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| Patent # | Description |
|---|---|
| 2018/0215813 |
ANTI-CGRP COMPOSITIONS AND USE THEREOF The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the... |
| 2018/0215812 |
PEPTIDES AND BINDING PARTNERS THEREFOR The invention provides a peptide obtainable from C. albicans as well as variants and fragments thereof, and labelled forms of these. The peptide is immunogenic... |
| 2018/0215811 |
ANTIBODY BINDING AGENTS THAT BIND ACINETOBACTOR AND USES THEREOF Presented herein, in certain embodiments, are compositions comprising antibody binding agents that specifically bind to A. baumannii and inhibit and/or block... |
| 2018/0215810 |
ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids... |
| 2018/0215808 |
ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids... |
| 2018/0215807 |
DETECTION OF CHO-MIF CONTAMINATIONS The invention concerns a detection method to enable the detection of complexes formed between antibodies and antigen which is endogenous to the production cell... |
| 2018/0215806 |
TUMOR-SELECTIVE CTLA-4 ANTAGONISTS Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular... |
| 2018/0215805 |
THERAPEUTIC AND DIAGNOSTIC AGENTS Provided herein is an isolated tumour necrosis factor receptor (TNFR) polypeptide capable of binding to TNF, or a TNF-binding fragment thereof, wherein the... |
| 2018/0215804 |
REDUCTION OF INFLAMMATORY DISEASE SYMPTOMS BY SHORT PEPTIDES THAT INHIBIT
SIGNALING THROUGH CD28 The present disclosure relates to a method for the treatment of a non-pathogen associated inflammatory disorders in a subject in need thereof, comprising... |
| 2018/0215803 |
DIAGNOSTIC AND THERAPEUTIC METHODS FOR EFMR (EPILEPSY AND MENTAL
RETARDATION LIMITED TO FEMALES) Methods and kits for the diagnosis of illnesses related to protocadherin 19 (PCDH19) protein deficiency or altered PCDH19 protein function are provided, as... |
| 2018/0215802 |
IDENTIFICATION OF NOVEL ANTI-FIBROTIC PEPTIDE IN C-TERMINAL REGION OF THE
MET RECEPTOR TYROSINE KINASE The invention provides anti-fibrotic peptides derived from the C-terminal region of the MET receptor tyrosine kinase. Polynucleotides encoding these peptides,... |
| 2018/0215801 |
CRYPTIC POLYPEPTIDES AND USES THEREOF The disclosure features, among other things, polypeptides comprising a Cryptic polypeptide, a functional fragment thereof, or variants of any of the foregoing.... |
| 2018/0215800 |
DOMINANT POSITIVE hnRNP-E1 POLYPEPTIDE COMPOSITIONS AND METHODS Described herein are compositions relating to engineered hnRNP-E1 variant polypeptides, nucleic acids encoding such polypeptides, engineered hnRNP-E1... |
| 2018/0215799 |
METHODS FOR TREATING PSYCHIATRIC DISORDERS OR SYMPTOMS THEREOF USING NCAM
PEPTIDE MIMETICS The present invention provides methods for treating or alleviating one or more symptoms of depression and/or anxiety in a subject comprising administering an... |
| 2018/0215798 |
Transgenic Plants with Enhanced Traits This disclosure provides plants having enhanced traits such as increased yield, increased nitrogen use efficiency and increased water use efficiency;... |
| 2018/0215797 |
Regulatory Protein Deficient Trichoderma Cells and Methods of Use Thereof The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells. |
| 2018/0215796 |
ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY BINDING CAPACITY IN
ACIDIC pH REGION A protein includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence includes a... |
| 2018/0215795 |
ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY-BINDING CAPACITY IN
ACIDIC pH REGIONS A protein includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence includes a... |
| 2018/0215794 |
TREATING CANCER WITH VIRAL NUCLEIC ACID This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal.... |
| 2018/0215793 |
Virus-Like Particle The present invention relates to a piscine myocarditis virus (PMCV) virus-like particle (VLP) which consists only of PMCV ORF1 protein. |
| 2018/0215792 |
TWO-DIMENSIONAL STRUCTURES FROM PEPTOID OLIGOMERS AND METHODS OF MAKING Materials and methods for forming self-assembled peptoid structures that are extremely stable, crystalline, free-standing and self-repairing are described.... |
| 2018/0215791 |
CONJUGATES THAT ARE CONFIGURED FOR TARGETED DELIVERY OF THERAPEUTIC
COMPOUNDS TO SENESCENT CELLS Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of... |
| 2018/0215790 |
METHOD OF TREATING MELANOCORTIN-4 RECEPTOR PATHWAY-ASSOCIATED DISORDERS The disclosure is related to a method of treating a disorder, such as obesity or a condition associated with obesity, such as hyperphagia, in a subject using a... |
| 2018/0215789 |
Concurrent Chemotherapy and Immunotherapy The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia... |
| 2018/0215788 |
Compounds and Compositions for the Treatment of Ophthalmic Disorders Described herein are methods and compositions featuring a first compound that is a linear peptidic NPR-B agonist and a second compound that is a prostaglandin... |
