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Patent # Description
2018/0221388 NON-IRRITATING TESTOSTERONE EMULSIONS
Disclosed herein are emulsions comprising testosterone or related androgens, castor oil, cyclodextrin, Pemulen TR-2, Polyoxyl 40, and other ingredients. The...
2018/0221387 COMPOSITION AND METHOD FOR ORAL DELIVERY OF ANDROGEN PRODRUGS
Provided oral testosterone undecanoate compositions can be administered to hypogonadal males with a meal without the fat content of the meal substantially...
2018/0221386 METHOD FOR VISUAL ENHANCEMENT AND POST PROCEDURE TREATMENT PROTOCOL
A new and novel method for determining post procedural treatment is disclosed herein. In one embodiment, the method includes the steps of: determining a depth...
2018/0221385 A PHARMACEUTICAL PREPARATION FOR IMPROVING ABSORPTION AND POSTPRANDIAL HYPOGLYCEMIC ACTION OF INSULIN
The present disclosure relates to compositions and combinations comprising one or more insulin(s) and one or more vasoactive agent(s), and use thereof for...
2018/0221384 COMPOSITIONS OF MIDAZOLAM FOR BUCCAL ADMINISTRATION IN THE TREATMENT OF SEIZURES TO OBTAIN RAPID ONSET OF ACTION
The present invention relates to a unit dosage composition in the form of a film or a water containing from 0.25 mg to 2 mg of midazolam or a pharmaceutically...
2018/0221383 Transnasal Anticonvulsive Pharmaceutical Composition Comprising Poorly Soluble Anticonvulsant
There is provided a transnasal anticonvulsive pharmaceutical composition including a poorly soluble anticonvulsant. The anticonvulsive pharmaceutical...
2018/0221382 INHIBITION OF MK2 IN THE TREATMENT OF CANCER
The present invention relates to the discovery that MK2 is highly expressed in cancer tissue and the inhibition of MK2 using an MK2 inhibitor represents a...
2018/0221381 Combined Inhibition Of The Vitamin D Receptor And Poly(ADP) Ribose Polymerase (PARP) In The Treatment Of Cancer
Methods for treating tumors comprise contacting tumor cells expressing the vitamin D receptor with a vitamin D receptor ligand that inhibits homologous...
2018/0221380 Use of 5H-Dibenz/b,f/Azepine-5-Carboxamide Derivatives for Treating Fibromyalgia
The use of 5H-dibenz/b,f/azepine-5-carboxamide derivatives for treating fibromyalgia. Useful 5H-dibenz/b,f/azepine-5-carboxamide derivatives include compounds...
2018/0221379 USES OF SALT-INDUCIBLE KINASE (SIK) INHIBITORS
The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using...
2018/0221378 TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY
This invention is in the area of improved compounds, compositions and methods of transiently protecting healthy cells, and in particular hematopoietic stem and...
2018/0221377 METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS
The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A.sub.2A receptor...
2018/0221376 Methods for treating cancer using HSP90 inhibitors
The disclosure also provides compositions and methods related to combination therapy with HSP90 inhibitors and BCL-2 pathway inhibitors for treating cancer....
2018/0221375 IMIPRIDONES FOR GLIOMAS
Imipridones selectively modulate Class A G protein-coupled receptors (GPCRs), such as the D2-like subfamily of dopamine receptors, and are useful for treating...
2018/0221374 DEUTERATED BARICITINIB
The present invention in one embodiment provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the variables shown...
2018/0221373 METHOD OF TREATING INSOMNIA
Methods for treating insomnia are disclosed. The methods are directed to administering a pharmaceutically effective amount of phosphodiesterase 5 (PDE5)...
2018/0221372 VITAMIN RECEPTOR DRUG DELIVERY CONJUGATES FOR TREATING INFLAMMATION
Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing...
2018/0221371 TREATMENT FOR THE FETUS WITH CONGENITAL HEART DISEASE
A method for treating injury or insult to the brain or nervous system caused by or associated with hypoxia, especially hypoxia associated with injury or insult...
2018/0221370 COMBINATION THERAPY
Reversing resistance to a B-Raf inhibitor for the treatment of a proliferative disease by obtaining a tumor sample from the patient and testing it for genetic...
2018/0221369 COMPOSITIONS AND METHODS FOR TREATING FIBROSING DISORDERS AND CANCER
The invention provides methods for treating fibrosis, chronic inflammation, chronic pancreatitis, cancer or inflammatory myofibroblastic tumors (IMTs) in a...
