSTIC AND THERAPEUTIC METHODS FOR EFMR (EPILEPSY AND MENTAL RETARDATION LIMITED TO FEMALES)
Methods and kits for the diagnosis of illnesses related to protocadherin 19 (PCDH19) protein deficiency or altered PCDH19 protein function are provided, as...
2018/0215802 IDENTIFICATION OF NOVEL ANTI-FIBROTIC PEPTIDE IN C-TERMINAL REGION OF THE MET RECEPTOR TYROSINE KINASE
The invention provides anti-fibrotic peptides derived from the C-terminal region of the MET receptor tyrosine kinase. Polynucleotides encoding these peptides,...
2018/0215801 CRYPTIC POLYPEPTIDES AND USES THEREOF
The disclosure features, among other things, polypeptides comprising a Cryptic polypeptide, a functional fragment thereof, or variants of any of the foregoing....
2018/0215800 DOMINANT POSITIVE hnRNP-E1 POLYPEPTIDE COMPOSITIONS AND METHODS
Described herein are compositions relating to engineered hnRNP-E1 variant polypeptides, nucleic acids encoding such polypeptides, engineered hnRNP-E1...
2018/0215799 METHODS FOR TREATING PSYCHIATRIC DISORDERS OR SYMPTOMS THEREOF USING NCAM PEPTIDE MIMETICS
The present invention provides methods for treating or alleviating one or more symptoms of depression and/or anxiety in a subject comprising administering an...
2018/0215798 Transgenic Plants with Enhanced Traits
This disclosure provides plants having enhanced traits such as increased yield, increased nitrogen use efficiency and increased water use efficiency;...
2018/0215797 Regulatory Protein Deficient Trichoderma Cells and Methods of Use Thereof
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
2018/0215796 ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY BINDING CAPACITY IN ACIDIC pH REGION
A protein includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence includes a...
2018/0215795 ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY-BINDING CAPACITY IN ACIDIC pH REGIONS
A protein includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence includes a...
2018/0215794 TREATING CANCER WITH VIRAL NUCLEIC ACID
This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal....
2018/0215793 Virus-Like Particle
The present invention relates to a piscine myocarditis virus (PMCV) virus-like particle (VLP) which consists only of PMCV ORF1 protein.
2018/0215792 TWO-DIMENSIONAL STRUCTURES FROM PEPTOID OLIGOMERS AND METHODS OF MAKING
Materials and methods for forming self-assembled peptoid structures that are extremely stable, crystalline, free-standing and self-repairing are described....
2018/0215791 CONJUGATES THAT ARE CONFIGURED FOR TARGETED DELIVERY OF THERAPEUTIC COMPOUNDS TO SENESCENT CELLS
Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of...
2018/0215790 METHOD OF TREATING MELANOCORTIN-4 RECEPTOR PATHWAY-ASSOCIATED DISORDERS
The disclosure is related to a method of treating a disorder, such as obesity or a condition associated with obesity, such as hyperphagia, in a subject using a...
2018/0215789 Concurrent Chemotherapy and Immunotherapy
The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia...
2018/0215788 Compounds and Compositions for the Treatment of Ophthalmic Disorders
Described herein are methods and compositions featuring a first compound that is a linear peptidic NPR-B agonist and a second compound that is a prostaglandin...
2018/0215787 Chromogenic And Fluorogenic Peptide Substrates For The Detection Of Serine Protease Activity
The present invention relates to chromogenic and fluorogenic substrates that can be used for the highly sensitive and selective detection of the activity of...
2018/0215786 REMOVAL OF PROTEIN AGGREGATES FROM BIOPHARMACEUTICAL PREPARATIONS IN A FLOW-THROUGH MODE
The present invention provides novel compositions and methods for removal of protein aggregates from a sample in a flow-through mode.
