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Patent # Description
2018/0222956 METHODS FOR TREATING MYELOPROLIFERATIVE DISORDERS
In part, the present disclosure relates methods for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera,...
2018/0222955 GENE THERAPY FOR DIABETIC NEUROPATHY USING AN HGF ISOFORM
The present invention relates to a pharmaceutical composition for the prevention or treatment of diabetic neuropathy, wherein the pharmaceutical composition...
2018/0222954 NEIL3 PEPTIDES AND VACCINES INCLUDING THE SAME
The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes...
2018/0222953 SARCOMERE BIOSENSOR AND METHODS OF USE THEREOF
Certain embodiments of the invention provide a polypeptide comprising: (a) an amino acid sequence encoding a first chromophore; (b) a first linker; (c) an...
2018/0222952 PROGRANULIN (PGRN) FRAGMENTS AND DERIVATIVES FOR TREATMENT OR ALLEVIATION OF LYSOSOMAL STORAGE DISEASES
The present invention provides peptides, compositions and methods for treatment and alleviation of lysosomal storage diseases and their diagnosis and...
2018/0222951 BRACHYURY DELETION MUTANTS, NON-YEAST VECTORS ENCODING BRACHYURY DELETION MUTANTS, AND THEIR USE
The invention provides Brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids,...
2018/0222950 LIGHT ACTIVATED PHOTOREACTION VIA GENETIC HYBRIDIZATION OF FAR-RED FLUORESCENT PROTEIN AND SILK
A method of disinfection of a surface of a subject of harmful microorganisms including pathogenic bacteria and viruses upon visible light irradiation using a...
2018/0222949 FUNCTIONALIZED PROTEIN-BASED MATERIALS AND THEIR USES
Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx...
2018/0222948 WHEAT PROTEIN ISOLATES AND PROCESSES FOR PRODUCING
Isolated wheat proteins that are substantially free of additives, processing aids, added acids, buffers, reagents, or added enzymes and compositions formed...
2018/0222947 PLANT DERIVED INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2018/0222946 FUSION PROTEINS AND COMBINATION VACCINES COMPRISING HAEMOPHILUS INFLUENZAE PROTEIN E AND PILIN A
The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to...
2018/0222945 MICROORGANISMS WITH BROADENED LIGHT ABSORPTION CAPABILITY AND INCREASED PHOTOSYNTHETIC ACTIVITY
Photosynthetic microorganisms with broadened light absorption capability and increased photosynthetic activity are described. Broadened light absorption is...
2018/0222944 EPITOPE FOCUSING BY VARIABLE EFFECTIVE ANTIGEN SURFACE CONCENTRATION
The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope...
2018/0222943 ANTIMICROBIAL PEPTIDE FOR NOSOCOMIAL INFECTIONS
A novel antimicrobial peptide is provided having an inhibitory effect on biofilms produced by biofilm-forming bacteria. The peptide is effective against wide...
2018/0222942 HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to...
2018/0222941 DEPDC1-DERIVED PEPTIDE AND VACCINE CONTAINING SAME
The present invention provides DEPDC1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides...
2018/0222940 MU OPIOID RECEPTOR AGONIST ANALOGS OF THE ENDOMORPHINS
The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain....
2018/0222939 AFFINITY SUPPORT AND METHOD FOR ISOLATING IMMUNOGLOBULIN
To provide an affinity support in which a binding property of a ligand to a target substance is improved. The affinity support contains a solid phase support...
2018/0222938 PURIFICATION OF PROTEINS USING HYDROPHOBIC INTERACTION CHROMATOGRAPHY
The present invention is directed to methods for purifying a protein of interest, e.g., an antibody, from a sample comprising the protein of interest and at...
2018/0222937 METHODS FOR PREPARATION OF BILE ACIDS AND DERIVATIVES THEREOF
The present application relates to a method of preparing compounds of Formula (A) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate...
2018/0222936 METHODS FOR THE SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters...
2018/0222935 RECOVERY OF STEVIOL GLYCOSIDES
The present invention relates a process for the recovery of one or more steviol glycosides from a steviol glycoside-containing fermentation broth, which method...
2018/0222934 DECOLORIZATION OF CONCENTRATED RHAMNOLIPID COMPOSITION
Provided is a method for decolorizing and optionally neutralizing a rhamnolipid composition comprising treating said composition with a percarbonate salt as...
