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Patent # Description
2018/0221489 ABSORPTION ENHANCERS FOR DRUG ADMINISTRATION
The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at...
2018/0221488 ANTIBODY FORMULATIONS
The present application describes antibody formulations, including monoclonal antibodies formulated in histidine-acetate buffer, as well as a formulation...
2018/0221487 NOVEL PROTEIN TRANSFECTION COMPOSITIONS AND USES THEREOF
The present invention provides novel protein transfection kits comprising protein transfection compositions, wherein the protein transfection composition...
2018/0221486 FILM-FORMING COMPOSITIONS BASED ON STARCHY MATERIAL AND ARTICLES OBTAINED THEREOF
The instant invention relates to new film-forming compositions based on starchy material, comprising isosorbide. The instant invention also relates to products...
2018/0221485 LIQUID PHARMACEUTICAL COMPOSITION FOR THE DELIVERY OF ACTIVE INGREDIENTS
The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients....
2018/0221484 METHOD AND APPARATUS FOR CREATING STRUCTURED WATER BY EXPOSING WATER TRANSVERSAL AND LONGITUDINAL TO ULTRA- LOW...
An apparatus and method is provided for healing and regeneration of live human and animal bodies and influencing interaction and intercommunication at the...
2018/0221483 TIMED RELEASE OF SUBSTANCES TO TREAT OCULAR DISORDERS
A system is disclosed for simple, non-invasive, sustained delivery of ophthalmic substances to the interior of the eye, for the prevention and treatment of eye...
2018/0221482 USE OF ANTIBODIES AGAINST ICAM-1 IN COMBINATION WITH AN ANTI CANCER DRUG IN THE TREATMENT OF PATIENTS
There is provided antibodies or antigen-binding fragments thereof with binding specificity for ICAM-1, together with further anti-cancer agents, and...
2018/0221481 TREATMENT OF ADVANCED HER2 EXPRESSING CANCER
Methods for the treatment of patients with HER2-positive, HER2-amplified and/or HER2-mutated advanced cancer by administration of pertuzumab plus trastuzumab...
2018/0221480 ANTI-VLA-4 ANTIBODIES
This invention relates to alpha-4 binding antibodies, and fragments thereof.
2018/0221479 AGENTS FOR USE IN THE TREATMENT OF GLIOMA
The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO IF and 111.degree., as well as IV0 (glioblastoma), in...
2018/0221478 TREATMENT OF PATIENTS DIAGNOSED WITH PANCREATIC DUCTAL ADENOCARCINOMA USING USING MONOCLONAL ANTIBODIES AGAINST...
The present disclosure relates to the field of immunotherapy of cancer, in particular pancreatic ductal adenocarcinoma (PDAC). Means and methods for treatment...
2018/0221477 TREATMENT OF CANCER WITH THERAPEUTIC MONOCLONAL ANTIBODY SPECIFIC FOR A TUMOR ASSOCIATED ANTIGEN AND AN IMMUNE...
The present document describes a method of inhibiting cancer tumor growth in a patient in need thereof, comprising at least a first treatment comprising steps...
2018/0221476 TREATMENT OF CANCER WITH THERAPEUTIC MONOCLONAL ANTIBODY SPECIFIC FOR A TUMOR ASSOCIATED ANTIGEN AND AN IMMUNE...
The present document describes a method of inhibiting cancer tumor growth in a patient in need thereof, comprising at least a first treatment comprising steps...
2018/0221475 METHODS TO ALTER THE TUMOR MICROENVIRONMENT FOR EFFECTIVE CANCER IMMUNOTHERAPY
Methods and compositions for altering the microenvironment of a tumor are provided. The methods comprise reducing the population of tumor-residing immune...
2018/0221474 IMMUNE MOTIFS IN PRODUCTS FROM DOMESTIC ANIMALS
The present invention provides a means to prepare a product from domestic animal milk, blood or eggs which comprises an array of T-cell exposed motifs similar...
2018/0221473 TREATMENT WITH ANTI-VEGF ANTIBODIES
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the...
2018/0221472 BENZAMIDE AND ACTIVE COMPOUND COMPOSITIONS AND METHODS OF USE
The present invention describes compositions, including pharmaceutical compositions, comprising a PD-1 axis binding antagonist, a CTLA4 antagonist, or a DNA...
2018/0221471 MONOVALENT ANTI-CD3 ADJUVANTS
This document provides methods and materials related to using monovalent anti-CD3 antibodies (e.g., monovalent anti-CD3 Fab fragments) as adjuvants to increase...
2018/0221470 VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery...
2018/0221469 USE OF A GENETICALLY MODIFIED INFECTIOUS MEASLES VIRUS WITH ENHANCED PRO-APOPTOTIC PROPERTIES (MV-DELTAC VIRUS)...
The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the...
2018/0221468 HAEMOPHILUS INFLUENZAE IMMUNOGEN
The present invention provides immunogens which can be used for vaccines against non-typeable Haemophilus influenzae (NTHi). The protein targeted is NTHi PDE1...
2018/0221467 GLYCOCONJUGATION PROCESSES AND COMPOSITIONS
The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ...
2018/0221466 USE OF ALPHA-TOXIN FOR TREATING AND PREVENTING STAPHYLOCOCCUS INFECTIONS
Vaccines comprising an S. aureus alpha-toxin antigen and a pharmaceutically acceptable carrier are provided, and are useful for treating and preventing...