| 2018/0215787 |
Chromogenic And Fluorogenic Peptide Substrates For The Detection Of Serine
Protease Activity The present invention relates to chromogenic and fluorogenic substrates that can be used for the highly sensitive and selective detection of the activity of... |
| 2018/0215786 |
REMOVAL OF PROTEIN AGGREGATES FROM BIOPHARMACEUTICAL PREPARATIONS IN A
FLOW-THROUGH MODE The present invention provides novel compositions and methods for removal of protein aggregates from a sample in a flow-through mode. |
| 2018/0215785 |
METHOD FOR PURIFYING ANTIBODY-LIKE PROTEIN A method for purifying an antibody-like protein includes adsorbing an antibody-like protein onto an affinity separation matrix by bringing the antibody-like... |
| 2018/0215784 |
METHOD FOR PREPARATION OF N-ACYL PEPTIDES, POLYPEPTIDES AND PROTEINS A method is provided for the preparation of an N-acyl peptide, N-acyl polypeptide or N-acyl protein comprising reacting a peptide, polypeptide or protein with... |
| 2018/0215783 |
BIOORTHOGONAL REACTION OF AN AMINE N-OXIDE AND A BORON AGENT Methods for chemoselective modification of a target molecule comprising an amine N-oxide in a biological sample are provided. Aspects of the methods include... |
| 2018/0215782 |
PEPTIDE SYNTHESIS METHOD The present invention has an object of providing a peptide synthesis method using a carrier capable of reversibly repeating the dissolved state and the... |
| 2018/0215781 |
BETUIN DERIVATIVES FOR PREVENTING OR TREATING HIV INFECTIONS The present invention relates to compounds characterized by having a structure according to the following Formula I: ##STR00001## or a pharmaceutically... |
| 2018/0215780 |
C-3 NOVEL TRITERPENONE WITH C-28 REVERSE AMIDE DERIVATIVES AS HIV
INHIBITORS Formula (I) The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for... |
| 2018/0215779 |
NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF Described herein are neuroactive steroids of the Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof; wherein R.sup.1a and R.sup.1b are as... |
| 2018/0215778 |
METHOD FOR PREPARING SUBSTITUTED 3,7-DIHYDROXY STEROIDS The invention relates to a 17.alpha.-alkynyl-androst-5-ene-3.beta.,7.beta.,17.beta.-triol compound essentially free of steroid side-product lacking an oxygen... |
| 2018/0215777 |
COMPLEXES FOR INTRACELLULAR IMAGING The present disclosure relates to complexes for intracellular imaging and also to methods and kits for intracellular imaging or cell labelling. Certain... |
| 2018/0215776 |
NUCLEOTIDE HEMI-SULFATE SALT FOR THE TREATMENT OF HEPATITIS C VIRUS A hemi-sulfate salt of the structure: ##STR00001## to treat a host infected with hepatitis C, as well as pharmaceutical compositions and dosage forms,... |
| 2018/0215775 |
PHARMACEUTICAL COMPOSITION FOR USE IN INHIBITING RECURRENCE, AGGRAVATION
AND METASTASIS OF HEPATOCARCINOMA The present application provides a pharmaceutical composition for use in inhibiting recurrence, aggravation or metastasis of liver cancer, in which the... |
| 2018/0215774 |
Low Temperature and Efficient Fractionation of Lignocellulosic Biomass
Using Recyclable Organic Solid Acids Methods of fractionating lignocellulosic biomass using hydrotropic sulfonic acids are provided. Also provided are methods of forming lignin particles, furans,... |
| 2018/0215773 |
HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic... |
| 2018/0215772 |
CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS Inhibitor compounds are disclosed. The compounds are effective in the treatment of diseases or conditions in which interleukin 1 .beta. activity is implicated.... |
| 2018/0215771 |
TUNABLE RARE-EARTH FCU-METAL-ORGANIC FRAMEWORKS Metal organic framework compositions can have a face centered cubic structure. |
| 2018/0215770 |
IMIDAZO-OXADIAZOLE AND IMIDAZO-THIADIAZOLE DERIVATIVES The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases. ##STR00001## |
| 2018/0215769 |
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ... |
| 2018/0215768 |
ASYMMETRIC PROCESS FOR THE PREPARATION OF THIENO-INDOLES DERIVATIVES The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (Ia) or (Ib), exploiting an asymmetric synthesis for... |
| 2018/0215767 |
SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of... |
| 2018/0215766 |
TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases,... |
| 2018/0215765 |
NEW BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORS The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, Y, W, m, n, p and q are as defined herein, ... |
| 2018/0215764 |
INDAZOLONES AS MODULATORS OF TNF SIGNALING The disclosure provides compounds of Formula (I) ##STR00001## pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and... |
| 2018/0215763 |
COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR Disclosed are compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof,... |
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