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Patent # Description
2018/0228912 NOVEL IMMUNOGENIC PEPTIDES
The invention relates to isolated immunogenic peptides comprising a MHC class II T cell epitope, and immediately adjacent or separated from said epitope a...
2018/0228911 CROSS-LINKED STAR-SHAPED SELF-ASSEMBLED POLYPEPTIDES AND ITS USE AS CARRIERS IN BIOMEDICAL APPLICATIONS
The invention relates to 3-arms star-shaped polypeptides derivatives which are able to self-assemble to form bioresponsive nanometric globular structures with...
2018/0228910 COMPOUNDS CONTAINING A VASCULAR DISRUPTING AGENT
The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP...
2018/0228909 CCK2R-DRUG CONJUGATES
The disclosure provided herein pertains to CCK2R-drug conjugates. In particular, the disclosure pertains to CCK2R-drug conjugates that target the delivery of...
2018/0228908 GENETICALLY ENCODED INTRINSICALLY DISORDERED STEALTH POLYMERS FOR DELIVERY AND METHODS OF USING SAME
Provided herein are conjugates including a polypeptide and one or more drug molecules. The polypeptide includes one or more charged motifs, and may further...
2018/0228907 CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME
The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of...
2018/0228906 Saccharide Derivative of a Toxic Payload and Antibody Conjugates Thereof
A molecule comprising a saccharide bound via an O-glycosidic bond to a hydroxyl group of a toxic payload molecule is disclosed. An antibody-drug conjugate...
2018/0228905 COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a...
2018/0228904 FORMULATION FOR TOPICAL WOUND TREATMENT
The present invention relates to new formulations, particularly useful in the topical treatment of skin and orormucosal wounds. Formulations can be either a...
2018/0228903 COMPOSITIONS WITH PERMEATION ENHANCERS FOR DRUG DELIVERY
The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent...
2018/0228902 PHARMACEUTICAL COMPOSITION FOR ADMINISTRATION TO NASAL MUCOSA
The present invention is intended to provide a nose drop having high absorption of peptide hormone oxytocin or an acid addition salt thereof, or a derivative...
2018/0228901 CLEAR AQUEOUS SOLUTION
The present invention provides a stable and clear aqueous liquid preparation containing ...
2018/0228900 IMMUNOGENIC COMPOSITION OF KILLED LEPTOSPIRA BACTERIA
The present invention pertains to a composition containing an immunogenic cell preparation of killed Leptospira bacteria in an ethylenediaminetetraacetic acid...
2018/0228899 METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENTS
The present disclosure provides inter alia compositions that comprise therapeutic agents (e.g., live attenuated viral antigens, therapeutic proteins, etc.) and...
2018/0228898 CONVENIENTLY IMPLANTABLE SUSTAINED RELEASE DRUG COMPOSITIONS
This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for...
2018/0228897 Compositions for Vapor Phase Delivery of Active Compounds, Methods of Making and Using Same, and Kits...
Compositions for vapor phase delivery of one or more active compounds. The compositions comprise one or more polyol and one or more active compound....
2018/0228896 VASCULAR ULCER TREATMENT
A patch for treating vascular ulcers caused by excessive enzymatic activity may include a substrate configured to span a vascular ulcer as well as a linking...
2018/0228895 Subcutaneous anti-HER2 Antibody Formulations and Uses Thereof
The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g....
2018/0228894 INHIBITION OF CXCR4 SIGNALING IN CANCER IMMUNOTHERAPY
The inventions describes a method for increasing effector T cell accumulation in cancer cell-containing sites of a tumor, comprising administering to a subject...
2018/0228893 COMBINATIONS AND USES THEREOF
The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a phosphoinositide 3-kinase inhibitor for the treatment of...
2018/0228892 KAPPA MYELOMA ANTIGEN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
The present invention provides compositions and methods for treating KMA-expressing malignancies including chimeric antigen receptors (CARs) and T cells...
2018/0228891 COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about...
2018/0228890 CROSS-REACTIVE T CELL EPITOPES OF HIV, SIV, AND FIV FOR VACCINES IN HUMANS AND CATS
The subject invention concerns methods and materials for inducing an immune response in an animal or person against an immunodeficiency virus, such as HIV,...
2018/0228889 Heat Stable Liquid Rotavirus Vaccine
The invention is directed to an oral vaccine composed of a micronized freeze-dried rotavirus particle emulsion with buffering excipients in a non-aqueous...
2018/0228888 LIVE RECOMBINANT MEASLES-M2 VIRUS - ITS USE IN ELICITING IMMUNITY AGAINST INFLUENZA VIRUSES
The invention relates to an active ingredient which is a live attenuated recombinant measles virus expressing influenza A virus antigen(s) and to its use in...