2018/0215785 METHOD FOR PURIFYING ANTIBODY-LIKE PROTEIN
A method for purifying an antibody-like protein includes adsorbing an antibody-like protein onto an affinity separation matrix by bringing the antibody-like...
2018/0215784 METHOD FOR PREPARATION OF N-ACYL PEPTIDES, POLYPEPTIDES AND PROTEINS
A method is provided for the preparation of an N-acyl peptide, N-acyl polypeptide or N-acyl protein comprising reacting a peptide, polypeptide or protein with...
2018/0215783 BIOORTHOGONAL REACTION OF AN AMINE N-OXIDE AND A BORON AGENT
Methods for chemoselective modification of a target molecule comprising an amine N-oxide in a biological sample are provided. Aspects of the methods include...
2018/0215782 PEPTIDE SYNTHESIS METHOD
The present invention has an object of providing a peptide synthesis method using a carrier capable of reversibly repeating the dissolved state and the...
2018/0215781 BETUIN DERIVATIVES FOR PREVENTING OR TREATING HIV INFECTIONS
The present invention relates to compounds characterized by having a structure according to the following Formula I: ##STR00001## or a pharmaceutically...
2018/0215780 C-3 NOVEL TRITERPENONE WITH C-28 REVERSE AMIDE DERIVATIVES AS HIV INHIBITORS
Formula (I) The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for...
2018/0215779 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Described herein are neuroactive steroids of the Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof; wherein R.sup.1a and R.sup.1b are as...
2018/0215778 METHOD FOR PREPARING SUBSTITUTED 3,7-DIHYDROXY STEROIDS
The invention relates to a 17.alpha.-alkynyl-androst-5-ene-3.beta.,7.beta.,17.beta.-triol compound essentially free of steroid side-product lacking an oxygen...
2018/0215777 COMPLEXES FOR INTRACELLULAR IMAGING
The present disclosure relates to complexes for intracellular imaging and also to methods and kits for intracellular imaging or cell labelling. Certain...
2018/0215776 NUCLEOTIDE HEMI-SULFATE SALT FOR THE TREATMENT OF HEPATITIS C VIRUS
A hemi-sulfate salt of the structure: ##STR00001## to treat a host infected with hepatitis C, as well as pharmaceutical compositions and dosage forms,...
2018/0215775 PHARMACEUTICAL COMPOSITION FOR USE IN INHIBITING RECURRENCE, AGGRAVATION AND METASTASIS OF HEPATOCARCINOMA
The present application provides a pharmaceutical composition for use in inhibiting recurrence, aggravation or metastasis of liver cancer, in which the...
2018/0215774 Low Temperature and Efficient Fractionation of Lignocellulosic Biomass Using Recyclable Organic Solid Acids
Methods of fractionating lignocellulosic biomass using hydrotropic sulfonic acids are provided. Also provided are methods of forming lignin particles, furans,...
2018/0215773 HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS
Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic...
2018/0215772 CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS
Inhibitor compounds are disclosed. The compounds are effective in the treatment of diseases or conditions in which interleukin 1 .beta. activity is implicated....
2018/0215771 TUNABLE RARE-EARTH FCU-METAL-ORGANIC FRAMEWORKS
Metal organic framework compositions can have a face centered cubic structure.
2018/0215770 IMIDAZO-OXADIAZOLE AND IMIDAZO-THIADIAZOLE DERIVATIVES
The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases. ##STR00001##
2018/0215769 POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
2018/0215768 ASYMMETRIC PROCESS FOR THE PREPARATION OF THIENO-INDOLES DERIVATIVES
The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (Ia) or (Ib), exploiting an asymmetric synthesis for...
2018/0215767 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0215766 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases,...
2018/0215765 NEW BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, Y, W, m, n, p and q are as defined herein, ...
2018/0215764 INDAZOLONES AS MODULATORS OF TNF SIGNALING
The disclosure provides compounds of Formula (I) ##STR00001## pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and...
2018/0215763 COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR
Disclosed are compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof,...
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