2018/0221465 ANTI-MALARIA COMPOSITIONS AND METHODS
Described herein are multilayer films that include modified polypeptide epitopes from Plasmodium falciparum, specifically a modified T* epitope. The multilayer...
2018/0221464 IMMUNOGENIC COMPOSITIONS, ANTIGEN SCREENING METHODS, AND METHODS OF GENERATING IMMUNE RESPONSES
An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses...
2018/0221463 Modified NK Cells and Uses Thereof
The present invention provides for modified natural killer (NK) cells that are resistant to TGF-.beta. stimulation due to suppressed Smad3 activity in these...
2018/0221462 USE OF ELAFIN FOR DISORDERS ASSOCIATED WITH ELASTASE INDEPENDENT INCREASE IN TROPONIN
The present invention relates to the use of elafin for the treatment and/or prevention of diseases or disorders associated with an increase in troponin levels,...
2018/0221461 CARBAPENEMASES FOR USE WITH ANTIBIOTICS FOR THE PROTECTION OF THE INTESTINAL MICROBIOME
This invention relates, in part, to various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
2018/0221460 TREATMENT OF MAMMALIAN PHYSIOLOGICAL REACTION OF IGE ANTIBODIES PRESENT IN SAID MAMMAL UPON CONTACT WITH THE...
A method is disclosed for blocking or reducing a physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact...
2018/0221458 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A method of treating a subject having or at risk for having an HIV-1 virus infection, by administering to the subject a therapeutically effective amount of a...
2018/0221457 GLYCEROL-3-PHOSPHATE PHOSPHATASE ACTIVATORS
The present disclosure relates to the identification and the use of activators of a mammalian glycerol-3-phosphate phosphatase (hG3PP) for increasing Gro3P...
2018/0221456 BACTERIOPHAGE LYSIN AND ANTIBIOTIC COMBINATIONS AGAINST GRAM POSITIVE BACTERIA
The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal...
2018/0221455 SAPOSIN B BINDS THE LIPOFUSCIN BISRETINOID A2E AND PREVENTS ITS ENZYMATIC AND PHOTO DEGRADATION
Disclosed herein are methods and compositions useful in the treatment and/or prevention of a disease or indication associated with accumulation of a...
2018/0221454 THIOREDOXIN, THIOREDOXIN PEPTIDES OR DERIVATIVES FOR TREATMENT OF AGE-RELATED HYPERTENSION
The incidence of high blood pressure is strikingly high with advancing age, and is an independent prognostic factor for the onset or progression of a variety...
2018/0221453 Articular Cartilage Mimetics
A scaffold for promoting cartilage formation is provided that includes a crosslinked electrospun fiber, wherein the crosslinked electrospun fiber consists...
2018/0221452 THERAPEUTIC AGENT PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG...
Embodiment of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many...
2018/0221451 LONG ACTING LIRAGLUTIDE COMPOSITIONS
The present invention relates to a composition comprising particles, wherein said particles comprise Poly(lactide-co-glycolide) polymer, therapeutically...
2018/0221450 Formulation Comprising A Stabilized Complex Of Corticotropin Releasing Hormone And Alpha-2 Macroglobulin
The present invention relates to a CRH formulation having improved stability/efficacy. The improved CRH formulation is particularly suitable for treatment of...
2018/0221449 Compositions for Changing Body Composition, Methods of Use, and Methods of Treatment
The present disclosure provides compositions including an amylin receptor agonist and a beta-2-adreno-receptor agonist (e.g., an anti-hyperglycemia agent),...
2018/0221448 NOVEL POLYPEPTIDE HAVING CHEMOKINE ACTIVITY
The present invention relates to a novel polypeptide having chemokine activity and, more specifically, to a polypeptide composed of the amino acid sequence...
2018/0221447 COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION
In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate...
2018/0221446 Angiogenically Effective Unit Dose Of FGF And Method Of Administering
The present invention provides a unit dose comprising 0.2 .mu.g/kg to 36 .mu.g/kg of a recombinant FGF or an angiogenically active fragment or mutein thereof....
2018/0221445 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR IMPROVING WOUND HEALING USING CD24
Provided are methods of improving wound healing in a subject by administering a therapeutically effective amount of CD24. Also provided are pharmaceutical...
2018/0221444 APPLICATIONS OF MUSSEL ADHESIVE PROTEIN PRODUCT IN TREATMENT AND PREVENTION OF DISEASES RELATED TO MELANIN
Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically...
2018/0221443 USE OF HUMAN SMALL LEUCINE ZIPPER PROTEIN IN OSTEOGENESIS PROCEDURE
The present invention relates to a use of a human small leucine zipper protein in the osteogenesis procedure. More specifically, sLZIP increases the...
2018/0221442 INHIBITION OF BONE LOSS AND INHIBITION OF ARTHRITIS BY CTHRC1
The invention features compositions and methods for inhibiting bone loss and arthritis.
2018/0221441 METHOD FOR IDENTIFYING, EXPANDING, AND REMOVING ADULT STEM CELLS AND CANCER STEM CELLS
The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the...
2018/0221440 METHOD OF TREATING RESPIRATORY DISORDERS
The invention relates to the use of agents that bind the complement protein C5 in the treatment of diseases associated with inappropriate complement...
2018/0221439 ANTIMICROBIAL FUSION PEPTIDES
Antimicrobial peptides, compositions and methods are described that are useful for treating infectious diseases, including those caused by drug resistant...
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