2018/0222933 INHERENTLY SELECTIVE PRECURSORS FOR DEPOSITION OF SECOND OR THIRD ROW TRANSITION METAL THIN FILMS
Inherently selective precursors for deposition of second or third row transition metal (e.g., tungsten or ruthenium) thin films are described. In an example, a...
2018/0222932 CHIRAL REAGENTS FOR PREPARATION OF HOMOGENEOUS OLIGOMERS
We provide diastereomerically pure or substantially diastereomerically pure activated phosphoramidochloridate morpholino nucleosides, methods of their...
2018/0222931 STAT6 INHIBITORS
The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods...
2018/0222930 PRODRUGS OF GLUTAMINE ANALOGS
The disclosure provides compounds having formula (I): ##STR00001## and the pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2, R.sub.2', and X...
2018/0222929 PHOTOINITIATORS FUNCTIONED AS BOTH INITIATORS AND NANOFILLERS
This invention relates to a photoinitiator compound comprising: a polyhedral oligomeric silsesquioxane (POSS) moiety and a photoinitiator moiety, wherein the...
2018/0222928 FLUORINATED CYCLOALKENE FUNCTIONALIZED SILICAS
Fluorinated cyclopentene moieties and fluorinated cyclopentene functionalized silica materials are provided. The fluorinated cyclopentene functionalized silica...
2018/0222927 ALKOXYSILANE COMPOUND OR SALT THEREOF, PREPARATION METHOD THEREFOR, AND HAIR COMPOSITION CONTAINING SAME
The present invention relates to an alkoxysilane salt compound having a novel structure, a preparation method therefor, and a hair composition containing the...
2018/0222926 COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY
The disclosure relates to a novel class of compounds that exhibit activity inhibitory activity toward arginase, and pharmaceutical compositions comprising the...
2018/0222925 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts...
2018/0222924 ENERGY STORAGE MOLECULAR MATERIAL, CRYSTAL DIELECTRIC LAYER AND CAPACITOR
The present disclosure provides an energy storage molecular material, crystal dielectric layer and capacitor which may solve a problem of the further increase...
2018/0222923 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B] PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a ...
2018/0222922 RADIOFLUORINATED 7-AMINO-5-THIO-THIAZOLO[4,5-D]PYRIMIDINES FOR IMAGING FRACTALKINE RECEPTOR (CX3CR1)
Radiofluorinated 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines targeting Fractalkine Receptor (CX.sub.3CR1) are disclosed. Methods of imaging ...
2018/0222921 HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS
The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related...
2018/0222920 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS
The present disclosure relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the...
2018/0222919 N-ALKYL-2-PHENOXYETHANAMINES, THEIR PREPARATION AND USE
The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen,...
2018/0222918 DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY
The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine...
2018/0222917 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA
The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.
2018/0222916 FUNCTIONALIZED NANOLUC INHIBITORS
Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds, and methods of using the...
2018/0222915 MODIFIED CYTOTOXINS AND THEIR THERAPEUTIC USE
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are...
2018/0222914 PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpha]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
2018/0222913 PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpha]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
2018/0222912 PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF
A pyrrole six-membered heteroaryl ring derivative, and the medicinal uses thereof are described. Specifically, the pyrrole six-membered heteroaryl ring...
2018/0222911 COMPOUNDS
A compound of Formula (I), or a salt thereof, ##STR00001## compositions comprising the compound, processes for its preparation and its use in therapy, for...
2018/0222910 COMPOUND FOR ORGANIC ELECTRICAL ELEMENT, ORGANIC ELECTRICAL ELEMENT USING COMPOUND, AND ELECTRONIC DEVICE THEREFOR
Provided is a novel compound capable of improving the light emitting efficiency, stability and life span of a device, and an organic electric element and an...
2018/0222909 PROCESS FOR THE PREPARATION OF IBRUTINIB AND NEW SYNTHESIS INTERMEDIATE
Subject-matter of the invention is a process for the preparation of ibrutinib and intermediate compound.
2018/0222908 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
2018/0222907 MACROCYCLIC FACTOR XIA INHIBITORS BEARING HETEROCYCLIC GROUPS
The present invention provides compounds of Formula (Ia): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the...
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