2018/0228887 COMPOSITIONS, METHODS OF ADMINISTRATION AND USES FOR TRIVALENT DENGUE VIRUS FORMULATIONS
Embodiments of the present invention report compositions and methods for vaccinating a subject using trivalent dengue virus vaccine compositions. In some...
2018/0228886 USE OF A LINEAR B CELL EPITOPE OF NS1 PROTEIN TO TREAT DENGUE VIRUS
Disclosed herein are isolated flavivirus polypeptides comprising an amino acid sequence at least 75% identical to one of SEQ ID NOs: 1-11, or a nucleic acid...
2018/0228885 BACTERIAL AND VIRAL VACCINE STRATEGY
The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly...
2018/0228884 VACCINE CONTAINING INACTIVATED CELLS OF STAPHYLOCOCCUS AUREUS MIXED WITH LEUCOCIDIN
An immunogenic composition containing leucocidin M/F antigen and capable of imparting a toxin-neutralizing activity to a ruminant animal as a subject animal....
2018/0228883 Use of the Salmonella SPP Type III Secretion Proteins as a Protective Vaccination
Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization...
2018/0228882 FUSION MOLECULE BASED ON TAA VARIANT
This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer...
2018/0228881 DIPEPTIDYLPEPTIDASE 4 INHIBITION ENHANCES LYMPHOCYTE TRAFFICKING, IMPROVING BOTH NATURALLY OCCURRING TUMOR...
The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in...
2018/0228880 Materials and Methods for Eliciting Targeted Antibody Responses In Vivo
Methods for generating and identifying antibodies specifically binding target molecules expressed by cells embedded in a three-dimensional extracellular matrix...
2018/0228879 Factor IX Polypeptides and Methods of Use Thereof
The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX;...
2018/0228878 Factor IX Polypeptides and Methods of Use Thereof
The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX;...
2018/0228877 AUGMENTED ACID ALPHA-GLUCOSIDASE FOR THE TREATMENT OF POMPE DISEASE
A method for treating Pompe disease including administration of recombinant human acid .alpha.-glucosidase having optimal glycosylation with...
2018/0228876 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a...
2018/0228875 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A personalized method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus, by determining a nucleic...
2018/0228874 METHODS AND COMPOSITIONS FOR RNRA-GUIDED TREATMENT OF HIV INFECTION
A pharmaceutical composition for use in inactivating an HIV-1 proviral DNA integrated into the genome of a host cell latently infected with a retrovirus...
2018/0228873 MUSSEL ADHESIVE PROTEIN PRODUCT AND APPLICATIONS THEREOF IN SUPPRESSION OF SKIN INFLAMMATIONS
Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications...
2018/0228872 METHODS AND COMPOSITIONS RELATED TO LONG HALF-LIFE COAGULATION COMPLEXES
Disclosed herein are methods and compositions related to coagulation factor complexes comprising a coagulation factor; a fusion protein; and a modifying...
2018/0228871 METHODS FOR THE MOBILIZATION AND USE OF T-CELLS WITH ENHANCED RECONSTITUTION POTENTIAL AND LIFE-SPAN
The disclosure provides a new source of peripheral blood naive/memory stem cells (i.e. (T.sub.N)/T.sub.SCM/T.sub.CM) T-cells with enhanced reconstitution...
2018/0228870 Angiopoietin-Based Interventions for Treating Cerebral Malaria
The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise...
2018/0228869 TREATMENT OF STEROID-INDUCED HYPERGLYCEMIA WITH FIBROBLAST GROWTH FACTOR (FGF) 1 ANALOGS
Methods of using FGF1 analogs, such as FGF1 mutant proteins having an N-terminal deletion, point mutation(s), or combinations thereof, to reduce blood glucose...
2018/0228868 COMPOSITIONS AND METHODS FOR MODULATION OF DIETARY AND MICROBIAL EXPOSURE
Among the various aspects of the present disclosure is the provision of compositions and methods for modulation of dietary and microbial exposure. The present...
2018/0228867 COMPOSITIONS AND METHODS FOR TREATMENT OF GCASE RELATED DISEASE STATES
Disclosed are compositions and methods of treating a neurodegenerative disease in an individual. The methods disclose administration of an Integrin...
2018/0228866 COMPOSITIONS
The present invention relates to a formulation comprising an inhibitor of NFAT activation for use in treating or preventing undesirable effects, more...
2018/0228865 PEPTIDE FOR PREVENTING OR TREATING INFLAMMATORY DISEASES AND USE THEREOF
The present invention relates to a peptide for preventing or treating inflammatory diseases and a use thereof. According to the novel dimeric peptide according...
2018/0228864 METHODS FOR THE PREVENTION OR TREATMENT OF VESSEL OCCLUSION INJURY
This invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods comprise administering to the...
2018/0228863 COMPOSITION AND METHOD FOR TREATMENT OF METABOLIC DISORDERS
The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are...
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