2018/0221368 SUBSTITUTED BENZOXAZEPINE FOR CANCER THERAPY
Implementations of the present invention include a compound and methods for inhibiting karyopherin beta 1 activity by administering to a patient in need...
2018/0221367 COMPOUNDS AND THEIR USE AS BACE INHIBITORS
The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic...
2018/0221365 NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases...
2018/0221364 METALLOENZYME INHIBITOR COMPOUNDS
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by...
2018/0221363 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases...
2018/0221362 EZH2 INHIBITORS AND MODULATION OF REGULATORY T-CELL FUNCTION
Provided herein are methods of treating cancers characterized by a high frequency of one or more suppressive immune cells, comprising administering a...
2018/0221361 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such...
2018/0221360 DOSE-DUMPING RESISTANT CONTROLLED RELEASE DOSAGE FORM
The present invention provides a simple and improved dosage form that provides a controlled release of methylphenidate contained in the core thereof. The...
2018/0221359 ADMINISTRATION OF ETHYL 3-[(2-{[4-(HEXYLOXYCARBONYL-AMINOIMINOMETHYL)PHENYL-AMINO]METHYL}-1-METHY- ...
The invention relates to a new administration form for the oral application of the active substance ethyl ...
2018/0221358 PHARMACEUTICAL COMPOSITIONS COMPRISING A LOCAL ANAESTHETIC SUCH AS BUPIVACAINE FOR LOCAL ADMINISTRATION TO THE...
The present invention relates to compositions comprising a lipophilic local anaesthetic, preferably bupivacaine or a pharmaceutically active salt thereof,...
2018/0221357 METHOD FOR THE TREATMENT OF POMPE DISEASE USING 1-DEOXYNOJIRIMYCIN DERIVATIVES
The present invention provides a method for increasing the activity of a mutant or wild-type .alpha.-glucosidase enzyme in vitro and in vivo by contacting the...
2018/0221356 METHOD OF WOUND HEALING
The present invention relates to a method of treating a wound, comprising administering to a subject in need thereof a therapeutically effective amount of an...
2018/0221355 USE OF GABOXADOL IN THE TREATMENT OF TINNITUS
Methods of treating tinnitus with gaboxadol or a pharmaceutically acceptable salt thereof are provided. Also provided are therapeutic compositions that may be...
2018/0221354 3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a ...
2018/0221353 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a ...
2018/0221352 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF
7-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0221351 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF
6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0221350 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole...
2018/0221349 THERAPEUTIC USE OF LEVOROTATORY SS-LACTAMS IN HEMATOPOIESIS, IMMUNO-ONCOLOGY THERAPY, AND REGULATION OF...
A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a...
2018/0221348 MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS
The present application provides for a compound of Formula I, ##STR00001## or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions...
2018/0221347 CFTR CORRECTOR FOR THE TREATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE
The present invention relates to the use of CFTR correctors in the treatment of genetic disorders affecting striated muscle selected from sarcoglycanopathies,...
2018/0221346 HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-.beta.) inhibitors thereby regulating angiogenesis. The...
2018/0221345 COMBINATION THERAPY OF HSP90 INHIBITORS WITH PLATINUM-CONTAINING AGENTS
A pharmaceutical combination comprising a platinum-containing anticancer agent, and an Hsp90 inhibitor according to the following formulae (I) & (Ia), a...
2018/0221344 CYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA
Disclosed are compounds of Formula (I) or a salt thereof, wherein: Ring A is 3- to 6-membered carbocyclic or heterocyclic ring; X is CR.sub.1 or N; Y is...
2018/0221343 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MACULAR DEGENERATION
The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted...
2018/0221342 HEPATITIS C VIRUS INHIBITORS
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function...
2018/0221341 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF
7-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0221340 METHODS AND COMPOSITIONS FOR DAILY OPHTHALMIC ADMINISTRATION OF PHENTOLAMINE TO IMPROVE VISUAL PERFORMANCE
The invention provides methods, compositions, and kits containing phentolamine for improving visual performance. In particular, the invention provides...
2018/0221339 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS
Disclosed herein are methods, compounds, and compositions that are useful for the diagnosis, treatment, or prevention of an ocular disorder, including in the...
2018/0221338 Topical Compositions Comprising Fipronil and Permethrin and Methods of Use
The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is...
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